PL338783A1 - Substituted 4-oxo-naphtyridin-3-carboxamides as ligands of cerebral gaba receptors - Google Patents

Substituted 4-oxo-naphtyridin-3-carboxamides as ligands of cerebral gaba receptors

Info

Publication number
PL338783A1
PL338783A1 PL98338783A PL33878398A PL338783A1 PL 338783 A1 PL338783 A1 PL 338783A1 PL 98338783 A PL98338783 A PL 98338783A PL 33878398 A PL33878398 A PL 33878398A PL 338783 A1 PL338783 A1 PL 338783A1
Authority
PL
Poland
Prior art keywords
naphtyridin
carboxamides
ligands
oxo
substituted
Prior art date
Application number
PL98338783A
Other languages
English (en)
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of PL338783A1 publication Critical patent/PL338783A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL98338783A 1997-08-25 1998-08-24 Substituted 4-oxo-naphtyridin-3-carboxamides as ligands of cerebral gaba receptors PL338783A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91818097A 1997-08-25 1997-08-25
PCT/US1998/017513 WO1999010347A1 (en) 1997-08-25 1998-08-24 Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands

Publications (1)

Publication Number Publication Date
PL338783A1 true PL338783A1 (en) 2000-11-20

Family

ID=25439933

Family Applications (1)

Application Number Title Priority Date Filing Date
PL98338783A PL338783A1 (en) 1997-08-25 1998-08-24 Substituted 4-oxo-naphtyridin-3-carboxamides as ligands of cerebral gaba receptors

Country Status (24)

Country Link
EP (1) EP1007526A1 (https=)
JP (1) JP2001514181A (https=)
KR (1) KR20010023313A (https=)
CN (1) CN1268136A (https=)
AP (1) AP2000001742A0 (https=)
AU (1) AU753800B2 (https=)
BG (1) BG104192A (https=)
BR (1) BR9811362A (https=)
CA (1) CA2301599C (https=)
EG (1) EG21717A (https=)
HU (1) HUP0003258A3 (https=)
IL (1) IL134291A0 (https=)
IS (1) IS5382A (https=)
LV (1) LV12539B (https=)
NO (1) NO20000822L (https=)
NZ (1) NZ502548A (https=)
OA (1) OA11293A (https=)
PE (1) PE130999A1 (https=)
PL (1) PL338783A1 (https=)
SI (1) SI20270A (https=)
SK (1) SK2162000A3 (https=)
TW (1) TW574221B (https=)
WO (1) WO1999010347A1 (https=)
YU (1) YU10500A (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60018274T2 (de) * 1999-05-06 2005-08-04 Neurogen Corp., Branford Substituierte 4-oxo-chinolin-3-carboxamide als gaba gehirnrezeptorliganden
WO2000071528A1 (en) * 1999-05-25 2000-11-30 Neurogen Corporation 4h-1,4-benzothiazine-2-carboxamides and their use as gaba brain receptor ligands
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
EP1326611B1 (en) 2000-10-12 2007-06-13 Merck & Co., Inc. Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
ATE345129T1 (de) 2000-10-12 2006-12-15 Merck & Co Inc Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
PL360944A1 (en) 2000-10-12 2004-09-20 Merck & Co, Inc. Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
US20020151591A1 (en) * 2000-10-17 2002-10-17 Anabella Villalobos Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
CZ20032338A3 (cs) * 2001-03-01 2004-08-18 Pfizeráproductsáinc Použití inversních agonistů GABA A v kombinaci s parciálními agonisty receptoru nikotinuŹ estrogenemŹ selektivními modulátory estrogenu nebo vitaminem E při léčení kognitivních poruch
AR036256A1 (es) 2001-08-17 2004-08-25 Merck & Co Inc Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento
EP1467970B1 (en) 2002-01-17 2007-08-22 Merck & Co., Inc. Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors
ATE409187T1 (de) 2002-03-15 2008-10-15 Merck & Co Inc N-(substituierte benzyl)-8-hydroxy-1,6- naphthyridin-7- carbonsäureamide als hiv- integrase-hemmer
WO2004106336A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Process for the preparation and purification of 1,5-naphthyridine-3-carboxyamides
WO2004106334A2 (en) * 2003-05-28 2004-12-09 Pfizer Products Inc. Process for the preparation of 1,5-naphthyridine-3-carboxy amides by direct ester amidation
NZ576036A (en) * 2006-10-16 2010-10-29 Bionomics Ltd Naphthyridine containing compounds for treating anxiety disorders
PL2083811T3 (pl) * 2006-11-22 2017-05-31 Clinical Research Associates, Llc Sposoby leczenia zespołu downa, zespołu łamliwego chromosomu x oraz autyzmu

