HUP0303803A2 - Enzimes eljárás ketonvegyületek enantioszelektív redukálására - Google Patents

Enzimes eljárás ketonvegyületek enantioszelektív redukálására

Info

Publication number
HUP0303803A2
HUP0303803A2 HU0303803A HUP0303803A HUP0303803A2 HU P0303803 A2 HUP0303803 A2 HU P0303803A2 HU 0303803 A HU0303803 A HU 0303803A HU P0303803 A HUP0303803 A HU P0303803A HU P0303803 A2 HUP0303803 A2 HU P0303803A2
Authority
HU
Hungary
Prior art keywords
keto compounds
compounds
enzymatic method
enantioselective reduction
water
Prior art date
Application number
HU0303803A
Other languages
English (en)
Inventor
Gert Bange
Klaus Breese
Antje Gupta
Peter Neubauer
Original Assignee
Juelich Enzyme Products Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7682020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0303803(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Juelich Enzyme Products Gmbh filed Critical Juelich Enzyme Products Gmbh
Publication of HUP0303803A2 publication Critical patent/HUP0303803A2/hu
Publication of HUP0303803A3 publication Critical patent/HUP0303803A3/hu
Publication of HU229667B1 publication Critical patent/HU229667B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A jelen találmány enzimes eljárásra vonatkozik, amellyel szervesketovegyületeket a megfelelő királis hidroxil-vegyületekké lehetredukálni. A találmány továbbá Lactobacillus minorból nyert alkohol-dehidrogenázra, valamint (S)-hidroxivegyület racemátból történőenantioszelektív kinyerésére alkalmas enzimes eljárásra vonatkozik. Azalkohol-dehidrogenázt a szubsztrátum vegyülettel vízből és vízzel nemelegyedő oldószerből álló kétfázisú rendszerben reagáltatják. Ó
HU0303803A 2001-04-20 2002-04-15 Enzymatic method for the enantioselective reduction of keto compounds HU229667B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10119274A DE10119274A1 (de) 2001-04-20 2001-04-20 Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen
PCT/EP2002/004143 WO2002086126A2 (de) 2001-04-20 2002-04-15 Enzymatisches verfahren zur enantioselektiven reduktion von ketoverbindungen

Publications (3)

Publication Number Publication Date
HUP0303803A2 true HUP0303803A2 (hu) 2004-03-01
HUP0303803A3 HUP0303803A3 (en) 2011-05-30
HU229667B1 HU229667B1 (en) 2014-04-28

Family

ID=7682020

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303803A HU229667B1 (en) 2001-04-20 2002-04-15 Enzymatic method for the enantioselective reduction of keto compounds

Country Status (13)

