DK3167897T3 - Stabiliserede væskeformige og lyofiliserede adamts13-formuleringer - Google Patents

Stabiliserede væskeformige og lyofiliserede adamts13-formuleringer Download PDF

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Publication number
DK3167897T3
DK3167897T3 DK15203085.4T DK15203085T DK3167897T3 DK 3167897 T3 DK3167897 T3 DK 3167897T3 DK 15203085 T DK15203085 T DK 15203085T DK 3167897 T3 DK3167897 T3 DK 3167897T3
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Denmark
Prior art keywords
lyofilized
stabilized liquid
adamts13 formulations
adamts13
formulations
Prior art date
Application number
DK15203085.4T
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Danish (da)
English (en)
Inventor
H Peter Matthiessen
Peter L Turecek
Hans-Peter Schwarz
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Baxalta GmbH
Baxalta Inc
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Publication of DK3167897T3 publication Critical patent/DK3167897T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886Metalloendopeptidases (3.4.24), e.g. collagenase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24087ADAMTS13 endopeptidase (3.4.24.87)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK15203085.4T 2009-09-21 2010-09-21 Stabiliserede væskeformige og lyofiliserede adamts13-formuleringer DK3167897T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24435309P 2009-09-21 2009-09-21
EP10759786.6A EP2480198B9 (en) 2009-09-21 2010-09-21 Stabilized liquid and lyophilized adamts13 formulations

Publications (1)

Publication Number Publication Date
DK3167897T3 true DK3167897T3 (da) 2021-04-19

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Family Applications (4)

Application Number Title Priority Date Filing Date
DK23172759.5T DK4218797T5 (da) 2009-09-21 2010-09-21 Stabiliseret væske og frysetørrede adamts13-formuleringer
DK10759786.6T DK2480198T3 (en) 2009-09-21 2010-09-21 STABILIZED VÆSKEFORMIGE- AND lyophilized ADAMTS13 FORMULATIONS
DK15203085.4T DK3167897T3 (da) 2009-09-21 2010-09-21 Stabiliserede væskeformige og lyofiliserede adamts13-formuleringer
DK20211228.0T DK3834841T3 (da) 2009-09-21 2010-09-21 Stabiliserede væskeformige og lyofiliserede adamts13-formuleringer

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DK23172759.5T DK4218797T5 (da) 2009-09-21 2010-09-21 Stabiliseret væske og frysetørrede adamts13-formuleringer
DK10759786.6T DK2480198T3 (en) 2009-09-21 2010-09-21 STABILIZED VÆSKEFORMIGE- AND lyophilized ADAMTS13 FORMULATIONS

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DK20211228.0T DK3834841T3 (da) 2009-09-21 2010-09-21 Stabiliserede væskeformige og lyofiliserede adamts13-formuleringer

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US (9) US8623352B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (5) EP2480198B9 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JP5819303B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (6) KR20180095738A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN104224705B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2010295299B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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CA (1) CA2774556A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (4) DK4218797T5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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ES (4) ES3001509T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (2) FI3834841T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR24C1049I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HR (1) HRP20160295T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUE028688T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2012DN02645A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (3) MX362382B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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Publication number Publication date
EP2480198A2 (en) 2012-08-01
US9572778B2 (en) 2017-02-21
FR24C1049I1 (fr) 2025-01-17
EP4467160A3 (en) 2025-01-15
EP4218797B1 (en) 2024-09-11
DK4218797T3 (da) 2024-12-09
US20180207245A1 (en) 2018-07-26
PL3834841T3 (pl) 2023-07-24
US20110229455A1 (en) 2011-09-22
DK4218797T5 (da) 2025-07-21
EA201200519A1 (ru) 2012-09-28
KR20210054598A (ko) 2021-05-13
HUE028688T2 (en) 2017-01-30
KR20190137954A (ko) 2019-12-11
US11564979B2 (en) 2023-01-31
CN102573792B (zh) 2014-10-15
JP5819303B2 (ja) 2015-11-24
PL2480198T3 (pl) 2016-09-30
EP4467160A2 (en) 2024-11-27
KR20220139456A (ko) 2022-10-14
MX339205B (es) 2016-05-16
EP2480198B9 (en) 2016-11-23
MX2019000547A (es) 2020-11-12
KR20120099646A (ko) 2012-09-11
WO2011035335A2 (en) 2011-03-24
CN104224705A (zh) 2014-12-24
JP2013505270A (ja) 2013-02-14
JP2015063556A (ja) 2015-04-09
DK2480198T3 (en) 2016-03-29
ES2865250T3 (es) 2021-10-15
EP2480198B1 (en) 2016-03-09
US10758599B2 (en) 2020-09-01
AU2010295299B2 (en) 2015-12-24
US20250099559A1 (en) 2025-03-27
US20140178357A1 (en) 2014-06-26
BR112012006283A2 (pt) 2016-05-31
US9351935B2 (en) 2016-05-31
PT3834841T (pt) 2023-06-19
FI3834841T3 (fi) 2023-06-05
DK3834841T3 (da) 2023-06-06
US20160375111A1 (en) 2016-12-29
KR20180095738A (ko) 2018-08-27
US20230130866A1 (en) 2023-04-27
MX362382B (es) 2019-01-14
US20200376098A1 (en) 2020-12-03
ES2579906T3 (es) 2016-08-17
PL4218797T3 (pl) 2025-02-10
ES3001509T3 (en) 2025-03-05
US8623352B2 (en) 2014-01-07
MX2012003414A (es) 2012-06-19
CN104224705B (zh) 2018-02-02
CN102573792A (zh) 2012-07-11
HRP20160295T1 (hr) 2016-05-20
EP3834841B1 (en) 2023-05-17
US20190247475A1 (en) 2019-08-15
BR112012006283B1 (pt) 2022-03-15
PL3167897T3 (pl) 2021-09-27
EP3167897B1 (en) 2021-01-27
EP3167897A1 (en) 2017-05-17
KR101891646B1 (ko) 2018-08-27
US10238720B2 (en) 2019-03-26
PT4218797T (pt) 2024-12-09
NZ598839A (en) 2014-03-28
FI4218797T3 (fi) 2024-12-07
EA024267B1 (ru) 2016-09-30
HK1173968A1 (zh) 2013-05-31
AU2010295299A1 (en) 2012-04-12
CA2774556A1 (en) 2011-03-24
EP4218797B9 (en) 2025-04-30
WO2011035335A3 (en) 2011-12-01
EP4218797A1 (en) 2023-08-02
KR20250008986A (ko) 2025-01-16
US9937244B2 (en) 2018-04-10
ES2948612T3 (es) 2023-09-14
EP3834841A1 (en) 2021-06-16
US12178861B2 (en) 2024-12-31
IN2012DN02645A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-09-11
US20170112906A1 (en) 2017-04-27

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