PL2877201T3 - Ciekła formulacja długo działającej insuliny i peptydu insulinotropowego - Google Patents
Ciekła formulacja długo działającej insuliny i peptydu insulinotropowegoInfo
- Publication number
- PL2877201T3 PL2877201T3 PL13822545T PL13822545T PL2877201T3 PL 2877201 T3 PL2877201 T3 PL 2877201T3 PL 13822545 T PL13822545 T PL 13822545T PL 13822545 T PL13822545 T PL 13822545T PL 2877201 T3 PL2877201 T3 PL 2877201T3
- Authority
- PL
- Poland
- Prior art keywords
- long
- liquid formulation
- acting insulin
- insulinotropic peptide
- insulinotropic
- Prior art date
Links
- 102000016261 Long-Acting Insulin Human genes 0.000 title 1
- 108010092217 Long-Acting Insulin Proteins 0.000 title 1
- 229940100066 Long-acting insulin Drugs 0.000 title 1
- 230000002473 insulinotropic effect Effects 0.000 title 1
- 239000012669 liquid formulation Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20120081478 | 2012-07-25 | ||
| PCT/KR2013/006676 WO2014017849A1 (en) | 2012-07-25 | 2013-07-25 | A liquid formulation of long-acting insulin and insulinotropic peptide |
| EP13822545.3A EP2877201B1 (en) | 2012-07-25 | 2013-07-25 | A liquid formulation of long-acting insulin and insulinotropic peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2877201T3 true PL2877201T3 (pl) | 2019-12-31 |
Family
ID=49997583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL13822545T PL2877201T3 (pl) | 2012-07-25 | 2013-07-25 | Ciekła formulacja długo działającej insuliny i peptydu insulinotropowego |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9833516B2 (pl) |
| EP (1) | EP2877201B1 (pl) |
| JP (2) | JP6403670B2 (pl) |
| KR (1) | KR102088863B1 (pl) |
| CN (2) | CN110269930A (pl) |
| AR (1) | AR092862A1 (pl) |
| AU (1) | AU2013293720B2 (pl) |
| BR (1) | BR112015001593B1 (pl) |
| CA (1) | CA2880037C (pl) |
| CY (1) | CY1122146T1 (pl) |
| DK (1) | DK2877201T3 (pl) |
| ES (1) | ES2743918T3 (pl) |
| HK (1) | HK1204291A1 (pl) |
| HU (1) | HUE045837T2 (pl) |
| MX (1) | MX358647B (pl) |
| PL (1) | PL2877201T3 (pl) |
| PT (1) | PT2877201T (pl) |
| RU (1) | RU2643766C2 (pl) |
| TW (1) | TWI630214B (pl) |
| WO (1) | WO2014017849A1 (pl) |
Families Citing this family (45)
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|---|---|---|---|---|
| HUE048608T2 (hu) | 2008-10-17 | 2020-08-28 | Sanofi Aventis Deutschland | Egy inzulin és egy GLP-1 agonista kombinációja |
| RU2537239C2 (ru) | 2009-11-13 | 2014-12-27 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая композиция, включающая агонист glp-1, инсулин и метионин |
| LT2498801T (lt) | 2009-11-13 | 2018-05-10 | Sanofi-Aventis Deutschland Gmbh | Farmacinė kompozicija, apimanti despro36eksendin-4(1-39)-lys6-nh2 ir metioniną |
| HUE031181T2 (en) | 2010-08-30 | 2017-06-28 | Sanofi Aventis Deutschland | Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
| KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
| AR090281A1 (es) | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| HRP20181300T1 (hr) | 2012-12-21 | 2018-10-05 | Sanofi | Derivati eksendina-4 kao dvostruki glp1/gip- ili trostruki glp1/gip/glukagon agonisti |
| TWI641381B (zh) | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物 |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| CN111658604A (zh) | 2014-01-09 | 2020-09-15 | 赛诺菲 | 胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂 |
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| AU2015205624A1 (en) | 2014-01-09 | 2016-07-14 | Sanofi | Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives |
| CN105916877A (zh) | 2014-01-20 | 2016-08-31 | 韩美药品株式会社 | 长效胰岛素及其用途 |
| SG11201608120TA (en) * | 2014-03-31 | 2016-11-29 | Hanmi Pharm Ind Co Ltd | Method for improving solubility of protein and peptide by using immunoglobulin fc fragment linkage |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
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| AR100639A1 (es) * | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
| AR100695A1 (es) | 2014-05-30 | 2016-10-26 | Hanmi Pharm Ind Co Ltd | Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| FI3229828T3 (fi) | 2014-12-12 | 2023-05-29 | Sanofi Aventis Deutschland | Glargiini-insuliinin/liksisenatidin vakiosuhteinen formulaatio |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
