PL1711184T3 - Pochodne (3-okso-3,4-dihydrochinoksalin-2-yloamino)benzamidu i związki pokrewne jako inhibitory fosforylazy glikogenowej do leczenia cukrzycy i otyłości - Google Patents
Pochodne (3-okso-3,4-dihydrochinoksalin-2-yloamino)benzamidu i związki pokrewne jako inhibitory fosforylazy glikogenowej do leczenia cukrzycy i otyłościInfo
- Publication number
- PL1711184T3 PL1711184T3 PL04815480T PL04815480T PL1711184T3 PL 1711184 T3 PL1711184 T3 PL 1711184T3 PL 04815480 T PL04815480 T PL 04815480T PL 04815480 T PL04815480 T PL 04815480T PL 1711184 T3 PL1711184 T3 PL 1711184T3
- Authority
- PL
- Poland
- Prior art keywords
- quinoxalin
- obesity
- dihydro
- oxo
- diabetes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53453404P | 2004-01-06 | 2004-01-06 | |
| PCT/US2004/043409 WO2005067932A1 (en) | 2004-01-06 | 2004-12-22 | (3-oxo-3, 4-dihydro-quinoxalin-2-yl-amino) -benzamide derivatives and related compound as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity |
| EP04815480A EP1711184B1 (en) | 2004-01-06 | 2004-12-22 | (3-oxo-3,4-dihydro-quinoxalin-2-yl-amino)-benzamide derivatives and related compounds as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1711184T3 true PL1711184T3 (pl) | 2007-12-31 |
Family
ID=34794290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04815480T PL1711184T3 (pl) | 2004-01-06 | 2004-12-22 | Pochodne (3-okso-3,4-dihydrochinoksalin-2-yloamino)benzamidu i związki pokrewne jako inhibitory fosforylazy glikogenowej do leczenia cukrzycy i otyłości |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20050148586A1 (pl) |
| EP (1) | EP1711184B1 (pl) |
| JP (1) | JP2007517800A (pl) |
| KR (1) | KR20060130159A (pl) |
| CN (1) | CN1901917A (pl) |
| AR (1) | AR047085A1 (pl) |
| AT (1) | ATE367161T1 (pl) |
| AU (1) | AU2004313246A1 (pl) |
| BR (1) | BRPI0418368A (pl) |
| CA (1) | CA2551639A1 (pl) |
| CO (1) | CO5700757A2 (pl) |
| CR (1) | CR8505A (pl) |
| CY (1) | CY1106881T1 (pl) |
| DE (1) | DE602004007693T2 (pl) |
| DK (1) | DK1711184T3 (pl) |
| EA (1) | EA200601287A1 (pl) |
| ES (1) | ES2290782T3 (pl) |
| HR (1) | HRP20070430T3 (pl) |
| IL (1) | IL176648A0 (pl) |
| MX (1) | MXPA06007715A (pl) |
| NO (1) | NO20063549L (pl) |
| PL (1) | PL1711184T3 (pl) |
| PT (1) | PT1711184E (pl) |
| SI (1) | SI1711184T1 (pl) |
| TW (1) | TW200533360A (pl) |
| WO (1) | WO2005067932A1 (pl) |
| ZA (1) | ZA200606530B (pl) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080048504A (ko) | 2005-09-29 | 2008-06-02 | 사노피-아벤티스 | 페닐- 및 피리디닐-1,2,4-옥사디아졸론 유도체, 이의제조방법 및 약제로서의 이의 용도 |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| KR20090047458A (ko) | 2006-08-08 | 2009-05-12 | 사노피-아벤티스 | 아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도 |
| DE102007005045B4 (de) | 2007-01-26 | 2008-12-18 | Sanofi-Aventis | Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007063671A1 (de) | 2007-11-13 | 2009-06-25 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| CN101951909B (zh) | 2008-03-05 | 2013-05-15 | 默克专利有限公司 | 作为胰岛素分泌刺激剂的吡啶并吡嗪酮类衍生物、获得它们的方法及其在治疗糖尿病中的用途 |
| EA021904B1 (ru) * | 2008-03-05 | 2015-09-30 | Мерк Патент Гмбх | Производные хиноксалинона в качестве стимуляторов секреции инсулина, способы их получения и их применение для лечения диабета |
| JP5596676B2 (ja) | 2008-06-16 | 2014-09-24 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | キノキサリンジオン誘導体 |
| AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120057A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN109793739A (zh) * | 2019-01-14 | 2019-05-24 | 北京理工大学 | 一种喹喔啉酮衍生物的结构、制备方法及用途 |
