PL147395B1 - Method of obtaining novel derivatives of three-ring oxyindolocarbonamide - Google Patents

Method of obtaining novel derivatives of three-ring oxyindolocarbonamide Download PDF

Info

Publication number
PL147395B1
PL147395B1 PL1985260270A PL26027085A PL147395B1 PL 147395 B1 PL147395 B1 PL 147395B1 PL 1985260270 A PL1985260270 A PL 1985260270A PL 26027085 A PL26027085 A PL 26027085A PL 147395 B1 PL147395 B1 PL 147395B1
Authority
PL
Poland
Prior art keywords
formula
het
compounds
group
mmol
Prior art date
Application number
PL1985260270A
Other languages
English (en)
Polish (pl)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of PL147395B1 publication Critical patent/PL147395B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
PL1985260270A 1984-08-24 1985-08-22 Method of obtaining novel derivatives of three-ring oxyindolocarbonamide PL147395B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1984/001371 WO1986001510A1 (en) 1984-08-24 1984-08-24 Tricyclic oxindole antiinflammatory agents

Publications (1)

Publication Number Publication Date
PL147395B1 true PL147395B1 (en) 1989-05-31

Family

ID=22182243

Family Applications (2)

Application Number Title Priority Date Filing Date
PL1985260270A PL147395B1 (en) 1984-08-24 1985-08-22 Method of obtaining novel derivatives of three-ring oxyindolocarbonamide
PL1985255089A PL147393B1 (en) 1984-08-24 1985-08-22 Method of obtaining novel derivatives of three-ring oxindolocarbonamide

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL1985255089A PL147393B1 (en) 1984-08-24 1985-08-22 Method of obtaining novel derivatives of three-ring oxindolocarbonamide

Country Status (21)

Country Link
US (1) US4695571A (OSRAM)
EP (1) EP0173520B1 (OSRAM)
JP (1) JPS6157554A (OSRAM)
KR (1) KR870001144B1 (OSRAM)
AT (1) ATE49211T1 (OSRAM)
AU (1) AU553859B2 (OSRAM)
CA (1) CA1244427A (OSRAM)
DE (1) DE3575140D1 (OSRAM)
DK (1) DK160098C (OSRAM)
EG (1) EG17287A (OSRAM)
ES (2) ES8704497A1 (OSRAM)
FI (1) FI79319C (OSRAM)
GR (1) GR852026B (OSRAM)
HU (2) HU203238B (OSRAM)
IE (1) IE58739B1 (OSRAM)
IL (1) IL76175A (OSRAM)
PH (1) PH23065A (OSRAM)
PL (2) PL147395B1 (OSRAM)
PT (1) PT81004B (OSRAM)
WO (1) WO1986001510A1 (OSRAM)
ZA (1) ZA856403B (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS63223492A (ja) * 1987-03-11 1988-09-16 Okawara Mfg Co Ltd 熱交換器
WO1990008146A1 (en) * 1989-01-10 1990-07-26 Pfizer Inc. Anti-inflammatory 1-heteroaryl-oxindole-3-carboxamides
HU215112B (hu) * 1989-01-10 1998-12-28 Pfizer Inc. Eljárás gyulladáscsökkentő 1-heteroaril-3-acil-2-oxindol-származékok előállítására
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
US5300655A (en) * 1989-04-18 1994-04-05 Pfizer Inc. 2-carboxy-thiophene derivatives
JPH04217684A (ja) * 1990-05-30 1992-08-07 Shionogi & Co Ltd アルド−ス還元酵素阻害物質
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
WO2005041957A1 (en) * 2003-10-29 2005-05-12 Pfizer Products Inc. Oxindole derivatives and their use as phosphodiesterase type 2 inhibitors
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
CN101594878A (zh) 2006-09-18 2009-12-02 雷普特药品公司 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3749731A (en) * 1971-07-08 1973-07-31 Warner Lambert Co 2-oxo-n-(2-thiazolyl)-3-indoline-carboxamide
US4644005A (en) * 1984-10-31 1987-02-17 Pfizer Inc. Oxindole antiinflammatory agents

