PH30916A - Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same. - Google Patents
Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same.Info
- Publication number
- PH30916A PH30916A PH45530A PH45530A PH30916A PH 30916 A PH30916 A PH 30916A PH 45530 A PH45530 A PH 45530A PH 45530 A PH45530 A PH 45530A PH 30916 A PH30916 A PH 30916A
- Authority
- PH
- Philippines
- Prior art keywords
- hydroxy
- processes
- preparation
- acyl
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929202442A GB9202442D0 (en) | 1992-02-05 | 1992-02-05 | Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
| GB929220427A GB9220427D0 (en) | 1992-09-28 | 1992-09-28 | Pyrazole derivatives processes for preparation thereof and pharmaceutical composition comprising the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH30916A true PH30916A (en) | 1997-12-23 |
Family
ID=26300272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH45530A PH30916A (en) | 1992-02-05 | 1993-06-06 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0554829B1 (hu) |
| JP (1) | JPH05246997A (hu) |
| KR (1) | KR100252151B1 (hu) |
| CN (1) | CN1045767C (hu) |
| AT (1) | ATE217613T1 (hu) |
| AU (1) | AU663149B2 (hu) |
| CA (1) | CA2088835A1 (hu) |
| DE (1) | DE69331920T2 (hu) |
| ES (1) | ES2173875T3 (hu) |
| HU (2) | HUT63392A (hu) |
| IL (1) | IL104311A (hu) |
| MX (1) | MX9300579A (hu) |
| PH (1) | PH30916A (hu) |
| RU (1) | RU2128172C1 (hu) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2690440B1 (fr) * | 1992-04-27 | 1995-05-19 | Rhone Poulenc Agrochimie | Arylpyrazoles fongicides. |
| FR2711140B1 (fr) * | 1993-10-12 | 1996-01-05 | Sanofi Sa | 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant. |
| US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| KR100229343B1 (ko) * | 1993-11-30 | 1999-11-01 | 윌리암스 로저 에이 | 염증치료용 치환 피라졸일벤젠술폰아미드 |
| US5475018A (en) | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
| US6492411B1 (en) | 1993-11-30 | 2002-12-10 | G. D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation |
| US6716991B1 (en) | 1993-11-30 | 2004-04-06 | G. D. Searle & Co. | Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation |
| US6613789B2 (en) | 1994-07-28 | 2003-09-02 | G. D. Searle & Co. | Heterocyclo-substituted imidazoles for the treatment of inflammation |
| US5616601A (en) * | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
| AU3815495A (en) * | 1994-11-08 | 1996-05-31 | Eisai Co. Ltd. | Pyrazole derivatives exhibiting anti-inflammatory and analgesic effects |
| KR100444802B1 (ko) * | 1995-05-25 | 2004-12-17 | 지.디. 썰 엘엘씨 | 3-할로알킬-1h-피라졸의제조방법 |
| US5756529A (en) * | 1995-09-29 | 1998-05-26 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
| GB9520584D0 (en) * | 1995-10-09 | 1995-12-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
| ID21775A (id) * | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| AU730224B2 (en) * | 1996-12-23 | 2001-03-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
| ZA985247B (en) * | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
| US6339099B1 (en) | 1997-06-20 | 2002-01-15 | Dupont Pharmaceuticals Company | Guanidine mimics as factor Xa inhibitors |
| AU750356B2 (en) * | 1997-09-24 | 2002-07-18 | Fujisawa Pharmaceutical Co., Ltd. | 1,5-diphenylpyrazole derivatives |
| AUPO941497A0 (en) * | 1997-09-24 | 1997-10-16 | Fujisawa Pharmaceutical Co., Ltd. | Novel compounds |
| US6271237B1 (en) | 1997-12-22 | 2001-08-07 | Dupont Pharmaceuticals Company | Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors |
| CA2314401A1 (en) * | 1997-12-22 | 1999-07-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors |
| IT1300055B1 (it) * | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
| KR19990080440A (ko) * | 1998-04-17 | 1999-11-05 | 성재갑 | 신규한 피라졸 유도체 |
| KR19990085450A (ko) * | 1998-05-18 | 1999-12-06 | 성재갑 | 피라졸 구조를 갖는 새로운 mek 단백질 저해제 |
| US6727238B2 (en) | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| US6294558B1 (en) | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| DE19904391A1 (de) * | 1999-02-04 | 2000-08-10 | Bayer Ag | Pyrazol-Alkylamide |
| DE60011100T2 (de) * | 1999-08-27 | 2005-06-16 | Abbott Laboratories, Abbott Park | Als cox-hemmer verwendbare sulfonylphenylpyrazol-verbindungen |
| ES2200787T3 (es) | 1999-12-03 | 2004-03-16 | Pfizer Products Inc. | Derivados de acetileno como agentes antiinflamatorios/analgesicos. |
| CN1423646A (zh) | 1999-12-03 | 2003-06-11 | 辉瑞产品公司 | 作为抗炎/镇痛剂的杂环－烷基磺酰基吡唑衍生物 |
| DK1104760T3 (da) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler |
| PT1104759E (pt) | 1999-12-03 | 2004-01-30 | Pfizer Prod Inc | Compostos heteroaril-fenil-pirazole como agentes anti-inflamatorios e analgesicos |
| ES2398093T3 (es) | 2000-03-24 | 2013-03-13 | Euro-Celtique S.A. | Pirazoles, triazoles y tetrazoles sustituidos con arilo como bloqueantes de los canales de sodio |
