PL2503004T3 - 17 alfa-propionian korteksolonu w I postaci krystalicznej - Google Patents

17 alfa-propionian korteksolonu w I postaci krystalicznej

Info

Publication number
PL2503004T3
PL2503004T3 PL12173152T PL12173152T PL2503004T3 PL 2503004 T3 PL2503004 T3 PL 2503004T3 PL 12173152 T PL12173152 T PL 12173152T PL 12173152 T PL12173152 T PL 12173152T PL 2503004 T3 PL2503004 T3 PL 2503004T3
Authority
PL
Poland
Prior art keywords
cortexolone
17alpha
propionate
crystalline form
crystalline
Prior art date
Application number
PL12173152T
Other languages
English (en)
Inventor
Mauro Ajani
Luigi Moro
Original Assignee
Cassiopea S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40278805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2503004(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cassiopea S P A filed Critical Cassiopea S P A
Publication of PL2503004T3 publication Critical patent/PL2503004T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
PL12173152T 2007-08-03 2008-07-24 17 alfa-propionian korteksolonu w I postaci krystalicznej PL2503004T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT001616A ITMI20071616A1 (it) 2007-08-03 2007-08-03 Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati.
EP08775319.0A EP2173891B1 (en) 2007-08-03 2008-07-24 Enzymatic process for obtaining cortexolone-17-alpha-propionate in crystalline form III
EP12173152.5A EP2503004B1 (en) 2007-08-03 2008-07-24 Cortexolone-17alpha-propionate in crystalline form I

Publications (1)

Publication Number Publication Date
PL2503004T3 true PL2503004T3 (pl) 2016-05-31

Family

ID=40278805

Family Applications (4)

Application Number Title Priority Date Filing Date
PL08775319T PL2173891T3 (pl) 2007-08-03 2008-07-24 Enzymatyczny sposób otrzymywania 17-alfa propionianu korteksolonu w III postaci krystalicznej
PL12173228T PL2503005T3 (pl) 2007-08-03 2008-07-24 17-alfa-propionian korteksolonu w krystalicznej postaci iv hydratu
PL15175112T PL2966175T3 (pl) 2007-08-03 2008-07-24 Kompozycje farmaceutyczne zawierające 17-alfa-propionian korteksolonu
PL12173152T PL2503004T3 (pl) 2007-08-03 2008-07-24 17 alfa-propionian korteksolonu w I postaci krystalicznej

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PL08775319T PL2173891T3 (pl) 2007-08-03 2008-07-24 Enzymatyczny sposób otrzymywania 17-alfa propionianu korteksolonu w III postaci krystalicznej
PL12173228T PL2503005T3 (pl) 2007-08-03 2008-07-24 17-alfa-propionian korteksolonu w krystalicznej postaci iv hydratu
PL15175112T PL2966175T3 (pl) 2007-08-03 2008-07-24 Kompozycje farmaceutyczne zawierające 17-alfa-propionian korteksolonu

Country Status (25)

