PL2756098T3 - Sposób wytwarzania biblioteki cząsteczek kwasów nukleinowych - Google Patents
Sposób wytwarzania biblioteki cząsteczek kwasów nukleinowychInfo
- Publication number
- PL2756098T3 PL2756098T3 PL12759455T PL12759455T PL2756098T3 PL 2756098 T3 PL2756098 T3 PL 2756098T3 PL 12759455 T PL12759455 T PL 12759455T PL 12759455 T PL12759455 T PL 12759455T PL 2756098 T3 PL2756098 T3 PL 2756098T3
- Authority
- PL
- Poland
- Prior art keywords
- nucleic acid
- acid molecules
- making library
- library
- making
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11181546A EP2570487A1 (en) | 2011-09-16 | 2011-09-16 | Nucleic acid transcription method |
| EP12177647 | 2012-07-24 | ||
| PCT/EP2012/068250 WO2013038010A2 (en) | 2011-09-16 | 2012-09-17 | Nucleic acid transcription method |
| EP12759455.4A EP2756098B1 (en) | 2011-09-16 | 2012-09-17 | Method for making library of nucleic acid molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2756098T3 true PL2756098T3 (pl) | 2018-12-31 |
Family
ID=46852009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12759455T PL2756098T3 (pl) | 2011-09-16 | 2012-09-17 | Sposób wytwarzania biblioteki cząsteczek kwasów nukleinowych |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10612018B2 (pl) |
| EP (2) | EP2756098B1 (pl) |
| KR (1) | KR102087062B1 (pl) |
| CN (1) | CN103930570B (pl) |
| AU (1) | AU2012307282B2 (pl) |
| CA (1) | CA2848240C (pl) |
| DK (1) | DK2756098T3 (pl) |
| ES (1) | ES2686043T3 (pl) |
| LT (1) | LT2756098T (pl) |
| PL (1) | PL2756098T3 (pl) |
| WO (1) | WO2013038010A2 (pl) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| PL2756098T3 (pl) | 2011-09-16 | 2018-12-31 | Lexogen Gmbh | Sposób wytwarzania biblioteki cząsteczek kwasów nukleinowych |
| CA2865575C (en) | 2012-02-27 | 2024-01-16 | Cellular Research, Inc. | Compositions and kits for molecular counting |
| EP3428290B1 (en) * | 2012-07-26 | 2022-04-06 | Illumina, Inc. | Compositions and methods for the amplification of nucleic acids |
| CN109913519B (zh) * | 2012-12-13 | 2022-12-02 | 合成基因组股份有限公司 | Peg-介导的核酸分子的组装 |
| US9567645B2 (en) | 2013-08-28 | 2017-02-14 | Cellular Research, Inc. | Massively parallel single cell analysis |
| EP2921556A1 (en) * | 2014-03-21 | 2015-09-23 | Lexogen GmbH | Copy number preserving RNA analysis method |
| WO2016058121A1 (zh) * | 2014-10-13 | 2016-04-21 | 深圳华大基因科技有限公司 | 一种核酸片段化方法和序列组合 |
| CN106715714B (zh) * | 2014-10-17 | 2021-11-09 | 深圳华大智造科技股份有限公司 | 一种用于核酸随机片段化的引物及核酸随机片段化方法 |
| CN104560974B (zh) * | 2014-12-26 | 2017-08-25 | 光明乳业股份有限公司 | 获得嗜热链球菌特异性序列的方法及其使用的半随机引物 |
| CN107208158B (zh) | 2015-02-27 | 2022-01-28 | 贝克顿迪金森公司 | 空间上可寻址的分子条形编码 |
| EP3835431B1 (en) | 2015-03-30 | 2022-11-02 | Becton, Dickinson and Company | Methods for combinatorial barcoding |
| US11390914B2 (en) | 2015-04-23 | 2022-07-19 | Becton, Dickinson And Company | Methods and compositions for whole transcriptome amplification |
| JP6940484B2 (ja) | 2015-09-11 | 2021-09-29 | セルラー リサーチ， インコーポレイテッド | ライブラリー正規化のための方法および組成物 |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| JP6924496B2 (ja) * | 2016-06-23 | 2021-08-25 | 国立研究開発法人理化学研究所 | ワンステップ逆転写テンプレートスイッチｐｃｒ |
| AU2017331459B2 (en) | 2016-09-26 | 2023-04-13 | Becton, Dickinson And Company | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
| CN108330186A (zh) * | 2017-01-18 | 2018-07-27 | 深圳华大智造科技有限公司 | 一种核酸测序方法、反应体系和试剂盒 |
| CN110382708A (zh) | 2017-02-01 | 2019-10-25 | 赛卢拉研究公司 | 使用阻断性寡核苷酸进行选择性扩增 |
| EP3585906A4 (en) * | 2017-02-27 | 2020-12-09 | Bioo Scientific Corporation | PROCEDURES AND KITS FOR DEPLOYMENT OF UNWANTED NUCLEIC ACIDS |