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204813A1 (es) * 1972-05-08 1976-03-05 Yamanouchi Pharma Co Ltd Proceso para la preparacion de derivados de ampilicina
GB1433774A (en) * 1973-02-26 1976-04-28 Allen & Hanburys Ltd Heterocyclic compounds apparatus for conveying articles
US4374138A (en) * 1981-11-13 1983-02-15 Warner-Lambert Company Antibacterial amide compounds, compositions, and methods of use
DD279875A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von aktivierten carbonsaeureestern
DD279887A1 (de) * 1987-07-03 1990-06-20 Inst Pharmakologische Forschun Verfahren zur herstellung von d-alpha-(4(1h)-1,5-naphthyridon-3-carboxamido)-benzylpenicillin und anderen beta-lactamantibiotika
DD295360A5 (de) * 1987-07-03 1991-10-31 Akad Wissenschaften Verfahren zur Herstellung von aktivierten Carbonsäureestern
JPS6461461A (en) * 1987-09-01 1989-03-08 Otsuka Pharma Co Ltd Benzohetero ring derivative

Also Published As

Publication number Publication date
KR20010023313A (ko) 2001-03-26
IL134291A0 (en) 2001-04-30
IS5382A (is) 2000-02-22
SI20270A (sl) 2000-12-31
SK2162000A3 (en) 2001-03-12
NO20000822L (no) 2000-04-13
CA2301599C (en) 2003-03-25
CN1268136A (zh) 2000-09-27
AP2000001742A0 (en) 2000-02-24
LV12539A (en) 2000-10-20
TW574221B (en) 2004-02-01
AU753800B2 (en) 2002-10-31
HUP0003258A2 (en) 2001-03-28
NO20000822D0 (no) 2000-02-18
EG21717A (en) 2002-02-27
NZ502548A (en) 2002-06-28
BR9811362A (pt) 2000-08-22
HUP0003258A3 (en) 2001-05-28
JP2001514181A (ja) 2001-09-11
OA11293A (en) 2002-11-19
CA2301599A1 (en) 1999-03-04
PE130999A1 (es) 1999-12-16
YU10500A (sh) 2002-10-18
EP1007526A1 (en) 2000-06-14
BG104192A (en) 2001-05-31
WO1999010347A1 (en) 1999-03-04
LV12539B (en) 2001-01-20
AU9117398A (en) 1999-03-16

Similar Documents

Publication Publication Date Title
PL338783A1 (en) Substituted 4-oxo-naphtyridin-3-carboxamides as ligands of cerebral gaba receptors
PL350095A1 (en) Ligands of melanocortinic receptors
GB9817407D0 (en) Chiral compounds
AU2218997A (en) Certain fused pyrrolecarboxamides as gaba brain receptor ligands
PL341652A1 (en) Derivatives of triazolopyridazine as ligands for gaba receptors
AU2217200A (en) 2-amino-9-alkylpurines: gaba brain receptor ligands
SG71785A1 (en) Deploymerization of polyamides
ZA983736B (en) New compounds
IL135729A0 (en) H3 receptor ligands of the phenyl-alkyl-imidazoles type
IL135433A0 (en) Novel compounds useful as neuro-protective agents
IL134408A0 (en) Anti-first- pass effect compounds
GB9713732D0 (en) Substituted triazinic compounds
CZ2000554A3 (cs) Substituované 4-oxonaftyridin-3-karboxamidy jako ligandy mozkových receptorů GABA
AU2653499A (en) Oxo-dipyridoimidazole-carboxamides: gaba brain receptor ligands
ZA976591B (en) Substituted triazolo-pyridazine derivatives as ligands for gaba receptors
GB9706561D0 (en) Alkanoic compounds
ZA9810176B (en) H3 receptor ligands of the phenyl-alkyl-imidazoles type
TW322697U (en) Structure of pre-frying machine
TW383619U (en) Improvement for filter element of filter
PL324063A1 (en) Filtering attachment
HU9701558D0 (en) New compounds
GB9701702D0 (en) Improvements relating to line tensioners
GB9701597D0 (en) Novel compounds
GB9711571D0 (en) Novel compounds
GB9710732D0 (en) Novel compounds