PH26391A - Method for treating gastrointestinal disorders - Google Patents
Method for treating gastrointestinal disorders Download PDFInfo
- Publication number
- PH26391A PH26391A PH38516A PH38516A PH26391A PH 26391 A PH26391 A PH 26391A PH 38516 A PH38516 A PH 38516A PH 38516 A PH38516 A PH 38516A PH 26391 A PH26391 A PH 26391A
- Authority
- PH
- Philippines
- Prior art keywords
- compound
- gastro
- administered
- alkyl
- acyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 21
- 208000018522 Gastrointestinal disease Diseases 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims description 64
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- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000003149 muscarinic antagonist Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 230000001769 paralizing effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000008024 pharmaceutical diluent Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000002325 prokinetic agent Substances 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- YORCIIVHUBAYBQ-UHFFFAOYSA-N propargyl bromide Chemical compound BrCC#C YORCIIVHUBAYBQ-UHFFFAOYSA-N 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- CFMYXEVWODSLAX-QOZOJKKESA-N tetrodotoxin Chemical compound O([C@@]([C@H]1O)(O)O[C@H]2[C@@]3(O)CO)[C@H]3[C@@H](O)[C@]11[C@H]2[C@@H](O)N=C(N)N1 CFMYXEVWODSLAX-QOZOJKKESA-N 0.000 description 1
- 229950010357 tetrodotoxin Drugs 0.000 description 1
- CFMYXEVWODSLAX-UHFFFAOYSA-N tetrodotoxin Natural products C12C(O)NC(=N)NC2(C2O)C(O)C3C(CO)(O)C1OC2(O)O3 CFMYXEVWODSLAX-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/182,645 US4920102A (en) | 1988-04-18 | 1988-04-18 | Method for treating gastrointestinal disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26391A true PH26391A (en) | 1992-07-02 |
Family
ID=22669415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH38516A PH26391A (en) | 1988-04-18 | 1989-04-17 | Method for treating gastrointestinal disorders |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4920102A (fr) |
| EP (1) | EP0349100B1 (fr) |
| JP (1) | JPH0825882B2 (fr) |
| KR (1) | KR970009580B1 (fr) |
| CN (1) | CN1023017C (fr) |
| AR (1) | AR244699A1 (fr) |
| AT (1) | ATE139782T1 (fr) |
| AU (1) | AU616746B2 (fr) |
| CA (1) | CA1328257C (fr) |
| DE (1) | DE68926728T2 (fr) |
| DK (1) | DK183589A (fr) |
| ES (1) | ES2088388T3 (fr) |
| GR (1) | GR3020604T3 (fr) |
| HU (1) | HU206365B (fr) |
| IE (1) | IE72969B1 (fr) |
| IL (1) | IL89996A (fr) |
| MX (1) | MX15701A (fr) |
| NZ (1) | NZ228768A (fr) |
| PH (1) | PH26391A (fr) |
| PT (1) | PT90293B (fr) |
| RU (1) | RU2086560C1 (fr) |
| ZA (1) | ZA892801B (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5106961A (en) * | 1987-05-26 | 1992-04-21 | Eli Lilly And Company | Erythromycin ring-contracted derivatives |
| US5068221A (en) * | 1989-05-09 | 1991-11-26 | Mathias John R | Treatment of motility disorders with a gnrh analog |
| US5434136A (en) * | 1990-12-14 | 1995-07-18 | Mathias; John R. | Treatment of motility disorders with a GNRH analog |
