ATE482226T1 - Synthese von derivaten der 2-deoxy-2-fluoro- arabinose - Google Patents

Synthese von derivaten der 2-deoxy-2-fluoro- arabinose

Info

Publication number
ATE482226T1
ATE482226T1 AT01115797T AT01115797T ATE482226T1 AT E482226 T1 ATE482226 T1 AT E482226T1 AT 01115797 T AT01115797 T AT 01115797T AT 01115797 T AT01115797 T AT 01115797T AT E482226 T1 ATE482226 T1 AT E482226T1
Authority
AT
Austria
Prior art keywords
arabinose
deoxy
fluoro
synthesis
derivatives
Prior art date
Application number
AT01115797T
Other languages
English (en)
Inventor
Gauri Sankar Lal
Original Assignee
Air Prod & Chem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Air Prod & Chem filed Critical Air Prod & Chem
Application granted granted Critical
Publication of ATE482226T1 publication Critical patent/ATE482226T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01115797T 2000-07-13 2001-07-11 Synthese von derivaten der 2-deoxy-2-fluoro- arabinose ATE482226T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/615,877 US6462191B1 (en) 2000-07-13 2000-07-13 Synthesis of 2-deoxy-2-fluoro-arabinose derivatives

Publications (1)

Publication Number Publication Date
ATE482226T1 true ATE482226T1 (de) 2010-10-15

Family

ID=24467170

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01115797T ATE482226T1 (de) 2000-07-13 2001-07-11 Synthese von derivaten der 2-deoxy-2-fluoro- arabinose

Country Status (5)

Country Link
US (1) US6462191B1 (de)
EP (1) EP1172369B1 (de)
JP (1) JP3987306B2 (de)
AT (1) ATE482226T1 (de)
DE (1) DE60143105D1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4577478B2 (ja) * 2002-12-04 2010-11-10 三菱瓦斯化学株式会社 糖質のフッ素化方法
EP2189467A3 (de) 2002-12-04 2010-09-08 Mitsubishi Gas Chemical Company, Inc. Fluorierungsverfahren mittels Mikrowellen
CA2574651C (en) * 2004-07-21 2013-05-21 Pharmasset, Inc. Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives
JP2006265156A (ja) * 2005-03-23 2006-10-05 Ajinomoto Co Inc ２−デオキシ−ｌ−リボフラノシルクロリド化合物の製造方法
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain Compounds, Compositions and Methods
ES2628580T3 (es) * 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de decitabina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer el tratamiento de cáncer
EP2417146B1 (de) * 2009-04-06 2016-07-13 Otsuka Pharmaceutical Co., Ltd. Derives de la (2'-deoxy-ribofuranosyl)-1,3,4,7-tetrahydro-(1,3)diazepin-2-one pour le traitment du cancer
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
JP5684787B2 (ja) * 2009-04-06 2015-03-18 大塚製薬株式会社 シチジンベースの抗新生物薬とシチジンデアミナーゼ阻害薬との組合せ、および癌の治療におけるその使用
US8680332B2 (en) * 2009-06-19 2014-03-25 Omegachem Inc. Disubstituted-aminodifluorosulfinium salts, process for preparing same and method of use as deoxofluorination reagents
WO2016144773A1 (en) 2015-03-06 2016-09-15 Abbvie Inc. Arabinosylated glycoproteins
CN116375775B (zh) * 2023-03-09 2024-09-10 江苏阿尔法集团福瑞药业(宿迁)有限公司 一种阿兹夫定中间体的合成方法
CN117586323A (zh) * 2023-11-08 2024-02-23 江苏阿尔法药业股份有限公司 一种阿兹夫定中间体的制备方法
CN117586324A (zh) * 2023-11-08 2024-02-23 江苏阿尔法药业股份有限公司 一种阿兹夫定中间体的合成工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4625020A (en) * 1983-11-18 1986-11-25 Bristol-Myers Company Nucleoside process
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
AT400953B (de) * 1994-08-25 1996-05-28 Joern Saischek Pentofuranosid-derivate, deren herstellung und verwendung
TW434252B (en) * 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
US6207860B1 (en) 1997-09-29 2001-03-27 Air Products And Chemicals, Inc. Thermally stable aminosulfur trifluorides
US6080886A (en) 1997-09-29 2000-06-27 Air Products And Chemicals, Inc. Fluorination with aminosulfur trifluorides

Also Published As

Publication number Publication date
EP1172369A1 (de) 2002-01-16
EP1172369B1 (de) 2010-09-22
JP3987306B2 (ja) 2007-10-10
US6462191B1 (en) 2002-10-08
JP2002193989A (ja) 2002-07-10
DE60143105D1 (de) 2010-11-04

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Legal Events

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