PL2729470T3 - Krystaliczna (1R,4R)-6'-fluoro-N,N-dimetylo-4-fenylo-4',9'-dihydro-3'H-spiro[cykloheksano-1,1'-pirano[3,4,b]indolo]-4-amina - Google Patents

Krystaliczna (1R,4R)-6'-fluoro-N,N-dimetylo-4-fenylo-4',9'-dihydro-3'H-spiro[cykloheksano-1,1'-pirano[3,4,b]indolo]-4-amina

Info

Publication number
PL2729470T3
PL2729470T3 PL12748646T PL12748646T PL2729470T3 PL 2729470 T3 PL2729470 T3 PL 2729470T3 PL 12748646 T PL12748646 T PL 12748646T PL 12748646 T PL12748646 T PL 12748646T PL 2729470 T3 PL2729470 T3 PL 2729470T3
Authority
PL
Poland
Prior art keywords
pyrano
indol
spiro
dihydro
cyclohexane
Prior art date
Application number
PL12748646T
Other languages
English (en)
Polish (pl)
Inventor
Stefan Kluge
Stefan Prühs
Michael Gruss
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of PL2729470T3 publication Critical patent/PL2729470T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
PL12748646T 2011-07-08 2012-07-06 Krystaliczna (1R,4R)-6'-fluoro-N,N-dimetylo-4-fenylo-4',9'-dihydro-3'H-spiro[cykloheksano-1,1'-pirano[3,4,b]indolo]-4-amina PL2729470T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11005587 2011-07-08
EP12748646.2A EP2729470B1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (1)

Publication Number Publication Date
PL2729470T3 true PL2729470T3 (pl) 2017-11-30

Family

ID=46717800

Family Applications (1)

Application Number Title Priority Date Filing Date
PL12748646T PL2729470T3 (pl) 2011-07-08 2012-07-06 Krystaliczna (1R,4R)-6'-fluoro-N,N-dimetylo-4-fenylo-4',9'-dihydro-3'H-spiro[cykloheksano-1,1'-pirano[3,4,b]indolo]-4-amina

Country Status (23)

Country Link
US (2) US8618156B2 (OSRAM)
EP (2) EP3235821B1 (OSRAM)
JP (2) JP6276689B2 (OSRAM)
CN (2) CN103649094B (OSRAM)
AR (1) AR087081A1 (OSRAM)
AU (2) AU2012283449B2 (OSRAM)
BR (1) BR112014000358A2 (OSRAM)
CA (1) CA2841032C (OSRAM)
CY (1) CY1120525T1 (OSRAM)
DK (2) DK3235821T3 (OSRAM)
EA (1) EA026750B1 (OSRAM)
ES (1) ES2641299T3 (OSRAM)
HR (1) HRP20170968T1 (OSRAM)
HU (1) HUE033043T2 (OSRAM)
IL (1) IL230331B (OSRAM)
LT (1) LT2729470T (OSRAM)
MX (1) MX2014000297A (OSRAM)
PL (1) PL2729470T3 (OSRAM)
PT (1) PT2729470T (OSRAM)
RS (1) RS56343B1 (OSRAM)
SI (1) SI2729470T1 (OSRAM)
TW (1) TWI585092B (OSRAM)
WO (1) WO2013007361A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2841032C (en) * 2011-07-08 2020-12-15 Grunenthal Gmbh Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
EA201791662A1 (ru) 2015-01-23 2017-12-29 Грюненталь Гмбх Цебранопадол для лечения от боли субъектов с нарушенной печеночной и/или нарушенной почечной функцией
EP3253374B1 (en) 2015-02-02 2018-11-28 ratiopharm GmbH Composition comprising cebranopadol in a dissolved form
CN109069483A (zh) 2016-02-29 2018-12-21 格吕伦塔尔有限公司 西博帕多的滴定
CA3141164C (en) * 2019-05-21 2023-09-05 Jiangsu Forefront Pharmaceutical Co., Ltd. New crystal form of treprostinil sodium salt and preparation method therefor
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
WO2024173714A1 (en) 2023-02-15 2024-08-22 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
RU2631481C2 (ru) * 2010-08-04 2017-09-22 Грюненталь Гмбх ЛЕКАРСТВЕННАЯ ДОЗИРОВАННАЯ ФОРМА, КОТОРАЯ СОДЕРЖИТ 6'-ФТОР-(N-МЕТИЛ-ИЛИ N, N-ДИМЕТИЛ-)-4-ФЕНИЛ-4', 9'-ДИГИДРО-3' Н-СПИРО[ЦИКЛОГЕКСАН-1, 1'-ПИРАНО[3, 4, b] ИНДОЛ]-4-АМИН ДЛЯ ЛЕЧЕНИЯ НОЦИЦЕПТИВНОЙ БОЛИ
CA2841032C (en) * 2011-07-08 2020-12-15 Grunenthal Gmbh Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Also Published As

