PL185618B1 - Nowe związki, pochodne 1-arylosulfonylo-, arylo(tio)-karbonylo-pirydazyny, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związki - Google Patents
Nowe związki, pochodne 1-arylosulfonylo-, arylo(tio)-karbonylo-pirydazyny, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związkiInfo
- Publication number
- PL185618B1 PL185618B1 PL96326669A PL32666996A PL185618B1 PL 185618 B1 PL185618 B1 PL 185618B1 PL 96326669 A PL96326669 A PL 96326669A PL 32666996 A PL32666996 A PL 32666996A PL 185618 B1 PL185618 B1 PL 185618B1
- Authority
- PL
- Poland
- Prior art keywords
- diazo
- hexahydro
- hexahydrophenanthrene
- dichlorobenzoyl
- cyclohepta
- Prior art date
Links
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- 125000000446 sulfanediyl group Chemical group *S* 0.000 title 1
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- -1 3,4-dichlorobenzoyl Chemical group 0.000 claims description 56
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- SLUNEGLMXGHOLY-UHFFFAOYSA-N benzene;hexane Chemical compound CCCCCC.C1=CC=CC=C1 SLUNEGLMXGHOLY-UHFFFAOYSA-N 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 230000031709 bromination Effects 0.000 description 1
- 238000005893 bromination reaction Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 125000000950 dibromo group Chemical group Br* 0.000 description 1
- 125000003963 dichloro group Chemical group Cl* 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000012259 ether extract Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003979 granulating agent Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000002496 iodine Chemical class 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 238000005567 liquid scintillation counting Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003146 progesterones Chemical class 0.000 description 1
- 230000003623 progesteronic effect Effects 0.000 description 1
- 229960001584 promegestone Drugs 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001525 receptor binding assay Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
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- 238000003756 stirring Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000012134 supernatant fraction Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/36—Benzo-cinnolines
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US790095P | 1995-11-06 | 1995-11-06 | |
| PCT/US1996/016227 WO1997017332A1 (en) | 1995-11-06 | 1996-10-10 | 1-arylsulphonyl, aryl(thio)carbonyl pyridazino derivatives and methods of preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL326669A1 PL326669A1 (en) | 1998-10-12 |
| PL185618B1 true PL185618B1 (pl) | 2003-06-30 |
Family
ID=21728709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL96326669A PL185618B1 (pl) | 1995-11-06 | 1996-10-10 | Nowe związki, pochodne 1-arylosulfonylo-, arylo(tio)-karbonylo-pirydazyny, sposób ich wytwarzania oraz kompozycja farmaceutyczna zawierająca te związki |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JP2000501073A (no) |
| KR (1) | KR100360614B1 (no) |
| CN (1) | CN1110485C (no) |
| AU (1) | AU704507B2 (no) |
| BR (1) | BR9611407A (no) |
| CZ (1) | CZ286789B6 (no) |
| HU (1) | HU225162B1 (no) |
| IL (1) | IL124320A (no) |
| MX (1) | MX9803605A (no) |
| NO (1) | NO310460B1 (no) |
| NZ (1) | NZ319979A (no) |
| PL (1) | PL185618B1 (no) |
| RU (1) | RU2175969C2 (no) |
| TW (1) | TW460467B (no) |
| UA (1) | UA48989C2 (no) |
| WO (1) | WO1997017332A1 (no) |
| ZA (1) | ZA969298B (no) |
-
1996
- 1996-10-10 RU RU98110813/04A patent/RU2175969C2/ru not_active IP Right Cessation
- 1996-10-10 WO PCT/US1996/016227 patent/WO1997017332A1/en active IP Right Grant
- 1996-10-10 PL PL96326669A patent/PL185618B1/pl not_active IP Right Cessation
- 1996-10-10 IL IL12432096A patent/IL124320A/en not_active IP Right Cessation
- 1996-10-10 CZ CZ19981380A patent/CZ286789B6/cs not_active IP Right Cessation
- 1996-10-10 HU HU0201305A patent/HU225162B1/hu not_active IP Right Cessation
- 1996-10-10 UA UA98052267A patent/UA48989C2/uk unknown
- 1996-10-10 NZ NZ319979A patent/NZ319979A/xx unknown
- 1996-10-10 JP JP9518177A patent/JP2000501073A/ja not_active Ceased
- 1996-10-10 AU AU72637/96A patent/AU704507B2/en not_active Ceased
- 1996-10-10 KR KR10-1998-0703345A patent/KR100360614B1/ko not_active IP Right Cessation
- 1996-10-10 CN CN96199481A patent/CN1110485C/zh not_active Expired - Fee Related
- 1996-10-10 BR BR9611407-0A patent/BR9611407A/pt not_active Application Discontinuation
- 1996-11-05 ZA ZA9609298A patent/ZA969298B/xx unknown
- 1996-11-25 TW TW085114479A patent/TW460467B/zh not_active IP Right Cessation
-
1998
- 1998-05-05 NO NO19982030A patent/NO310460B1/no unknown
- 1998-05-06 MX MX9803605A patent/MX9803605A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU704507B2 (en) | 1999-04-22 |
| BR9611407A (pt) | 1999-12-28 |
| CN1110485C (zh) | 2003-06-04 |
| CZ286789B6 (en) | 2000-07-12 |
| KR100360614B1 (ko) | 2003-06-02 |
| CZ138098A3 (cs) | 1998-09-16 |
| PL326669A1 (en) | 1998-10-12 |
| CN1207091A (zh) | 1999-02-03 |
| TW460467B (en) | 2001-10-21 |
| HU225162B1 (en) | 2006-07-28 |
| JP2000501073A (ja) | 2000-02-02 |
| AU7263796A (en) | 1997-05-29 |
| NO982030D0 (no) | 1998-05-05 |
| IL124320A (en) | 2001-10-31 |
| HUP0201305A2 (hu) | 2002-12-28 |
| MX9803605A (es) | 1998-09-30 |
| NO310460B1 (no) | 2001-07-09 |
| HUP0201305A3 (en) | 2003-02-28 |
| NO982030L (no) | 1998-06-23 |
| IL124320A0 (en) | 1998-12-06 |
| NZ319979A (en) | 1999-11-29 |
| UA48989C2 (uk) | 2002-09-16 |
| ZA969298B (en) | 1998-05-05 |
| WO1997017332A1 (en) | 1997-05-15 |
| KR19990067340A (ko) | 1999-08-16 |
| RU2175969C2 (ru) | 2001-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Decisions on the lapse of the protection rights |
Effective date: 20071010 |