PT101147A - Deteccao imunoquimica de residuos de glicosilacao avancada in vivo - Google Patents
Deteccao imunoquimica de residuos de glicosilacao avancada in vivoInfo
- Publication number
- PT101147A PT101147A PT101147A PT10114792A PT101147A PT 101147 A PT101147 A PT 101147A PT 101147 A PT101147 A PT 101147A PT 10114792 A PT10114792 A PT 10114792A PT 101147 A PT101147 A PT 101147A
- Authority
- PT
- Portugal
- Prior art keywords
- disclosed
- age
- vivo
- advanced glycosylation
- advanced
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 230000000984 immunochemical effect Effects 0.000 title 1
- 108010005094 Advanced Glycation End Products Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/723—Glycosylated haemoglobin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81157991A | 1991-12-20 | 1991-12-20 | |
| US07/956,849 US5624804A (en) | 1991-12-20 | 1992-10-01 | Immunochemical detection of In vivo advanced glycosylation end products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT101147A true PT101147A (pt) | 1994-03-31 |
Family
ID=27123501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT101147A PT101147A (pt) | 1991-12-20 | 1992-12-18 | Deteccao imunoquimica de residuos de glicosilacao avancada in vivo |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US5624804A (pt) |
| EP (1) | EP0623216B1 (pt) |
| JP (1) | JPH07502534A (pt) |
| KR (1) | KR100257733B1 (pt) |
| CN (1) | CN1053964C (pt) |
| AT (1) | ATE196549T1 (pt) |
| AU (1) | AU681340B2 (pt) |
| CA (1) | CA2126209A1 (pt) |
| DE (1) | DE69231473T2 (pt) |
| ES (1) | ES2150936T3 (pt) |
| PT (1) | PT101147A (pt) |
| WO (1) | WO1993013421A1 (pt) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869534A (en) * | 1992-05-21 | 1999-02-09 | The Picower Institute For Medical Research | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom |
| US7585512B1 (en) * | 1990-05-08 | 2009-09-08 | Thomas Jefferson University | Composition and method of using tumor cells |
| US5624804A (en) * | 1991-12-20 | 1997-04-29 | The Rockefeller University | Immunochemical detection of In vivo advanced glycosylation end products |
| AU712004B2 (en) * | 1993-03-11 | 1999-10-28 | Picower Institute For Medical Research, The | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom |
| WO1995020979A1 (en) * | 1994-02-03 | 1995-08-10 | The Picower Institute For Medical Research | Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis |
| US6410598B1 (en) | 1994-02-03 | 2002-06-25 | Michael P. Vitek | Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis |
| US5610076A (en) * | 1994-04-29 | 1997-03-11 | Alteon Inc. | Method for detecting hemoglobin advanced glycosylation endproducts |
| JP2002514888A (ja) * | 1994-12-30 | 2002-05-21 | アルテオン インコーポレイテッド | 生物試料における進行性グリコシル化終末産物に特異的なモノクローナル抗体 |
| US5744318A (en) * | 1994-12-30 | 1998-04-28 | Alteon Inc. | Monoclonal antibody for the detection of advanced glycosylation endproducts in biological samples |
| CN1142778C (zh) * | 1995-01-18 | 2004-03-24 | 奥尔顿有限公司 | 噻唑鎓化合物用于预防和逆转高级糖基化终产物形成的用途 |
| US5811242A (en) * | 1995-10-24 | 1998-09-22 | Tokuyama Corporation | Marker and reagent for diabetes mellitus and diabetes mellitus complication |
| US5811401A (en) * | 1995-11-30 | 1998-09-22 | The Picower Institute For Medical Research | Advanced glycosylation endproducts and methods of use therefor |
| CA2241924A1 (en) * | 1995-12-26 | 1997-07-03 | The Picower Institute For Medical Research | Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts |
| AU1431397A (en) * | 1995-12-29 | 1997-07-28 | Alteon Inc. | 6-(n-carboxymethylamino)caproate, salts thereof and methods of use therefor |
| US6033862A (en) * | 1996-10-30 | 2000-03-07 | Tokuyama Corporation | Marker and immunological reagent for dialysis-related amyloidosis, diabetes mellitus and diabetes mellitus complications |
| US6380165B1 (en) * | 1997-09-19 | 2002-04-30 | The Picower Institute For Medical Research | Immunological advanced glycation endproduct crosslink |
