PT1026147E - Compostos uteis como intermediarios na producao de derivados de piperidina - Google Patents
Compostos uteis como intermediarios na producao de derivados de piperidinaInfo
- Publication number
- PT1026147E PT1026147E PT00200419T PT00200419T PT1026147E PT 1026147 E PT1026147 E PT 1026147E PT 00200419 T PT00200419 T PT 00200419T PT 00200419 T PT00200419 T PT 00200419T PT 1026147 E PT1026147 E PT 1026147E
- Authority
- PT
- Portugal
- Prior art keywords
- compounds
- uteric
- intermediaries
- production
- piperidine derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8310293A | 1993-06-24 | 1993-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1026147E true PT1026147E (pt) | 2004-04-30 |
Family
ID=22176189
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT00200419T PT1026147E (pt) | 1993-06-24 | 1994-06-21 | Compostos uteis como intermediarios na producao de derivados de piperidina |
| PT03077245T PT1369409E (pt) | 1993-06-24 | 1994-06-21 | Sais do acido boronico e sua utilizacao na preparacao de medicamentos para o tratamento da trombose |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03077245T PT1369409E (pt) | 1993-06-24 | 1994-06-21 | Sais do acido boronico e sua utilizacao na preparacao de medicamentos para o tratamento da trombose |
Country Status (16)
| Country | Link |
|---|---|
| US (9) | US5589487A (enFirst) |
| EP (4) | EP0703902B1 (enFirst) |
| JP (4) | JP3034047B2 (enFirst) |
| KR (2) | KR100387347B1 (enFirst) |
| AT (3) | ATE254594T1 (enFirst) |
| AU (1) | AU670004B2 (enFirst) |
| CA (1) | CA2147126C (enFirst) |
| DE (3) | DE69433346T2 (enFirst) |
| DK (3) | DK1026147T3 (enFirst) |
| ES (3) | ES2211444T3 (enFirst) |
| FI (1) | FI109691B (enFirst) |
| HU (1) | HU226559B1 (enFirst) |
| NO (2) | NO308599B1 (enFirst) |
| NZ (1) | NZ268513A (enFirst) |
| PT (2) | PT1026147E (enFirst) |
| WO (1) | WO1995000482A1 (enFirst) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994003170A1 (en) * | 1992-08-03 | 1994-02-17 | Sepracor Inc. | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
| US20020007068A1 (en) | 1999-07-16 | 2002-01-17 | D'ambra Thomas E. | Piperidine derivatives and process for their production |
| DK1026147T3 (da) | 1993-06-24 | 2004-03-22 | Albany Molecular Res Inc | Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater |
| HU226037B1 (en) | 1993-06-25 | 2008-03-28 | Aventis Inc | Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates |
| CA2585705C (en) * | 1994-05-18 | 2012-04-17 | Aventis Pharmaceuticals Inc. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
| US20030045722A1 (en) * | 1994-05-18 | 2003-03-06 | Henton Daniel R. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
| PT812195E (pt) * | 1995-02-28 | 2003-03-31 | Aventis Pharma Inc | Composicao farmaceutica para compostos de piperidinoalcanol |
| US6201124B1 (en) * | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US6153754A (en) | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US5925761A (en) * | 1997-02-04 | 1999-07-20 | Sepracor Inc. | Synthesis of terfenadine and derivatives |
| ZA985939B (en) | 1997-07-08 | 2000-01-10 | Aristocrat Leisure Ind Pty Ltd | Slot machine game and system with improved jackpot feature. |
| PT998272E (pt) * | 1997-08-26 | 2003-09-30 | Aventis Pharma Inc | Composicao farmaceutica para combinacao do descongestionante piperidinoalcanol |
| US6194431B1 (en) * | 1998-04-14 | 2001-02-27 | Paul D. Rubin | Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors |
| US6730791B2 (en) | 1998-07-02 | 2004-05-04 | Aventis Pharmaceuticals Inc. | Antihistaminic piperidine derivatives and intermediates for the preparation thereof |
| US6683094B2 (en) | 1998-07-02 | 2004-01-27 | Aventis Pharmaceuticals Inc. | Antihistaminic piperidine derivatives and intermediates for the preparation thereof |
| AU2007200674C1 (en) * | 1998-07-02 | 2011-02-24 | Aventisub Llc | Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof |
| DK1091938T3 (da) * | 1998-07-02 | 2011-02-07 | Aventisub Ii Inc | Antihistamin piperidinderivativer og mellemprodukter til fremstilling af disse |