| WO2018175296A2 (en) * | 2017-03-20 | 2018-09-27 | President And Fellows Of Harvard College | Programmable nucleic acid synthesis cascade |
| WO2018226293A1 (en) | 2017-06-05 | 2018-12-13 | Becton, Dickinson And Company | Sample indexing for single cells |
| AU2018386331B2 (en) * | 2017-12-15 | 2025-04-10 | Baylor College Of Medicine | Methods and compositions for the amplification of mRNA |
| EP3788170B1 (en) | 2018-05-03 | 2025-01-01 | Becton, Dickinson and Company | Molecular barcoding on opposite transcript ends |
| EP3788171B1 (en) | 2018-05-03 | 2023-04-05 | Becton, Dickinson and Company | High throughput multiomics sample analysis |
| WO2020072380A1 (en) | 2018-10-01 | 2020-04-09 | Cellular Research, Inc. | Determining 5' transcript sequences |
| EP3877520B1 (en) | 2018-11-08 | 2025-03-19 | Becton, Dickson And Company | Whole transcriptome analysis of single cells using random priming |
| EP4745247A2 (en) | 2018-12-13 | 2026-05-20 | Becton Dickinson Co | SELECTIVE EXTENSION IN A SINGLE-CELL WHOLE-TRANSCRIPTOME ANALYSIS |
| EP3666904A1 (en) * | 2018-12-14 | 2020-06-17 | Lexogen GmbH | Nucleic acid amplification and identification method |
| CN110699426B (zh) * | 2019-01-02 | 2022-01-28 | 上海臻迪基因科技有限公司 | 基因目标区域富集方法及试剂盒 |
| CN113574178B (zh) | 2019-01-23 | 2024-10-29 | 贝克顿迪金森公司 | 与抗体关联的寡核苷酸 |
| CN120099139A (zh) | 2019-02-14 | 2025-06-06 | 贝克顿迪金森公司 | 杂合体靶向和全转录物组扩增 |
| CN120099137A (zh) | 2019-07-22 | 2025-06-06 | 贝克顿迪金森公司 | 单细胞染色质免疫沉淀测序测定 |
| US11447819B2 (en) * | 2019-10-25 | 2022-09-20 | Guardant Health, Inc. | Methods for 3′ overhang repair |
| EP4055160B1 (en) | 2019-11-08 | 2024-04-10 | Becton Dickinson and Company | Using random priming to obtain full-length v(d)j information for immune repertoire sequencing |
| CN110846724B (zh) * | 2019-12-03 | 2023-04-28 | 江西海普洛斯医学检验实验室有限公司 | 构建mRNA链特异文库的方法及试剂盒 |
| CA3166578A1 (en) | 2019-12-31 | 2021-07-08 | Singular Genomics Systems, Inc. | Polynucleotide barcodes for long read sequencing |
| EP4090763B1 (en) | 2020-01-13 | 2024-12-04 | Becton Dickinson and Company | Methods and compositions for quantitation of proteins and rna |
| WO2021146219A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Cell capture using du-containing oligonucleotides |
| ES2993319T3 (en) | 2020-01-29 | 2024-12-27 | Becton Dickinson Co | Barcoded wells for spatial mapping of single cells through sequencing |
| CN115151810A (zh) | 2020-02-25 | 2022-10-04 | 贝克顿迪金森公司 | 实现使用单细胞样品作为单色补偿对照的双特异性探针 |
| EP4146824A1 (en) * | 2020-05-07 | 2023-03-15 | Northeastern University | Methods and compositions for high-fidelity sequence analysis of individual long and ultralong nucleic acid molecules |
| US11661625B2 (en) | 2020-05-14 | 2023-05-30 | Becton, Dickinson And Company | Primers for immune repertoire profiling |
| CN115803445A (zh) | 2020-06-02 | 2023-03-14 | 贝克顿迪金森公司 | 用于5撇基因表达测定的寡核苷酸和珠 |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| WO2022026909A1 (en) | 2020-07-31 | 2022-02-03 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| CN111944886B (zh) * | 2020-08-24 | 2022-09-27 | 北京梓熙生物科技有限公司 | 一种合成寡聚脱氧核糖核苷酸的方法和试剂盒 |
| US11739443B2 (en) | 2020-11-20 | 2023-08-29 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
| CN114606575B (zh) * | 2020-12-03 | 2025-02-14 | 广东菲鹏生物有限公司 | 组合物及文库构建方法 |
| US12392771B2 (en) | 2020-12-15 | 2025-08-19 | Becton, Dickinson And Company | Single cell secretome analysis |
