PL367043A1 - Enzymatyczny sposób selektywnej względem enancjomeru redukcji związków ketonowych - Google Patents
Enzymatyczny sposób selektywnej względem enancjomeru redukcji związków ketonowychInfo
- Publication number
- PL367043A1 PL367043A1 PL02367043A PL36704302A PL367043A1 PL 367043 A1 PL367043 A1 PL 367043A1 PL 02367043 A PL02367043 A PL 02367043A PL 36704302 A PL36704302 A PL 36704302A PL 367043 A1 PL367043 A1 PL 367043A1
- Authority
- PL
- Poland
- Prior art keywords
- adh
- hydroxy
- halo
- nitro
- aryl
- Prior art date
Links
- 125000000468 ketone group Chemical group 0.000 title abstract 3
- 238000006911 enzymatic reaction Methods 0.000 title 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 abstract 8
- 108010021809 Alcohol dehydrogenase Proteins 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- -1 hydroxy, amino Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 241000186864 Weissella minor Species 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002440 hydroxy compounds Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- HGASFNYMVGEKTF-UHFFFAOYSA-N octan-1-ol;hydrate Chemical compound O.CCCCCCCCO HGASFNYMVGEKTF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10119274A DE10119274A1 (de) | 2001-04-20 | 2001-04-20 | Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL367043A1 true PL367043A1 (pl) | 2005-02-21 |
| PL207271B1 PL207271B1 (pl) | 2010-11-30 |
Family
ID=7682020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL367043A PL207271B1 (pl) | 2001-04-20 | 2002-04-15 | Sposób enancjoselektywnej redukcji związku ketonowego |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20040265978A1 (pl) |
| EP (2) | EP1383899B1 (pl) |
| JP (2) | JP4417628B2 (pl) |
| AT (1) | ATE443770T1 (pl) |
| CZ (1) | CZ20032820A3 (pl) |
| DE (2) | DE10119274A1 (pl) |
| DK (1) | DK1383899T3 (pl) |
| ES (1) | ES2334016T3 (pl) |
| HU (1) | HU229667B1 (pl) |
| PL (1) | PL207271B1 (pl) |
| PT (1) | PT1383899E (pl) |
| SK (1) | SK288326B6 (pl) |
| WO (1) | WO2002086126A2 (pl) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10208007A1 (de) * | 2002-02-26 | 2003-09-18 | Forschungszentrum Juelich Gmbh | Verfahren zur Herstellung von Alkoholen aus Substraten mittels Oxidoreduktasen, Zweiphasensystem umfassend eine wässrige Phase und eine organische Phase sowie Vorrichtung zur Durchführung des Verfahrens |
| WO2004009807A1 (en) * | 2002-07-20 | 2004-01-29 | Degussa Ag | Two-phase alcohol dehydrogenase-based coupled enzymatic reaction system |
| DE10300335B4 (de) * | 2003-01-09 | 2008-06-26 | Iep Gmbh | Oxidoreduktase |
| DE10313972A1 (de) * | 2003-03-27 | 2004-10-21 | Degussa Ag | Gekoppeltes cofaktorabhängiges enzymatisches Reaktionssystem |
| DE10327454A1 (de) * | 2003-06-18 | 2005-01-20 | Juelich Enzyme Products Gmbh | Oxidoreduktase aus Pichia capsulata |
| DE102004007029A1 (de) * | 2004-02-12 | 2005-09-08 | Consortium für elektrochemische Industrie GmbH | Verfahren zur enantioselektiven Reduktion von Ketoverbindungen durch Enzyme |
| AT501928B1 (de) * | 2004-10-27 | 2010-09-15 | Iep Gmbh | Verfahren zur herstellung von chiralen alkoholen |
| AT501496B1 (de) * | 2005-02-21 | 2007-03-15 | Iep Gmbh | Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen |
| AT502395B1 (de) | 2005-07-27 | 2007-03-15 | Iep Gmbh | Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen |
| AT502185B1 (de) * | 2005-09-23 | 2007-02-15 | Iep Gmbh | Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen |
| DE102006009744A1 (de) * | 2006-03-02 | 2007-09-06 | Wacker Chemie Ag | Herstellung von (S)-2-Butanol durch oxidative Racematspaltung |
| AT503486B1 (de) * | 2006-04-11 | 2008-05-15 | Iep Gmbh | Verfahren zur enantioselektiven reduktion von steroiden |
| US7879585B2 (en) * | 2006-10-02 | 2011-02-01 | Codexis, Inc. | Ketoreductase enzymes and uses thereof |
| AT504542B1 (de) | 2006-12-07 | 2008-09-15 | Iep Gmbh | Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten |
| JP2010517574A (ja) | 2007-02-08 | 2010-05-27 | コデクシス， インコーポレイテッド | ケトレダクターゼおよびその使用 |
| US7977078B2 (en) * | 2007-08-24 | 2011-07-12 | Codexis, Inc. | Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane |
