PL2480198T3 - Stabilizowane płynne i liofilizowane preparaty adamts13 - Google Patents

Stabilizowane płynne i liofilizowane preparaty adamts13

Info

Publication number
PL2480198T3
PL2480198T3 PL10759786.6T PL10759786T PL2480198T3 PL 2480198 T3 PL2480198 T3 PL 2480198T3 PL 10759786 T PL10759786 T PL 10759786T PL 2480198 T3 PL2480198 T3 PL 2480198T3
Authority
PL
Poland
Prior art keywords
stabilized liquid
adamts13 formulations
lyophilized adamts13
lyophilized
formulations
Prior art date
Application number
PL10759786.6T
Other languages
English (en)
Polish (pl)
Inventor
H. Peter Matthiessen
Peter L. Turecek
Hans-Peter Schwarz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL2480198T3 publication Critical patent/PL2480198T3/pl

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24087ADAMTS13 endopeptidase (3.4.24.87)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL10759786.6T 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13 PL2480198T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24435309P 2009-09-21 2009-09-21

Publications (1)

Publication Number Publication Date
PL2480198T3 true PL2480198T3 (pl) 2016-09-30

Family

ID=43598388

Family Applications (4)

Application Number Title Priority Date Filing Date
PL10759786.6T PL2480198T3 (pl) 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13
PL15203085T PL3167897T3 (pl) 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13
PL23172759.5T PL4218797T3 (pl) 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13
PL20211228.0T PL3834841T3 (pl) 2009-09-21 2010-09-21 Stabilizowane ciekłe i liofilizowane preparaty adamts13

Family Applications After (3)

Application Number Title Priority Date Filing Date
PL15203085T PL3167897T3 (pl) 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13
PL23172759.5T PL4218797T3 (pl) 2009-09-21 2010-09-21 Stabilizowane płynne i liofilizowane preparaty adamts13
PL20211228.0T PL3834841T3 (pl) 2009-09-21 2010-09-21 Stabilizowane ciekłe i liofilizowane preparaty adamts13

Country Status (21)

Country Link
US (9) US8623352B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (5) EP2480198B9 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JP5819303B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (6) KR20190137954A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN104224705B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2010295299B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR112012006283B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2774556A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (4) DK3167897T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EA (1) EA024267B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (4) ES3001509T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (2) FI4218797T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR24C1049I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HR (1) HRP20160295T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUE028688T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2012DN02645A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (3) MX362382B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ598839A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (4) PL2480198T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (2) PT4218797T (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2011035335A2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2685503T3 (es) 2008-12-05 2018-10-09 Baxalta GmbH Métodos de medida de la división in vivo de Factor von Willebrand mediada por ADAMTS13 y utilización de los mismos
ES3001509T3 (en) 2009-09-21 2025-03-05 Takeda Pharmaceuticals Co Stabilized liquid and lyophilized adamts13 formulations
EP3311847A1 (en) * 2012-02-16 2018-04-25 Atyr Pharma, Inc. Histidyl-trna synthetases for treating autoimmune and inflammatory diseases
CN103566362B (zh) * 2012-07-21 2015-07-29 复旦大学 重组adamts13在制备脑出血药物中的用途
WO2014075033A2 (en) 2012-11-09 2014-05-15 Puget Sound Blood Center Protein stabilizing factors
WO2014145050A1 (en) 2013-03-15 2014-09-18 Atyr Pharma, Inc. Histidyl-trna synthetase-fc conjugates
AU2013203062C1 (en) * 2013-03-15 2018-06-28 Takeda Pharmaceutical Company Limited Subcutaneous administration of adamts13
EP4285930A3 (en) * 2014-06-26 2024-02-28 Amgen Inc. Protein formulations
GB201510870D0 (en) * 2015-05-26 2015-08-05 Baxalta Inc And Katholieke Universiteit Leuven And Baxalta Gmbh Treatment of infarction
ES2983978T3 (es) * 2016-01-08 2024-10-28 Univ Kyoto Medicina que comprende ADAMTS13 como ingrediente principal
IL264372B2 (en) * 2016-08-04 2024-05-01 Baxalta Inc Use of ADAMTS13 for the treatment, improvement and/or prevention of vascular infarct crisis in sickle cell disease
EP4360652A3 (en) 2016-11-04 2024-06-26 Takeda Pharmaceutical Company Limited Adeno-associated virus formulations
EP3612215B1 (en) 2017-04-20 2024-08-28 aTyr Pharma, Inc. Compositions for treating lung inflammation
WO2019019998A1 (zh) * 2017-07-25 2019-01-31 江苏恒瑞医药股份有限公司 一种il-15蛋白复合物药物组合物及其用途
AU2019299964A1 (en) * 2018-07-11 2021-01-21 Takeda Pharmaceutical Company Limited AAV compositions
EP4037704A4 (en) 2019-10-04 2023-04-26 The Children's Medical Center Corporation Adamts13 treatment to enhance graft survival
CN115836126A (zh) 2020-04-02 2023-03-21 武田药品工业株式会社 Adamts13变体、组合物及其用途
JP2023526546A (ja) 2020-05-22 2023-06-21 武田薬品工業株式会社 コロナウイルス疾患の合併症の治療及び診断のための、adamts13組成物及び方法
IL300596A (en) * 2020-08-13 2023-04-01 Hadasit Medical Res Services & Development Limited Mutants of disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (adamts-13), preparations and their uses in therapeutic methods
JP2025509154A (ja) 2022-03-08 2025-04-11 エクアシールド メディカル リミテッド ロボット医薬品調製システムにおける流体移送ステーション
WO2024151093A1 (ko) * 2023-01-11 2024-07-18 주식회사 녹십자 혈전성 질환의 예방 또는 치료를 위한 신규한 액상 제형물

