PL370074A1 - Piranony użyteczne jako inhibitory ATM - Google Patents

Piranony użyteczne jako inhibitory ATM

Info

Publication number
PL370074A1
PL370074A1 PL03370074A PL37007403A PL370074A1 PL 370074 A1 PL370074 A1 PL 370074A1 PL 03370074 A PL03370074 A PL 03370074A PL 37007403 A PL37007403 A PL 37007403A PL 370074 A1 PL370074 A1 PL 370074A1
Authority
PL
Poland
Prior art keywords
atm inhibitors
pyranones
useful
pyranones useful
sulfonamino
Prior art date
Application number
PL03370074A
Other languages
English (en)
Inventor
Graeme Cameron Murray Smith
Niall Morrison Barr Martin
Stephen Philip Jackson
Mark James O'connor
Alan Yin Kai Lau
Xiao-Ling Fan Cockcroft
Ian Timothy Williams Matthews
Keith Allan Menear
Laurent Jean Martin Rigoreau
Marc Geoffrey Hummersone
Roger John Griffin
Original Assignee
Kudos Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0204350.3A external-priority patent/GB0204350D0/en
Application filed by Kudos Pharmaceuticals Ltd filed Critical Kudos Pharmaceuticals Ltd
Publication of PL370074A1 publication Critical patent/PL370074A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • AIDS & HIV (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL03370074A 2002-02-25 2003-02-24 Piranony użyteczne jako inhibitory ATM PL370074A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0204350.3A GB0204350D0 (en) 2002-02-25 2002-02-25 ATM inhibitors
US39588402P 2002-07-15 2002-07-15

Publications (1)

Publication Number Publication Date
PL370074A1 true PL370074A1 (pl) 2005-05-16

Family

ID=27758841

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03370074A PL370074A1 (pl) 2002-02-25 2003-02-24 Piranony użyteczne jako inhibitory ATM

Country Status (20)

Country Link
EP (2) EP2174939A1 (pl)
JP (1) JP2005521689A (pl)
CN (1) CN100358891C (pl)
AT (1) ATE451365T1 (pl)
AU (1) AU2003209990B8 (pl)
BR (1) BR0307944A (pl)
CA (1) CA2473100A1 (pl)
CY (1) CY1109835T1 (pl)
DE (1) DE60330442D1 (pl)
DK (1) DK1485377T5 (pl)
ES (1) ES2336206T3 (pl)
GB (1) GB2401606B (pl)
HK (1) HK1069827A1 (pl)
MX (1) MXPA04007809A (pl)
NO (1) NO329806B1 (pl)
NZ (1) NZ534821A (pl)
PL (1) PL370074A1 (pl)
PT (1) PT1485377E (pl)
SI (1) SI1485377T1 (pl)
WO (1) WO2003070726A1 (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7151102B2 (en) 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
DE60335359D1 (de) 2002-04-30 2011-01-27 Kudos Pharm Ltd Phthalazinonderivate
US7122189B2 (en) * 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
US7413738B2 (en) 2002-08-13 2008-08-19 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on biodegradable linkers
US7449464B2 (en) 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
US20070099186A1 (en) * 2003-05-01 2007-05-03 D Adda Di Fagagna Fabrizio Methods and means for the treatment of disorders associated with cellular senescence
DE602004026071D1 (de) 2003-08-13 2010-04-29 Kudos Pharm Ltd Aminopyrone und ihre verwendung als atm inhibitoren
TWI338000B (en) 2003-12-01 2011-03-01 Kudos Pharm Ltd Dna damage repair inhibitors for treatment of cancer
WO2005118543A1 (ja) * 2004-06-03 2005-12-15 Ono Pharmaceutical Co., Ltd. キナーゼ阻害薬およびその用途
BRPI0515498A (pt) 2004-09-20 2008-07-29 Kudos Pharm Ltd inibidores de dna-pk
TW200638938A (en) * 2005-02-09 2006-11-16 Kudos Pharm Ltd ATM inhibitors
AR054438A1 (es) 2005-04-15 2007-06-27 Kudos Pharm Ltd Inhibidores de adn -pk
UY29774A1 (es) * 2005-08-31 2007-03-30 Kudos Pharm Ltd Inhibidor de atm
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
WO2009034326A1 (en) 2007-09-14 2009-03-19 Astrazeneca Ab Phthalazinone derivatives
CN102238945B (zh) 2008-10-07 2014-10-29 阿斯利康(英国)有限公司 药物制剂514
EP2486923B1 (en) * 2011-02-11 2015-09-09 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Histone deacetylase (HDAC) inhibiting compounds and method of making same
AU2012275841A1 (en) 2011-06-27 2014-01-16 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
EP3042900B1 (en) * 2013-08-29 2020-09-23 Fujifilm Corporation Novel morpholine derivative or salt thereof
EP4171651A1 (en) 2020-06-24 2023-05-03 AstraZeneca UK Limited Combination of antibody-drug conjugate and atm inhibitor
CN112094210A (zh) * 2020-09-24 2020-12-18 江苏扬农化工股份有限公司 一种取代的亚磺酸盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0331250B1 (en) * 1988-03-02 1994-04-13 Merck & Co. Inc. Antihypercholesterolemic agents
JPH05501886A (ja) * 1990-06-29 1993-04-08 ジ・アップジョン・カンパニー 抗アテローム性動脈硬化症性および抗血栓性２―アミノ―６―フェニル―４ｈ―ピラン―４―オン類
IL129871A (en) * 1994-05-06 2003-11-23 Pharmacia & Upjohn Inc Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections
JP3851661B2 (ja) * 1996-05-14 2006-11-29 第一製薬株式会社 新規生理活性物質及びその製造方法
FR2765579A1 (fr) * 1997-07-01 1999-01-08 Lipha Nouveaux derives de 4-hydroxy-2h-1-(thio)pyran-2-ones leurs preparations et leurs utilisations comme rodonticides
DE69833952T2 (de) * 1997-09-26 2006-12-07 Toray Industries, Inc. Zyklische ketonderivate und ihre pharmazeutische verwendung
DE69917237T2 (de) * 1998-03-12 2005-05-04 Teijin Ltd. Benzofurylpyron-derivate

