PL1912979T3 - Pochodne fenylo-{3-(3-(1H-pirol-2-ilo)-[1,2,4]oksadiazol-5-ilo]piperydyn-1-ylo}-metanonu i związki pokrewne jako dodatnie allosteryczne modulatory metabotropowych receptorów glutaminianowych - Google Patents
Pochodne fenylo-{3-(3-(1H-pirol-2-ilo)-[1,2,4]oksadiazol-5-ilo]piperydyn-1-ylo}-metanonu i związki pokrewne jako dodatnie allosteryczne modulatory metabotropowych receptorów glutaminianowychInfo
- Publication number
- PL1912979T3 PL1912979T3 PL06779899T PL06779899T PL1912979T3 PL 1912979 T3 PL1912979 T3 PL 1912979T3 PL 06779899 T PL06779899 T PL 06779899T PL 06779899 T PL06779899 T PL 06779899T PL 1912979 T3 PL1912979 T3 PL 1912979T3
- Authority
- PL
- Poland
- Prior art keywords
- oxadiazol
- pyrrol
- piperidin
- phenyl
- related compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 title 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 title 1
- 230000003281 allosteric effect Effects 0.000 title 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 title 1
- 102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 abstract 1
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000027232 peripheral nervous system disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003233 pyrroles Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0510141.5A GB0510141D0 (en) | 2005-05-18 | 2005-05-18 | Novel compounds B3 |
| PCT/IB2006/002047 WO2006123257A2 (en) | 2005-05-18 | 2006-05-17 | Phenyl-3-{(3-(1h-pyrrol-2-yl)-[1, 2 , 4]0xadiaz0l-5-yl]piperidin-1-yl}-methanone derivatives and related compounds as positive allosteric modulators of metabotropic glutamate receptors |
| EP06779899A EP1912979B1 (en) | 2005-05-18 | 2006-05-17 | Phenyl-{3-(3-(1h-pyrrol-2-yl)-[1,2,4]oxadiazol-5-yl]piperidin-1-yl}-methanone derivatives and related compounds as positive allosteric modulators of metabotropic glutamate receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1912979T3 true PL1912979T3 (pl) | 2011-11-30 |
Family
ID=34708379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06779899T PL1912979T3 (pl) | 2005-05-18 | 2006-05-17 | Pochodne fenylo-{3-(3-(1H-pirol-2-ilo)-[1,2,4]oksadiazol-5-ilo]piperydyn-1-ylo}-metanonu i związki pokrewne jako dodatnie allosteryczne modulatory metabotropowych receptorów glutaminianowych |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20090203737A1 (https=) |
| EP (1) | EP1912979B1 (https=) |
| JP (2) | JP2008540637A (https=) |
| KR (1) | KR20080014046A (https=) |
| CN (1) | CN101218234B (https=) |
| AT (1) | ATE513828T1 (https=) |
| AU (1) | AU2006248657B2 (https=) |
| BR (1) | BRPI0610059A2 (https=) |
| CA (1) | CA2608324A1 (https=) |
| CY (1) | CY1111859T1 (https=) |
| DK (1) | DK1912979T3 (https=) |
| EA (1) | EA014081B1 (https=) |
| ES (1) | ES2367663T3 (https=) |
| GB (1) | GB0510141D0 (https=) |
| IL (1) | IL187187A0 (https=) |
| MX (1) | MX2007014403A (https=) |
| NO (1) | NO20076480L (https=) |
| NZ (1) | NZ564202A (https=) |
| PL (1) | PL1912979T3 (https=) |
| PT (1) | PT1912979E (https=) |
| UA (1) | UA92494C2 (https=) |
| WO (1) | WO2006123257A2 (https=) |
| ZA (1) | ZA200710279B (https=) |
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|---|---|---|---|---|
| EP1893606A2 (en) * | 2005-05-18 | 2008-03-05 | Addex Pharma SA | Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510141D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
| GB0510140D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B2 |
| GB0510139D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| GB0622202D0 (en) * | 2006-11-07 | 2006-12-20 | Addex Pharmaceuticals Sa | Novel compounds |
| JP2010533147A (ja) | 2007-07-13 | 2010-10-21 | アデックス ファルマ エス．エイ． | 代謝調節型グルタミン酸レセプターのモジュレーターとしてのピラゾール誘導体 |