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5250421A (en) 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5804420A (en) 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
CN101683522B (zh) 1999-02-22 2013-05-01 巴克斯特国际有限公司 新的无白蛋白的因子ⅷ制剂
JP2001227510A (ja) 2000-02-15 2001-08-24 Tomoe Tech Res Co 複作動型の空気式アクチュエータ
JP3783507B2 (ja) 2000-02-16 2006-06-07 日本精工株式会社 トロイダル型無段変速機用ディスクの加工方法
US6926894B2 (en) 2000-11-22 2005-08-09 Baxter Aktiengesellschaft Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV
JP2003284570A (ja) 2001-04-25 2003-10-07 Chemo Sero Therapeut Res Inst フォンビルブラント因子(vWF)切断酵素
US7037658B2 (en) 2001-08-16 2006-05-02 Regents Of University Of Michigan Methods and compositions for detecting variant ADAMTS13 genes
ITPR20010055A1 (it) 2001-08-31 2003-03-03 Vetroarredo Spa Procedimento e impianto per la realizzazione di mattoni in vetro.
KR100472006B1 (ko) 2002-10-09 2005-03-10 동부아남반도체 주식회사 모스 트랜지스터 제조 방법
JP5112692B2 (ja) * 2003-07-07 2013-01-09 ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル フォンビルブランド因子(vwf)マルチマーを検出する方法およびシステム
GB0404693D0 (en) * 2004-03-02 2004-04-07 Univ London Pharmaceutical preparations for the treatment of ocular surface and other disorders
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
DK1902141T3 (da) 2005-06-17 2012-05-07 Baxter Int ADAMTS 13-holdige sammensætninger med thrombolytisk virkning
JP4880997B2 (ja) * 2005-12-28 2012-02-22 アルフレッサファーマ株式会社 Adamts13の安定化方法
KR101422435B1 (ko) 2006-01-04 2014-07-22 박스터 헬쓰케어 에스에이 올리고펩티드-무함유 세포 배양 배지
ES3001509T3 (en) * 2009-09-21 2025-03-05 Takeda Pharmaceuticals Co Stabilized liquid and lyophilized adamts13 formulations
US8823352B2 (en) 2011-07-11 2014-09-02 Linear Technology Corporation Switching power supply having separate AC and DC current sensing paths

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Publication number Publication date
BR112012006283A2 (pt) 2016-05-31
JP5819303B2 (ja) 2015-11-24
US9937244B2 (en) 2018-04-10
DK4218797T5 (da) 2025-07-21
EA024267B1 (ru) 2016-09-30
FI4218797T3 (fi) 2024-12-07
KR20180095738A (ko) 2018-08-27
ES3001509T3 (en) 2025-03-05
PT3834841T (pt) 2023-06-19
MX2019000547A (es) 2020-11-12
WO2011035335A3 (en) 2011-12-01
FR24C1049I1 (fr) 2025-01-17
CN102573792A (zh) 2012-07-11
EP4467160A3 (en) 2025-01-15
EP4467160A2 (en) 2024-11-27
EP2480198B9 (en) 2016-11-23
DK2480198T3 (en) 2016-03-29
US20170112906A1 (en) 2017-04-27
NZ598839A (en) 2014-03-28
JP2015063556A (ja) 2015-04-09
KR20250008986A (ko) 2025-01-16
PT4218797T (pt) 2024-12-09
EP2480198A2 (en) 2012-08-01
FI3834841T3 (fi) 2023-06-05
BR112012006283B1 (pt) 2022-03-15
KR20190137954A (ko) 2019-12-11
ES2579906T3 (es) 2016-08-17
KR20210054598A (ko) 2021-05-13
EP3834841A1 (en) 2021-06-16
JP2013505270A (ja) 2013-02-14
EP4218797A1 (en) 2023-08-02
EP4218797B1 (en) 2024-09-11
MX2012003414A (es) 2012-06-19
PL4218797T3 (pl) 2025-02-10
DK3834841T3 (da) 2023-06-06
US20190247475A1 (en) 2019-08-15
ES2865250T3 (es) 2021-10-15
US11564979B2 (en) 2023-01-31
US20110229455A1 (en) 2011-09-22
CA2774556A1 (en) 2011-03-24
EP3167897B1 (en) 2021-01-27
US20230130866A1 (en) 2023-04-27
US9572778B2 (en) 2017-02-21
KR20220139456A (ko) 2022-10-14
AU2010295299A1 (en) 2012-04-12
CN104224705A (zh) 2014-12-24
US8623352B2 (en) 2014-01-07
KR20120099646A (ko) 2012-09-11
MX362382B (es) 2019-01-14
PL3834841T3 (pl) 2023-07-24
EP3834841B1 (en) 2023-05-17
EA201200519A1 (ru) 2012-09-28
US9351935B2 (en) 2016-05-31
PL3167897T3 (pl) 2021-09-27
MX339205B (es) 2016-05-16
HRP20160295T1 (hr) 2016-05-20
US20160375111A1 (en) 2016-12-29
CN102573792B (zh) 2014-10-15
KR101891646B1 (ko) 2018-08-27
US20140178357A1 (en) 2014-06-26
US20180207245A1 (en) 2018-07-26
WO2011035335A2 (en) 2011-03-24
EP4218797B9 (en) 2025-04-30
US12178861B2 (en) 2024-12-31
US10758599B2 (en) 2020-09-01
ES2948612T3 (es) 2023-09-14
US10238720B2 (en) 2019-03-26
EP2480198B1 (en) 2016-03-09
DK4218797T3 (da) 2024-12-09
HUE028688T2 (en) 2017-01-30
EP3167897A1 (en) 2017-05-17
CN104224705B (zh) 2018-02-02
HK1173968A1 (zh) 2013-05-31
IN2012DN02645A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-09-11
AU2010295299B2 (en) 2015-12-24
US20250099559A1 (en) 2025-03-27
US20200376098A1 (en) 2020-12-03
DK3167897T3 (da) 2021-04-19

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