| US5523418A (en) * | 1991-04-09 | 1996-06-04 | Abbott Laboratories | Macrocyclic lactam prokinetic agents |
| DE69211845T2 (de) * | 1991-04-09 | 1997-01-23 | Abbott Lab | Macrozyklische laktam-prokinetika |
| DE4200145A1 (de) * | 1992-01-07 | 1993-07-08 | Kali Chemie Pharma Gmbh | 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| KR0179379B1 (ko) * | 1992-01-21 | 1999-04-01 | 찰스 엠.브록 | 4"-데옥시에리트로마이신 유도체 |
| US5470961A (en) * | 1992-03-19 | 1995-11-28 | Takeda Chemical Ind., Ltd. | 14 and/or 15-hydroxy 6,9 hemiacetal erythromycin derivatives |
| FR2697524B1 (fr) * | 1992-11-05 | 1994-12-23 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| US5712253A (en) * | 1996-06-18 | 1998-01-27 | Abbott Laboratories | Macrocyclic 13-membered ring derivatives of erythromycins A and B |
| DE19644195A1 (de) * | 1996-10-24 | 1998-04-30 | Solvay Pharm Gmbh | 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6165985A (en) * | 1998-02-13 | 2000-12-26 | Solvay Pharmaceuticals Gmbh | 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them |
| DE19805822B4 (de) * | 1998-02-13 | 2009-02-05 | Solvay Pharmaceuticals Gmbh | 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US5955440A (en) * | 1998-03-27 | 1999-09-21 | Abbott Laboratories | Macrolide LHRH antagonists |
| US5972898A (en) * | 1998-03-27 | 1999-10-26 | Abbott Laboratories | 3',3-N-bis-substituted macrolide LHRH antagonists |
| US6020521A (en) * | 1998-08-26 | 2000-02-01 | Abbott Laboratories | Macrolide LHRH antagonists |
| US6387885B1 (en) | 1998-08-26 | 2002-05-14 | Abbott Laboratories | 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists |
| US6451806B2 (en) | 1999-09-29 | 2002-09-17 | Adolor Corporation | Methods and compositions involving opioids and antagonists thereof |
| US6469030B2 (en) | 1999-11-29 | 2002-10-22 | Adolor Corporation | Methods for the treatment and prevention of ileus |
| PT1489090E (pt) * | 2000-08-17 | 2006-05-31 | Kitasato Inst | Novos derivados de pseudoeritromicina |
| GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
| US20040067896A1 (en) * | 2002-07-25 | 2004-04-08 | The Kitasato Institute | Novel pseudoerythromycin derivatives |
| US7521428B2 (en) * | 2002-10-29 | 2009-04-21 | The Kitasato Institute | Macrolide derivatives having effect of potentiating antifungal activity |
| US7521420B2 (en) | 2003-06-18 | 2009-04-21 | Tranzyme Pharma, Inc. | Macrocyclic antagonists of the motilin receptor |
| CA2632779A1 (fr) * | 2005-12-08 | 2007-06-14 | Pfizer Inc. | Procede de demethylation du groupe 3'-dimethylamino de composants d'erythromycine |
| JP5684474B2 (ja) | 2006-09-11 | 2015-03-11 | オセラ セラピューティクス， インコーポレイテッド | 胃腸の運動障害疾患の治療のためのモチリン受容体の大環状アンタゴニスト |
| US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
| FR2995605B1 (fr) * | 2012-09-18 | 2014-09-19 | Sanofi Sa | Derives de macrolides, leur preparation et leur application therapeutique. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4547491A (en) * | 1984-07-18 | 1985-10-15 | Merck & Co., Inc. | C-8A-Oxo-avermectin and milbemycin derivatives, pharmaceutical compositions and method of use |