| EP2198018B1 (en) | 2007-09-13 | 2013-11-20 | Codexis, Inc. | Ketoreductase polypeptides for the reduction of acetophenones |
| TWI601825B (zh) | 2007-09-27 | 2017-10-11 | Ｉｅｐ有限公司 | 對映異構選擇性酶催化還原中間產物之方法 |
| ATE547513T1 (de) | 2007-09-28 | 2012-03-15 | Codexis Inc | Ketoreduktase-polypeptide und verwendungen davon |
| SI2205727T1 (sl) | 2007-10-01 | 2015-09-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za izdelavo azetidinona |
| WO2009133464A2 (en) | 2008-04-30 | 2009-11-05 | Danisco A/S | Oxidation process |
| US8288141B2 (en) * | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| EP2329013B1 (en) | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| US8273554B2 (en) | 2008-08-29 | 2012-09-25 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| EP2226386A1 (de) | 2009-03-05 | 2010-09-08 | IEP GmbH | Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen |
| AU2009348523B2 (en) * | 2009-06-22 | 2015-02-26 | Sk Biopharmaceuticals Co., Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| SG10201405022PA (en) | 2009-08-19 | 2014-10-30 | Codexis Inc | Ketoreductase polypeptides for the preparation of phenylephrine |
| US8404461B2 (en) * | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| AU2010343048A1 (en) | 2009-12-29 | 2012-06-28 | Butamax(Tm) Advanced Biofuels Llc | Alcohol dehydrogenases (ADH) useful for fermentive production of lower alkyl alcohols |
| HUE026367T2 (en) | 2010-05-04 | 2016-06-28 | Codexis Inc | Biocatalysts for ezetimibe synthesis |
| WO2011147957A1 (de) | 2010-05-27 | 2011-12-01 | Pharmazell Gmbh | NEUARTIGE 7α-HYDROXYSTEROID DEHYDROGENASE-KNOCKOUT-MUTANTEN UND DEREN VERWENDUNG |
| AU2012207381B2 (en) | 2011-01-18 | 2016-05-19 | General Atomics | Hydrolase enzyme substrates and uses thereof |
| MX354373B (es) * | 2012-05-17 | 2018-02-28 | Genentech Inc | Proceso para hacer compuestos de ciclopentapirimidina hidroxilada y sus sales. |
| EA027209B1 (ru) | 2012-06-18 | 2017-06-30 | Лабораторио Кимико Интернационале С.П.А. | Ферментативное восстановление |
| DE102013104418B4 (de) | 2013-04-30 | 2018-09-27 | Cambrex Iep Gmbh | Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol |
| ES2653559T3 (es) * | 2013-12-11 | 2018-02-07 | F. Hoffmann-La Roche Ag | Procedimiento para la preparación de una 2-(4-aminofenil)morfolina quiral |
| CN115057796A (zh) * | 2015-12-01 | 2022-09-16 | 焦作健康元生物制品有限公司 | 光学活性的β-羟基酯类化合物的中间体 |
| AU2018360502B2 (en) * | 2017-11-01 | 2024-05-02 | Melinta Therapeutics, Llc | Synthesis of boronate ester derivatives and uses thereof |
| WO2024150146A1 (en) | 2023-01-12 | 2024-07-18 | Novartis Ag | Engineered ketoreductase polypeptides |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4014573C1 (pl) | 1990-05-07 | 1991-10-10 | Forschungszentrum Juelich Gmbh, 5170 Juelich, De | |
| US5225339A (en) * | 1992-02-26 | 1993-07-06 | The Scripps Research Institute | Lactobacillus kefir alcohol dehydrogenase |
| US5385833A (en) * | 1992-02-26 | 1995-01-31 | The Scripps Research Institute | Pseudomonas sp. ATCC No. 49794 alcohol dehydrogenase |
| US5719039A (en) * | 1995-06-01 | 1998-02-17 | University Of Iowa Research Foundation | Enzyme-surfactant ion-pair complex catalyzed reactions in organic solvents |
| DE19610984A1 (de) * | 1996-03-21 | 1997-09-25 | Boehringer Mannheim Gmbh | Alkohol-Dehydrogenase und deren Verwendung zur enzymatischen Herstellung chiraler Hydroxyverbindungen |
-
2001
- 2001-04-20 DE DE10119274A patent/DE10119274A1/de not_active Withdrawn
-
2002
- 2002-04-15 US US10/475,150 patent/US20040265978A1/en not_active Abandoned
- 2002-04-15 DK DK02737953.6T patent/DK1383899T3/da active
- 2002-04-15 JP JP2002583640A patent/JP4417628B2/ja not_active Expired - Fee Related
- 2002-04-15 PT PT02737953T patent/PT1383899E/pt unknown
- 2002-04-15 HU HU0303803A patent/HU229667B1/hu not_active IP Right Cessation
- 2002-04-15 DE DE50213871T patent/DE50213871D1/de not_active Expired - Lifetime
- 2002-04-15 EP EP02737953A patent/EP1383899B1/de not_active Revoked
- 2002-04-15 SK SK1269-2003A patent/SK288326B6/sk not_active IP Right Cessation