| WO2022232539A1 (en) * | 2021-04-30 | 2022-11-03 | William Marsh Rice University | Compositions and methods for chimeric amplicon formation |
| US20230002805A1 (en) * | 2021-06-25 | 2023-01-05 | Enzo Biochem, Inc. | Use of organic cationic compounds to accelerate nucleic acid hybridization, synthesis, and amplification |
| WO2022272150A2 (en) * | 2021-06-25 | 2022-12-29 | Singular Genomics Systems, Inc. | Linked transcript sequencing |
| WO2025185331A1 (en) * | 2024-03-04 | 2025-09-12 | Cytotest Inc. | Methods for constructing a library of polynucleotides having nucleic acids of interest |
| WO2025199320A1 (en) * | 2024-03-20 | 2025-09-25 | Cornell University | Methods and compositions for transcriptome characterization |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| FR2593343B1 (fr) | 1986-01-20 | 1988-03-25 | Thomson Csf | Matrice d'elements photosensibles et son procede de fabrication, procede de lecture associe, et application de cette matrice a la prise de vue d'images |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| US5310652A (en) | 1986-08-22 | 1994-05-10 | Hoffman-La Roche Inc. | Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| MX9203138A (es) * | 1991-03-12 | 1992-09-01 | Biogen Inc | Dominio de enlace cd2-de antigeno 3 (lfa-3) asociado con funcion linfositos. |
| JP3398957B2 (ja) | 1991-12-24 | 2003-04-21 | ザ・プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | Ｄｎａの特定部位の突然変異誘発 |
| EP0686200A4 (en) | 1993-01-27 | 1997-07-02 | Oncor Inc | AMPLIFICATION OF NUCLEIC ACID SEQUENCES |
| US5554730A (en) | 1993-03-09 | 1996-09-10 | Middlesex Sciences, Inc. | Method and kit for making a polysaccharide-protein conjugate |
| US5658751A (en) | 1993-04-13 | 1997-08-19 | Molecular Probes, Inc. | Substituted unsymmetrical cyanine dyes with selected permeability |
| US5436134A (en) | 1993-04-13 | 1995-07-25 | Molecular Probes, Inc. | Cyclic-substituted unsymmetrical cyanine dyes |
| GB2293238A (en) | 1994-09-13 | 1996-03-20 | Inceltec Ltd | Primers for replication and/or amplification reactions |
| DE19518505A1 (de) | 1995-05-19 | 1996-11-21 | Max Planck Gesellschaft | Verfahren zur Genexpressionsanalyse |
| ATE428801T1 (de) | 1996-06-04 | 2009-05-15 | Univ Utah Res Found | Überwachung der hybridisierung während pcr |
| US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5849497A (en) | 1997-04-03 | 1998-12-15 | The Research Foundation Of State University Of New York | Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker |
| US6261770B1 (en) | 1997-05-13 | 2001-07-17 | Display Systems Biotech Aps | Method to clone mRNAs |
| CA2330277A1 (en) | 1998-04-27 | 1999-11-04 | Sidney Kimmel Cancer Center | Reduced complexity nucleic acid targets and methods of using same |
| FR2779154B1 (fr) | 1998-05-27 | 2002-07-12 | Bio Merieux | Procede d'amplification d'au moins une sequence nucleotidique particuliere et amorces de mise en oeuvre |
| US6335439B1 (en) | 1998-06-11 | 2002-01-01 | Isis Pharmaceuticals, Inc. | Method of preparing phosphoramidites |
| US6406891B1 (en) | 1998-09-28 | 2002-06-18 | Board Of Regents, The University Of Texas System | Dual RT procedure for cDNA synthesis |
| US7084125B2 (en) | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
| US6734291B2 (en) | 1999-03-24 | 2004-05-11 | Exiqon A/S | Synthesis of [2.2.1]bicyclo nucleosides |
| EP1130113A1 (en) * | 2000-02-15 | 2001-09-05 | Johannes Petrus Schouten | Multiplex ligation dependent amplification assay |
| AU2001241939A1 (en) * | 2000-02-28 | 2001-09-12 | Maxygen, Inc. | Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation |
