CN106083966B - 氟取代含半乳糖苷结构三氮唑类去甲斑蝥素衍生物及其制备方法与应用 - Google Patents
氟取代含半乳糖苷结构三氮唑类去甲斑蝥素衍生物及其制备方法与应用 Download PDFInfo
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- CN106083966B CN106083966B CN201610398110.7A CN201610398110A CN106083966B CN 106083966 B CN106083966 B CN 106083966B CN 201610398110 A CN201610398110 A CN 201610398110A CN 106083966 B CN106083966 B CN 106083966B
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- galactoside
- triazole
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- 239000011737 fluorine Substances 0.000 title claims abstract description 19
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- -1 triazole norcantharidin derivative Chemical class 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims description 6
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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CN201610398110.7A CN106083966B (zh) | 2016-06-06 | 2016-06-06 | 氟取代含半乳糖苷结构三氮唑类去甲斑蝥素衍生物及其制备方法与应用 |
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CN106083966B true CN106083966B (zh) | 2018-10-23 |
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CN111253415B (zh) * | 2020-03-17 | 2022-08-09 | 遵义医科大学 | 去甲斑蝥素羧酸三氟苄酯及其合成方法和应用 |
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CN101717411B (zh) * | 2009-11-19 | 2012-10-10 | 绍兴文理学院 | 去甲基斑蝥素衍生物磷酸二钠盐及其合成方法与用途 |
CN101812066A (zh) * | 2010-03-04 | 2010-08-25 | 绍兴文理学院 | 吡唑并n-取代去甲去氢斑蝥素酰亚胺衍生物及其合成方法、活性测试方法与应用 |
CN102276673B (zh) * | 2011-06-21 | 2014-12-24 | 中国科学院成都生物研究所 | 一种2-脱氧-β-D-吡喃葡萄糖基三唑类化合物的制备方法 |
CN104817605B (zh) * | 2015-04-14 | 2017-09-08 | 湖北工程学院 | 2‑(1’,2’,3’‑三氮唑‑4’‑氧苄基)‑1,3,4,6‑o‑乙酰基‑d‑葡萄糖及其制备方法和应用 |
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