- 2002-04-15 PL PL367043A patent/PL207271B1/pl unknown
- 2002-04-15 AT AT02737953T patent/ATE443770T1/de active
- 2002-04-15 ES ES02737953T patent/ES2334016T3/es not_active Expired - Lifetime
- 2002-04-15 CZ CZ20032820A patent/CZ20032820A3/cs unknown
- 2002-04-15 WO PCT/EP2002/004143 patent/WO2002086126A2/de active Application Filing
- 2002-04-15 EP EP09010760A patent/EP2123760A1/de not_active Withdrawn
-
2007
- 2007-06-19 US US11/820,418 patent/US8361765B2/en not_active Expired - Fee Related
-
2009
- 2009-06-23 JP JP2009148703A patent/JP2009207499A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20032820A3 (cs) | 2004-02-18 |
| WO2002086126A2 (de) | 2002-10-31 |
| US20090017510A1 (en) | 2009-01-15 |
| PL207271B1 (pl) | 2010-11-30 |
| EP2123760A1 (de) | 2009-11-25 |
| HUP0303803A2 (hu) | 2004-03-01 |
| HU229667B1 (en) | 2014-04-28 |
| SK288326B6 (sk) | 2016-01-07 |
| ATE443770T1 (de) | 2009-10-15 |
| EP1383899B1 (de) | 2009-09-23 |
| DK1383899T3 (da) | 2010-01-25 |
| SK12692003A3 (sk) | 2004-05-04 |
| DE10119274A1 (de) | 2002-10-31 |
| US8361765B2 (en) | 2013-01-29 |
| EP1383899A2 (de) | 2004-01-28 |
| US20040265978A1 (en) | 2004-12-30 |
| JP4417628B2 (ja) | 2010-02-17 |
| ES2334016T3 (es) | 2010-03-04 |
| PT1383899E (pt) | 2009-12-24 |
| JP2009207499A (ja) | 2009-09-17 |
| HUP0303803A3 (en) | 2011-05-30 |
| WO2002086126A3 (de) | 2003-11-06 |
| JP2004527251A (ja) | 2004-09-09 |
| DE50213871D1 (de) | 2009-11-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL367043A1 (pl) | Enzymatyczny sposób selektywnej względem enancjomeru redukcji związków ketonowych | |
| EP2064331B1 (en) | Process for preparation of optically active N-protected 3-aminopyrrolidine or N-protected 3-aminopiperidine by optical resolution of racemic amine mixtures employing an omega-transaminase | |
| EP1987152B1 (en) | Process for the preparation of optically active chiral amines | |
| US9580732B2 (en) | Oxidation and amination of primary alcohols | |
| CA2869218C (en) | Oxidoreductases for the stereoselective reduction of keto compounds | |
| IL174890A0 (en) | Optimised micro-organism strains for nadph-consuming biosynthetic pathways | |
| US20090104659A1 (en) | Novel aldolase and production process of 4-hydroxy-l-isoleucine | |
| US20090198072A1 (en) | Methods and systems for increasing production of equilibrium reactions | |
| PL1633779T3 (pl) | Oksydoreduktaza z Pichia capsulata | |
| AU2002354851A1 (en) | Process for the preparation of l-amino acids using strains of the enterobacteriaceae family which contain an attenuated aceb gene | |
| EP1186666A3 (fr) | Utilisation d'inhibiteurs d'HPPD comme agents de sélection dans la transformation de plantes | |
| JP2008530978A (ja) | ４−ハイドロキシ−ｌ−イソロイシン又はその塩の製造法 | |
| US20160053236A1 (en) | Composition and methods for the production of l-homoalanine | |
| US5344768A (en) | Process for the preparation of pyrrolo-quinoline quinone | |
| AU6821900A (en) | Process for the fermentative preparation of l-amino acids with amplification of the zwf gene | |
| EP1553170B1 (en) | Novel carbonyl reductase, gene thereof and method of using the same | |
| AU6431600A (en) | Process for the fermentative preparation of l-amino acids with amplification of the gnd gene | |
| PT1224315E (pt) | Processo microbiologico para a preparacao de aldeidos e/ou acidos carboxilicos aromaticos | |
| US7115735B2 (en) | Dehydrogenase and a gene encoding the same | |
| AU5982200A (en) | Process for the fermentative preparation of l-amino acids with amplification of the tkt gene | |
| JP2005095167A (ja) | 光学活性環状アミノ酸の製造方法 | |
| JP3078296B2 (ja) | ４―ヒドロキシ―ｌ―プロリンの製造法 | |
| EP2861750B1 (en) | Process for producing chiral 1-substituted 3-piperidinols employing oxidoreductases | |
| TW202509230A (zh) | 4-(胺基甲基)環己烷-1-羧酸之製造方法 | |
| DE102004037669A1 (de) | (R)- und (S)-1,4-Dichlor-butan-2-ol und Verfahren zu deren Herstellung durch enantioselektive enzymatische Reduktion von 1,4-Dichlor-butan-2-on |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RECP | Rectifications of patent specification |