PT1038522E - Derivados enantiomericos anticonvulsivos de aminoacidos - Google Patents
Derivados enantiomericos anticonvulsivos de aminoacidosInfo
- Publication number
- PT1038522E PT1038522E PT00109377T PT00109377T PT1038522E PT 1038522 E PT1038522 E PT 1038522E PT 00109377 T PT00109377 T PT 00109377T PT 00109377 T PT00109377 T PT 00109377T PT 1038522 E PT1038522 E PT 1038522E
- Authority
- PT
- Portugal
- Prior art keywords
- anticonvulsives
- amino acids
- enantiomeric derivatives
- animal
- enantiomeric
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1352296P | 1996-03-15 | 1996-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1038522E true PT1038522E (pt) | 2004-10-29 |
Family
ID=21760388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00109377T PT1038522E (pt) | 1996-03-15 | 1997-03-17 | Derivados enantiomericos anticonvulsivos de aminoacidos |
| PT97916897T PT888289E (pt) | 1996-03-15 | 1997-03-17 | Derivados enantiomericos de aminoacidos anticonvulsivos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97916897T PT888289E (pt) | 1996-03-15 | 1997-03-17 | Derivados enantiomericos de aminoacidos anticonvulsivos |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP1038522B1 (https=) |
| JP (1) | JP3145414B2 (https=) |
| AT (2) | ATE268169T1 (https=) |
| AU (1) | AU718577B2 (https=) |
| CA (1) | CA2248317C (https=) |
| DE (3) | DE69729392T2 (https=) |
| DK (2) | DK1038522T3 (https=) |
| ES (2) | ES2218024T3 (https=) |
| FR (1) | FR09C0006I2 (https=) |
| NL (1) | NL300376I1 (https=) |
| PT (2) | PT1038522E (https=) |
| WO (1) | WO1997033861A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048899A (en) * | 1997-03-17 | 2000-04-11 | Research Corporation Tech., Inc. | Anticonvulsant enantiomeric amino acid derivatives |
| EP1642889A1 (en) * | 2004-10-02 | 2006-04-05 | Schwarz Pharma Ag | Improved synthesis scheme for lacosamide |
| EP1873527A1 (en) | 2006-06-30 | 2008-01-02 | Schwarz Pharma Ag | Method for identifying CRMP modulators |
| US8093426B2 (en) * | 2007-12-04 | 2012-01-10 | Ranbaxy Laboratories Limited | Intermediate compounds and their use in preparation of lacosamide |
| DE102008059155A1 (de) | 2008-11-27 | 2010-06-02 | Ratiopharm Gmbh | Trockenverarbeitung und neue Formen von Lacosamid |
| WO2011015617A1 (en) | 2009-08-06 | 2011-02-10 | Medichem, S.A. | Solid forms of an n-(phenylmethyl)propanamide derivative and processes of preparation |
| EP2480524A1 (en) * | 2009-09-25 | 2012-08-01 | Cadila Healthcare Limited | Processes for the preparation of lacosamide and intermediates thereof |
| IT1398044B1 (it) * | 2010-01-29 | 2013-02-07 | Archimica Srl | Processo per la preparazione della lacosamide |
| CA2788451A1 (en) | 2010-02-08 | 2011-08-11 | Natco Pharma Limited | A process for the preparation of lacosamide |
| US8907132B2 (en) | 2010-02-09 | 2014-12-09 | Msn Laboratories Private Limited | Process for preparing (R)-2-acetamido-N-benzyl-3-methoxy-propionamide |
| EP2399901A1 (en) | 2010-06-23 | 2011-12-28 | Archimica GmbH | Intermediate for producing lacosamide and a process for its preparation and conversion to lacosamide |
| EP2621893A1 (en) | 2010-10-01 | 2013-08-07 | UCB Pharma GmbH | Process for the preparation of amino acid derivatives |
| WO2012051551A1 (en) * | 2010-10-15 | 2012-04-19 | Nektar Therapeutics | N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides |
