PH26995A - Antiretroviral aryloxy substituted furan ketones - Google Patents
Antiretroviral aryloxy substituted furan ketones Download PDFInfo
- Publication number
- PH26995A PH26995A PH39760A PH39760A PH26995A PH 26995 A PH26995 A PH 26995A PH 39760 A PH39760 A PH 39760A PH 39760 A PH39760 A PH 39760A PH 26995 A PH26995 A PH 26995A
- Authority
- PH
- Philippines
- Prior art keywords
- compound
- methyl
- ketone
- furyl
- composition according
- Prior art date
Links
- -1 furan ketones Chemical class 0.000 title claims abstract description 48
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 title abstract description 28
- 230000000798 anti-retroviral effect Effects 0.000 title abstract description 3
- 125000004104 aryloxy group Chemical group 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 14
- 239000001301 oxygen Substances 0.000 claims abstract description 14
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 8
- 239000011593 sulfur Substances 0.000 claims abstract description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 7
- 150000001875 compounds Chemical class 0.000 claims description 43
- 239000000203 mixture Substances 0.000 claims description 29
- 125000000217 alkyl group Chemical group 0.000 claims description 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- IMAHEGKHJZPRFU-UHFFFAOYSA-N 1-[5-(6-phenoxyhexoxy)furan-2-yl]ethanone Chemical compound O1C(C(=O)C)=CC=C1OCCCCCCOC1=CC=CC=C1 IMAHEGKHJZPRFU-UHFFFAOYSA-N 0.000 claims description 7
- 239000003937 drug carrier Substances 0.000 claims description 4
- OGESPMKGOXTMKF-UHFFFAOYSA-N 1-[5-(10-phenoxydecoxy)furan-2-yl]ethanone Chemical compound O1C(C(=O)C)=CC=C1OCCCCCCCCCCOC1=CC=CC=C1 OGESPMKGOXTMKF-UHFFFAOYSA-N 0.000 claims description 3
- 206010038997 Retroviral infections Diseases 0.000 claims description 3
- 229940125782 compound 2 Drugs 0.000 claims 4
- 238000011282 treatment Methods 0.000 abstract description 10
- 208000005074 Retroviridae Infections Diseases 0.000 abstract description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
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- 230000035484 reaction time Effects 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 239000012312 sodium hydride Substances 0.000 description 4
- 229910000104 sodium hydride Inorganic materials 0.000 description 4
- 238000010189 synthetic method Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28781788A | 1988-12-21 | 1988-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26995A true PH26995A (en) | 1993-02-01 |
Family
ID=23104486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH39760A PH26995A (en) | 1988-12-21 | 1989-12-21 | Antiretroviral aryloxy substituted furan ketones |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0374885B1 (xx) |
| JP (1) | JP2911151B2 (xx) |
| KR (1) | KR0137139B1 (xx) |
| CN (1) | CN1043710A (xx) |
| AT (1) | ATE105288T1 (xx) |
| AU (1) | AU621435B2 (xx) |
| CA (1) | CA2005990C (xx) |
| DE (1) | DE68915133T2 (xx) |
| DK (1) | DK650189A (xx) |
| ES (1) | ES2056187T3 (xx) |
| FI (1) | FI896135A0 (xx) |
| HU (1) | HU205098B (xx) |
| IL (1) | IL92800A0 (xx) |
| NO (1) | NO172891C (xx) |
| NZ (1) | NZ231857A (xx) |
| PH (1) | PH26995A (xx) |
| PT (1) | PT92634B (xx) |
| ZA (1) | ZA899743B (xx) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4939173A (en) * | 1988-12-14 | 1990-07-03 | Merrell Dow Pharmaceuticals Inc. | Aryloxy alkanols as anti-retrovirus agents |