Country Link
US (9) US8785427B2 (pl)
EP (5) EP2503004B1 (pl)
JP (3) JP5646992B2 (pl)
KR (1) KR101495192B1 (pl)
CN (3) CN104861023B (pl)
AR (3) AR072235A1 (pl)
AU (1) AU2008285784B2 (pl)
BR (1) BRPI0814163A2 (pl)
CA (3) CA2871025C (pl)
DK (4) DK2173891T3 (pl)
ES (4) ES2732326T3 (pl)
HR (4) HRP20140421T1 (pl)
HU (3) HUE026507T2 (pl)
IT (1) ITMI20071616A1 (pl)
LT (1) LT2966175T (pl)
MX (4) MX363701B (pl)
NZ (3) NZ615953A (pl)
PL (4) PL2173891T3 (pl)
PT (4) PT2503004E (pl)
RS (4) RS53310B (pl)
RU (2) RU2482190C2 (pl)
SI (4) SI2503005T1 (pl)
TR (1) TR201909129T4 (pl)
WO (1) WO2009019138A2 (pl)
ZA (2) ZA201000587B (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20071616A1 (it) 2007-08-03 2009-02-04 Cosmo Spa Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati.
ITMI20132157A1 (it) 2013-12-20 2015-06-21 Cosmo Dermatos Srl Cortexolone 17alfa-propionate for use in the treatment of skin wounds and/or atrophic skin disorders . cortexolone 17alfa-propionato per uso nel trattamento delle ferite della pelle e/o disordini atrofici della pelle.
EP3006453A1 (en) * 2014-10-08 2016-04-13 Cosmo Technologies Ltd. 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors
EP3108879A1 (en) * 2015-06-25 2016-12-28 Cassiopea S.p.A. High concentration formulation
CN112028956A (zh) * 2020-09-10 2020-12-04 那路新 合成21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮的方法
CH719319B1 (it) * 2020-10-19 2024-08-15 Ind Chimica Srl Processo per la preparazione di 21-(acetilossi)-17-(1-ossopropossi)-pregn-4-ene-3,20-dione
IT202100008429A1 (it) 2021-04-06 2022-10-06 Farmabios Spa Processo per la preparazione di cortexolone 17α-propionato e sua nuova forma cristallina idrata
CN114410727B (zh) * 2022-01-25 2023-09-19 山东诺明康药物研究院有限公司 一种克拉考特酮的制备方法
CN115073546A (zh) * 2022-06-01 2022-09-20 浙江神洲药业有限公司 一种新型雄激素受体抑制剂的制备方法
CN115466301A (zh) * 2022-08-29 2022-12-13 扬州奥锐特药业有限公司 一种甾体化合物，其晶型a及它们的制备方法和用途
WO2024165502A1 (en) 2023-02-07 2024-08-15 Farmabios S.P.A. Cocrystals of cortexolone 17-propionate and methods for their preparation
WO2024208997A1 (en) 2023-04-07 2024-10-10 Cassiopea S.P.A. Clascoterone and minoxidil combination therapy for use in treating hair loss

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB791771A (en) 1954-07-29 1958-03-12 Merck & Co Inc Steroid compounds
US2985650A (en) 1958-05-28 1961-05-23 Syntex Sa 6alpha-ammonio-derivatives of 11-keto cortical hormones
DE1195748B (de) 1961-06-24 1965-07-01 Vismara Francesco Spa Verfahren zur Herstellung von 1'-substituierten 17alpha, 21-(1'-Alkoxy)-methylendioxysterioden
NL6605514A (pl) * 1966-04-25 1967-10-26
NL6605515A (pl) * 1966-04-25 1967-10-26
US3780177A (en) 1967-06-16 1973-12-18 Warner Lambert Co 17-butyrate,21-ester derivatives of 6alpha,9alpha-difluoroprednisolone,compositions and use
US3733318A (en) 1972-03-23 1973-05-15 Syntex Corp 21-orthoesters of cortical steroids and methods of preparing same
JPS5910799B2 (ja) * 1975-07-15 1984-03-12 大正製薬株式会社 プレグナン系ステロイド １７−エステル類の製法
GB2109817B (en) 1981-11-18 1985-07-03 Ibm Electrodeposition of chromium
