PL367263A1 - Spiropyrazole compounds - Google Patents

Spiropyrazole compounds

Info

Publication number
PL367263A1
PL367263A1 PL02367263A PL36726302A PL367263A1 PL 367263 A1 PL367263 A1 PL 367263A1 PL 02367263 A PL02367263 A PL 02367263A PL 36726302 A PL36726302 A PL 36726302A PL 367263 A1 PL367263 A1 PL 367263A1
Authority
PL
Poland
Prior art keywords
spiropyrazole
compounds
spiropyrazole compounds
whereinz
compound
Prior art date
Application number
PL02367263A
Other languages
English (en)
Polish (pl)
Inventor
R.Richard Goehring
Donald Kyle
Gary Lee
Parviz Gharagozloo
Sam Victory
Original Assignee
Euro-Celtique, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro-Celtique, S.A. filed Critical Euro-Celtique, S.A.
Publication of PL367263A1 publication Critical patent/PL367263A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Dental Preparations (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
PL02367263A 2001-04-18 2002-04-18 Spiropyrazole compounds PL367263A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28467501P 2001-04-18 2001-04-18

Publications (1)

Publication Number Publication Date
PL367263A1 true PL367263A1 (en) 2005-02-21

Family

ID=23091099

Family Applications (1)

Application Number Title Priority Date Filing Date
PL02367263A PL367263A1 (en) 2001-04-18 2002-04-18 Spiropyrazole compounds

Country Status (27)

