PL94990B1 - - Google Patents
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- Publication number
- PL94990B1 PL94990B1 PL1975179425A PL17942575A PL94990B1 PL 94990 B1 PL94990 B1 PL 94990B1 PL 1975179425 A PL1975179425 A PL 1975179425A PL 17942575 A PL17942575 A PL 17942575A PL 94990 B1 PL94990 B1 PL 94990B1
- Authority
- PL
- Poland
- Prior art keywords
- rutoside
- reaction
- mono
- complexing agent
- water
- Prior art date
Links
- 238000000034 method Methods 0.000 claims description 28
- 229960004555 rutoside Drugs 0.000 claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 14
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 229910021538 borax Inorganic materials 0.000 claims description 10
- 239000004328 sodium tetraborate Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 6
- 235000017281 sodium acetate Nutrition 0.000 claims description 6
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 6
- 239000008139 complexing agent Substances 0.000 claims description 5
- 239000001632 sodium acetate Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 3
- 239000012736 aqueous medium Substances 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000003054 catalyst Substances 0.000 claims 3
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 150000001638 boron Chemical class 0.000 claims 1
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 18
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 239000000047 product Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000002585 base Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 3
- 239000004327 boric acid Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 230000035484 reaction time Effects 0.000 description 3
- 238000004611 spectroscopical analysis Methods 0.000 description 3
- RNHDAKUGFHSZEV-UHFFFAOYSA-N 1,4-dioxane;hydrate Chemical compound O.C1COCCO1 RNHDAKUGFHSZEV-UHFFFAOYSA-N 0.000 description 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical class C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 2
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- IQMUMKJNLGYVNS-UHFFFAOYSA-N butan-1-ol;methanol;hydrate Chemical compound O.OC.CCCCO IQMUMKJNLGYVNS-UHFFFAOYSA-N 0.000 description 2
- 210000002808 connective tissue Anatomy 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 239000012429 reaction media Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- VLXSIHLNPYRFFN-UHFFFAOYSA-N 1,4-dioxane;methanol Chemical compound OC.C1COCCO1 VLXSIHLNPYRFFN-UHFFFAOYSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 238000003747 Grignard reaction Methods 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- PTQWFLCGYPLVQU-UHFFFAOYSA-M [Na+].CC([O-])=O.OB(O)O Chemical compound [Na+].CC([O-])=O.OB(O)O PTQWFLCGYPLVQU-UHFFFAOYSA-M 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 208000015669 capillary disease Diseases 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- XENVCRGQTABGKY-ZHACJKMWSA-N chlorohydrin Chemical compound CC#CC#CC#CC#C\C=C\C(Cl)CO XENVCRGQTABGKY-ZHACJKMWSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- HQVFCQRVQFYGRJ-UHFFFAOYSA-N formic acid;hydrate Chemical compound O.OC=O HQVFCQRVQFYGRJ-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000037997 venous disease Diseases 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/07—Benzo[b]pyran-4-ones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH495974A CH581127A5 (it) | 1974-04-09 | 1974-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL94990B1 true PL94990B1 (it) | 1977-09-30 |
Family
ID=4285494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1975179425A PL94990B1 (it) | 1974-04-09 | 1975-04-08 |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS6114156B2 (it) |
| AT (1) | AT352303B (it) |
| BE (1) | BE826835A (it) |
| CA (1) | CA1039717A (it) |
| CH (1) | CH581127A5 (it) |
| DE (1) | DE2515084A1 (it) |
| ES (1) | ES435842A1 (it) |
| FR (1) | FR2267327B1 (it) |
| GB (1) | GB1497157A (it) |
| HU (1) | HU173551B (it) |
| IL (1) | IL46949A (it) |
| IT (1) | IT7947504A0 (it) |
| NL (1) | NL7504056A (it) |
| PL (1) | PL94990B1 (it) |
| SU (1) | SU576937A3 (it) |
| YU (1) | YU39316B (it) |
| ZA (1) | ZA752081B (it) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES469101A1 (es) * | 1978-04-25 | 1978-11-16 | Espanola Prod Quimicos | Procedimiento de obtencion de eteres hidrosolubles de hidro-xiflavonas. |
| FR2787111B1 (fr) * | 1998-12-11 | 2001-02-23 | Negma Lab | Troxerutine a forte teneur en trihydroxy-ethyl-rutoside, a mouillabilite elevee, et procede de preparation |
| CN104177461B (zh) * | 2013-05-21 | 2016-11-09 | 济南新力特科技有限公司 | 三羟乙基芦丁的制备方法 |
| KR101809943B1 (ko) * | 2014-05-23 | 2017-12-18 | 지난 신라이트 테크놀로지 컴퍼니 리미티드 | 트리하이드록시에틸 루토사이드의 제조방법 |
-
1974
- 1974-04-09 CH CH495974A patent/CH581127A5/xx not_active IP Right Cessation
-
1975
- 1975-03-18 BE BE154466A patent/BE826835A/xx not_active IP Right Cessation
- 1975-03-21 ES ES435842A patent/ES435842A1/es not_active Expired
- 1975-03-21 GB GB12020/75A patent/GB1497157A/en not_active Expired
- 1975-03-25 CA CA223,011A patent/CA1039717A/en not_active Expired
- 1975-03-26 IL IL46949A patent/IL46949A/en unknown
- 1975-04-02 ZA ZA00752081A patent/ZA752081B/xx unknown
- 1975-04-02 YU YU843/75A patent/YU39316B/xx unknown
- 1975-04-04 NL NL7504056A patent/NL7504056A/xx not_active Application Discontinuation
- 1975-04-07 DE DE19752515084 patent/DE2515084A1/de active Granted
- 1975-04-07 HU HU75ZI181A patent/HU173551B/hu unknown
- 1975-04-08 FR FR7510880A patent/FR2267327B1/fr not_active Expired
- 1975-04-08 SU SU7502122433A patent/SU576937A3/ru active
- 1975-04-08 PL PL1975179425A patent/PL94990B1/pl unknown
- 1975-04-08 AT AT264575A patent/AT352303B/de not_active IP Right Cessation
- 1975-04-09 JP JP50043140A patent/JPS6114156B2/ja not_active Expired
-
1979
- 1979-01-02 IT IT7947504A patent/IT7947504A0/it unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATA264575A (de) | 1979-02-15 |
| HU173551B (hu) | 1979-06-28 |
| IL46949A0 (en) | 1975-05-22 |
| AT352303B (de) | 1979-09-10 |
| DE2515084A1 (de) | 1975-10-23 |
| JPS50140449A (it) | 1975-11-11 |
| AU7947275A (en) | 1976-09-30 |
| SU576937A3 (ru) | 1977-10-15 |
| NL7504056A (nl) | 1975-10-13 |
| BE826835A (fr) | 1975-07-16 |
| ZA752081B (en) | 1976-02-25 |
| JPS6114156B2 (it) | 1986-04-17 |
| GB1497157A (en) | 1978-01-05 |
| IL46949A (en) | 1977-10-31 |
| DE2515084C2 (it) | 1988-03-31 |
| ES435842A1 (es) | 1976-12-01 |
| YU39316B (en) | 1984-10-31 |
| IT7947504A0 (it) | 1979-01-02 |
| CH581127A5 (it) | 1976-10-29 |
| FR2267327A1 (it) | 1975-11-07 |
| CA1039717A (en) | 1978-10-03 |
| FR2267327B1 (it) | 1981-08-07 |
| YU84375A (en) | 1982-02-28 |
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