| JPS6187625A (ja) * | 1984-10-05 | 1986-05-06 | Satoshi Omura | 消化管収縮運動促進剤 |
| EP0215355B1 (fr) * | 1985-08-31 | 1994-04-06 | Kitasato Kenkyusho | Dérivé d'érythromycine et son procédé de préparation |
| CA1321581C (fr) * | 1987-05-26 | 1993-08-24 | Herbert A. Kirst | Macrolides contractes en anneaux |
-
1988
- 1988-04-18 US US07/182,645 patent/US4920102A/en not_active Expired - Lifetime
-
1989
- 1989-04-17 ZA ZA892801A patent/ZA892801B/xx unknown
- 1989-04-17 IE IE122489A patent/IE72969B1/en not_active IP Right Cessation
- 1989-04-17 IL IL8999689A patent/IL89996A/en not_active IP Right Cessation
- 1989-04-17 AU AU33107/89A patent/AU616746B2/en not_active Ceased
- 1989-04-17 CA CA000596863A patent/CA1328257C/fr not_active Expired - Fee Related
- 1989-04-17 PT PT90293A patent/PT90293B/pt not_active IP Right Cessation
- 1989-04-17 PH PH38516A patent/PH26391A/en unknown
- 1989-04-17 HU HU891879A patent/HU206365B/hu not_active IP Right Cessation
- 1989-04-17 DK DK183589A patent/DK183589A/da not_active Application Discontinuation
- 1989-04-17 AR AR89313685A patent/AR244699A1/es active
- 1989-04-17 NZ NZ228768A patent/NZ228768A/xx unknown
- 1989-04-18 CN CN89102358A patent/CN1023017C/zh not_active Expired - Fee Related
- 1989-04-18 DE DE68926728T patent/DE68926728T2/de not_active Expired - Fee Related
- 1989-04-18 JP JP1099889A patent/JPH0825882B2/ja not_active Expired - Lifetime
- 1989-04-18 MX MX1570189A patent/MX15701A/es unknown
- 1989-04-18 KR KR89005088A patent/KR970009580B1/ko not_active IP Right Cessation
- 1989-04-18 EP EP89303813A patent/EP0349100B1/fr not_active Expired - Lifetime
- 1989-04-18 ES ES89303813T patent/ES2088388T3/es not_active Expired - Lifetime
- 1989-04-18 AT AT89303813T patent/ATE139782T1/de not_active IP Right Cessation
-
1992
- 1992-08-04 RU SU925052262A patent/RU2086560C1/ru active
-
1996
- 1996-07-23 GR GR960401963T patent/GR3020604T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT90293A (pt) | 1989-11-10 |
| HUT49625A (en) | 1989-10-30 |
| KR970009580B1 (en) | 1997-06-14 |
| MX15701A (es) | 1993-11-01 |
| CA1328257C (fr) | 1994-04-05 |
| DE68926728T2 (de) | 1996-11-28 |
| DE68926728D1 (de) | 1996-08-01 |
| EP0349100A3 (fr) | 1991-11-13 |
| IE72969B1 (en) | 1997-05-07 |
| EP0349100B1 (fr) | 1996-06-26 |
| AU3310789A (en) | 1989-10-19 |
| US4920102A (en) | 1990-04-24 |
| KR900016220A (ko) | 1990-11-12 |
| AR244699A1 (es) | 1993-11-30 |
| ES2088388T3 (es) | 1996-08-16 |
| GR3020604T3 (en) | 1996-10-31 |
| DK183589D0 (da) | 1989-04-17 |
| HU206365B (en) | 1992-10-28 |
| ATE139782T1 (de) | 1996-07-15 |
| JPH0825882B2 (ja) | 1996-03-13 |
| RU2086560C1 (ru) | 1997-08-10 |
| JPH01311096A (ja) | 1989-12-15 |
| AU616746B2 (en) | 1991-11-07 |
| DK183589A (da) | 1989-10-19 |
| NZ228768A (en) | 1990-10-26 |
| IL89996A0 (en) | 1989-12-15 |
| EP0349100A2 (fr) | 1990-01-03 |
| IL89996A (en) | 1994-08-26 |
| IE891224L (en) | 1989-10-18 |
| CN1023017C (zh) | 1993-12-08 |
| CN1037517A (zh) | 1989-11-29 |
| PT90293B (pt) | 1994-07-29 |
| ZA892801B (en) | 1990-12-28 |
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