DE3243482A1 (de) 1982-11-22 1984-05-24 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6(alpha)-methylkortikoide, ihre herstellung und verwendung
DE3402330A1 (de) 1984-01-20 1985-07-25 Schering AG, 1000 Berlin und 4709 Bergkamen 1(alpha),2(alpha)-methylen-6-methylen- und 6(alpha)-methyl-pregnene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4920216A (en) 1987-05-28 1990-04-24 The Trustees Of Columbia In The City Of New York Selective chlorination of steroids and other substrates directed by covalently linked pyridine derivatives acting as templates
US5264428A (en) 1990-02-16 1993-11-23 Kanoldt Arzneimittel Gmbh Use of stigmasta-4-en-3-one in the treatment of androgen dependent diseases
JPH08135789A (ja) 1994-11-09 1996-05-31 Komatsu Ltd 車両の油圧式駆動装置の変速装置およびその変速制御方法
DE19653730C2 (de) 1996-12-11 1999-06-24 Schering Ag Immobilisierte Proteine aus Rohextrakt und deren Verwendung zur Umsetzung von Estern
TW473469B (en) 1997-06-25 2002-01-21 Teijin Ltd Vitamin D3-derivatives and agents for treating inflammatory respiratory diseases prepared from the same
JP2004530703A (ja) 2001-05-22 2004-10-07 ファイザー・プロダクツ・インク 結晶形アジスロマイシン
ITMI20011762A1 (it) 2001-08-10 2003-02-10 Cosmo Spa Esteri di 17alfa,21-diidrossipregnene, loro uso come agenti anti-androgenetici e procedimenti per la loro preparazione
WO2004060347A2 (en) 2002-09-03 2004-07-22 Transform Pharmaceuticals, Inc. Pharmaceutical propylene glycol solvate compositions
WO2003080042A1 (fr) 2002-03-27 2003-10-02 Shionogi & Co., Ltd. Inhibiteur de decomposition pour matrice extracellulaire de cartilage
AU2003255355A1 (en) 2002-08-02 2004-02-25 Schering Aktiengesellschaft Progesterone receptor modulators having an increased antigonadotropic activity for use in female fertility testing and hormone replacement therapy
JP2006506445A (ja) 2002-08-28 2006-02-23 ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド 治療処置の方法
DE602004021238D1 (de) 2003-03-05 2009-07-09 Merck Frosst Company Stickstoffmonoxid freisetzende prodrugs von diaryl-2-(5h)-furanonen als inhibitoren von cyclooxygenase-2
US20050008704A1 (en) 2003-07-11 2005-01-13 Ray Anup Kumar Pharmaceutical composition for solubility enhancement of hydrophobic drugs
JP2008189549A (ja) 2005-05-12 2008-08-21 Astellas Pharma Inc カルボン酸誘導体またはその塩
PE20070343A1 (es) * 2005-07-29 2007-05-12 Medivir Ab Inhibidores macrociclicos del virus de la hepatitis c
ITMI20051695A1 (it) * 2005-09-14 2007-03-15 Cosmo Spa Uso di 17a-esteri c3-c10 del 9,11-deidrocortexolone cme agenti anti-gonadotropinici
ITMI20071616A1 (it) 2007-08-03 2009-02-04 Cosmo Spa Processo enzimatico per l'ottenimento di 17-alfa monoesteri del cortexolone e/o suoi 9,11-deidroderivati.
BR112013014021A8 (pt) 2010-12-06 2017-10-03 Follica Inc Métodos para tratamento de calvície e promoção de crescimento de cabelos
ITMI20132157A1 (it) 2013-12-20 2015-06-21 Cosmo Dermatos Srl Cortexolone 17alfa-propionate for use in the treatment of skin wounds and/or atrophic skin disorders . cortexolone 17alfa-propionato per uso nel trattamento delle ferite della pelle e/o disordini atrofici della pelle.
EP3108879A1 (en) 2015-06-25 2016-12-28 Cassiopea S.p.A. High concentration formulation

