ATE482226T1 - Synthese von derivaten der 2-deoxy-2-fluoro- arabinose - Google Patents
Synthese von derivaten der 2-deoxy-2-fluoro- arabinoseInfo
- Publication number
- ATE482226T1 ATE482226T1 AT01115797T AT01115797T ATE482226T1 AT E482226 T1 ATE482226 T1 AT E482226T1 AT 01115797 T AT01115797 T AT 01115797T AT 01115797 T AT01115797 T AT 01115797T AT E482226 T1 ATE482226 T1 AT E482226T1
- Authority
- AT
- Austria
- Prior art keywords
- arabinose
- deoxy
- fluoro
- synthesis
- derivatives
- Prior art date
Links
- NJYXSKVOTDPOAT-WDCZJNDASA-N (2s,3r,4r)-2-fluoro-3,4,5-trihydroxypentanal Chemical class OC[C@@H](O)[C@@H](O)[C@H](F)C=O NJYXSKVOTDPOAT-WDCZJNDASA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000002243 furanoses Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/615,877 US6462191B1 (en) | 2000-07-13 | 2000-07-13 | Synthesis of 2-deoxy-2-fluoro-arabinose derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE482226T1 true ATE482226T1 (de) | 2010-10-15 |
Family
ID=24467170
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01115797T ATE482226T1 (de) | 2000-07-13 | 2001-07-11 | Synthese von derivaten der 2-deoxy-2-fluoro- arabinose |
Country Status (5)
Country | Link |
---|---|
US (1) | US6462191B1 (de) |
EP (1) | EP1172369B1 (de) |
JP (1) | JP3987306B2 (de) |
AT (1) | ATE482226T1 (de) |
DE (1) | DE60143105D1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004050676A1 (ja) * | 2002-12-04 | 2004-06-17 | Mitsubishi Gas Chemical Company, Inc. | フッ素化方法 |
JP4577478B2 (ja) * | 2002-12-04 | 2010-11-10 | 三菱瓦斯化学株式会社 | 糖質のフッ素化方法 |
PT1773856E (pt) * | 2004-07-21 | 2012-05-14 | Gilead Pharmasset Llc | Preparação de 2-desoxi-2-fluoro-d-ribofuranosilo pirimidinas e purinas substituídas com alquilo e seus derivados |
JP2006265156A (ja) * | 2005-03-23 | 2006-10-05 | Ajinomoto Co Inc | 2−デオキシ−l−リボフラノシルクロリド化合物の製造方法 |
JO2778B1 (en) * | 2007-10-16 | 2014-03-15 | ايساي انك | Certain vehicles, installations and methods |
UY32546A (es) * | 2009-04-06 | 2010-10-29 | Eisai Inc | Composiciones y metodos para tratar cancer |
US8609631B2 (en) | 2009-04-06 | 2013-12-17 | Eisai Inc. | Compositions and methods for treating cancer |
JP5684787B2 (ja) * | 2009-04-06 | 2015-03-18 | 大塚製薬株式会社 | シチジンベースの抗新生物薬とシチジンデアミナーゼ阻害薬との組合せ、および癌の治療におけるその使用 |
TWI477508B (zh) * | 2009-04-06 | 2015-03-21 | Otsuka Pharma Co Ltd | 用以治療癌症之組成物及方法 |
KR20120046718A (ko) * | 2009-06-19 | 2012-05-10 | 오메가켐 아인엔씨. | 이치환된-아미노디플루오로설피늄 염, 이의 제조방법 및 데옥소플루오르화제로의 사용방법 |
WO2016144773A1 (en) | 2015-03-06 | 2016-09-15 | Abbvie Inc. | Arabinosylated glycoproteins |
CN116375775A (zh) * | 2023-03-09 | 2023-07-04 | 江苏福瑞康泰药业有限公司 | 一种阿兹夫定中间体的合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4625020A (en) * | 1983-11-18 | 1986-11-25 | Bristol-Myers Company | Nucleoside process |
US5817799A (en) * | 1990-07-23 | 1998-10-06 | The United States Of America As Represented By The Department Of Health And Human Services | 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides |
AT400953B (de) * | 1994-08-25 | 1996-05-28 | Joern Saischek | Pentofuranosid-derivate, deren herstellung und verwendung |
TW434252B (en) * | 1997-07-23 | 2001-05-16 | Univ Georgia Res Found | Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine |
US6080886A (en) | 1997-09-29 | 2000-06-27 | Air Products And Chemicals, Inc. | Fluorination with aminosulfur trifluorides |
US6207860B1 (en) | 1997-09-29 | 2001-03-27 | Air Products And Chemicals, Inc. | Thermally stable aminosulfur trifluorides |
-
2000
- 2000-07-13 US US09/615,877 patent/US6462191B1/en not_active Expired - Fee Related
-
2001
- 2001-07-11 EP EP01115797A patent/EP1172369B1/de not_active Expired - Lifetime
- 2001-07-11 DE DE60143105T patent/DE60143105D1/de not_active Expired - Lifetime
- 2001-07-11 AT AT01115797T patent/ATE482226T1/de not_active IP Right Cessation
- 2001-07-13 JP JP2001214168A patent/JP3987306B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6462191B1 (en) | 2002-10-08 |
EP1172369B1 (de) | 2010-09-22 |
EP1172369A1 (de) | 2002-01-16 |
DE60143105D1 (de) | 2010-11-04 |
JP2002193989A (ja) | 2002-07-10 |
JP3987306B2 (ja) | 2007-10-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |