PH27060A - Hybrid interferons their use as pharmaceutical compositions and as intermediate products for the preparation of anti-bodies and the use thereof and processes for preparing them - Google Patents
Hybrid interferons their use as pharmaceutical compositions and as intermediate products for the preparation of anti-bodies and the use thereof and processes for preparing them Download PDFInfo
- Publication number
- PH27060A PH27060A PH34995A PH34995A PH27060A PH 27060 A PH27060 A PH 27060A PH 34995 A PH34995 A PH 34995A PH 34995 A PH34995 A PH 34995A PH 27060 A PH27060 A PH 27060A
- Authority
- PH
- Philippines
- Prior art keywords
- leu
- ser
- arg
- interferon
- gln
- Prior art date
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- 102000014150 Interferons Human genes 0.000 title claims abstract description 102
- 108010050904 Interferons Proteins 0.000 title claims abstract description 102
- 238000000034 method Methods 0.000 title claims description 23
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 6
- 229940047124 interferons Drugs 0.000 title abstract description 47
- 238000002360 preparation method Methods 0.000 title abstract description 18
- 230000008569 process Effects 0.000 title description 12
- 239000013067 intermediate product Substances 0.000 title description 2
- 229940079322 interferon Drugs 0.000 claims abstract description 93
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 20
- 239000012634 fragment Substances 0.000 claims description 54
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 15
- 229920001184 polypeptide Polymers 0.000 claims description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
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- 108010056582 methionylglutamic acid Proteins 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
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- 230000000144 pharmacologic effect Effects 0.000 description 1
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- 239000006187 pill Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108010031719 prolyl-serine Proteins 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 108010069117 seryl-lysyl-aspartic acid Proteins 0.000 description 1
- FESBVLZDDCQLFY-UHFFFAOYSA-N sete Chemical compound [Te]=[Se] FESBVLZDDCQLFY-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- MSTPNDZQVGSTET-UHFFFAOYSA-M sodium;2-anilino-6-sulfanylidene-1h-1,3,5-triazine-4-thiolate Chemical compound [Na+].N1C(=S)N=C([S-])N=C1NC1=CC=CC=C1 MSTPNDZQVGSTET-UHFFFAOYSA-M 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Soft Magnetic Materials (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863607835 DE3607835A1 (de) | 1986-03-10 | 1986-03-10 | Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH27060A true PH27060A (en) | 1993-02-01 |
Family
ID=6295926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH34995A PH27060A (en) | 1986-03-10 | 1987-03-10 | Hybrid interferons their use as pharmaceutical compositions and as intermediate products for the preparation of anti-bodies and the use thereof and processes for preparing them |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4917887A (ko) |
| EP (1) | EP0236920B1 (ko) |
| JP (1) | JPS62282595A (ko) |
| KR (1) | KR950008191B1 (ko) |
| AT (1) | ATE81671T1 (ko) |
| AU (1) | AU600702B2 (ko) |
| DD (2) | DD276493A5 (ko) |
| DE (2) | DE3607835A1 (ko) |
| DK (1) | DK120387A (ko) |
| ES (1) | ES2052502T3 (ko) |
| FI (2) | FI871012A (ko) |
| GR (1) | GR3006844T3 (ko) |
| HU (1) | HU206896B (ko) |
| IE (2) | IE940131L (ko) |
| IL (1) | IL81832A0 (ko) |
| NO (1) | NO870967L (ko) |
| NZ (1) | NZ219549A (ko) |
| PH (1) | PH27060A (ko) |
| PT (1) | PT84427B (ko) |
| SU (1) | SU1604164A3 (ko) |
| ZA (1) | ZA871679B (ko) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3633323A1 (de) * | 1986-10-01 | 1988-04-07 | Boehringer Ingelheim Int | Neue monoklonale antikoerper gegen ifn-omega, verfahren zu ihrer herstellung und deren verwendung zur reinigung sowie zum nachweis von ifn-omega |
| DE3642096A1 (de) * | 1986-12-10 | 1988-06-16 | Boehringer Ingelheim Int | Pferde-(gamma)-interferon |
| AT389318B (de) * | 1987-10-22 | 1989-11-27 | Boehringer Ingelheim Int | Neue hybridomzellinien, welche neue monoklonale antikoerper gegen ifn-omega produzieren, verfahren zu ihrer herstellung und die verwendung der neuen monoklonalen antikoerper zur reinigung sowie zum nachweis von ifn-omega |