| US6505059B1 (en) | 1998-04-06 | 2003-01-07 | The General Hospital Corporation | Non-invasive tissue glucose level monitoring |
| US20020091324A1 (en) * | 1998-04-06 | 2002-07-11 | Nikiforos Kollias | Non-invasive tissue glucose level monitoring |
| US7899518B2 (en) * | 1998-04-06 | 2011-03-01 | Masimo Laboratories, Inc. | Non-invasive tissue glucose level monitoring |
| US6728560B2 (en) | 1998-04-06 | 2004-04-27 | The General Hospital Corporation | Non-invasive tissue glucose level monitoring |
| US6721582B2 (en) | 1999-04-06 | 2004-04-13 | Argose, Inc. | Non-invasive tissue glucose level monitoring |
| CN2445326Y (zh) * | 2000-10-09 | 2001-08-29 | 刘永详 | 测定被糖化蛋白的免疫分析装置 |
| ATE283481T1 (de) * | 2001-03-22 | 2004-12-15 | Hoffmann La Roche | Verfahren zum auffinden von reagenzien und festphasenkomponenten in spezifischen bindungsassays, frei von fortgeschrittenen glykosylierungsendprodukten |
| UY27304A1 (es) * | 2001-05-24 | 2002-12-31 | Avanir Pharmaceuticals | Inhibidores del factor inhibidor de la migración de los macrófagos y métodos para su identificación |
| GB0221686D0 (en) * | 2002-09-19 | 2002-10-30 | Univ Ulster | Biomarker |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| JP2007503388A (ja) * | 2003-08-22 | 2007-02-22 | アバニール・ファーマシューティカルズ | マクロファージ遊走阻止因子の阻害剤としての置換ナフチリジン誘導体、およびヒト疾患の治療におけるそれらの使用 |
| CN100489526C (zh) * | 2004-01-16 | 2009-05-20 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种人脑红蛋白检测及诊断试剂盒，其制备方法及用途 |
| JP2008534502A (ja) * | 2005-03-24 | 2008-08-28 | アバニール・ファーマシューティカルズ | マクロファージ遊走阻止因子の阻害剤としてのチエノピリジノン誘導体 |
| GB0605689D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
| CA2647122A1 (en) * | 2006-03-24 | 2007-10-04 | Metanomics Gmbh | Means and method for diagnosing diabetes |
| DE102006026173A1 (de) * | 2006-06-06 | 2007-12-20 | Fachhochschule Südwestfalen | Verfahren zur nichtinvasiven Diagnose von Diabetes |
| ES2616728T3 (es) * | 2008-05-23 | 2017-06-14 | Siwa Corporation | Procedimientos y composiciones para facilitar la regeneración |
| WO2011040599A1 (ja) | 2009-10-02 | 2011-04-07 | シャープ株式会社 | 血管状態モニタリング装置およびモニタリング方法 |
| US9173604B2 (en) | 2010-03-19 | 2015-11-03 | Sharp Kabushiki Kaisha | Measurement device, measurement method, measurement result processing device, measurement system, measurement result processing method, control program, and recording medium |
| US9649376B2 (en) | 2010-09-27 | 2017-05-16 | Siwa Corporation | Selective removal of age-modified cells for treatment of atherosclerosis |
| US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
| KR101939401B1 (ko) | 2011-11-10 | 2019-01-16 | 가천대학교 산학협력단 | 단핵식세포계 세포의 ａｇｅ-알부민 합성 또는 분비 저해제를 유효성분으로 포함하는 허혈성 심장질환 예방 또는 치료용 조성물 |
| ES2908203T3 (es) * | 2014-09-19 | 2022-04-28 | Siwa Corp | Anticuerpos anti-age para el tratamiento de inflamación y trastornos autoinmunes |
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| KR20180056689A (ko) | 2015-10-13 | 2018-05-29 | 시와 코퍼레이션 | 항-age 항체 및 이의 사용 방법 |
| JP6553491B2 (ja) * | 2015-11-26 | 2019-07-31 | オリエンタル酵母工業株式会社 | 最終糖化産物（ＡＧＥｓ）が関連する疾患の罹患又はそのリスクを予測する方法 |
| WO2017143073A1 (en) * | 2016-02-19 | 2017-08-24 | Siwa Corporation | Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (age) |
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| US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
| CN106769349B (zh) * | 2017-01-06 | 2020-01-21 | 上海君联医疗设备有限公司 | 血液中异常糖基化蛋白细胞的检测方法 |
| EP3609923A1 (en) | 2017-04-13 | 2020-02-19 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
| CA3062082A1 (en) * | 2017-05-04 | 2018-11-08 | Siwa Corporation | Diagnostic advanced glycation end-product antibodies |
| US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
| CN108776131B (zh) * | 2018-03-19 | 2020-06-09 | 深圳市南山区疾病预防控制中心 | 一种食品中AGEs含量的检测方法 |
| WO2020023532A1 (en) | 2018-07-23 | 2020-01-30 | Siwa Corporation | Methods and compositions for treating chronic effects of radiation and chemical exposure |