| US6362375B1 (en) | 1999-12-03 | 2002-03-26 | College Of The Holy Cross | Process for the preparation of aryl ketones generating reduced amounts of toxic byproducts |
| US6613906B1 (en) | 2000-06-06 | 2003-09-02 | Geneva Pharmaceuticals, Inc. | Crystal modification |
| GB0018691D0 (en) * | 2000-07-28 | 2000-09-20 | Rolabo Sl | Process |
| US6613907B2 (en) | 2000-11-08 | 2003-09-02 | Amr Technology, Inc. | Process for the production of piperidine derivatives with microorganisms |
| US20030021849A1 (en) * | 2001-04-09 | 2003-01-30 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
| EP1392303A4 (en) * | 2001-04-09 | 2005-01-26 | Teva Pharma | FEXOFENADINE HYDROCHLORIDE POLYMORPHS |
| US6743941B2 (en) | 2001-06-15 | 2004-06-01 | Aventis Pharma Deutschland Gmbh | Process for the production of piperidine derivatives |
| SK712003A3 (en) * | 2001-06-25 | 2003-12-02 | Aurobindo Pharma Ltd | Process for the preparation of 4-(cyclopropylcarbonyl)-alpha, alpha-dimethylphenylacetic acid |
| US6593499B2 (en) * | 2001-08-29 | 2003-07-15 | Council Of Scientific & Industrial Research | Process for the preparation of phenyl ketones |
| EP1453509A2 (en) * | 2001-11-08 | 2004-09-08 | Teva Pharmaceutical Industries Ltd. | Polymorphs of fexofenadine base |
| IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
| AU2003248657A1 (en) * | 2002-06-10 | 2003-12-22 | Teva Pharmaceutical Industries Ltd. | Polymorphic form xvi of fexofenadine hydrochloride |
| US20050026890A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease |
| US20050065183A1 (en) * | 2003-07-31 | 2005-03-24 | Indranil Nandi | Fexofenadine composition and process for preparing |
| GB0319935D0 (en) | 2003-08-26 | 2003-09-24 | Cipla Ltd | Polymorphs |
| TW200517114A (en) | 2003-10-15 | 2005-06-01 | Combinatorx Inc | Methods and reagents for the treatment of immunoinflammatory disorders |
| EP1628959A2 (en) * | 2004-04-26 | 2006-03-01 | Teva Pharmaceutical Industries Ltd | Crystalline forms of fexofenadine hydrochloride and processes for their preparation |
| ITMI20041568A1 (it) * | 2004-07-30 | 2004-10-30 | Dipharma Spa | "polimorfi di fexofenadina base" |
| US7498443B2 (en) * | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of carebastine |
| US7498345B2 (en) | 2004-09-17 | 2009-03-03 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US20060148851A1 (en) * | 2004-09-28 | 2006-07-06 | Shlomit Wizel | Fexofenadine crystal form and processes for its preparation thereof |
| US7568973B2 (en) | 2005-09-09 | 2009-08-04 | Igt | Server based gaming system having multiple progressive awards |
| US7841939B2 (en) | 2005-09-09 | 2010-11-30 | Igt | Server based gaming system having multiple progressive awards |
| AU2006311577B2 (en) | 2005-11-09 | 2013-02-07 | Zalicus Inc. | Methods, compositions, and kits for the treatment of medical conditions |
| US7780520B2 (en) | 2006-03-15 | 2010-08-24 | Igt | Gaming device having multiple different types of progressive awards |
| WO2007135693A2 (en) * | 2006-05-18 | 2007-11-29 | Ind-Swift Laboratories Limited | Intermediates useful for the preparation of antihistaminic piperidine derivative |
| ITMI20061492A1 (it) * | 2006-07-27 | 2008-01-28 | Archimica Srl | Processo per la preparazione di fexofenadina. |
| US8070597B2 (en) | 2006-08-03 | 2011-12-06 | Igt | Gaming device and method having multiple progressive award levels and a secondary game for advancing through the progressive award levels |
| US9047733B2 (en) | 2006-11-08 | 2015-06-02 | Igt | Gaming system and method for providing multiple level progressive awards with increased odds of winning higher level progressive awards |
| EP2105134A1 (en) | 2008-03-24 | 2009-09-30 | Ranbaxy Laboratories Limited | Stable amorphous fexofenadine hydrochloride |
| WO2009136412A2 (en) * | 2008-04-25 | 2009-11-12 | Matrix Laboratories Limited | PROCESS FOR PREPARATION OF 4-[4-(4-(HYDROXYDIPHENYLMETHYL)- 1-PIPERIDINYL]-1-OXOBUTYL]-α,α-DIMETHYLBENZENE ACETIC ACID METHYL ESTER AND USE THEREOF |
| JP5654450B2 (ja) * | 2008-05-07 | 2015-01-14 | カルディオキシル ファーマシューティカルズ，インク． | ニトロキシル供与体としての新規ニトロソ化合物およびその使用方法 |