| BRPI0817211A2 (pt) | 2007-09-20 | 2017-05-16 | Irm Llc | composto composições como moduladores da atividade de gpr119 |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| US8273900B2 (en) | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| US20100317630A1 (en) * | 2009-02-04 | 2010-12-16 | Recordati Ireland Limited | Novel heterocyclic compounds as mglu5 antagonists |
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| EP2421370A4 (en) * | 2009-04-23 | 2012-12-12 | Merck Sharp & Dohme | 2-alkyl-piperidine-mGluR5 receptor MODULATORS |
| GB0912946D0 (en) | 2009-07-24 | 2009-09-02 | Addex Pharmaceuticals Sa | New compounds 5 |
| US8772301B2 (en) | 2009-12-18 | 2014-07-08 | Sunovion Pharmaceuticals, Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
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| JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
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| RS55593B1 (sr) | 2012-11-13 | 2017-06-30 | Array Biopharma Inc | Jedinjenja biciklične uree, tiouree, guanidina i cijanoguanidina korisna za lečenje bola |
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| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| WO2024059207A2 (en) * | 2022-09-15 | 2024-03-21 | Vanderbilt University | Pyrazoloether analogs as mglu5 negative allosteric modulators and methods of making and using the same |
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2006
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- 2006-05-17 KR KR1020077029429A patent/KR20080014046A/ko not_active Ceased
- 2006-05-17 EP EP06779899A patent/EP1912979B1/en not_active Not-in-force
- 2006-05-17 JP JP2008511823A patent/JP2008540637A/ja active Pending
- 2006-05-17 BR BRPI0610059-7A patent/BRPI0610059A2/pt not_active IP Right Cessation
- 2006-05-17 AT AT06779899T patent/ATE513828T1/de active
- 2006-05-17 DK DK06779899.1T patent/DK1912979T3/da active
- 2006-05-17 CN CN2006800251802A patent/CN101218234B/zh not_active Expired - Fee Related
- 2006-05-17 WO PCT/IB2006/002047 patent/WO2006123257A2/en not_active Ceased
- 2006-05-17 PT PT06779899T patent/PT1912979E/pt unknown
- 2006-05-17 US US11/920,490 patent/US20090203737A1/en not_active Abandoned
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- 2006-05-17 PL PL06779899T patent/PL1912979T3/pl unknown
- 2006-05-17 NZ NZ564202A patent/NZ564202A/en not_active IP Right Cessation
- 2006-05-17 UA UAA200714061A patent/UA92494C2/ru unknown
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2011
- 2011-09-22 CY CY20111100921T patent/CY1111859T1/el unknown
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Also Published As
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| CN101218234A (zh) | 2008-07-09 |
| CA2608324A1 (en) | 2006-11-23 |
| ZA200710279B (en) | 2009-03-25 |
| WO2006123257A8 (en) | 2007-03-15 |
| HK1112909A1 (en) | 2008-09-19 |
| DK1912979T3 (da) | 2011-08-22 |
| GB0510141D0 (en) | 2005-06-22 |
| JP2012184254A (ja) | 2012-09-27 |
| US20090203737A1 (en) | 2009-08-13 |
| ATE513828T1 (de) | 2011-07-15 |
| PT1912979E (pt) | 2011-08-22 |
| KR20080014046A (ko) | 2008-02-13 |
| CY1111859T1 (el) | 2015-11-04 |
| IL187187A0 (en) | 2008-02-09 |
| AU2006248657A1 (en) | 2006-11-23 |
| JP2008540637A (ja) | 2008-11-20 |
| EP1912979A2 (en) | 2008-04-23 |
| MX2007014403A (es) | 2008-04-21 |
| BRPI0610059A2 (pt) | 2010-05-25 |
| UA92494C2 (ru) | 2010-11-10 |
| EA014081B1 (ru) | 2010-08-30 |
| EP1912979B1 (en) | 2011-06-22 |
| NZ564202A (en) | 2011-04-29 |
| CN101218234B (zh) | 2011-12-14 |
| AU2006248657B2 (en) | 2012-07-19 |
| EA200702470A1 (ru) | 2008-06-30 |
| NO20076480L (no) | 2008-01-28 |
| WO2006123257A2 (en) | 2006-11-23 |
| WO2006123257A3 (en) | 2007-05-03 |
| ES2367663T3 (es) | 2011-11-07 |
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