Country Link
US (2) US6635653B2 (enExample)
EP (1) EP1385515B1 (enExample)
JP (1) JP4342181B2 (enExample)
KR (1) KR100628292B1 (enExample)
CN (1) CN1516584A (enExample)
AT (1) ATE403429T1 (enExample)
AU (1) AU2002311833B2 (enExample)
BR (1) BR0209127A (enExample)
CA (1) CA2444634C (enExample)
CY (1) CY1108454T1 (enExample)
CZ (1) CZ20032849A3 (enExample)
DE (1) DE60228071D1 (enExample)
DK (1) DK1385515T3 (enExample)
ES (1) ES2312584T3 (enExample)
HU (1) HUP0401333A3 (enExample)
IL (2) IL158485A0 (enExample)
MX (1) MXPA03009604A (enExample)
NO (1) NO20034660L (enExample)
NZ (1) NZ528978A (enExample)
PL (1) PL367263A1 (enExample)
PT (1) PT1385515E (enExample)
RU (1) RU2299883C2 (enExample)
SI (1) SI1385515T1 (enExample)
UA (1) UA74439C2 (enExample)
WO (1) WO2002085355A1 (enExample)
YU (1) YU82403A (enExample)
ZA (1) ZA200308103B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL158485A0 (en) * 2001-04-18 2004-05-12 Euro Celtique Sa Spiropyrazole compounds
US7566728B2 (en) 2002-03-29 2009-07-28 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
JP4712384B2 (ja) 2002-09-09 2011-06-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体
EP1551400A2 (en) * 2002-10-17 2005-07-13 Euro-Celtique S.A. Preparation of triazospiro compounds
US20040242583A1 (en) * 2003-01-20 2004-12-02 Aventis Pharma Deutschland Gmbh Pyrimido[5,4-e][1,2,4]triazine-5,7-diones, processes for preparing them and their use
WO2004103305A2 (en) * 2003-05-16 2004-12-02 Euroceltique S.A. Spiropyrazole compound
WO2005011665A1 (en) * 2003-07-22 2005-02-10 Arakis Ltd. The use of proglumide for the treatment of emesis
US20110008327A1 (en) 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100173864A1 (en) 2004-03-29 2010-07-08 Cheng Jin Q Compositions including triciribine and one or more platinum compounds and methods of use thereof
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
US20100028339A1 (en) 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
LT2574341T (lt) 2004-03-29 2017-09-11 University Of South Florida Navikų ir vėžio efektyvus gydymas triciribino fosfatu
CN101137657B (zh) 2005-03-08 2011-02-02 詹森药业有限公司 作为神经激肽（nk1）拮抗剂的二氮杂-螺-[4.4]-壬烷衍生物
CN1870631B (zh) * 2005-11-11 2010-04-14 华为技术有限公司 媒体网关的门控方法
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
AU2007325355A1 (en) 2006-11-28 2008-06-05 Janssen Pharmaceutica N.V. Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl) -1,3,8-triaza-spiro[4.5]decan-4-one
DE602008002690D1 (de) * 2007-01-16 2010-11-04 Purdue Pharma Lp Heterozyklische substituierte piperidine als orl-1-liganden
EP2150552B1 (en) 2007-04-09 2013-01-02 Janssen Pharmaceutica NV 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
ES2920605T3 (es) 2007-08-31 2022-08-05 Purdue Pharma Lp Intermedios de piperidina
NZ590416A (en) 2008-07-21 2012-10-26 Purdue Pharma Lp Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof
UA107943C2 (xx) * 2009-11-16 2015-03-10 Lilly Co Eli Сполуки спіропіперидину як антагоністи рецептора orl-1
ES2613631T3 (es) 2010-12-22 2017-05-25 Purdue Pharma L.P. Compuestos de piperidina de tipo quinoxalina sustituidos con fósforo y usos de los mismos
WO2013080036A1 (en) 2011-12-01 2013-06-06 Purdue Pharma L.P. Azetidine-substituted quinoxaline-type piperidine compounds and uses thereof
US9085561B2 (en) 2012-07-30 2015-07-21 Purdue Pharma L.P. Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9951038B2 (en) 2012-12-27 2018-04-24 Purdue Pharma L.P. Quinazolin-4(3H)-one-type piperidine compounds and uses thereof
US9963458B2 (en) 2012-12-27 2018-05-08 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
US9090618B2 (en) 2012-12-27 2015-07-28 Purdue Pharma L.P. Substituted benzimidazole-type piperidine compounds and uses thereof
WO2014102592A2 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Oxime/substituted quinoxaline-type piperidine compounds and uses thereof
WO2014102590A1 (en) 2012-12-27 2014-07-03 Purdue Pharma L.P. Substituted piperidin-4-amino-type compounds and uses thereof
IL322013A (en) 2016-07-29 2025-09-01 Janssen Pharmaceutica Nv Niraparib or its salts for use in the treatment of prostate cancer
CN111825681A (zh) * 2020-07-07 2020-10-27 扬州大学 一种合成(e)-亚苄基螺吡唑吡咯嗪酮类化合物的方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB157497A (enExample) *
US3161645A (en) 1962-12-18 1964-12-15 Res Lab Dr C Janssen N V 1-(1-aroylpropyl-4-piperidyl)-2-benzimidazolinones and related compounds
US3318900A (en) 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
US3325499A (en) 1964-11-02 1967-06-13 Mcneilab Inc 1-(1-hydrocarbyl-4-piperdyl)-2-indolinone
US3923993A (en) * 1973-06-28 1975-12-02 American Home Prod Process for treating neuroendocrinopathic diseases employing fluspirilene
DE2609645A1 (de) 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
US4329353A (en) 1980-10-22 1982-05-11 Janssen Pharmaceutica, N.V. 1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
US4410528A (en) 1980-05-16 1983-10-18 Kyowa Hakko Kogyo Co., Ltd. Hypotensive piperidine derivatives
JPS58180481A (ja) 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
JPS60120872A (ja) 1983-12-01 1985-06-28 Kyowa Hakko Kogyo Co Ltd 新規なヘテロ環状化合物及び強心剤
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
CA2187767A1 (en) 1994-04-14 1995-10-26 Joel R. Huff Alpha1c adrenergic receptor antagonists
FR2722190B1 (fr) 1994-07-05 1996-10-04 Sanofi Sa Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
FR2725206B1 (fr) * 1994-09-29 1996-12-06 Roussel Uclaf Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US5767118A (en) 1994-10-26 1998-06-16 Merck & Co., Inc. 4-Heterocyclic peperidines promote release of growth hormone
US5574044A (en) 1994-10-27 1996-11-12 Merck & Co., Inc. Muscarine antagonists
CA2231773A1 (en) 1995-09-13 1997-03-20 Shigeru Aono Phenylpiperidine derivative
AU2388697A (en) 1996-04-19 1997-11-12 Neurosearch A/S 1-(4-piperidyl)-benzimidazoles having neurotrophic activity
US6063796A (en) 1997-04-04 2000-05-16 Merck & Co., Inc. Somatostatin agonists
CA2291094C (en) 1997-05-30 2008-02-26 Banyu Pharmaceutical Co., Ltd. 2-oxoimidazole derivative
JPH10330377A (ja) 1997-06-02 1998-12-15 Kyowa Hakko Kogyo Co Ltd ピペリジン誘導体
US6166037A (en) 1997-08-28 2000-12-26 Merck & Co., Inc. Pyrrolidine and piperidine modulators of chemokine receptor activity
EP0921125B1 (en) 1997-12-05 2002-01-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro[4,5]decan-4-on derivatives
US6166209A (en) 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
BR9907104A (pt) 1998-01-19 2000-10-24 Pfizer Compostos de 4-(2-ceto-1-benzimidazolinil)piperidina como agonistas do receptor orl1
EP1072263A4 (en) 1998-03-26 2004-03-31 Japan Tobacco Inc AMID DERIVATIVES AND NOCICEPTINANT AGONISTS
JP2002515503A (ja) * 1998-05-18 2002-05-28 ノボ ノルディスク アクティーゼルスカブ オピオイド受容体のサブタイプへの高い親和性を有する新規１，３，８−トリアザスピロ〔４，５〕デカノン
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ID29137A (id) 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
MA26659A1 (fr) 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
SE9904652D0 (sv) 1999-12-17 1999-12-17 Astra Pharma Prod Novel Compounds
EP1315490B1 (en) 2000-09-06 2008-11-12 Ortho-McNeil Pharmaceutical, Inc. A method for treating allergies using substituted pyrazoles
IL158485A0 (en) * 2001-04-18 2004-05-12 Euro Celtique Sa Spiropyrazole compounds

