PL372701A1 - Azabicykliczne, azatricykliczne i azaspirocykliczne pochodne aminocykloheksanu jako antagoniści receptorów NMDA, 5HT3 i neuronowych receptorów nikotynowych - Google Patents

Azabicykliczne, azatricykliczne i azaspirocykliczne pochodne aminocykloheksanu jako antagoniści receptorów NMDA, 5HT3 i neuronowych receptorów nikotynowych

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Publication number
PL372701A1
PL372701A1 PL03372701A PL37270103A PL372701A1 PL 372701 A1 PL372701 A1 PL 372701A1 PL 03372701 A PL03372701 A PL 03372701A PL 37270103 A PL37270103 A PL 37270103A PL 372701 A1 PL372701 A1 PL 372701A1
Authority
PL
Poland
Prior art keywords
azatricyclic
aminocyclohexane
azabicyclic
nmda
receptor antagonists
Prior art date
Application number
PL03372701A
Other languages
English (en)
Inventor
Christopher Graham Raphael Parsons
Markus Henrich
Wojciech Danysz
Ivars Kalvinsh
Valerjans Kauss
Aigars Jirgensons
Markus Gold
Maksims Vanejevs
Original Assignee
Merz Pharma Gmbh & Co.Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co.Kgaa filed Critical Merz Pharma Gmbh & Co.Kgaa
Publication of PL372701A1 publication Critical patent/PL372701A1/pl

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    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
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  • Otolaryngology (AREA)
  • AIDS & HIV (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL03372701A 2002-03-21 2003-03-21 Azabicykliczne, azatricykliczne i azaspirocykliczne pochodne aminocykloheksanu jako antagoniści receptorów NMDA, 5HT3 i neuronowych receptorów nikotynowych PL372701A1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36638602P 2002-03-21 2002-03-21

Publications (1)

Publication Number Publication Date
PL372701A1 true PL372701A1 (pl) 2005-07-25

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PL03372701A PL372701A1 (pl) 2002-03-21 2003-03-21 Azabicykliczne, azatricykliczne i azaspirocykliczne pochodne aminocykloheksanu jako antagoniści receptorów NMDA, 5HT3 i neuronowych receptorów nikotynowych

Country Status (19)

Country Link
US (4) US7022729B2 (pl)
EP (1) EP1485086A1 (pl)
JP (1) JP4262606B2 (pl)
KR (1) KR100741257B1 (pl)
CN (1) CN1638762A (pl)
AR (1) AR039008A1 (pl)
AU (1) AU2003216855B2 (pl)
CA (1) CA2474637A1 (pl)
CO (1) CO5611104A2 (pl)
EA (1) EA007098B1 (pl)
GE (1) GEP20063954B (pl)
IL (1) IL164041A0 (pl)
MX (1) MXPA04007755A (pl)
NO (1) NO20044481L (pl)
PL (1) PL372701A1 (pl)
TW (1) TW200306189A (pl)
UA (1) UA77778C2 (pl)
WO (1) WO2003080046A1 (pl)
ZA (1) ZA200406940B (pl)

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EP2111858A1 (en) 2008-04-25 2009-10-28 EPFL Ecole Polytechnique Fédérale de Lausanne Novel treatment for alzheimer's disease
US20090275597A1 (en) * 2008-05-02 2009-11-05 Forest Laboratories Holdings Limited Methods of treating cns disorders
CN102918021B (zh) * 2010-05-27 2015-02-11 塔加西普特公司 烟碱受体非竞争性拮抗剂
BR112014010719A2 (pt) * 2011-11-03 2017-05-02 Targacept Inc moduladores não competitivos de receptor nicotínico
US9173878B2 (en) 2012-01-25 2015-11-03 Tohoku University Brain function improving agent
EA029052B1 (ru) 2013-03-14 2018-02-28 Бёрингер Ингельхайм Интернациональ Гмбх Замещенные (бензилцианометил)амиды 2-азабицикло[2.2.1]гептан-3-карбоновых кислот в качестве ингибиторов катепсина с
AP2017009733A0 (en) 2014-09-12 2017-02-28 Boehringer Ingelheim Int Spirocyclic inhibitors of cathepsin c

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US20040034055A1 (en) 2004-02-19
US7022729B2 (en) 2006-04-04
CN1638762A (zh) 2005-07-13
KR20040091005A (ko) 2004-10-27
CO5611104A2 (es) 2006-02-28
UA77778C2 (en) 2007-01-15
GEP20063954B (en) 2006-10-25
CA2474637A1 (en) 2003-10-02
IL164041A0 (en) 2005-12-18
AU2003216855A1 (en) 2003-10-08
US20060019982A1 (en) 2006-01-26
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EA200401230A1 (ru) 2005-02-24
JP2005525385A (ja) 2005-08-25
WO2003080046A1 (en) 2003-10-02
EA007098B1 (ru) 2006-06-30
ZA200406940B (en) 2005-09-22
MXPA04007755A (es) 2004-10-15
AR039008A1 (es) 2005-02-02
AU2003216855B2 (en) 2005-08-18
NO20044481L (no) 2004-10-20
JP4262606B2 (ja) 2009-05-13
US20070185151A1 (en) 2007-08-09
US20060019983A1 (en) 2006-01-26
KR100741257B1 (ko) 2007-07-19
TW200306189A (en) 2003-11-16
US7238703B2 (en) 2007-07-03

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