Also Published As

Publication number Publication date
CN1639154A (zh) 2005-07-13
NZ534821A (en) 2006-07-28
BR0307944A (pt) 2005-02-01
AU2003209990A1 (en) 2003-09-09
CA2473100A1 (en) 2003-08-28
EP1485377B1 (en) 2009-12-09
NO20044063L (no) 2004-09-24
ATE451365T1 (de) 2009-12-15
EP1485377A1 (en) 2004-12-15
GB0419534D0 (en) 2004-10-06
DK1485377T3 (da) 2010-04-19
JP2005521689A (ja) 2005-07-21
AU2003209990B2 (en) 2008-10-09
ES2336206T3 (es) 2010-04-09
GB2401606A (en) 2004-11-17
HK1069827A1 (en) 2005-06-03
GB2401606B (en) 2005-08-31
EP1485377B8 (en) 2010-02-24
ES2336206T9 (es) 2011-03-24
MXPA04007809A (es) 2004-10-15
EP1485377B9 (en) 2010-10-06
SI1485377T1 (sl) 2010-04-30
CN100358891C (zh) 2008-01-02
CY1109835T1 (el) 2014-09-10
EP2174939A1 (en) 2010-04-14
WO2003070726A1 (en) 2003-08-28
DK1485377T5 (da) 2010-12-06
NO329806B1 (no) 2010-12-20
PT1485377E (pt) 2010-03-12
AU2003209990B8 (en) 2008-10-30
DE60330442D1 (de) 2010-01-21

Similar Documents

Publication Publication Date Title
HK1069827A1 (en) Pyranones useful as atm inhibitors.
ZA200601595B (en) Aminopyrones and their use as ATM inhibitors
GB0226593D0 (en) Compounds
TWI266761B (en) Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents
MXPA02011974A (es) Derivados de quinazolina sustituidos y su uso como inhibidores.
HRP20070307T3 (en) Derivatives of n-[ phenyl(pyrrolidine-2-yl)methyl]benzamide and n-[ (azepan-2-yl)phenylmethyl]benzamide, preparation method thereof and application of same in therapeutics
UA88329C2 (en) Dna-pk inhibitors
CY1111310T1 (el) Ενωσεις για την αγωγη μεταβολικων διαταραχων
HUP0301607A2 (hu) Szelektív neurokinin antagonista hatású nitrogéntartalmú heterociklusos vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
GEP20125523B (en) Metabolites of (thio) carbamoyl-cyclohexane derivatives
FI931763A0 (fi) 4,1-bensoxazepinderivat och deras anvaendning
WO2001098248A3 (en) Hiv integrase inhibitors
ZA200106514B (en) Heterocyclic compounds intermediates thereof and elastase inhibitors.
TW200638938A (en) ATM inhibitors
HRP20020440B1 (en) 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof
FI935798A0 (fi) Alkylsubstituerade heterocykliska foereningar
ATE500243T1 (de) Carbonsäureamidverbindung und deren verwendung
NZ506908A (en) Cephalosporines having cyclic aminoguanidine substituents as antibiotics
ES2166710A1 (es) Nuevos compuestos heterociclicos con actividad antiinflamatoria.
IL178548A (en) Derivatives of 14,15-dihydro 20,21-dinoreburnamenin-14-ol and applications thereof
TR200402333T4 (tr) Artropodisidal karboksanilidler

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)