| ES2241964T3 (es) | 2001-07-05 | 2005-11-01 | Pfizer Products Inc. | Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos. |
| GT200200183A (es) | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
| WO2003037336A1 (en) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | 1-(5-sulfonyl-pyridin-2-yl)-5-(methylidene-cycloalkylmethoxy)-1h-pyrazole-4-carbonitrile derivatives and other compounds as cyclooxygenase inhibitors for the treatment of arthritis, neurodegeneration and colon cancer |
| KR20050013553A (ko) | 2002-05-24 | 2005-02-04 | 파마시아 코포레이션 | 디아릴 피라졸의 합성 |
| EP1539679A4 (en) | 2002-06-28 | 2007-07-04 | Nitromed Inc | OXIM- AND / OR HYDRAZO-CONTAINING, NITROSED AND / OR NITROSYLATED CYCLOOXIGENASE-2 SELECTIVE INHIBITORS, COMPOSITIONS AND USE METHODS |
| US20060079566A1 (en) | 2003-10-03 | 2006-04-13 | Ching-Shih Chen | PDK-1/Akt signaling inhibitors |
| JP4745971B2 (ja) * | 2003-10-03 | 2011-08-10 | ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション | ＰＤＫ−１／Ａｋｔシグナル伝達インヒビター |
| JP2007518686A (ja) * | 2003-10-17 | 2007-07-12 | 田辺製薬株式会社 | 高コンダクタンス型カルシウム感受性ｋチャネル開口薬 |
| US8039502B2 (en) | 2007-07-24 | 2011-10-18 | The Ohio State University Research Foundation | Anti-infective agents against intracellular pathogens |
| US7888354B2 (en) * | 2007-11-13 | 2011-02-15 | Taisho Pharmaceutical Co., Ltd | Phenylpyrazole derivatives |
| DE102008015032A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| DE102008015033A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| US20120108823A1 (en) | 2009-04-22 | 2012-05-03 | The Ohio State University Research Foundation | Anti-francisella agents |
| DE102009036604A1 (de) | 2009-07-30 | 2011-02-03 | Aicuris Gmbh & Co. Kg | Substituierte Bis-Arylpyrazolamide mit terminaler primärer Amidfunktionalisierung und ihre Verwendung |
| BR112013002484B1 (pt) * | 2010-09-21 | 2021-10-13 | Eisai R&D Management Co. , Ltd. | Composto, composição farmacêutica, e, usos de um composto |
| DE102011055815A1 (de) | 2011-11-29 | 2013-05-29 | Aicuris Gmbh & Co. Kg | Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung |
| DE102012016908A1 (de) | 2012-08-17 | 2014-02-20 | Aicuris Gmbh & Co. Kg | Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1130808A (en) * | 1979-10-05 | 1982-08-31 | Ronald G. Micetich | 3-(or 5-) trifluoromethyl-1-aryl pyrazoles |
| US4826868A (en) * | 1986-05-29 | 1989-05-02 | Ortho Pharmaceutical Corporation | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use |
| AU611437B2 (en) * | 1987-05-29 | 1991-06-13 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamides and method for synthesizing the same |
| PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| JPH08181316A (ja) * | 1994-12-22 | 1996-07-12 | Mitsubishi Electric Corp | 半導体装置及びその製造方法 |
-
1993
- 1993-01-05 IL IL104311A patent/IL104311A/xx not_active IP Right Cessation
- 1993-01-26 JP JP5010379A patent/JPH05246997A/ja active Pending
- 1993-02-02 EP EP93101569A patent/EP0554829B1/en not_active Expired - Lifetime
- 1993-02-02 AU AU32174/93A patent/AU663149B2/en not_active Ceased
- 1993-02-02 AT AT93101569T patent/ATE217613T1/de not_active IP Right Cessation
- 1993-02-02 DE DE69331920T patent/DE69331920T2/de not_active Expired - Fee Related
- 1993-02-02 ES ES93101569T patent/ES2173875T3/es not_active Expired - Lifetime
- 1993-02-03 MX MX9300579A patent/MX9300579A/es not_active IP Right Cessation
- 1993-02-04 CA CA002088835A patent/CA2088835A1/en not_active Abandoned
- 1993-02-04 KR KR1019930001455A patent/KR100252151B1/ko not_active IP Right Cessation
- 1993-02-04 CN CN93101069A patent/CN1045767C/zh not_active Expired - Fee Related
- 1993-02-04 RU RU93004484A patent/RU2128172C1/ru active
- 1993-02-05 HU HU9300309A patent/HUT63392A/hu unknown
- 1993-06-06 PH PH45530A patent/PH30916A/en unknown
-
1995
- 1995-06-22 HU HU95P/P00347P patent/HU211509A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL104311A (en) | 1997-07-13 |
| EP0554829B1 (en) | 2002-05-15 |
| JPH05246997A (ja) | 1993-09-24 |
| HU211509A9 (en) | 1995-11-28 |
| AU3217493A (en) | 1993-08-12 |
| CN1075959A (zh) | 1993-09-08 |
| DE69331920D1 (de) | 2002-06-20 |
| ES2173875T3 (es) | 2002-11-01 |
| DE69331920T2 (de) | 2002-09-26 |
| AU663149B2 (en) | 1995-09-28 |
| ATE217613T1 (de) | 2002-06-15 |
| RU2128172C1 (ru) | 1999-03-27 |
| KR100252151B1 (ko) | 2000-09-01 |
| KR930017873A (ko) | 1993-09-20 |
| IL104311A0 (en) | 1993-05-13 |
| MX9300579A (es) | 1993-09-30 |
| HUT63392A (en) | 1993-08-30 |
| EP0554829A3 (en) | 1994-06-08 |
| CN1045767C (zh) | 1999-10-20 |
| HU9300309D0 (en) | 1993-04-28 |
| EP0554829A2 (en) | 1993-08-11 |
| CA2088835A1 (en) | 1993-08-06 |
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