| AU621434B2 (en) * | 1988-12-21 | 1992-03-12 | Merrell Dow Pharmaceuticals Inc. | Antiretroviral furan ketones |
| JP2738908B2 (ja) * | 1994-01-20 | 1998-04-08 | 保芦 将人 | 抗ウイルス粉末素材と抗ウイルスエキス |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4011334A (en) * | 1975-10-03 | 1977-03-08 | Richardson-Merrell Inc. | Use of substituted furan and thiophene carboxaldehydes as hypolipidemic agents |
| ES518136A0 (es) * | 1981-12-14 | 1984-06-01 | Syntex Inc | Un procedimiento para la preparacion de eteres alquil-naftilicos. |
| CA1243322A (en) * | 1984-01-23 | 1988-10-18 | Joshua Rokach | Antagonists of slow reacting substances of anaphylaxis |
| US4644009A (en) * | 1984-10-29 | 1987-02-17 | Usv Pharmaceutical Corporation | Aryl-alkyl heterocyclic compounds |
| AU621434B2 (en) * | 1988-12-21 | 1992-03-12 | Merrell Dow Pharmaceuticals Inc. | Antiretroviral furan ketones |
-
1989
- 1989-12-19 AU AU46978/89A patent/AU621435B2/en not_active Ceased
- 1989-12-19 ZA ZA899743A patent/ZA899743B/xx unknown
- 1989-12-19 IL IL92800A patent/IL92800A0/xx unknown
- 1989-12-19 CA CA002005990A patent/CA2005990C/en not_active Expired - Fee Related
- 1989-12-19 NZ NZ231857A patent/NZ231857A/xx unknown
- 1989-12-20 DK DK650189A patent/DK650189A/da not_active Application Discontinuation
- 1989-12-20 KR KR1019890019005A patent/KR0137139B1/ko not_active IP Right Cessation
- 1989-12-20 EP EP89123558A patent/EP0374885B1/en not_active Expired - Lifetime
- 1989-12-20 NO NO895159A patent/NO172891C/no unknown
- 1989-12-20 DE DE68915133T patent/DE68915133T2/de not_active Expired - Fee Related
- 1989-12-20 FI FI896135A patent/FI896135A0/fi not_active Application Discontinuation
- 1989-12-20 HU HU896705A patent/HU205098B/hu not_active IP Right Cessation
- 1989-12-20 AT AT8989123558T patent/ATE105288T1/de not_active IP Right Cessation
- 1989-12-20 JP JP1330946A patent/JP2911151B2/ja not_active Expired - Fee Related
- 1989-12-20 PT PT92634A patent/PT92634B/pt not_active IP Right Cessation
- 1989-12-20 ES ES89123558T patent/ES2056187T3/es not_active Expired - Lifetime
- 1989-12-21 CN CN89109421A patent/CN1043710A/zh active Pending
- 1989-12-21 PH PH39760A patent/PH26995A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0374885A1 (en) | 1990-06-27 |
| AU4697889A (en) | 1990-08-30 |
| KR900009621A (ko) | 1990-07-05 |
| JP2911151B2 (ja) | 1999-06-23 |
| HUT52491A (en) | 1990-07-28 |
| JPH02221270A (ja) | 1990-09-04 |
| NZ231857A (en) | 1991-10-25 |
| DE68915133T2 (de) | 1994-08-18 |
| IL92800A0 (en) | 1990-09-17 |
| PT92634B (pt) | 1995-09-12 |
| ZA899743B (en) | 1990-09-26 |
| DK650189A (da) | 1990-06-22 |
| CN1043710A (zh) | 1990-07-11 |
| HU205098B (en) | 1992-03-30 |
| NO172891B (no) | 1993-06-14 |
| PT92634A (pt) | 1990-06-29 |
| ES2056187T3 (es) | 1994-10-01 |
| DE68915133D1 (de) | 1994-06-09 |
| KR0137139B1 (ko) | 1998-04-25 |
| FI896135A0 (fi) | 1989-12-20 |
| ATE105288T1 (de) | 1994-05-15 |
| CA2005990A1 (en) | 1990-06-21 |
| NO895159L (no) | 1990-06-22 |
| CA2005990C (en) | 1999-12-28 |
| HU896705D0 (en) | 1990-02-28 |
| DK650189D0 (da) | 1989-12-20 |
| NO172891C (no) | 1993-09-22 |
| EP0374885B1 (en) | 1994-05-04 |
| NO895159D0 (no) | 1989-12-20 |
| AU621435B2 (en) | 1992-03-12 |
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