| US6368801B1 (en) | 2000-04-12 | 2002-04-09 | Molecular Staging, Inc. | Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase |
| US6391592B1 (en) | 2000-12-14 | 2002-05-21 | Affymetrix, Inc. | Blocker-aided target amplification of nucleic acids |
| EP1253205A1 (en) | 2001-04-24 | 2002-10-30 | LION Bioscience AG | Method of blocking amplification of selected sequences |
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US20040009512A1 (en) | 2002-05-02 | 2004-01-15 | Manuel Ares | Arrays for detection of products of mRNA splicing |
| US20050069991A1 (en) * | 2003-03-25 | 2005-03-31 | Hyman Edward D. | Method for plasmid preparation by conversion of open circular plasmid to supercoiled plasmid |
| US20050100911A1 (en) | 2003-08-06 | 2005-05-12 | Perlegen Sciences, Inc. | Methods for enriching populations of nucleic acid samples |
| DE602006013831D1 (de) | 2005-06-23 | 2010-06-02 | Keygene Nv | Verbesserte strategien zur sequenzierung komplexer genome unter verwendung von sequenziertechniken mit hohem durchsatz |
| ATE551349T1 (de) | 2005-11-30 | 2012-04-15 | Epict Technologies Corp | Methode unter verwendung von reversibel blockierten markierungsoligonukleotiden |
| ES2394633T3 (es) | 2005-12-22 | 2013-02-04 | Keygene N.V. | Estrategias mejoradas para elaboración de perfiles de transcritos usando tecnologías de secuenciación de alto rendimiento |
| US8883411B2 (en) * | 2006-03-01 | 2014-11-11 | Xiaioian Gao | Making nucleic acid sequences in parallel and use |
| US20100009355A1 (en) * | 2006-03-14 | 2010-01-14 | Kolodney Michael S | Selective amplification of minority mutations using primer blocking high-affinity oligonucleotides |
| WO2008093098A2 (en) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
| US8008010B1 (en) * | 2007-06-27 | 2011-08-30 | Applied Biosystems, Llc | Chimeric oligonucleotides for ligation-enhanced nucleic acid detection, methods and compositions therefor |
| US8071338B2 (en) | 2007-08-08 | 2011-12-06 | Roche Molecular Systems, Inc. | Suppression of amplification using an oligonucleotide and a polymerase significantly lacking 5′-3′ nuclease activity |
| ES2419183T3 (es) * | 2007-08-20 | 2013-08-19 | Erasmus University Medical Center Rotterdam | Procedimiento para predecir el color del iris |
| US8298768B2 (en) | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
| EP2238162A1 (en) | 2008-01-24 | 2010-10-13 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Induced internalization of surface receptors |
| US8034568B2 (en) * | 2008-02-12 | 2011-10-11 | Nugen Technologies, Inc. | Isothermal nucleic acid amplification methods and compositions |
| CA2718905A1 (en) | 2008-03-17 | 2009-09-24 | Expressive Research B.V. | Expression-linked gene discovery |
| KR20100019220A (ko) * | 2008-08-08 | 2010-02-18 | 삼성전자주식회사 | 열순환을 포함하는 다중 치환 증폭에 의하여 표적 핵산 서열을 증폭하는 방법 |
| WO2011019964A1 (en) * | 2009-08-12 | 2011-02-17 | Nugen Technologies, Inc. | Methods, compositions, and kits for generating nucleic acid products substantially free of template nucleic acid |
| EP2333104A1 (en) | 2009-12-11 | 2011-06-15 | Lexogen GmbH | RNA analytics method |
| EP2354243A1 (en) | 2010-02-03 | 2011-08-10 | Lexogen GmbH | Complexity reduction method |
| PL2756098T3 (pl) | 2011-09-16 | 2018-12-31 | Lexogen Gmbh | Sposób wytwarzania biblioteki cząsteczek kwasów nukleinowych |
| WO2016005524A1 (en) | 2014-07-09 | 2016-01-14 | Lexogen Gmbh | Methods and products for quantifying rna transcript variants |
-
2012