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| UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
| GB201607918D0 (en) | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
| KR102698929B1 (ko) | 2016-09-23 | 2024-08-27 | 한미약품 주식회사 | 인슐린 수용체와의 결합력이 감소된, 인슐린 아날로그 및 이의 용도 |
| MX2019011297A (es) | 2017-03-23 | 2019-11-12 | Hanmi Pharm Ind Co Ltd | Complejo de analogo de insulina con afinidad reducida por el receptor de insulina y uso del mismo. |
| WO2019066603A1 (ko) * | 2017-09-29 | 2019-04-04 | 한미약품 주식회사 | 효력이 향상된 지속성 단백질 결합체 |
| TWI705820B (zh) * | 2018-06-22 | 2020-10-01 | 美商美國禮來大藥廠 | Gip/glp1促效劑組合物 |
| CN110628723B (zh) * | 2019-09-05 | 2021-05-04 | 清华大学 | 基因修饰MSCs治疗2型糖尿病 |
| MX2022006703A (es) * | 2019-12-06 | 2022-07-12 | CSL Behring Lengnau AG | Composiciones estables de multimeros fc. |
| CA3179472A1 (en) * | 2020-05-22 | 2021-11-25 | Sung Hee Hong | Liquid formulation of long-acting conjugate of glp-2 |
| CN115811970A (zh) * | 2020-05-22 | 2023-03-17 | 韩美药品株式会社 | 胰高血糖素、glp-1和gip三重激动剂的长效缀合物的液体制剂 |
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| KR101330868B1 (ko) | 2010-06-08 | 2013-11-18 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 인슐린 유도체 약물 결합체 |
| KR101324828B1 (ko) | 2010-06-08 | 2013-11-01 | 한미사이언스 주식회사 | 면역글로불린 단편을 이용한 단쇄 인슐린 아날로그 약물 결합체 |
| KR101337797B1 (ko) | 2010-07-14 | 2013-12-06 | 한미사이언스 주식회사 | 지속형 인간 성장 호르몬 결합체 액상 제제 |
| KR101303388B1 (ko) | 2010-10-26 | 2013-09-03 | 한미사이언스 주식회사 | 지속형 인터페론 알파 결합체의 액상 제제 |
| UA113626C2 (xx) * | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії |
-
2013
- 2013-07-24 AR ARP130102652A patent/AR092862A1/es not_active Application Discontinuation
- 2013-07-25 WO PCT/KR2013/006676 patent/WO2014017849A1/en not_active Ceased
- 2013-07-25 ES ES13822545T patent/ES2743918T3/es active Active
- 2013-07-25 DK DK13822545.3T patent/DK2877201T3/da active
- 2013-07-25 US US14/416,231 patent/US9833516B2/en active Active
- 2013-07-25 HU HUE13822545A patent/HUE045837T2/hu unknown
- 2013-07-25 BR BR112015001593-0A patent/BR112015001593B1/pt active IP Right Grant
- 2013-07-25 CN CN201910644022.4A patent/CN110269930A/zh active Pending
- 2013-07-25 KR KR1020130087917A patent/KR102088863B1/ko active Active
- 2013-07-25 HK HK15104957.6A patent/HK1204291A1/xx unknown
- 2013-07-25 EP EP13822545.3A patent/EP2877201B1/en active Active
- 2013-07-25 MX MX2015001217A patent/MX358647B/es active IP Right Grant
- 2013-07-25 AU AU2013293720A patent/AU2013293720B2/en active Active
- 2013-07-25 JP JP2015524185A patent/JP6403670B2/ja active Active
- 2013-07-25 CN CN201380039763.0A patent/CN104519904A/zh active Pending
- 2013-07-25 TW TW102126622A patent/TWI630214B/zh active
- 2013-07-25 PT PT13822545T patent/PT2877201T/pt unknown
- 2013-07-25 RU RU2015104489A patent/RU2643766C2/ru active
- 2013-07-25 PL PL13822545T patent/PL2877201T3/pl unknown
- 2013-07-25 CA CA2880037A patent/CA2880037C/en active Active
-
2018
- 2018-05-31 JP JP2018104433A patent/JP6686070B2/ja active Active
-
2019
- 2019-08-22 CY CY20191100898T patent/CY1122146T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1204291A1 (en) | 2015-11-13 |
| JP6403670B2 (ja) | 2018-10-10 |
| AU2013293720B2 (en) | 2018-05-10 |
| CN110269930A (zh) | 2019-09-24 |
| AR092862A1 (es) | 2015-05-06 |
| BR112015001593B1 (pt) | 2023-12-26 |
| JP2018138615A (ja) | 2018-09-06 |
| MX2015001217A (es) | 2015-09-07 |
| JP6686070B2 (ja) | 2020-04-22 |
| KR20140015208A (ko) | 2014-02-06 |
| EP2877201A1 (en) | 2015-06-03 |
| MX358647B (es) | 2018-08-29 |
| ES2743918T3 (es) | 2020-02-21 |
| JP2015524429A (ja) | 2015-08-24 |
| EP2877201B1 (en) | 2019-06-05 |
| US20150190528A1 (en) | 2015-07-09 |
| CN104519904A (zh) | 2015-04-15 |
| BR112015001593A2 (pt) | 2019-07-30 |
| PT2877201T (pt) | 2019-09-10 |
| CA2880037A1 (en) | 2014-01-30 |
| HUE045837T2 (hu) | 2020-01-28 |
| CA2880037C (en) | 2021-08-17 |
| RU2015104489A (ru) | 2016-09-20 |
| RU2643766C2 (ru) | 2018-02-05 |
| CY1122146T1 (el) | 2021-01-27 |
| DK2877201T3 (da) | 2019-09-16 |
| TW201410704A (zh) | 2014-03-16 |
| WO2014017849A1 (en) | 2014-01-30 |
| US9833516B2 (en) | 2017-12-05 |
| AU2013293720A1 (en) | 2015-02-12 |
| TWI630214B (zh) | 2018-07-21 |
| EP2877201A4 (en) | 2016-03-30 |
| KR102088863B1 (ko) | 2020-03-13 |
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