Also Published As

Publication number Publication date
FI861704A7 (fi) 1986-04-23
ZA856403B (en) 1987-04-29
IE58739B1 (en) 1993-11-03
HU203238B (en) 1991-06-28
EP0173520A2 (en) 1986-03-05
IE852081L (en) 1986-02-24
EG17287A (en) 1993-02-28
FI79319B (fi) 1989-08-31
PL255089A1 (en) 1986-12-30
ES8706116A1 (es) 1987-06-01
US4695571A (en) 1987-09-22
ATE49211T1 (de) 1990-01-15
JPS6157554A (ja) 1986-03-24
KR870002143A (ko) 1987-03-30
DK382685A (da) 1986-02-25
PT81004A (en) 1985-09-01
FI79319C (fi) 1989-12-11
EP0173520B1 (en) 1990-01-03
PL147393B1 (en) 1989-05-31
CA1244427A (en) 1988-11-08
KR870001144B1 (ko) 1987-06-11
AU4663785A (en) 1986-02-27
IL76175A0 (en) 1985-12-31
ES8704497A1 (es) 1987-04-01
AU553859B2 (en) 1986-07-31
HU902020D0 (en) 1990-07-28
ES546377A0 (es) 1987-04-01
PT81004B (pt) 1987-12-30
PH23065A (en) 1989-03-27
EP0173520A3 (en) 1986-05-14
DE3575140D1 (de) 1990-02-08
ES552044A0 (es) 1987-06-01
HUT47580A (en) 1989-03-28
HU203350B (en) 1991-07-29
IL76175A (en) 1989-08-15
WO1986001510A1 (en) 1986-03-13
DK160098C (da) 1991-06-24
GR852026B (OSRAM) 1985-12-19
DK160098B (da) 1991-01-28
JPH0450316B2 (OSRAM) 1992-08-13
DK382685D0 (da) 1985-08-23
FI861704A0 (fi) 1986-04-23

Similar Documents

Publication Publication Date Title
PL147395B1 (en) Method of obtaining novel derivatives of three-ring oxyindolocarbonamide
EP0193415B1 (en) Spiro-3-heteroazolidine compounds and salts thereof, their preparation and pharmaceutical agents thereof
US3995039A (en) Pyrazolo [1,5-a] [1,3,5] triazines
US4495101A (en) Antiinflammatory 5H-tetrazolo (5,1-c)(1,4)benzodiazepine derivatives
PL173789B1 (pl) Sposób wytwarzania nowych pochodnych amidyny
EP0104522B1 (en) New pyrazolo(3,4-b)pyridine derivatives and process for producing them
KR870001269B1 (ko) 옥스인돌 카복스 아미드 유도체의 제조방법
US4678802A (en) 1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
JPS6225150B2 (OSRAM)
CA1256105A (en) Substituted 1,8-naphthyridinones, processes for their preparation and pharmaceutical compositions containing them
US5049637A (en) 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino-[1,2-a]azepino derivatives and 10-aza, 10-oxa and 10-thia analogues
US4190659A (en) Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-carboxylic acid esters
US3993650A (en) Pyrrolo [3,4-d] pyrimidines
US4432990A (en) 5-Aminoimidazoles as immunoregulants
JPH0378854B2 (OSRAM)
PL147397B1 (en) Method of obtaining novel derivatives of spiro imidazolidine
US4157340A (en) N,N'-[Bis(N-cyanoguanyl)]cystamine derivatives
US4539400A (en) Pyridin-3-yl substituted ortho-fused pyrrole derivatives
US4968708A (en) Imidazo[2,1-B]benzothiazole compounds and antiulcer compositions containing the same
US5281708A (en) 9-Substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors of PNP
US4666914A (en) Anti-inflammatory and anti-allergic substituted-2,3-dihydro-6-(hydroxy)pyrimido[2,1-f]-purine-4,8(1H,9H)-diones
US4599346A (en) Propan-2-ol derivatives, a process for their production and medicaments containing these compounds
JPH04221386A (ja) ４Ｈ−ピロロ［１，２−ａ］チエノ［２，３−ｆ］［１，４］ジアゼピンの新規誘導体、それらの製造方法及びこれらを含有する医薬品組成物
US4055644A (en) Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones
US4010159A (en) Pyrrolo[3,4-d]pyrimidines and methods for their preparation