PL364646A1 - Synteza kwasu 4-fenylomasłowego - Google Patents

Synteza kwasu 4-fenylomasłowego

Info

Publication number
PL364646A1
PL364646A1 PL02364646A PL36464602A PL364646A1 PL 364646 A1 PL364646 A1 PL 364646A1 PL 02364646 A PL02364646 A PL 02364646A PL 36464602 A PL36464602 A PL 36464602A PL 364646 A1 PL364646 A1 PL 364646A1
Authority
PL
Poland
Prior art keywords
phenylbutyric acid
synthesis
butyrolactone
formula
base
Prior art date
Application number
PL02364646A
Other languages
English (en)
Other versions
PL201802B1 (pl
Inventor
Leszek Musial
Stanislaw R. Burzynski
Original Assignee
Stanislaw R. Burzynski
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanislaw R. Burzynski filed Critical Stanislaw R. Burzynski
Publication of PL364646A1 publication Critical patent/PL364646A1/pl
Publication of PL201802B1 publication Critical patent/PL201802B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Sposób wytwarzania związków o wzorze (I) w reakcji związków aromatycznych z butyrolaktonem, a następnie zobojętnienie zasadą. Reakcję można prowadzić w obecności katalizatora. Korzystnymi katalizatorami są kwasy Lewisa. Korzystnym produktem o wzorze (I) jest kwas 4-fenylomasłowy, który otrzymuje się w reakcji benzenu z butyrolaktonem; w obecności chlorku glinu, a następnie zobojętnia zasadą.
PL364646A 2001-05-21 2002-05-02 Sposób wytwarzania pochodnych kwasu 4-fenylomasłowego PL201802B1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/862,074 US6372938B1 (en) 2001-05-21 2001-05-21 Synthesis of 4-phenylbutyric acid
PCT/US2002/013946 WO2002094756A1 (en) 2001-05-21 2002-05-02 Synthesis of 4-phenylbutyric acid

Publications (2)

Publication Number Publication Date
PL364646A1 true PL364646A1 (pl) 2004-12-13
PL201802B1 PL201802B1 (pl) 2009-05-29

Family

ID=25337569

Family Applications (1)

Application Number Title Priority Date Filing Date
PL364646A PL201802B1 (pl) 2001-05-21 2002-05-02 Sposób wytwarzania pochodnych kwasu 4-fenylomasłowego

Country Status (12)

Country Link
US (1) US6372938B1 (pl)
EP (1) EP1404638B1 (pl)
JP (1) JP4338401B2 (pl)
KR (1) KR100905139B1 (pl)
CN (1) CN1266105C (pl)
AT (1) ATE517857T1 (pl)
CA (1) CA2447803C (pl)
HU (1) HU229996B1 (pl)
IL (2) IL158914A0 (pl)
PL (1) PL201802B1 (pl)
RU (1) RU2297998C2 (pl)
WO (1) WO2002094756A1 (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1291015A1 (en) * 2001-09-10 2003-03-12 Lunamed AG Dosage forms having prolonged active ingredient release
EP1511707B1 (en) * 2002-06-03 2010-05-19 Showa Denko K.K. Process for producing aromatic compounds by friedel-crafts reaction
US20060045912A1 (en) * 2004-08-30 2006-03-02 Peter Truog 4-phenylbutyric acid controlled-release formulations for therapeutic use
US20070004805A1 (en) * 2005-07-01 2007-01-04 Navinta Llc Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate
US7968604B2 (en) * 2005-09-23 2011-06-28 Jeong-Woo Cho Pharmaceutical composition for prevention and treatment of drug or alcohol addiction or bipolar disorder using sodium phenylbutyrate
CN102933078A (zh) * 2010-04-06 2013-02-13 拜耳知识产权有限责任公司 4-苯基丁酸和/或其盐用于提高植物应激耐受性的用途
KR101374241B1 (ko) * 2010-11-17 2014-03-14 전북대학교병원 페닐부틸산（４－ｐｈｅｎｙｌｂｕｔｙｒｉｃ ａｃｉｄ）또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는, 천식 치료용 약학적 조성물
EP2599477A1 (en) 2011-11-30 2013-06-05 Lunamed AG 4-Phenylbutyric acid sustained release formulation
FR2993141B1 (fr) 2012-07-11 2014-11-28 Inst Rech Developpement Ird Utilisation de l'acide 4-phenylbutyrique pour ameliorer la tolerance des plantes aux bioagresseurs
CN103304403B (zh) * 2013-05-24 2015-04-22 苏州诚和医药化学有限公司 一种4-苯-1-丁酸的合成方法
CN103304402B (zh) * 2013-05-24 2015-04-22 苏州诚和医药化学有限公司 一种制备4-苯-1-丁酸的方法
US9914692B2 (en) * 2016-05-25 2018-03-13 Horizon Therapeutics, Llc Procedure for the preparation of 4-phenyl butyrate and uses thereof
CN106117045A (zh) * 2016-06-22 2016-11-16 北京阳光诺和药物研究有限公司 一种苯基丁酸的纯化方法
CN108530290A (zh) * 2018-06-04 2018-09-14 福州华博立乐新材料科技有限公司 一种4-苯基-1-丁酸的合成方法
CN110317132B (zh) * 2019-07-26 2021-09-10 南京工业大学 一种苯丁酸钠的制备方法
FR3110336B1 (fr) 2020-05-20 2022-12-23 Inst Des Sciences Et Industries Du Vivant Et De Lenvir Utilisation de l’Acide 4-phénylbutyrique et/ou de l’Acide 3-phénylbutyrique et/ou de l’Acide 2-phénylbutyrique pour la Prévention et le Traitement des Maladies Cryptogamiques
IT202300019125A1 (it) * 2023-09-18 2025-03-18 Dipharma Francis Srl Metodo di purificazione di un farmaco usato per il trattamento di disturbi del ciclo dell’urea
WO2024200617A1 (en) * 2023-03-28 2024-10-03 Dipharma Francis S.R.L. Process and intermediates for preparing a drug for the treatment of urea cycle disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037376A (en) 1991-10-21 2000-03-14 The United States Of America As Represented By The Department Of Health And Human Services Methods for therapy of cancer

Also Published As

Publication number Publication date
IL158914A (en) 2010-04-29
EP1404638B1 (en) 2011-07-27
RU2297998C2 (ru) 2007-04-27
JP2004527577A (ja) 2004-09-09
WO2002094756A1 (en) 2002-11-28
KR100905139B1 (ko) 2009-06-29
CN1511133A (zh) 2004-07-07
RU2003136765A (ru) 2005-04-10
PL201802B1 (pl) 2009-05-29
IL158914A0 (en) 2004-05-12
HK1065996A1 (en) 2005-03-11
EP1404638A1 (en) 2004-04-07
HUP0400053A3 (en) 2006-01-30
HU229996B1 (hu) 2015-04-28
CA2447803A1 (en) 2002-11-28
JP4338401B2 (ja) 2009-10-07
ATE517857T1 (de) 2011-08-15
KR20040025679A (ko) 2004-03-24
CN1266105C (zh) 2006-07-26
US6372938B1 (en) 2002-04-16
HUP0400053A2 (hu) 2004-04-28
CA2447803C (en) 2009-04-07

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