SI1711184T1 - (3-okso-3,4-dihidro-kinoksalin-2-il-amino)-benzamidni derivati in sorodne spojine kot inhibitorji glikogen-fosforilaze za zdravljenje diabetesa in debelosti - Google Patents
(3-okso-3,4-dihidro-kinoksalin-2-il-amino)-benzamidni derivati in sorodne spojine kot inhibitorji glikogen-fosforilaze za zdravljenje diabetesa in debelostiInfo
- Publication number
- SI1711184T1 SI1711184T1 SI200430449T SI200430449T SI1711184T1 SI 1711184 T1 SI1711184 T1 SI 1711184T1 SI 200430449 T SI200430449 T SI 200430449T SI 200430449 T SI200430449 T SI 200430449T SI 1711184 T1 SI1711184 T1 SI 1711184T1
- Authority
- SI
- Slovenia
- Prior art keywords
- quinoxalin
- obesity
- dihydro
- oxo
- diabetes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53453404P | 2004-01-06 | 2004-01-06 | |
| PCT/US2004/043409 WO2005067932A1 (en) | 2004-01-06 | 2004-12-22 | (3-oxo-3, 4-dihydro-quinoxalin-2-yl-amino) -benzamide derivatives and related compound as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity |
| EP04815480A EP1711184B1 (en) | 2004-01-06 | 2004-12-22 | (3-oxo-3,4-dihydro-quinoxalin-2-yl-amino)-benzamide derivatives and related compounds as glycogen phosphorylase inhibitors for the treatment of diabetes and obesity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1711184T1 true SI1711184T1 (sl) | 2007-12-31 |
Family
ID=34794290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200430449T SI1711184T1 (sl) | 2004-01-06 | 2004-12-22 | (3-okso-3,4-dihidro-kinoksalin-2-il-amino)-benzamidni derivati in sorodne spojine kot inhibitorji glikogen-fosforilaze za zdravljenje diabetesa in debelosti |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20050148586A1 (sl) |
| EP (1) | EP1711184B1 (sl) |
| JP (1) | JP2007517800A (sl) |
| KR (1) | KR20060130159A (sl) |
| CN (1) | CN1901917A (sl) |
| AR (1) | AR047085A1 (sl) |
| AT (1) | ATE367161T1 (sl) |
| AU (1) | AU2004313246A1 (sl) |
| BR (1) | BRPI0418368A (sl) |
| CA (1) | CA2551639A1 (sl) |
| CO (1) | CO5700757A2 (sl) |
| CR (1) | CR8505A (sl) |
| CY (1) | CY1106881T1 (sl) |
| DE (1) | DE602004007693T2 (sl) |
| DK (1) | DK1711184T3 (sl) |
| EA (1) | EA200601287A1 (sl) |
| ES (1) | ES2290782T3 (sl) |
| HR (1) | HRP20070430T3 (sl) |
| IL (1) | IL176648A0 (sl) |
| MX (1) | MXPA06007715A (sl) |
| NO (1) | NO20063549L (sl) |
| PL (1) | PL1711184T3 (sl) |
| PT (1) | PT1711184E (sl) |
| SI (1) | SI1711184T1 (sl) |
| TW (1) | TW200533360A (sl) |
| WO (1) | WO2005067932A1 (sl) |
| ZA (1) | ZA200606530B (sl) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101272784A (zh) | 2005-09-29 | 2008-09-24 | 塞诺菲-安万特股份有限公司 | 苯基-和吡啶基-1,2,4-噁二唑酮衍生物、它们的制备方法和它们作为药物的用途 |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| CA2666193A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use |
| DE102007005045B4 (de) | 2007-01-26 | 2008-12-18 | Sanofi-Aventis | Phenothiazin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102007054497B3 (de) | 2007-11-13 | 2009-07-23 | Sanofi-Aventis Deutschland Gmbh | Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung |
| ES2632964T3 (es) | 2008-03-05 | 2017-09-18 | Merck Patent Gmbh | Derivados de piridopirazinonas estimuladores de la secreción de insulina, métodos para obtenerlos y uso de los mismos para el tratamiento de la diabetes |
| US8415352B2 (en) | 2008-03-05 | 2013-04-09 | MERCK Patent Gesellschaft mit beschränkter Haftung | Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
| PT2285786E (pt) * | 2008-06-16 | 2014-01-07 | Merck Patent Gmbh | Derivados de quinoxalinediona |
| EP2310372B1 (en) | 2008-07-09 | 2012-05-23 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| US8846666B2 (en) | 2011-03-08 | 2014-09-30 | Sanofi | Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120050A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN109793739A (zh) * | 2019-01-14 | 2019-05-24 | 北京理工大学 | 一种喹喔啉酮衍生物的结构、制备方法及用途 |
