UA48989C2 - Derivatives of 1-arylsulfonyl, aryl(thio)carbonylpyridazine, method of their preparation, pharmaceutical composition and method of treatment - Google Patents

Derivatives of 1-arylsulfonyl, aryl(thio)carbonylpyridazine, method of their preparation, pharmaceutical composition and method of treatment

Info

Publication number
UA48989C2
UA48989C2 UA98052267A UA98052267A UA48989C2 UA 48989 C2 UA48989 C2 UA 48989C2 UA 98052267 A UA98052267 A UA 98052267A UA 98052267 A UA98052267 A UA 98052267A UA 48989 C2 UA48989 C2 UA 48989C2
Authority
UA
Ukraine
Prior art keywords
derivatives
carbonylpyridazine
arylsulfonyl
thio
aryl
Prior art date
Application number
UA98052267A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Дональд У. Комбз
Original Assignee
Орто-Макнейл Фармасьютікел, Інк.
Орто-Макнейл Фармасьютикел, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орто-Макнейл Фармасьютікел, Інк., Орто-Макнейл Фармасьютикел, Инк. filed Critical Орто-Макнейл Фармасьютікел, Інк.
Publication of UA48989C2 publication Critical patent/UA48989C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/36—Benzo-cinnolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Described are derivatives of 1-arylsulfonyl, arylcarbonyl, aryl(thio)carbonylpyridazine and methods for preparation thereof. Described are new nonsteroid heterocyclic compounds showing activity of progestin and/or antiprogestin and having high in vitro likeness to progestin of receptor of uterus, breast or bones. Nonsteroid heterocyclic derivatives are used for contraception, menopause, osteoporosis or endometriosis.
UA98052267A 1995-11-06 1996-10-10 Derivatives of 1-arylsulfonyl, aryl(thio)carbonylpyridazine, method of their preparation, pharmaceutical composition and method of treatment UA48989C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US790095P 1995-11-06 1995-11-06
PCT/US1996/016227 WO1997017332A1 (en) 1995-11-06 1996-10-10 1-arylsulphonyl, aryl(thio)carbonyl pyridazino derivatives and methods of preparation

Publications (1)

Publication Number Publication Date
UA48989C2 true UA48989C2 (en) 2002-09-16

Family

ID=21728709

Family Applications (1)

Application Number Title Priority Date Filing Date
UA98052267A UA48989C2 (en) 1995-11-06 1996-10-10 Derivatives of 1-arylsulfonyl, aryl(thio)carbonylpyridazine, method of their preparation, pharmaceutical composition and method of treatment

Country Status (17)

Country Link
JP (1) JP2000501073A (en)
KR (1) KR100360614B1 (en)
CN (1) CN1110485C (en)
AU (1) AU704507B2 (en)
BR (1) BR9611407A (en)
CZ (1) CZ286789B6 (en)
HU (1) HU225162B1 (en)
IL (1) IL124320A (en)
MX (1) MX9803605A (en)
NO (1) NO310460B1 (en)
NZ (1) NZ319979A (en)
PL (1) PL185618B1 (en)
RU (1) RU2175969C2 (en)
TW (1) TW460467B (en)
UA (1) UA48989C2 (en)
WO (1) WO1997017332A1 (en)
ZA (1) ZA969298B (en)

Also Published As

Publication number Publication date
NO310460B1 (en) 2001-07-09
IL124320A0 (en) 1998-12-06
RU2175969C2 (en) 2001-11-20
CZ138098A3 (en) 1998-09-16
IL124320A (en) 2001-10-31
CZ286789B6 (en) 2000-07-12
HUP0201305A2 (en) 2002-12-28
MX9803605A (en) 1998-09-30
AU7263796A (en) 1997-05-29
ZA969298B (en) 1998-05-05
HU225162B1 (en) 2006-07-28
BR9611407A (en) 1999-12-28
CN1110485C (en) 2003-06-04
AU704507B2 (en) 1999-04-22
CN1207091A (en) 1999-02-03
HUP0201305A3 (en) 2003-02-28
PL326669A1 (en) 1998-10-12
NO982030L (en) 1998-06-23
NO982030D0 (en) 1998-05-05
TW460467B (en) 2001-10-21
KR100360614B1 (en) 2003-06-02
JP2000501073A (en) 2000-02-02
KR19990067340A (en) 1999-08-16
NZ319979A (en) 1999-11-29
WO1997017332A1 (en) 1997-05-15
PL185618B1 (en) 2003-06-30

Similar Documents

Publication Publication Date Title
DE68928897D1 (en) METHOD AND SYSTEM FOR PREVENTION
AP2001002054A0 (en) Use of biogenic estrogen sulfamates for hormone replacement therapy.
HUP9902121A2 (en) Indole derivatives as antagonists of gonadotropin releasing hormone and pharmaceutical compositions containing them
ES2033850T3 (en) PHARMACEUTICAL FORM CONSISTING OF A DOSAGE COMBINATION, INTENDED FOR THE TREATMENT OF PRE-MENOPAUSIC WOMEN.
AU2001273945A1 (en) 8beta-substituted-11beta-pentyl- and 11beta-hexyl-estra-1,3,5(10)-triene derivatives
NZ262569A (en) Reducing bone loss by administration of 3,4-diphenylbenzo[b]pyran derivatives
MY151187A (en) Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
EA201200377A1 (en) METHOD OF ORAL CONTRACEPTION IN WOMEN, METHOD OF MANAGING UNDESIRABLE BLEEDING AND INTENDED FOR USE IN THESE METHODS
PT956024E (en) MONOPHASIC ORAL CONTRACEPTIVE METHOD AND COVER ("KIT") COMPREHENDING A COMBINATION OF A PROGESTINE AND ESTROGEN
AU2284001A (en) Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone
EP0129500A3 (en) 1-alkyl-androsta-1,4-diene-3,17-diones, process for their preparation and pharmaceutical compositions containing them
YU57201A (en) 16-hydroxyestratrienes as selective estrogens
UA48989C2 (en) Derivatives of 1-arylsulfonyl, aryl(thio)carbonylpyridazine, method of their preparation, pharmaceutical composition and method of treatment
IL147123A0 (en) Compositions containing soluble forms of hla-g for treating inflammatory skin pathologies
IL99123A0 (en) Pharmaceutical compositions for treatment of bone wasting diseases,comprising estrogen derivatives
ATE183740T1 (en) ALPHA-SUBSTITUTED 1-BENZYL NAPHTHYL DERIVATIVES
GR1000989B (en) Method for preparing a composition for the osteoporosis and hormone imbalance treatment
HUP0202371A3 (en) Diacylhydrazine derivatives, process for producing them, use of these derivatives for producing of pharmaceutical compositions and pharmaceutical compositions
EP0902025A3 (en) Benzothiophenes for treatment of estrogen related conditions
HUP0203443A2 (en) Novel contraceptive medicament and method for producing the same
NZ330603A (en) Hyaluronic acid derivatives used as cervical ripening agents
AU9399898A (en) Benzothiophenes
PL352029A1 (en) 14-beta-h-sterols, pharmaceutical compositions containing these sterols and use of these derivatives for obtaining drugs to regulate meioses
HUP9903310A3 (en) Indole derivatives for the treatment of osteoporosis pharmaceutical compositions containing them, process for producing them and their medical use