- 2012-09-17 PL PL12759455T patent/PL2756098T3/pl unknown
- 2012-09-17 KR KR1020147010187A patent/KR102087062B1/ko active Active
- 2012-09-17 WO PCT/EP2012/068250 patent/WO2013038010A2/en not_active Ceased
- 2012-09-17 CN CN201280056141.4A patent/CN103930570B/zh active Active
- 2012-09-17 CA CA2848240A patent/CA2848240C/en active Active
- 2012-09-17 EP EP12759455.4A patent/EP2756098B1/en active Active
- 2012-09-17 US US14/241,311 patent/US10612018B2/en active Active
- 2012-09-17 LT LTEP12759455.4T patent/LT2756098T/lt unknown
- 2012-09-17 DK DK12759455.4T patent/DK2756098T3/en active
- 2012-09-17 ES ES12759455.4T patent/ES2686043T3/es active Active
- 2012-09-17 EP EP17184341.0A patent/EP3263718A1/en not_active Ceased
- 2012-09-17 AU AU2012307282A patent/AU2012307282B2/en active Active
-
2017
- 2017-08-10 US US15/674,472 patent/US11021705B2/en active Active
-
2021
- 2021-04-09 US US17/226,688 patent/US20210332355A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2848240C (en) | 2020-09-29 |
| WO2013038010A2 (en) | 2013-03-21 |
| EP2756098B1 (en) | 2018-06-06 |
| AU2012307282A1 (en) | 2014-03-20 |
| CA2848240A1 (en) | 2013-03-21 |
| KR20140065448A (ko) | 2014-05-29 |
| CN103930570A (zh) | 2014-07-16 |
| US11021705B2 (en) | 2021-06-01 |
| AU2012307282B2 (en) | 2018-03-15 |
| DK2756098T3 (en) | 2018-09-03 |
| CN103930570B (zh) | 2018-01-09 |
| EP3263718A1 (en) | 2018-01-03 |
| US10612018B2 (en) | 2020-04-07 |
| KR102087062B1 (ko) | 2020-03-11 |
| US20210332355A1 (en) | 2021-10-28 |
| EP2756098A2 (en) | 2014-07-23 |
| ES2686043T3 (es) | 2018-10-16 |
| US20150152409A1 (en) | 2015-06-04 |
| WO2013038010A3 (en) | 2013-05-30 |
| US20170342409A1 (en) | 2017-11-30 |
| LT2756098T (lt) | 2018-09-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LT2756098T (lt) | Nukleorūgščių molekulių bibliotekos sudarymo būdas | |
| EP2539450A4 (en) | METHOD FOR MANUFACTURING NUCLEIC ACID BANKS | |
| GB2500120B (en) | Method of producing fluid identification system including DNA | |
| PT3829176T (pt) | Método de construção de lista de fusão | |
| SG11201400635UA (en) | Method for detecting target nucleic acid | |
| GB2503856B (en) | Methods for nucleic acid purification | |
| PL2694642T3 (pl) | Sposób odmładzania komórek | |
| SG10201604562PA (en) | Biotechnological production of 3-hydroxyisobutyric acid | |
| ZA201308852B (en) | Process of making beta-hydroxyamino compounds | |
| IL224318B (en) | A method for the automated synthesis of small molecules | |
| EP2740804A4 (en) | PROCESS FOR NUCLEIC ACID ANALYSIS | |
| IL231834A0 (en) | An improved method for the production of macrochroses | |
| ZA201306472B (en) | Process for production of sulphuric acid | |
| EP2669663A4 (en) | METHOD FOR IDENTIFYING POLYMORPHISMS OF NUCLEIC ACID MOLECULES | |
| EP2841602A4 (en) | METHOD FOR DETERMINING THE INTEGRITY OF AN RNA | |
| EP2697334A4 (en) | PROCESS FOR THE PRODUCTION OF RETAINING AGENTS | |
| ZA201304938B (en) | Process for producing nitrile-fatty acid compounds | |
| PL2675555T3 (pl) | Sposób wytwarzania i analizy prionów | |
| EP2669376A4 (en) | METHOD FOR IDENTIFYING POLYMORPHISM OF A NUCLEIC ACID MOLECULE | |
| HUP1100695A2 (en) | Method for determining the sequence of fragmented nucleic acids | |
| PL2760978T3 (pl) | Sposób wytwarzania biogazu | |
| EP2774995A4 (en) | METHOD OF MEASURING THE ABUNDANCE OF GENES | |
| GB201119607D0 (en) | Method of manufacture | |
| GB201110178D0 (en) | Method of analysing reagent beads | |
| AU2011901418A0 (en) | Method for Production of Proppants |