CY1122146T1 - Μια υγρη μορφοποιηση μακρας διαρκειας δρασης και ινσουλινοτροπο πεπτιδιο - Google Patents
Μια υγρη μορφοποιηση μακρας διαρκειας δρασης και ινσουλινοτροπο πεπτιδιοInfo
- Publication number
- CY1122146T1 CY1122146T1 CY20191100898T CY191100898T CY1122146T1 CY 1122146 T1 CY1122146 T1 CY 1122146T1 CY 20191100898 T CY20191100898 T CY 20191100898T CY 191100898 T CY191100898 T CY 191100898T CY 1122146 T1 CY1122146 T1 CY 1122146T1
- Authority
- CY
- Cyprus
- Prior art keywords
- liquid formulation
- insulin
- peptide
- long
- moduling
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
Η παρούσα εφεύρεση σχετίζεται με μια υγρή μορφοποίηση ενός συνδυασμού ινσουλίνης και ινσουλινοτρόπου πεπτιδίου μακράς διάρκειας δράσης, που περιλαμβάνει ινσουλίνη η οποία είναι ένα ενεργό από άποψη φυσιολογίας πεπτίδιο, ινσουλινοτρόπο πεπτίδιο, και σταθεροποιητή χωρίς αλβουμίνη, όπου ο σταθεροποιητής περιλαμβάνει ένα ρυθμιστικό διάλυμα, μια αλκοόλη σακχάρου, μια μη ιοντική επιφανειοδραστική ουσία, και έναν ισοτονικό παράγοντα· και με μια μέθοδο για την παρασκευή της υγρής μορφοποίησης. Η υγρή μορφοποίηση της παρούσας εφεύρεσης δεν περιέχει μια αλβουμίνη ορού ανθρώπου και δυνητικά τοξικούς παράγοντες για το σώμα, και έτσι έχει εξαιρετική σταθερότητα αποθήκευσης για το σύζευγμα ινσουλίνης και το ινσουλινοτρόπο πεπτιδικό σύζευγμα σε υψηλή συγκέντρωση, χωρίς κάποιον κίνδυνο μόλυνσης από ιό.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20120081478 | 2012-07-25 | ||
PCT/KR2013/006676 WO2014017849A1 (en) | 2012-07-25 | 2013-07-25 | A liquid formulation of long-acting insulin and insulinotropic peptide |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122146T1 true CY1122146T1 (el) | 2021-01-27 |
Family
ID=49997583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100898T CY1122146T1 (el) | 2012-07-25 | 2019-08-22 | Μια υγρη μορφοποιηση μακρας διαρκειας δρασης και ινσουλινοτροπο πεπτιδιο |
Country Status (20)
Country | Link |
---|---|
US (1) | US9833516B2 (el) |
EP (1) | EP2877201B1 (el) |
JP (2) | JP6403670B2 (el) |
KR (1) | KR102088863B1 (el) |
CN (2) | CN104519904A (el) |
AR (1) | AR092862A1 (el) |
AU (1) | AU2013293720B2 (el) |
BR (1) | BR112015001593B1 (el) |
CA (1) | CA2880037C (el) |
CY (1) | CY1122146T1 (el) |
DK (1) | DK2877201T3 (el) |
ES (1) | ES2743918T3 (el) |
HK (1) | HK1204291A1 (el) |
HU (1) | HUE045837T2 (el) |
MX (1) | MX358647B (el) |
PL (1) | PL2877201T3 (el) |
PT (1) | PT2877201T (el) |
RU (1) | RU2643766C2 (el) |
TW (1) | TWI630214B (el) |
WO (1) | WO2014017849A1 (el) |
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ES2855146T3 (es) | 2009-11-13 | 2021-09-23 | Sanofi Aventis Deutschland | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
US9707176B2 (en) | 2009-11-13 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
PT2611458T (pt) | 2010-08-30 | 2016-12-16 | Sanofi Aventis Deutschland | Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
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UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