Also Published As

Publication number Publication date
ES2554934T3 (es) 2015-12-28
EP2966175B1 (en) 2019-05-08
EP2503005A3 (en) 2012-10-03
US20220280531A1 (en) 2022-09-08
EP2966175A1 (en) 2016-01-13
CN101743316A (zh) 2010-06-16
RU2012113839A (ru) 2013-10-20
HRP20151298T1 (hr) 2016-01-01
EP2503004A1 (en) 2012-09-26
US20190083511A1 (en) 2019-03-21
PT2503004E (pt) 2015-12-09
NZ599437A (en) 2013-11-29
HUE044237T2 (hu) 2019-10-28
HUE026206T2 (hu) 2016-05-30
CA2691445A1 (en) 2009-02-12
SI2503005T1 (sl) 2015-12-31
ZA201100133B (en) 2014-03-26
ES2732326T3 (es) 2019-11-21
US20160324873A1 (en) 2016-11-10
ES2462946T3 (es) 2014-05-26
US9433628B2 (en) 2016-09-06
PT2503005E (pt) 2015-12-09
RS53310B (en) 2014-10-31
US20110092472A1 (en) 2011-04-21
JP6108944B2 (ja) 2017-04-05
NZ615953A (en) 2015-03-27
CN101743316B (zh) 2013-09-04
US11207332B2 (en) 2021-12-28
AU2008285784A1 (en) 2009-02-12
MX363701B (es) 2019-03-29
PT2966175T (pt) 2019-06-27
US20200155572A1 (en) 2020-05-21
DK2503004T3 (en) 2015-11-02
PL2503005T3 (pl) 2016-05-31
CA2871039C (en) 2017-11-28
PL2173891T3 (pl) 2014-07-31
JP2013163683A (ja) 2013-08-22
RS58950B1 (sr) 2019-08-30
CN103450304A (zh) 2013-12-18
WO2009019138A3 (en) 2009-10-15
AR072235A1 (es) 2010-08-18
AU2008285784B2 (en) 2014-06-26
CA2871039A1 (en) 2009-02-12
JP6174645B2 (ja) 2017-08-02
AR111202A2 (es) 2019-06-12
BRPI0814163A2 (pt) 2015-01-20
CA2871025A1 (en) 2009-02-12
RS54361B1 (en) 2016-04-28
WO2009019138A2 (en) 2009-02-12
RU2599452C2 (ru) 2016-10-10
US20140179654A1 (en) 2014-06-26
DK2503005T3 (en) 2015-11-16
RU2482190C2 (ru) 2013-05-20
AR111351A2 (es) 2019-07-03
HRP20140421T1 (hr) 2014-06-06
NZ600767A (en) 2013-11-29
PL2966175T3 (pl) 2019-11-29
HRP20151174T1 (hr) 2015-12-04
CN104861023A (zh) 2015-08-26
DK2173891T3 (da) 2014-04-28
EP2173891A2 (en) 2010-04-14
JP2016014045A (ja) 2016-01-28
SI2966175T1 (sl) 2019-08-30
KR101495192B1 (ko) 2015-02-25
US10159682B2 (en) 2018-12-25
JP5646992B2 (ja) 2014-12-24
EP2503005B1 (en) 2015-09-02
US20160051566A1 (en) 2016-02-25
ES2551910T3 (es) 2015-11-24
HRP20191143T1 (hr) 2019-09-20
EP3521298A1 (en) 2019-08-07
US9486458B2 (en) 2016-11-08
RU2010107599A (ru) 2011-09-10
EP2503004B1 (en) 2015-09-02
LT2966175T (lt) 2019-08-26
JP2010535173A (ja) 2010-11-18
TR201909129T4 (tr) 2019-07-22
ITMI20071616A1 (it) 2009-02-04
DK2966175T3 (da) 2019-07-01
HUE026507T2 (hu) 2016-06-28
MX2010001256A (es) 2010-05-17
US8785427B2 (en) 2014-07-22
CN104861023B (zh) 2017-04-12
PT2173891E (pt) 2014-05-19
RS54354B1 (en) 2016-04-28
MX2019003639A (es) 2019-06-17
SI2503004T1 (sl) 2015-12-31
CN103450304B (zh) 2016-05-25
CA2871025C (en) 2016-05-24
US10716796B2 (en) 2020-07-21
US20230104965A1 (en) 2023-04-06
US10166245B2 (en) 2019-01-01
EP2173891B1 (en) 2014-02-12
US20160326210A1 (en) 2016-11-10
ZA201000587B (en) 2011-04-28
MX363238B (es) 2019-03-15
SI2173891T1 (sl) 2014-06-30
EP2503005A2 (en) 2012-09-26
CA2691445C (en) 2017-11-28
US11938141B2 (en) 2024-03-26
KR20100044845A (ko) 2010-04-30

Similar Documents

Publication Publication Date Title
GB0720484D0 (en) Cells
PL2503004T3 (pl) 17 alfa-propionian korteksolonu w I postaci krystalicznej
GB0819182D0 (en) Crystalline forms
ZA201008295B (en) Improvements in feedwells
IL181653A0 (en) Conseption change in lightning
GB0700534D0 (en) Composition
GB0709551D0 (en) Improvements in or relating to stairlifts
ZA201101587B (en) Salinity tolerance in plants
GB0705885D0 (en) Composition
GB0718710D0 (en) Improvements in or relating to stairlifts
GB0706343D0 (en) Composition
GB0702446D0 (en) Composition
PT2173710E (pt) Nova forma cristalina
GB0807870D0 (en) Improvements in actuators
GB0703719D0 (en) Composition
GB0711469D0 (en) Improvements in or relating to devices
GB0706739D0 (en) Composition
GB0704651D0 (en) Composition
GB0704659D0 (en) Composition
GB0823515D0 (en) Improvements in bivvies
GB0803204D0 (en) Improvements in scraper
GB0813734D0 (en) Com-fee 2 in 1
IL213288A0 (en) Crystalline forms
GB0817164D0 (en) Crystalline forms
GB0700936D0 (en) Cells