Also Published As

Publication number Publication date
CA2444634A1 (en) 2002-10-31
DK1385515T3 (da) 2008-10-27
UA74439C2 (uk) 2005-12-15
BR0209127A (pt) 2006-03-21
EP1385515A4 (en) 2004-06-30
NO20034660D0 (no) 2003-10-17
NO20034660L (no) 2003-12-17
SI1385515T1 (sl) 2008-12-31
NZ528978A (en) 2004-06-25
US6635653B2 (en) 2003-10-21
EP1385515A1 (en) 2004-02-04
YU82403A (sh) 2006-08-17
ES2312584T3 (es) 2009-03-01
JP2004531531A (ja) 2004-10-14
KR100628292B1 (ko) 2006-09-27
HK1062885A1 (en) 2004-12-03
HUP0401333A2 (hu) 2004-10-28
ZA200308103B (en) 2004-10-18
JP4342181B2 (ja) 2009-10-14
MXPA03009604A (es) 2004-04-02
AU2002311833B2 (en) 2005-04-28
WO2002085355A1 (en) 2002-10-31
ATE403429T1 (de) 2008-08-15
EP1385515B1 (en) 2008-08-06
RU2003133455A (ru) 2005-05-10
DE60228071D1 (de) 2008-09-18
KR20040008159A (ko) 2004-01-28
CN1516584A (zh) 2004-07-28
CY1108454T1 (el) 2014-04-09
CA2444634C (en) 2011-06-07
IL158485A0 (en) 2004-05-12
IL158485A (en) 2009-09-01
RU2299883C2 (ru) 2007-05-27
PT1385515E (pt) 2008-09-15
US20030027834A1 (en) 2003-02-06
US20040087641A1 (en) 2004-05-06
HUP0401333A3 (en) 2004-11-29
CZ20032849A3 (en) 2004-03-17

Similar Documents

Publication Publication Date Title
IL158485A (en) Spiropyrazole compounds
YU82303A (sh) Analozi nociceptina
MY126559A (en) Fungicidal 2-methoxybenzophenones
MY134892A (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and their use
DK1385514T3 (da) Spiroinden- og spiroindanforbindelser
DE60214392D1 (de) 1,4-disubstituierte benzokondensierte cycloalkyl harnstoffverbindungen
WO2003006425A3 (en) Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
GB0124627D0 (en) Novel compounds
WO2002072506A3 (en) 7-pyrollyl tetracycline compounds and methods of use thereof
CY1113578T1 (el) 2,3-διυδρο-6-νιτροϊμιδαζο 2,1 -b-οξαζολια
HK1056114A1 (zh) 血子板减少模仿剂
MXPA02003977A (es) Inhibidores de adhesion de celula mediada por al°2.
MXPA04003886A (es) Tiofen- y tiazolsulfonamidas como agentes antineoplasticos.
MXPA03009602A (es) Analogos de nociceptina.
SE0004245D0 (sv) Novel compounds and their use
SI1975164T1 (sl) Oktahidrobenzimidazolonske spojine kot analgetiki
AU2003268342A8 (en) Antimicrobial compositions
MXPA05006450A (es) Nuevo derivado de 2,4-diamino-1,3,5-triazina.
SV2003000981A (es) Fenil-heterociclil-eteres ref. pcs10973
WO2005009345A3 (en) 2-desmethyl ansamycin compounds
EG23207A (en) Novel fungicidal compositions based on propamocarsand pyridylmethylbenzamide derivatives.
IL152632A0 (en) Trimethyldecenyl compounds
MXPA05003881A (es) Preparacion de compuestos triazospiro.
SE9901062D0 (sv) Use for conifer sapling protection
WO2003044877A3 (en) Light emitting device and compounds for use therein

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)