CA2841032C - Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine - Google Patents

Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine Download PDF

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CA2841032C
CA2841032C CA2841032A CA2841032A CA2841032C CA 2841032 C CA2841032 C CA 2841032C CA 2841032 A CA2841032 A CA 2841032A CA 2841032 A CA2841032 A CA 2841032A CA 2841032 C CA2841032 C CA 2841032C
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crystalline form
pharmaceutical composition
active ingredient
theta
use according
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French (fr)
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CA2841032A1 (en
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Michael Gruss
Stefan Pruhs
Stefan Kluge
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Park Therapeutics Inc
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Gruenenthal GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
CA2841032A 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine Active CA2841032C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11005587.8 2011-07-08
EP11005587 2011-07-08
PCT/EP2012/002839 WO2013007361A1 (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Publications (2)

Publication Number Publication Date
CA2841032A1 CA2841032A1 (en) 2013-01-17
CA2841032C true CA2841032C (en) 2020-12-15

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CA2841032A Active CA2841032C (en) 2011-07-08 2012-07-06 Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Country Status (23)

Country Link
US (2) US8618156B2 (OSRAM)
EP (2) EP3235821B1 (OSRAM)
JP (2) JP6276689B2 (OSRAM)
CN (2) CN103649094B (OSRAM)
AR (1) AR087081A1 (OSRAM)
AU (2) AU2012283449B2 (OSRAM)
BR (1) BR112014000358A2 (OSRAM)
CA (1) CA2841032C (OSRAM)
CY (1) CY1120525T1 (OSRAM)
DK (2) DK3235821T3 (OSRAM)
EA (1) EA026750B1 (OSRAM)
ES (1) ES2641299T3 (OSRAM)
HR (1) HRP20170968T1 (OSRAM)
HU (1) HUE033043T2 (OSRAM)
IL (1) IL230331B (OSRAM)
LT (1) LT2729470T (OSRAM)
MX (1) MX2014000297A (OSRAM)
PL (1) PL2729470T3 (OSRAM)
PT (1) PT2729470T (OSRAM)
RS (1) RS56343B1 (OSRAM)
SI (1) SI2729470T1 (OSRAM)
TW (1) TWI585092B (OSRAM)
WO (1) WO2013007361A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2841032C (en) * 2011-07-08 2020-12-15 Grunenthal Gmbh Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
EA201791662A1 (ru) 2015-01-23 2017-12-29 Грюненталь Гмбх Цебранопадол для лечения от боли субъектов с нарушенной печеночной и/или нарушенной почечной функцией
EP3253374B1 (en) 2015-02-02 2018-11-28 ratiopharm GmbH Composition comprising cebranopadol in a dissolved form
CN109069483A (zh) 2016-02-29 2018-12-21 格吕伦塔尔有限公司 西博帕多的滴定
CA3141164C (en) * 2019-05-21 2023-09-05 Jiangsu Forefront Pharmaceutical Co., Ltd. New crystal form of treprostinil sodium salt and preparation method therefor
CN112254496A (zh) * 2020-09-25 2021-01-22 榆林学院 一种煤泥收集装置
WO2024129782A1 (en) 2022-12-12 2024-06-20 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain
WO2024173714A1 (en) 2023-02-15 2024-08-22 Park Therapeutics, Inc. Regimens and compositions useful for alleviating pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
RU2631481C2 (ru) * 2010-08-04 2017-09-22 Грюненталь Гмбх ЛЕКАРСТВЕННАЯ ДОЗИРОВАННАЯ ФОРМА, КОТОРАЯ СОДЕРЖИТ 6'-ФТОР-(N-МЕТИЛ-ИЛИ N, N-ДИМЕТИЛ-)-4-ФЕНИЛ-4', 9'-ДИГИДРО-3' Н-СПИРО[ЦИКЛОГЕКСАН-1, 1'-ПИРАНО[3, 4, b] ИНДОЛ]-4-АМИН ДЛЯ ЛЕЧЕНИЯ НОЦИЦЕПТИВНОЙ БОЛИ
CA2841032C (en) * 2011-07-08 2020-12-15 Grunenthal Gmbh Crystalline (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

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Publication number Publication date
EP2729470A1 (en) 2014-05-14
ES2641299T3 (es) 2017-11-08
US20130012563A1 (en) 2013-01-10
WO2013007361A9 (en) 2013-12-27
EA026750B1 (ru) 2017-05-31
MX2014000297A (es) 2014-01-31
IL230331B (en) 2018-11-29
PL2729470T3 (pl) 2017-11-30
AU2012283449A1 (en) 2014-02-20
TW201311694A (zh) 2013-03-16
EP3235821B1 (en) 2020-04-08
AU2017204572A1 (en) 2017-07-27
WO2013007361A1 (en) 2013-01-17
JP6559165B2 (ja) 2019-08-14
LT2729470T (lt) 2017-08-25
JP2017081981A (ja) 2017-05-18
US20130231381A1 (en) 2013-09-05
US8765800B2 (en) 2014-07-01
JP6276689B2 (ja) 2018-02-07
EP3235821A1 (en) 2017-10-25
AU2012283449B2 (en) 2017-04-06
EP2729470B1 (en) 2017-06-21
DK2729470T3 (en) 2017-09-11
RS56343B1 (sr) 2017-12-29
HRP20170968T1 (hr) 2017-09-22
AR087081A1 (es) 2014-02-12
EA201400120A1 (ru) 2014-06-30
AU2012283449A8 (en) 2014-03-27
HUE033043T2 (hu) 2017-11-28
SI2729470T1 (sl) 2017-10-30
CY1120525T1 (el) 2019-07-10
US8618156B2 (en) 2013-12-31
AU2017204572B2 (en) 2018-05-24
BR112014000358A2 (pt) 2017-01-10
PT2729470T (pt) 2017-10-02
JP2014518226A (ja) 2014-07-28
CN103649094B (zh) 2017-05-24
TWI585092B (zh) 2017-06-01
CN103649094A (zh) 2014-03-19
DK3235821T3 (da) 2020-04-20
WO2013007361A8 (en) 2013-04-04
CN106939005A (zh) 2017-07-11
CA2841032A1 (en) 2013-01-17

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