| CA2724607A1 (en) * | 2008-05-30 | 2009-12-31 | Fairfield Clinical Trials, Llc | Method and composition for skin inflammation and discoloration |
| US20100092479A1 (en) * | 2008-08-18 | 2010-04-15 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| EP2289867A3 (en) | 2009-08-19 | 2012-04-25 | Jubilant Organosys Limited | A process for producing 4-(4-halo-1-oxybutyl)-alpha,alpha-dimethylbenzene acetic acid or alkyl esters thereof |
| US20110130711A1 (en) * | 2009-11-19 | 2011-06-02 | Follica, Inc. | Hair growth treatment |
| CN102070512B (zh) * | 2009-11-21 | 2014-11-19 | 浙江华海药业股份有限公司 | 一种高纯度非索非那定及其中间体的合成路线与制备方法 |
| US20110160200A1 (en) * | 2009-11-23 | 2011-06-30 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension |
| CN102962288A (zh) * | 2012-11-21 | 2013-03-13 | 苏州江南航天机电工业有限公司 | 圆弧状大板与直板拼接工艺 |
| ITMI20131652A1 (it) * | 2013-10-07 | 2015-04-08 | Dipharma Francis Srl | Procedimento per la purificazione di derivati dell'acido 2-fenil-2-metil-propanoico |
| PT3365327T (pt) * | 2015-10-22 | 2020-02-06 | Sanofi Aventis Deutschland | Processo para a preparação de fexofenadina e de intermediários usados no mesmo |
| CN116178222B (zh) * | 2021-11-29 | 2025-04-25 | 上海晓明检测技术服务有限公司 | 环磺酮代谢物m9的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4028404A (en) * | 1967-07-31 | 1977-06-07 | Allen & Hanburys Limited | Acetic acid derivatives |
| GB1242169A (en) * | 1969-04-09 | 1971-08-11 | Ucb Sa | Piperidine derivatives |
| US3839431A (en) * | 1970-07-13 | 1974-10-01 | Squibb & Sons Inc | Cyclopropylmethylphenylacetic acids and derivatives |
| US3898271A (en) * | 1971-06-08 | 1975-08-05 | Squibb & Sons Inc | Cyclopropylmethylphenylacetic acids and derivatives |
| BE794596A (fr) * | 1972-01-28 | 1973-05-16 | Richardson Merrell Inc | Piperidinoalcanone-oximes substituees et leur procede de preparation |
| BE794598A (fr) * | 1972-01-28 | 1973-05-16 | Richardson Merrell Inc | Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation |
| US3878217A (en) * | 1972-01-28 | 1975-04-15 | Richardson Merrell Inc | Alpha-aryl-4-substituted piperidinoalkanol derivatives |
| US3965257A (en) * | 1972-01-28 | 1976-06-22 | Richardson-Merrell Inc. | Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions |
| US3806526A (en) * | 1972-01-28 | 1974-04-23 | Richardson Merrell Inc | 1-aroylalkyl-4-diphenylmethyl piperidines |
| US3931197A (en) * | 1974-02-08 | 1976-01-06 | Richardson-Merrell Inc. | Substituted piperidine derivatives |
| US3941795A (en) * | 1974-02-08 | 1976-03-02 | Richardson-Merrell Inc. | α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES |
| US3946022A (en) * | 1974-03-04 | 1976-03-23 | Richardson-Merrell Inc. | Piperidine derivatives |
| US3956296A (en) * | 1974-12-11 | 1976-05-11 | A. H. Robins Company, Incorporated | 1-Substituted-4-benzylpiperidines |
| US3922276A (en) * | 1974-12-11 | 1975-11-25 | Robins Co Inc A H | 1-Substituted-4-benzylidenepiperidines |
| DD141422A5 (de) * | 1978-01-27 | 1980-04-30 | Schering Ag | Verfahren zur herstellung von phenylessigsaeure-derivaten |
| US4254130A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| US4285958A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof |
| US4285957A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof |
| US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| GB8321157D0 (en) * | 1983-08-05 | 1983-09-07 | Fordonal Sa | Piperidine derivatives |
| IT1200123B (it) | 1985-09-27 | 1989-01-05 | Ind Chimica Srl | Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo |
| US4742175A (en) * | 1986-05-07 | 1988-05-03 | Merrell Dow Pharmaceuticals Inc. | Preparation of polymorphically pure terfenadine |
| EP0635004B1 (en) * | 1992-04-10 | 2002-07-17 | Merrell Pharmaceuticals Inc. | 4-diphenylmethyl piperidine derivatives and process for their preparation |
| WO1994003170A1 (en) * | 1992-08-03 | 1994-02-17 | Sepracor Inc. | Terfenadine metabolites and their optically pure isomers for treating allergic disorders |
| US20020007068A1 (en) * | 1999-07-16 | 2002-01-17 | D'ambra Thomas E. | Piperidine derivatives and process for their production |
