NZ319979A - 1-Arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and methods of preparation - Google Patents

1-Arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and methods of preparation

Info

Publication number
NZ319979A
NZ319979A NZ319979A NZ31997996A NZ319979A NZ 319979 A NZ319979 A NZ 319979A NZ 319979 A NZ319979 A NZ 319979A NZ 31997996 A NZ31997996 A NZ 31997996A NZ 319979 A NZ319979 A NZ 319979A
Authority
NZ
New Zealand
Prior art keywords
arylsulphonyl
arylcarbonyl
preparation
methods
arylthiocarbonyl
Prior art date
Application number
NZ319979A
Inventor
Donald W Combs
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of NZ319979A publication Critical patent/NZ319979A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/36—Benzo-cinnolines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A compound of formula I wherein: L is CO, CS or SO2; R1 and R2 are independently H, halo, alkyl, haloalkyl, nitro, cyano, carboxyl or carboalkoxy provided that when L is SO2, R1 and R2 are not both H; R3 is independently selected from 1-3 members of H, halo, alkyl, haloalkyl, nitro, carboxyl or carboalkoxy and X is (CH2)n or Y-(CH2)n-1 with Y being O or S and n is 1-3 is claimed. A pharmaceutical composition containing a compound of formula I useful for the treatment of contraception, menopause, endometriosis, breast cancer, cyclesychrony, pregnancy termination, labour induction or osteoporosis is claimed.
NZ319979A 1995-11-06 1996-10-10 1-Arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and methods of preparation NZ319979A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US790095P 1995-11-06 1995-11-06
PCT/US1996/016227 WO1997017332A1 (en) 1995-11-06 1996-10-10 1-arylsulphonyl, aryl(thio)carbonyl pyridazino derivatives and methods of preparation

Publications (1)

Publication Number Publication Date
NZ319979A true NZ319979A (en) 1999-11-29

Family

ID=21728709

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ319979A NZ319979A (en) 1995-11-06 1996-10-10 1-Arylsulphonyl, arylcarbonyl and arylthiocarbonyl pyridazino derivatives and methods of preparation

Country Status (17)

Country Link
JP (1) JP2000501073A (en)
KR (1) KR100360614B1 (en)
CN (1) CN1110485C (en)
AU (1) AU704507B2 (en)
BR (1) BR9611407A (en)
CZ (1) CZ286789B6 (en)
HU (1) HU225162B1 (en)
IL (1) IL124320A (en)
MX (1) MX9803605A (en)
NO (1) NO310460B1 (en)
NZ (1) NZ319979A (en)
PL (1) PL185618B1 (en)
RU (1) RU2175969C2 (en)
TW (1) TW460467B (en)
UA (1) UA48989C2 (en)
WO (1) WO1997017332A1 (en)
ZA (1) ZA969298B (en)

Also Published As

Publication number Publication date
AU704507B2 (en) 1999-04-22
BR9611407A (en) 1999-12-28
CN1110485C (en) 2003-06-04
CZ286789B6 (en) 2000-07-12
KR100360614B1 (en) 2003-06-02
CZ138098A3 (en) 1998-09-16
PL326669A1 (en) 1998-10-12
CN1207091A (en) 1999-02-03
TW460467B (en) 2001-10-21
HU225162B1 (en) 2006-07-28
PL185618B1 (en) 2003-06-30
JP2000501073A (en) 2000-02-02
AU7263796A (en) 1997-05-29
NO982030D0 (en) 1998-05-05
IL124320A (en) 2001-10-31
HUP0201305A2 (en) 2002-12-28
MX9803605A (en) 1998-09-30
NO310460B1 (en) 2001-07-09
HUP0201305A3 (en) 2003-02-28
NO982030L (en) 1998-06-23
IL124320A0 (en) 1998-12-06
UA48989C2 (en) 2002-09-16
ZA969298B (en) 1998-05-05
WO1997017332A1 (en) 1997-05-15
KR19990067340A (en) 1999-08-16
RU2175969C2 (en) 2001-11-20

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