| CN112480109B (zh) * | 2020-11-16 | 2022-04-01 | 浙江大学 | 吡啶并[2,3-b]吡嗪-3(4H)-酮类衍生物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0008864A1 (en) * | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| KR100196356B1 (ko) * | 1993-09-28 | 1999-06-15 | 오스카 아끼히꼬 | 당뇨병 치료제 |
| SE9800836D0 (sv) * | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
| WO2000042026A1 (en) * | 1999-01-15 | 2000-07-20 | Novo Nordisk A/S | Non-peptide glp-1 agonists |
| CN1377356A (zh) * | 1999-09-30 | 2002-10-30 | 纽罗杰有限公司 | 亚烷基二胺取代的杂环 |
-
2004
- 2004-12-22 EA EA200601287A patent/EA200601287A1/ru unknown
- 2004-12-22 EP EP04815480A patent/EP1711184B1/en active Active
- 2004-12-22 AT AT04815480T patent/ATE367161T1/de not_active IP Right Cessation
- 2004-12-22 CN CNA2004800399887A patent/CN1901917A/zh active Pending
- 2004-12-22 DE DE602004007693T patent/DE602004007693T2/de not_active Expired - Fee Related
- 2004-12-22 US US11/019,505 patent/US20050148586A1/en not_active Abandoned
- 2004-12-22 JP JP2006547399A patent/JP2007517800A/ja not_active Withdrawn
- 2004-12-22 CA CA002551639A patent/CA2551639A1/en not_active Abandoned
- 2004-12-22 KR KR1020067015598A patent/KR20060130159A/ko not_active Application Discontinuation
- 2004-12-22 AU AU2004313246A patent/AU2004313246A1/en not_active Abandoned
- 2004-12-22 PT PT04815480T patent/PT1711184E/pt unknown
- 2004-12-22 BR BRPI0418368-1A patent/BRPI0418368A/pt not_active Application Discontinuation
- 2004-12-22 MX MXPA06007715A patent/MXPA06007715A/es not_active Application Discontinuation
- 2004-12-22 SI SI200430449T patent/SI1711184T1/sl unknown
- 2004-12-22 WO PCT/US2004/043409 patent/WO2005067932A1/en active Application Filing
- 2004-12-22 PL PL04815480T patent/PL1711184T3/pl unknown
- 2004-12-22 ES ES04815480T patent/ES2290782T3/es active Active
- 2004-12-22 DK DK04815480T patent/DK1711184T3/da active
-
2005
- 2005-01-05 AR ARP050100030A patent/AR047085A1/es not_active Application Discontinuation
- 2005-01-05 TW TW094100198A patent/TW200533360A/zh unknown
-
2006
- 2006-06-29 IL IL176648A patent/IL176648A0/en unknown
- 2006-07-05 CR CR8505A patent/CR8505A/es not_active Application Discontinuation
- 2006-07-14 CO CO06068718A patent/CO5700757A2/es not_active Application Discontinuation
- 2006-08-04 ZA ZA200606530A patent/ZA200606530B/en unknown
- 2006-08-04 NO NO20063549A patent/NO20063549L/no not_active Application Discontinuation
-
2007
- 2007-09-19 HR HR20070430T patent/HRP20070430T3/xx unknown
- 2007-09-19 CY CY20071101214T patent/CY1106881T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20070430T3 (en) | 2007-11-30 |
| ATE367161T1 (de) | 2007-08-15 |
| IL176648A0 (en) | 2006-10-31 |
| JP2007517800A (ja) | 2007-07-05 |
| EP1711184A1 (en) | 2006-10-18 |
| PL1711184T3 (pl) | 2007-12-31 |
| TW200533360A (en) | 2005-10-16 |
| KR20060130159A (ko) | 2006-12-18 |
| CO5700757A2 (es) | 2006-11-30 |
| AR047085A1 (es) | 2006-01-04 |
| CY1106881T1 (el) | 2012-09-26 |
| CN1901917A (zh) | 2007-01-24 |
| PT1711184E (pt) | 2007-09-24 |
| EP1711184B1 (en) | 2007-07-18 |
| ZA200606530B (en) | 2008-02-27 |
| US20050148586A1 (en) | 2005-07-07 |
| DK1711184T3 (da) | 2007-11-05 |
| DE602004007693D1 (de) | 2007-08-30 |
| EA200601287A1 (ru) | 2006-10-27 |
| ES2290782T3 (es) | 2008-02-16 |
| CA2551639A1 (en) | 2005-07-28 |
| WO2005067932A1 (en) | 2005-07-28 |
| BRPI0418368A (pt) | 2007-05-15 |
| CR8505A (es) | 2008-09-09 |
| NO20063549L (no) | 2006-09-12 |
| MXPA06007715A (es) | 2007-01-26 |
| DE602004007693T2 (de) | 2008-06-05 |
| AU2004313246A1 (en) | 2005-07-28 |
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