| DK1026147T3 (da) * | 1993-06-24 | 2004-03-22 | Albany Molecular Res Inc | Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater |
| HU226037B1 (en) * | 1993-06-25 | 2008-03-28 | Aventis Inc | Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates |
| US6147216A (en) | 1993-06-25 | 2000-11-14 | Merrell Pharmaceuticals Inc. | Intermediates useful for the preparation of antihistaminic piperidine derivatives |
| US7022882B2 (en) * | 2000-10-06 | 2006-04-04 | The Regents Of The University Of California | NMDA receptor channel blocker with neuroprotective activity |
-
1994
- 1994-06-21 DK DK00200419T patent/DK1026147T3/da active
- 1994-06-21 DE DE69433346T patent/DE69433346T2/de not_active Expired - Lifetime
- 1994-06-21 PT PT00200419T patent/PT1026147E/pt unknown
- 1994-06-21 EP EP94920762A patent/EP0703902B1/en not_active Expired - Lifetime
- 1994-06-21 KR KR1019950705909A patent/KR100387347B1/ko not_active Expired - Lifetime
- 1994-06-21 AT AT00200419T patent/ATE254594T1/de active
- 1994-06-21 NZ NZ268513A patent/NZ268513A/en not_active IP Right Cessation
- 1994-06-21 ES ES00200419T patent/ES2211444T3/es not_active Expired - Lifetime
- 1994-06-21 DE DE69434696T patent/DE69434696T2/de not_active Expired - Lifetime
- 1994-06-21 WO PCT/US1994/006873 patent/WO1995000482A1/en not_active Ceased
- 1994-06-21 DK DK94920762T patent/DK0703902T3/da active
- 1994-06-21 AT AT03077245T patent/ATE322473T1/de active
- 1994-06-21 EP EP00200419A patent/EP1026147B1/en not_active Expired - Lifetime
- 1994-06-21 ES ES94920762T patent/ES2129130T3/es not_active Expired - Lifetime
- 1994-06-21 DE DE69415319T patent/DE69415319T2/de not_active Expired - Lifetime
- 1994-06-21 PT PT03077245T patent/PT1369409E/pt unknown
- 1994-06-21 EP EP96200338A patent/EP0723958A1/en not_active Ceased
- 1994-06-21 HU HU9503719A patent/HU226559B1/hu unknown
- 1994-06-21 DK DK03077245T patent/DK1369409T3/da active
- 1994-06-21 JP JP7502981A patent/JP3034047B2/ja not_active Expired - Lifetime
- 1994-06-21 AT AT94920762T patent/ATE174589T1/de active
- 1994-06-21 KR KR10-2002-7009756A patent/KR100387348B1/ko not_active Expired - Lifetime
- 1994-06-21 EP EP03077245A patent/EP1369409B1/en not_active Expired - Lifetime
- 1994-06-21 CA CA002147126A patent/CA2147126C/en not_active Expired - Lifetime
- 1994-06-21 AU AU71748/94A patent/AU670004B2/en not_active Expired
- 1994-06-21 ES ES03077245T patent/ES2261871T3/es not_active Expired - Lifetime
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1995
- 1995-02-02 US US08/382,425 patent/US5589487A/en not_active Expired - Lifetime
- 1995-02-02 US US08/382,649 patent/US5750703A/en not_active Expired - Lifetime
- 1995-05-31 US US08/456,273 patent/US5578610A/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,991 patent/US5581011A/en not_active Expired - Lifetime
- 1995-12-12 NO NO19955023A patent/NO308599B1/no not_active IP Right Cessation
- 1995-12-27 FI FI956270A patent/FI109691B/fi not_active IP Right Cessation
-
1996
- 1996-08-08 US US08/700,556 patent/US5663412A/en not_active Expired - Lifetime
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1997
- 1997-12-19 US US08/994,357 patent/US5994549A/en not_active Expired - Lifetime
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1998
- 1998-09-24 JP JP26960698A patent/JP3195297B2/ja not_active Expired - Lifetime
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1999
- 1999-09-21 NO NO994582A patent/NO994582D0/no not_active Application Discontinuation
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2000
- 2000-08-01 JP JP2000233271A patent/JP3658291B2/ja not_active Expired - Lifetime
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2001
- 2001-11-15 JP JP2001350148A patent/JP4124998B2/ja not_active Expired - Lifetime
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2005
- 2005-10-14 US US11/250,924 patent/US7238834B2/en not_active Expired - Fee Related
-
2006
- 2006-06-19 US US11/455,531 patent/US7390906B2/en not_active Expired - Fee Related
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2008
- 2008-05-29 US US12/128,799 patent/US20080227983A1/en not_active Abandoned
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