| CN112480109B (zh) * | 2020-11-16 | 2022-04-01 | 浙江大学 | 吡啶并[2,3-b]吡嗪-3(4H)-酮类衍生物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0008864A1 (en) * | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| CN1114834A (zh) * | 1993-09-28 | 1996-01-10 | 大塚制药株式会社 | 抗糖尿病剂 |
| SE9800836D0 (sv) * | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
| EP1147094A1 (en) * | 1999-01-15 | 2001-10-24 | Novo Nordisk A/S | Non-peptide glp-1 agonists |
| CA2379640C (en) * | 1999-09-30 | 2006-11-28 | Neurogen Corporation | Certain alkylene diamine-substituted heterocycles |
-
2004
- 2004-12-22 DE DE602004007693T patent/DE602004007693T2/de not_active Expired - Fee Related
- 2004-12-22 CA CA002551639A patent/CA2551639A1/en not_active Abandoned
- 2004-12-22 WO PCT/US2004/043409 patent/WO2005067932A1/en active Application Filing
- 2004-12-22 JP JP2006547399A patent/JP2007517800A/ja not_active Withdrawn
- 2004-12-22 CN CNA2004800399887A patent/CN1901917A/zh active Pending
- 2004-12-22 EP EP04815480A patent/EP1711184B1/en active Active
- 2004-12-22 US US11/019,505 patent/US20050148586A1/en not_active Abandoned
- 2004-12-22 KR KR1020067015598A patent/KR20060130159A/ko not_active Application Discontinuation
- 2004-12-22 BR BRPI0418368-1A patent/BRPI0418368A/pt not_active Application Discontinuation
- 2004-12-22 PT PT04815480T patent/PT1711184E/pt unknown
- 2004-12-22 AU AU2004313246A patent/AU2004313246A1/en not_active Abandoned
- 2004-12-22 EA EA200601287A patent/EA200601287A1/ru unknown
- 2004-12-22 DK DK04815480T patent/DK1711184T3/da active
- 2004-12-22 ES ES04815480T patent/ES2290782T3/es active Active
- 2004-12-22 SI SI200430449T patent/SI1711184T1/sl unknown
- 2004-12-22 MX MXPA06007715A patent/MXPA06007715A/es not_active Application Discontinuation
- 2004-12-22 AT AT04815480T patent/ATE367161T1/de not_active IP Right Cessation
- 2004-12-22 PL PL04815480T patent/PL1711184T3/pl unknown
-
2005
- 2005-01-05 AR ARP050100030A patent/AR047085A1/es not_active Application Discontinuation
- 2005-01-05 TW TW094100198A patent/TW200533360A/zh unknown
-
2006
- 2006-06-29 IL IL176648A patent/IL176648A0/en unknown
- 2006-07-05 CR CR8505A patent/CR8505A/es not_active Application Discontinuation
- 2006-07-14 CO CO06068718A patent/CO5700757A2/es not_active Application Discontinuation
- 2006-08-04 NO NO20063549A patent/NO20063549L/no not_active Application Discontinuation
- 2006-08-04 ZA ZA200606530A patent/ZA200606530B/en unknown
-
2007
- 2007-09-19 CY CY20071101214T patent/CY1106881T1/el unknown
- 2007-09-19 HR HR20070430T patent/HRP20070430T3/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR8505A (es) | 2008-09-09 |
| BRPI0418368A (pt) | 2007-05-15 |
| MXPA06007715A (es) | 2007-01-26 |
| EP1711184A1 (en) | 2006-10-18 |
| KR20060130159A (ko) | 2006-12-18 |
| DE602004007693T2 (de) | 2008-06-05 |
| EA200601287A1 (ru) | 2006-10-27 |
| CA2551639A1 (en) | 2005-07-28 |
| SI1711184T1 (sl) | 2007-12-31 |
| ZA200606530B (en) | 2008-02-27 |
| WO2005067932A1 (en) | 2005-07-28 |
| AU2004313246A1 (en) | 2005-07-28 |
| CO5700757A2 (es) | 2006-11-30 |
| NO20063549L (no) | 2006-09-12 |
| US20050148586A1 (en) | 2005-07-07 |
| CN1901917A (zh) | 2007-01-24 |
| ATE367161T1 (de) | 2007-08-15 |
| DK1711184T3 (da) | 2007-11-05 |
| HRP20070430T3 (en) | 2007-11-30 |
| EP1711184B1 (en) | 2007-07-18 |
| DE602004007693D1 (de) | 2007-08-30 |
| AR047085A1 (es) | 2006-01-04 |
| PT1711184E (pt) | 2007-09-24 |
| IL176648A0 (en) | 2006-10-31 |
| JP2007517800A (ja) | 2007-07-05 |
| TW200533360A (en) | 2005-10-16 |
| ES2290782T3 (es) | 2008-02-16 |
| CY1106881T1 (el) | 2012-09-26 |
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