PL45510B1 - - Google Patents

Info

Publication number

PL45510B1

PL45510B1 PL45510A PL4551060A PL45510B1 PL 45510 B1 PL45510 B1 PL 45510B1 PL 45510 A PL45510 A PL 45510A PL 4551060 A PL4551060 A PL 4551060A PL 45510 B1 PL45510 B1 PL 45510B1

Authority

PL

Poland

Prior art keywords

hydroxy

aqua

cobalamin

cobalamine

contact

Prior art date

1960-03-03

Links

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• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 29
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 24
• FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 21
• 238000000034 method Methods 0.000 claims description 20
• 229920001282 polysaccharide Polymers 0.000 claims description 14
• 239000005017 polysaccharide Substances 0.000 claims description 14
• -1 polysaccharide ion Chemical class 0.000 claims description 11
• 239000000243 solution Substances 0.000 claims description 8
• 229920002678 cellulose Polymers 0.000 claims description 7
• 239000001913 cellulose Substances 0.000 claims description 7
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
• 239000000783 alginic acid Substances 0.000 claims description 6
• 235000010443 alginic acid Nutrition 0.000 claims description 6
• 229920000615 alginic acid Polymers 0.000 claims description 6
• 229960001126 alginic acid Drugs 0.000 claims description 6
• 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 6
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 6
• 230000001476 alcoholic effect Effects 0.000 claims description 5
• 239000000203 mixture Substances 0.000 claims description 4
• 150000004804 polysaccharides Chemical class 0.000 claims description 4
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
• 150000004781 alginic acids Chemical class 0.000 claims description 3
• DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims description 2
• 239000003463 adsorbent Substances 0.000 claims description 2
• 239000007864 aqueous solution Substances 0.000 claims description 2
• 230000003139 buffering effect Effects 0.000 claims description 2
• 125000004432 carbon atom Chemical group C* 0.000 claims description 2
• 238000005342 ion exchange Methods 0.000 claims description 2
• RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 14
• 239000002253 acid Substances 0.000 description 12
• 229960002104 cyanocobalamin Drugs 0.000 description 7
• 235000000639 cyanocobalamin Nutrition 0.000 description 7
• 239000011666 cyanocobalamin Substances 0.000 description 7
• 229940088594 vitamin Drugs 0.000 description 7
• 239000011782 vitamin Substances 0.000 description 7
• 235000013343 vitamin Nutrition 0.000 description 7
• 229930003231 vitamin Natural products 0.000 description 7
• 239000002156 adsorbate Substances 0.000 description 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
• 229940010007 cobalamins Drugs 0.000 description 4
• 150000001867 cobalamins Chemical class 0.000 description 4
• 239000000126 substance Substances 0.000 description 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
• 239000012141 concentrate Substances 0.000 description 3
• 150000003722 vitamin derivatives Chemical class 0.000 description 3
• 238000005406 washing Methods 0.000 description 3
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• 150000001875 compounds Chemical class 0.000 description 2
• LELOWRISYMNNSU-UHFFFAOYSA-N hydrogen cyanide Chemical compound N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 description 2
• 102000004169 proteins and genes Human genes 0.000 description 2
• 108090000623 proteins and genes Proteins 0.000 description 2
• 230000000717 retained effect Effects 0.000 description 2
• 238000001179 sorption measurement Methods 0.000 description 2
• 239000000725 suspension Substances 0.000 description 2
• WXNZTHHGJRFXKQ-UHFFFAOYSA-N 4-chlorophenol Chemical compound OC1=CC=C(Cl)C=C1 WXNZTHHGJRFXKQ-UHFFFAOYSA-N 0.000 description 1
• 241000226657 Clarkia concinna Species 0.000 description 1
• 229920000742 Cotton Polymers 0.000 description 1
• 241000195493 Cryptophyta Species 0.000 description 1
• 239000005909 Kieselgur Substances 0.000 description 1
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
• 102000002262 Thromboplastin Human genes 0.000 description 1
• 108010000499 Thromboplastin Proteins 0.000 description 1
• 230000000274 adsorptive effect Effects 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 239000012736 aqueous medium Substances 0.000 description 1
• 238000005119 centrifugation Methods 0.000 description 1
• 239000003795 chemical substances by application Substances 0.000 description 1
• 125000003346 cobalamin group Chemical group 0.000 description 1
• 238000010828 elution Methods 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 238000000855 fermentation Methods 0.000 description 1
• 230000004151 fermentation Effects 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 150000002605 large molecules Chemical class 0.000 description 1
• 229920002521 macromolecule Polymers 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 239000002609 medium Substances 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 230000003647 oxidation Effects 0.000 description 1
• 238000007254 oxidation reaction Methods 0.000 description 1
• 230000020477 pH reduction Effects 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 238000000746 purification Methods 0.000 description 1
• 239000002002 slurry Substances 0.000 description 1
• 229940075554 sorbate Drugs 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
• 235000019156 vitamin B Nutrition 0.000 description 1
• 239000011720 vitamin B Substances 0.000 description 1
• 239000002023 wood Substances 0.000 description 1