| EP3840840A1 (en) | 2018-08-23 | 2021-06-30 | Siwa Corporation | Anti carboxymethyl lysine antibodies and ultrasound for removing age-modified cells |
| CN111040001B (zh) * | 2019-12-27 | 2021-04-16 | 山西医科大学 | 安定代谢物葡萄糖醛酸结合物的制备方法 |
| EP4143238A1 (en) * | 2020-05-01 | 2023-03-08 | Siwa Corporation | Methods of treating infections |
| WO2022093195A1 (en) | 2020-10-27 | 2022-05-05 | Siwa Corporation | Methods and compositions for treating osteoarthritis using anti-age antibodies or age antigens |
| WO2022125776A2 (en) | 2020-12-09 | 2022-06-16 | Siwa Corporation | Methods and compositions for treating kidney diseases |
| CA3229602A1 (en) | 2021-08-20 | 2023-02-23 | Siwa Corporation | Methods and compositions for treating fibrotic diseases |
| CN114814239B (zh) * | 2022-05-13 | 2025-03-25 | 郑州标源生物科技有限公司 | 一种糖尿病标志物的复合质控品及其制备方法、应用 |
| WO2024102157A1 (en) | 2022-11-09 | 2024-05-16 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3654090A (en) * | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
| NL154598B (nl) * | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US4016043A (en) * | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| JPH0766253B2 (ja) * | 1986-06-20 | 1995-07-19 | 松下電器産業株式会社 | マトリクス型画像表示装置 |
| AU600306B2 (en) * | 1986-09-12 | 1990-08-09 | Rockefeller University, The | Methods and agents for removing advanced glycosylation endproducts |
| ATE92488T1 (de) * | 1987-09-17 | 1993-08-15 | Univ Rockefeller | Glycosylierte endstoffe und damit verbundene verfahren. |
| US5223392A (en) * | 1988-01-25 | 1993-06-29 | Exocell, Inc. | Monoclonal antibodies against glycated albumin, hybrid cell lines producing these antibodies, and use therefore |
| US5624804A (en) * | 1991-12-20 | 1997-04-29 | The Rockefeller University | Immunochemical detection of In vivo advanced glycosylation end products |
-
1992
- 1992-10-01 US US07/956,849 patent/US5624804A/en not_active Expired - Lifetime
- 1992-12-18 PT PT101147A patent/PT101147A/pt not_active Application Discontinuation
- 1992-12-19 CN CN92115235A patent/CN1053964C/zh not_active Expired - Fee Related
- 1992-12-21 DE DE69231473T patent/DE69231473T2/de not_active Expired - Fee Related
- 1992-12-21 JP JP5511864A patent/JPH07502534A/ja active Pending
- 1992-12-21 WO PCT/US1992/011158 patent/WO1993013421A1/en not_active Ceased
- 1992-12-21 AT AT93902713T patent/ATE196549T1/de not_active IP Right Cessation
- 1992-12-21 AU AU34187/93A patent/AU681340B2/en not_active Ceased
- 1992-12-21 EP EP93902713A patent/EP0623216B1/en not_active Expired - Lifetime
- 1992-12-21 CA CA002126209A patent/CA2126209A1/en not_active Abandoned
- 1992-12-21 ES ES93902713T patent/ES2150936T3/es not_active Expired - Lifetime
- 1992-12-21 KR KR1019940702138A patent/KR100257733B1/ko not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/486,513 patent/US5702704A/en not_active Expired - Lifetime
- 1995-06-07 US US08/487,055 patent/US5683887A/en not_active Expired - Lifetime
- 1995-06-07 US US08/476,381 patent/US5629408A/en not_active Expired - Lifetime
- 1995-06-07 US US08/484,869 patent/US5733546A/en not_active Expired - Fee Related
- 1995-06-07 US US08/472,398 patent/US5712101A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69231473T2 (de) | 2001-02-08 |
| WO1993013421A1 (en) | 1993-07-08 |
| EP0623216A1 (en) | 1994-11-09 |
| US5702704A (en) | 1997-12-30 |
| CN1079825A (zh) | 1993-12-22 |
| KR100257733B1 (ko) | 2000-06-01 |
| US5683887A (en) | 1997-11-04 |
| ATE196549T1 (de) | 2000-10-15 |
| ES2150936T3 (es) | 2000-12-16 |
| KR940704003A (ko) | 1994-12-12 |
| AU681340B2 (en) | 1997-08-28 |
| AU3418793A (en) | 1993-07-28 |
| CA2126209A1 (en) | 1993-07-08 |
| US5733546A (en) | 1998-03-31 |
| EP0623216B1 (en) | 2000-09-20 |
| US5712101A (en) | 1998-01-27 |
| CN1053964C (zh) | 2000-06-28 |
| US5624804A (en) | 1997-04-29 |
| US5629408A (en) | 1997-05-13 |
| JPH07502534A (ja) | 1995-03-16 |
| DE69231473D1 (de) | 2000-10-26 |
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