| HUE031138T2 (en) | 2010-10-19 | 2017-06-28 | Euticals Gmbh | A method of producing lacosamide |
| EP2468261A1 (en) | 2010-12-02 | 2012-06-27 | UCB Pharma GmbH | Formulation of lacosamide |
| BR112013013525A2 (pt) | 2010-12-02 | 2016-10-18 | Ucb Pharma Gmbh | formulação de liberação controlada sólida de lacosamida para administração oral, composição farmacêutica sólida, e, método para a prevenção, alívio e/ou tratamento de uma doença do sistema nervoso central |
| CN104771356A (zh) * | 2014-01-09 | 2015-07-15 | 山东方明药业集团股份有限公司 | 一种拉科酰胺注射液及其制备方法 |
| US11278634B1 (en) | 2021-02-12 | 2022-03-22 | Extrovis Ag | Stable parenteral composition of lacosamide |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378729A (en) * | 1985-02-15 | 1995-01-03 | Research Corporation Technologies, Inc. | Amino acid derivative anticonvulsant |
| ATE62222T1 (de) * | 1985-02-15 | 1991-04-15 | Res Corp Technologies Inc | Aminosaeure-derivate und ihre anwendung zur herstellung eines antikrampfmittels. |
-
1997
- 1997-03-17 WO PCT/US1997/004579 patent/WO1997033861A1/en not_active Ceased
- 1997-03-17 EP EP00109377A patent/EP1038522B1/en not_active Expired - Lifetime
- 1997-03-17 JP JP53292897A patent/JP3145414B2/ja not_active Expired - Lifetime
- 1997-03-17 DE DE69729392T patent/DE69729392T2/de not_active Expired - Lifetime
- 1997-03-17 ES ES00109377T patent/ES2218024T3/es not_active Expired - Lifetime
- 1997-03-17 AU AU25394/97A patent/AU718577B2/en not_active Expired
- 1997-03-17 ES ES97916897T patent/ES2157567T3/es not_active Expired - Lifetime
- 1997-03-17 DK DK00109377T patent/DK1038522T3/da active
- 1997-03-17 DE DE69705210T patent/DE69705210T2/de not_active Expired - Lifetime
- 1997-03-17 PT PT00109377T patent/PT1038522E/pt unknown
- 1997-03-17 DK DK97916897T patent/DK0888289T3/da active
- 1997-03-17 DE DE122009000010C patent/DE122009000010I2/de active Active
- 1997-03-17 AT AT00109377T patent/ATE268169T1/de active
- 1997-03-17 EP EP97916897A patent/EP0888289B1/en not_active Expired - Lifetime
- 1997-03-17 CA CA002248317A patent/CA2248317C/en not_active Expired - Lifetime
- 1997-03-17 PT PT97916897T patent/PT888289E/pt unknown
- 1997-03-17 AT AT97916897T patent/ATE202079T1/de active
-
2009
- 2009-02-16 NL NL300376C patent/NL300376I1/nl unknown
- 2009-02-26 FR FR09C0006C patent/FR09C0006I2/fr active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0888289A1 (en) | 1999-01-07 |
| ES2157567T3 (es) | 2001-08-16 |
| FR09C0006I2 (fr) | 2009-12-18 |
| CA2248317A1 (en) | 1997-09-18 |
| DE69705210T2 (de) | 2001-09-20 |
| DE122009000010I2 (de) | 2010-10-21 |
| ES2218024T3 (es) | 2004-11-16 |
| DE69705210D1 (de) | 2001-07-19 |
| EP0888289B1 (en) | 2001-06-13 |
| ATE268169T1 (de) | 2004-06-15 |
| NL300376I1 (nl) | 2009-05-06 |
| EP1038522B1 (en) | 2004-06-02 |
| EP1038522A3 (en) | 2003-01-15 |
| AU2539497A (en) | 1997-10-01 |
| CA2248317C (en) | 2003-12-02 |
| JP3145414B2 (ja) | 2001-03-12 |
| DE122009000010I1 (de) | 2009-05-20 |
| EP1038522A2 (en) | 2000-09-27 |
| FR09C0006I1 (https=) | 2009-04-17 |
| ATE202079T1 (de) | 2001-06-15 |
| DK0888289T3 (da) | 2001-09-03 |
| JP2000505476A (ja) | 2000-05-09 |
| DE69729392T2 (de) | 2005-06-02 |
| DE69729392D1 (de) | 2004-07-08 |
| AU718577B2 (en) | 2000-04-13 |
| WO1997033861A1 (en) | 1997-09-18 |
| DK1038522T3 (da) | 2004-10-11 |
| PT888289E (pt) | 2001-09-28 |
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