ES2688367T3 (es) | 2012-12-21 | 2018-11-02 | Sanofi | Derivados de exendina-4 como agonistas duales de GLP1/GIP o trigonales de GLP1/GIP/glucagón |
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2013
- 2013-07-24 AR ARP130102652A patent/AR092862A1/es not_active Application Discontinuation
- 2013-07-25 BR BR112015001593-0A patent/BR112015001593B1/pt active IP Right Grant
- 2013-07-25 MX MX2015001217A patent/MX358647B/es active IP Right Grant
- 2013-07-25 TW TW102126622A patent/TWI630214B/zh active
- 2013-07-25 EP EP13822545.3A patent/EP2877201B1/en active Active
- 2013-07-25 CN CN201380039763.0A patent/CN104519904A/zh active Pending
- 2013-07-25 US US14/416,231 patent/US9833516B2/en active Active
- 2013-07-25 JP JP2015524185A patent/JP6403670B2/ja active Active
- 2013-07-25 PL PL13822545T patent/PL2877201T3/pl unknown
- 2013-07-25 KR KR1020130087917A patent/KR102088863B1/ko active IP Right Grant
- 2013-07-25 RU RU2015104489A patent/RU2643766C2/ru active
- 2013-07-25 WO PCT/KR2013/006676 patent/WO2014017849A1/en active Application Filing
- 2013-07-25 ES ES13822545T patent/ES2743918T3/es active Active
- 2013-07-25 CN CN201910644022.4A patent/CN110269930A/zh active Pending
- 2013-07-25 PT PT13822545T patent/PT2877201T/pt unknown
- 2013-07-25 CA CA2880037A patent/CA2880037C/en active Active
- 2013-07-25 DK DK13822545.3T patent/DK2877201T3/da active
- 2013-07-25 AU AU2013293720A patent/AU2013293720B2/en active Active
- 2013-07-25 HU HUE13822545A patent/HUE045837T2/hu unknown
-
2015
- 2015-05-26 HK HK15104957.6A patent/HK1204291A1/xx unknown
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- 2018-05-31 JP JP2018104433A patent/JP6686070B2/ja active Active
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Also Published As
Publication number | Publication date |
---|---|
TW201410704A (zh) | 2014-03-16 |
EP2877201A4 (en) | 2016-03-30 |
US9833516B2 (en) | 2017-12-05 |
CN110269930A (zh) | 2019-09-24 |
RU2015104489A (ru) | 2016-09-20 |
EP2877201A1 (en) | 2015-06-03 |
MX358647B (es) | 2018-08-29 |
AU2013293720A1 (en) | 2015-02-12 |
BR112015001593B1 (pt) | 2023-12-26 |
MX2015001217A (es) | 2015-09-07 |
CA2880037A1 (en) | 2014-01-30 |
WO2014017849A1 (en) | 2014-01-30 |
HK1204291A1 (en) | 2015-11-13 |
US20150190528A1 (en) | 2015-07-09 |
JP6686070B2 (ja) | 2020-04-22 |
CA2880037C (en) | 2021-08-17 |
CN104519904A (zh) | 2015-04-15 |
TWI630214B (zh) | 2018-07-21 |
KR102088863B1 (ko) | 2020-03-13 |
ES2743918T3 (es) | 2020-02-21 |
RU2643766C2 (ru) | 2018-02-05 |
JP2015524429A (ja) | 2015-08-24 |
AR092862A1 (es) | 2015-05-06 |
AU2013293720B2 (en) | 2018-05-10 |
JP2018138615A (ja) | 2018-09-06 |
KR20140015208A (ko) | 2014-02-06 |
HUE045837T2 (hu) | 2020-01-28 |
EP2877201B1 (en) | 2019-06-05 |
BR112015001593A2 (pt) | 2019-07-30 |
JP6403670B2 (ja) | 2018-10-10 |
PT2877201T (pt) | 2019-09-10 |
PL2877201T3 (pl) | 2019-12-31 |
DK2877201T3 (da) | 2019-09-16 |
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