| US5000973A (en) * | 1989-05-30 | 1991-03-19 | Nabisco Brands, Inc. | Nutritionally-balanced canine biscuits containing an inorganic pyrophosphate |
| US5000940A (en) * | 1989-05-30 | 1991-03-19 | Nabisco Brands, Inc. | Devices, compositions and the like having or containing an inorganic pyrophosphate |
| US5000943A (en) * | 1989-05-30 | 1991-03-19 | Nabisco Brands, Inc. | Canine biscuits containing an inorganic pyrophosphate |
| US5047231A (en) * | 1989-05-30 | 1991-09-10 | Nabisco Brands, Inc. | Raw hide containing an inorganic pyrophosphate |
| US5015485A (en) * | 1989-05-30 | 1991-05-14 | Nabisco Brands, Inc. | Dog biscuits having a coating containing an inorganic pyrophosphate |
| EP0626448A3 (de) * | 1993-05-26 | 1998-01-14 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Verfahren zur Herstellung und Reinigung von alpha-Interferon |
| US5939286A (en) * | 1995-05-10 | 1999-08-17 | University Of Florida | Hybrid interferon tau/alpha polypeptides, their recombinant production, and methods using them |
| US6204022B1 (en) | 1996-04-12 | 2001-03-20 | Pepgen Corporation And University Of Florida | Low-toxicity human interferon-alpha analogs |
| JP2001523480A (ja) | 1997-11-20 | 2001-11-27 | バイカル インコーポレイテッド | サイトカイン発現ポリヌクレオチドおよびそれらの組成物を用いた癌の処置 |
| US6353091B1 (en) * | 1998-03-13 | 2002-03-05 | Brown University Research Founddation | Human N-type calcium channel isoform |
| US6685933B1 (en) | 1998-07-28 | 2004-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Interferon α hybrids |
| US20020197235A1 (en) | 2000-11-03 | 2002-12-26 | Moran Stanford Mark | Method for short-term and long-term drug dosimetry |
| FR2821625B1 (fr) * | 2001-03-01 | 2003-05-16 | Genodyssee | Nouveaux polynucleotides comportant un polymorphisme de type snp fonctionnel dans la sequence nucleotidique du gene ifn-alpha-2 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques |
| FR2823220B1 (fr) | 2001-04-04 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo) |
| CN1568369A (zh) * | 2001-08-12 | 2005-01-19 | 派普根公司 | 杂合的干扰素/干扰素Tau蛋白、组合物和使用方法 |
| DE60237721D1 (de) * | 2001-11-09 | 2010-10-28 | Intarcia Therapeutics Inc | Kombinationstherapie mit omega-interferon zur behandlung von hepatitis c virus oder gelbfieber virus infektionen |
| US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| EP1615945B1 (en) | 2003-04-09 | 2011-09-28 | BioGeneriX AG | Glycopegylation methods and proteins/peptides produced by the methods |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| ES2351527T3 (es) | 2006-05-30 | 2011-02-07 | Intarcia Therapeutics, Inc | Modulador de flujo en dos piezas con conducto interno para un sistema osmótico de administración. |
| EP2359808B1 (en) | 2006-08-09 | 2013-05-22 | Intarcia Therapeutics, Inc | Osmotic delivery systems and piston assemblies |
| EP2157967B1 (en) | 2007-04-23 | 2013-01-16 | Intarcia Therapeutics, Inc | Suspension formulations of insulinotropic peptides and uses thereof |
| CA2726861C (en) | 2008-02-13 | 2014-05-27 | Intarcia Therapeutics, Inc. | Devices, formulations, and methods for delivery of multiple beneficial agents |
| EP3323423B1 (en) | 2009-09-28 | 2020-06-17 | Intarcia Therapeutics, Inc | Rapid establishment and/or termination of substantial steady-state drug delivery |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| AU2014235003A1 (en) * | 2013-03-15 | 2015-09-17 | Janssen Biotech, Inc. | Interferon alpha and omega antibody antagonists |
| TWI713453B (zh) * | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| MA44390A (fr) | 2015-06-03 | 2019-01-23 | Intarcia Therapeutics Inc | Systèmes de mise en place et de retrait d'implant |
| SG11201810102SA (en) | 2016-05-16 | 2018-12-28 | Intarcia Therapeutics Inc | Glucagon-receptor selective polypeptides and methods of use thereof |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI77877C (fi) * | 1979-04-20 | 1989-05-10 | Technobiotic Ltd | Foerfarande foer framstaellning och rening av human le-formig interferonprotein. |
| US4456748A (en) * | 1981-02-23 | 1984-06-26 | Genentech, Inc. | Hybrid human leukocyte interferons |
| ES8302778A1 (es) * | 1980-11-10 | 1983-02-01 | Genentech Inc | Un procedimiento para producir un polipeptido antiviral. |
| US4414150A (en) * | 1980-11-10 | 1983-11-08 | Genentech, Inc. | Hybrid human leukocyte interferons |
| JPH064673B2 (ja) * | 1980-11-10 | 1994-01-19 | ゲネンテツク・インコ−ポレ−テツド | ハイブリド型ヒト白血球インタフエロン |