Country Link
US (2) US20040265978A1 (hu)
EP (2) EP1383899B1 (hu)
JP (2) JP4417628B2 (hu)
AT (1) ATE443770T1 (hu)
CZ (1) CZ20032820A3 (hu)
DE (2) DE10119274A1 (hu)
DK (1) DK1383899T3 (hu)
ES (1) ES2334016T3 (hu)
HU (1) HU229667B1 (hu)
PL (1) PL207271B1 (hu)
PT (1) PT1383899E (hu)
SK (1) SK288326B6 (hu)
WO (1) WO2002086126A2 (hu)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
DE10208007A1 (de) * 2002-02-26 2003-09-18 Forschungszentrum Juelich Gmbh Verfahren zur Herstellung von Alkoholen aus Substraten mittels Oxidoreduktasen, Zweiphasensystem umfassend eine wässrige Phase und eine organische Phase sowie Vorrichtung zur Durchführung des Verfahrens
KR20050026498A (ko) * 2002-07-20 2005-03-15 데구사 아게 알콜 탈수소효소를 기재로 하는 2상 복합 효소 반응 시스템
DE10300335B4 (de) * 2003-01-09 2008-06-26 Iep Gmbh Oxidoreduktase
DE10313972A1 (de) * 2003-03-27 2004-10-21 Degussa Ag Gekoppeltes cofaktorabhängiges enzymatisches Reaktionssystem
DE10327454A1 (de) * 2003-06-18 2005-01-20 Juelich Enzyme Products Gmbh Oxidoreduktase aus Pichia capsulata
DE102004007029A1 (de) * 2004-02-12 2005-09-08 Consortium für elektrochemische Industrie GmbH Verfahren zur enantioselektiven Reduktion von Ketoverbindungen durch Enzyme
AT501928B1 (de) * 2004-10-27 2010-09-15 Iep Gmbh Verfahren zur herstellung von chiralen alkoholen
AT501496B1 (de) * 2005-02-21 2007-03-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
AT502395B1 (de) * 2005-07-27 2007-03-15 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
AT502185B1 (de) * 2005-09-23 2007-02-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von ketoverbindungen
DE102006009744A1 (de) * 2006-03-02 2007-09-06 Wacker Chemie Ag Herstellung von (S)-2-Butanol durch oxidative Racematspaltung
AT503486B1 (de) * 2006-04-11 2008-05-15 Iep Gmbh Verfahren zur enantioselektiven reduktion von steroiden
EP2066788B1 (en) 2006-10-02 2014-07-23 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
AT504542B1 (de) 2006-12-07 2008-09-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
CN101627116B (zh) 2007-02-08 2013-07-10 科德克希思公司 酮还原酶及其用途
US7977078B2 (en) 2007-08-24 2011-07-12 Codexis, Inc. Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
JP5973131B2 (ja) * 2007-09-13 2016-08-23 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
TWI601825B (zh) 2007-09-27 2017-10-11 Ｉｅｐ有限公司 對映異構選擇性酶催化還原中間產物之方法
WO2009042984A1 (en) * 2007-09-28 2009-04-02 Codexis, Inc. Ketoreductase polypeptides and uses thereof
SI2205727T1 (sl) 2007-10-01 2015-09-30 Codexis, Inc. Polipeptidi ketoreduktaze za izdelavo azetidinona
CN102083996A (zh) 2008-04-30 2011-06-01 丹尼斯科公司 氧化方法
WO2010025287A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8426178B2 (en) * 2008-08-27 2013-04-23 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010025085A2 (en) 2008-08-29 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4s)-3[(5s)-5(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
EP2226386A1 (de) 2009-03-05 2010-09-08 IEP GmbH Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
RU2508290C2 (ru) * 2009-06-22 2014-02-27 ЭсКей БАЙОФАРМАСЬЮТИКАЛЗ КО., ЛТД. Способ получения (r)-1-арил-2-тетразолилэтилового эфира карбаминовой кислоты
SG10201405022PA (en) 2009-08-19 2014-10-30 Codexis Inc Ketoreductase polypeptides for the preparation of phenylephrine
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
CA2784903A1 (en) 2009-12-29 2011-07-28 Butamax(Tm) Advanced Biofuels Llc Alcohol dehydrogenases (adh) useful for fermentive production of lower alkyl alcohols
US9040262B2 (en) 2010-05-04 2015-05-26 Codexis, Inc. Biocatalysts for ezetimibe synthesis
NZ603816A (en) 2010-05-27 2014-06-27 Pharmazell Gmbh Novel 7alpha-hydroxysteroid dehydrogenase knockout mutants and use thereof
CA2824858A1 (en) 2011-01-18 2012-07-26 General Atomics Hydrolase enzyme substrates and uses thereof
CN104471070B (zh) * 2012-05-17 2018-09-25 基因泰克公司 制备羟基化环戊并嘧啶化合物和其盐的方法
EP2861750B1 (en) 2012-06-18 2016-11-23 Laboratorio Chimico Internazionale S.p.A. Process for producing chiral 1-substituted 3-piperidinols employing oxidoreductases
DE102013104418B4 (de) 2013-04-30 2018-09-27 Cambrex Iep Gmbh Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol
KR20160097291A (ko) 2013-12-11 2016-08-17 에프. 호프만-라 로슈 아게 키랄 2-아릴 모폴린의 제조 방법
CN106811491B (zh) * 2015-12-01 2022-07-19 焦作健康元生物制品有限公司 光学活性的β-羟基酯类化合物的制备方法及其中间体

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DE4014573C1 (hu) 1990-05-07 1991-10-10 Forschungszentrum Juelich Gmbh, 5170 Juelich, De
US5385833A (en) * 1992-02-26 1995-01-31 The Scripps Research Institute Pseudomonas sp. ATCC No. 49794 alcohol dehydrogenase
US5225339A (en) * 1992-02-26 1993-07-06 The Scripps Research Institute Lactobacillus kefir alcohol dehydrogenase
US5719039A (en) * 1995-06-01 1998-02-17 University Of Iowa Research Foundation Enzyme-surfactant ion-pair complex catalyzed reactions in organic solvents
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Also Published As

Publication number Publication date
PL367043A1 (en) 2005-02-21
SK288326B6 (sk) 2016-01-07
US20040265978A1 (en) 2004-12-30
HU229667B1 (en) 2014-04-28
DK1383899T3 (da) 2010-01-25
EP1383899A2 (de) 2004-01-28
WO2002086126A3 (de) 2003-11-06
JP4417628B2 (ja) 2010-02-17
CZ20032820A3 (cs) 2004-02-18
US8361765B2 (en) 2013-01-29
EP1383899B1 (de) 2009-09-23
HUP0303803A3 (en) 2011-05-30
ES2334016T3 (es) 2010-03-04
PL207271B1 (pl) 2010-11-30
SK12692003A3 (sk) 2004-05-04
US20090017510A1 (en) 2009-01-15
DE50213871D1 (de) 2009-11-05
ATE443770T1 (de) 2009-10-15
WO2002086126A2 (de) 2002-10-31
EP2123760A1 (de) 2009-11-25
JP2004527251A (ja) 2004-09-09
DE10119274A1 (de) 2002-10-31
JP2009207499A (ja) 2009-09-17
PT1383899E (pt) 2009-12-24

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