Publication number Publication date
EP2729470A1 (en) 2014-05-14
ES2641299T3 (es) 2017-11-08
US20130012563A1 (en) 2013-01-10
WO2013007361A9 (en) 2013-12-27
EA026750B1 (ru) 2017-05-31
MX2014000297A (es) 2014-01-31
IL230331B (en) 2018-11-29
CA2841032C (en) 2020-12-15
AU2012283449A1 (en) 2014-02-20
TW201311694A (zh) 2013-03-16
EP3235821B1 (en) 2020-04-08
AU2017204572A1 (en) 2017-07-27
WO2013007361A1 (en) 2013-01-17
JP6559165B2 (ja) 2019-08-14
LT2729470T (lt) 2017-08-25
JP2017081981A (ja) 2017-05-18
US20130231381A1 (en) 2013-09-05
US8765800B2 (en) 2014-07-01
JP6276689B2 (ja) 2018-02-07
EP3235821A1 (en) 2017-10-25
AU2012283449B2 (en) 2017-04-06
EP2729470B1 (en) 2017-06-21
DK2729470T3 (en) 2017-09-11
RS56343B1 (sr) 2017-12-29
HRP20170968T1 (hr) 2017-09-22
AR087081A1 (es) 2014-02-12
EA201400120A1 (ru) 2014-06-30
AU2012283449A8 (en) 2014-03-27
HUE033043T2 (hu) 2017-11-28
SI2729470T1 (sl) 2017-10-30
CY1120525T1 (el) 2019-07-10
US8618156B2 (en) 2013-12-31
AU2017204572B2 (en) 2018-05-24
BR112014000358A2 (pt) 2017-01-10
PT2729470T (pt) 2017-10-02
JP2014518226A (ja) 2014-07-28
CN103649094B (zh) 2017-05-24
TWI585092B (zh) 2017-06-01
CN103649094A (zh) 2014-03-19
DK3235821T3 (da) 2020-04-20
WO2013007361A8 (en) 2013-04-04
CN106939005A (zh) 2017-07-11
CA2841032A1 (en) 2013-01-17

Similar Documents

Publication Publication Date Title
IL230331B (en) (r1, 4r)-6' fluoro-n, n--dimethyl-4-phenyl-4', 9'-dihydro-3' h-spiro[cyclohexane-1,1'-pyrano[4,3,b] Crystalline indole]4–amine
IL235655B (en) Pharmaceutical preparation containing (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4','9'-dihydro-3'h-spiro [cyclohexane-1,1'-pyrano[b, 4,3]indole]-4-amine and the derivative of propionic acid
IL235654A (en) Pharmaceutical Composition Containing (1r, 4r) - 6 '- Fluoro - n, n - Dimethyl - 4 - Phenyl - 4', 9 '- Dihydro - 3'h - Spiro [Cyclohexane - 1, 1' - Pirano [3, 4 , b] indole] - 4 - reliable and anticonvulsant drug
IL233048A0 (en) Solid forms of (r4,r1)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano [4, 3,b]indole]–4–amine hydrochloride
IL233047A0 (en) Process for the preparation of (-'6-(r4,r1fluoro-(n,n-dimethyl and n-methyl)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano –[b,4,3]indole]–4–amine
IL235658A (en) Pharmaceutical Composition Containing (1r, 4r) - 6 '- Fluoro - n, n - Dimethyl - 4 - Phenyl - 4', 9 '- Dihydro - 3'h - Spiro [Cyclohexane - 1, 1' - Pirano [3, 4 , b] indole] - 4 - amine and gabapentinoid
IL235653A0 (en) A pharmaceutical preparation containing (1r, 4r) - 6' - fluoro - n, n - dimethyl - 4 - phenyl - 4', 9' - dihydro - 3'h - spiro [cyclohexane - 1, 1' - pyrano [3, 4 ,b] indole] – 4 – amine and a non-steroidal anti-rheumatic drug
IL235652B (en) A pharmaceutical preparation containing (1r, 4r) - 6' - fluoro - n, n - dimethyl - 4 - phenyl - 4', 9' - dihydro -3'h - spiro [cyclohexane - 1, 1' - pyrano [3, 4 ,b] indole] – 4 – amine and oxicam
IL235657A0 (en) Pharmacy device containing (1r, 4r) - 6' - fluoro - n, n - dimethyl - 4 - phenyl - 4', 9' - dihydro - 3'h - spiro [cyclohexane - 1, 1' - pyrano [3, 4 ,b] indole] – 4 – amine and antidepressants
IL233049A0 (en) Solid forms of (1r, 4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro-[cyclohexane-1,1'-pyrano [4, 3,b]indole]-4-amine and sulfuric acid
IL235656B (en) A pharmaceutical preparation containing (1r, 4r) - 6' - fluoro - n, n - dimethyl - 4 - phenyl - 4', 9' - dihydro - 3'h - spiro [cyclohexane - 1, 1' - pyrano [3, 4 ,b] Indole] - 4 - amine and a component of salicylic acid