| AU1155083A (en) * | 1982-01-19 | 1983-07-28 | Cetus Corporation | Multiclass hybrid interferons |
| IT1167610B (it) * | 1982-01-19 | 1987-05-13 | Cetus Corp | Interfreron ibrido multiclasse, composizione farmaceutica che lo contiene e procedimento di produzione |
| DE3247922A1 (de) * | 1982-12-24 | 1984-06-28 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten |
| DE3409966A1 (de) * | 1984-03-19 | 1985-09-26 | Hoechst Ag, 6230 Frankfurt | Gentechnologisches verfahren zur herstellung von human-gammainterferon und mittel zur durchfuehrung dieses verfahrens |
| DE3428370A1 (de) * | 1984-08-01 | 1986-02-13 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Interferon, genetische sequenzen, die hierfuer codieren, und diese produzierende organismen |
| DE3584198D1 (de) * | 1984-08-01 | 1991-10-31 | Boehringer Ingelheim Int | Neue genetische sequenzen, die durch sie codierten interferon-peptide vom typ i und diese sie produzierende organismen. |
| EP0174143B1 (en) * | 1984-08-27 | 1989-11-08 | Genentech, Inc. | Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor |
| EP0173935A1 (en) * | 1984-08-31 | 1986-03-12 | University Patents, Inc. | Hybrid lymphoblastoid-leukocyte human interferons |
| EP0205404B1 (en) * | 1985-06-11 | 1992-07-15 | Ciba-Geigy Ag | Hybrid interferons |
| US4935233A (en) * | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
-
1986
- 1986-03-10 DE DE19863607835 patent/DE3607835A1/de not_active Withdrawn
-
1987
- 1987-03-04 AT AT87103030T patent/ATE81671T1/de not_active IP Right Cessation
- 1987-03-04 ES ES87103030T patent/ES2052502T3/es not_active Expired - Lifetime
- 1987-03-04 DE DE8787103030T patent/DE3782259D1/de not_active Expired - Fee Related
- 1987-03-04 EP EP87103030A patent/EP0236920B1/de not_active Expired - Lifetime
- 1987-03-06 AU AU69786/87A patent/AU600702B2/en not_active Ceased
- 1987-03-09 PT PT84427A patent/PT84427B/pt not_active IP Right Cessation
- 1987-03-09 HU HU87995A patent/HU206896B/hu unknown
- 1987-03-09 DK DK120387A patent/DK120387A/da not_active Application Discontinuation
- 1987-03-09 IE IE940131A patent/IE940131L/xx unknown
- 1987-03-09 IL IL81832A patent/IL81832A0/xx not_active IP Right Cessation
- 1987-03-09 US US07/023,634 patent/US4917887A/en not_active Expired - Fee Related
- 1987-03-09 SU SU874202086A patent/SU1604164A3/ru active
- 1987-03-09 NO NO870967A patent/NO870967L/no unknown
- 1987-03-09 FI FI871012A patent/FI871012A/fi not_active Application Discontinuation
- 1987-03-09 IE IE59187A patent/IE60573B1/en not_active IP Right Cessation
- 1987-03-09 NZ NZ219549A patent/NZ219549A/xx unknown
- 1987-03-09 ZA ZA871679A patent/ZA871679B/xx unknown
- 1987-03-09 JP JP62053911A patent/JPS62282595A/ja active Pending
- 1987-03-09 DD DD32350187A patent/DD276493A5/de not_active IP Right Cessation
- 1987-03-09 DD DD87300598A patent/DD266118A5/de not_active IP Right Cessation
- 1987-03-10 KR KR1019870002106A patent/KR950008191B1/ko active IP Right Grant
- 1987-03-10 PH PH34995A patent/PH27060A/en unknown
-
1992
- 1992-12-11 FI FI925631A patent/FI925631A0/fi not_active Application Discontinuation
-
1993
- 1993-01-21 GR GR930400095T patent/GR3006844T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU1604164A3 (ru) | 1990-10-30 |
| NO870967D0 (no) | 1987-03-09 |
| AU600702B2 (en) | 1990-08-23 |
| FI871012A0 (fi) | 1987-03-09 |
| ZA871679B (en) | 1988-11-30 |
| DD276493A5 (de) | 1990-02-28 |
| JPS62282595A (ja) | 1987-12-08 |
| DK120387D0 (da) | 1987-03-09 |
| IL81832A0 (en) | 1987-10-20 |
| PT84427A (de) | 1987-04-01 |
| DE3607835A1 (de) | 1987-09-24 |
| NZ219549A (en) | 1990-07-26 |
| HU206896B (en) | 1993-01-28 |
| DK120387A (da) | 1987-09-11 |
| DE3782259D1 (de) | 1992-11-26 |
| IE940131L (en) | 1987-09-10 |
| ES2052502T3 (es) | 1994-07-16 |
| ATE81671T1 (de) | 1992-11-15 |
| FI871012A (fi) | 1987-09-11 |
| NO870967L (no) | 1987-09-11 |
| AU6978687A (en) | 1987-09-17 |
| IE870591L (en) | 1987-09-10 |
| HUT44074A (en) | 1988-01-28 |
| KR870009020A (ko) | 1987-10-22 |
| EP0236920A2 (de) | 1987-09-16 |
| EP0236920A3 (en) | 1988-03-02 |
| FI925631A (fi) | 1992-12-11 |
| FI925631A0 (fi) | 1992-12-11 |
| DD266118A5 (de) | 1989-03-22 |
| US4917887A (en) | 1990-04-17 |
| GR3006844T3 (ko) | 1993-06-30 |
| KR950008191B1 (ko) | 1995-07-26 |
| IE60573B1 (en) | 1994-07-27 |
| PT84427B (pt) | 1989-10-04 |
| EP0236920B1 (de) | 1992-10-21 |
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