PH26099A - Method for preparing 3-(N-phenylacetyl-aminopiperidine) 2,6-dion - Google Patents
Method for preparing 3-(N-phenylacetyl-aminopiperidine) 2,6-dion Download PDFInfo
- Publication number
- PH26099A PH26099A PH39525A PH39525A PH26099A PH 26099 A PH26099 A PH 26099A PH 39525 A PH39525 A PH 39525A PH 39525 A PH39525 A PH 39525A PH 26099 A PH26099 A PH 26099A
- Authority
- PH
- Philippines
- Prior art keywords
- dion
- glutamine
- phenylacetyl
- phenylacetylaminopiperidine
- reaction mixture
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 10
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 16
- 239000011541 reaction mixture Substances 0.000 claims description 14
- 239000000243 solution Substances 0.000 claims description 10
- 229930182816 L-glutamine Natural products 0.000 claims description 8
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 8
- -1 phenylacetyl halide Chemical class 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 4
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- VMZCDNSFRSVYKQ-UHFFFAOYSA-N 2-phenylacetyl chloride Chemical group ClC(=O)CC1=CC=CC=C1 VMZCDNSFRSVYKQ-UHFFFAOYSA-N 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 15
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical class NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 description 14
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- ITESSSIUDOPQKI-UHFFFAOYSA-N 2-phenyl-n-piperidin-1-ylacetamide Chemical compound C1CCCCN1NC(=O)CC1=CC=CC=C1 ITESSSIUDOPQKI-UHFFFAOYSA-N 0.000 description 4
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- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/295,372 US4918193A (en) | 1989-01-11 | 1989-01-11 | Methods for preparing 3-[N-phenyl-acetylaminopiperidine]-2,6-dion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH26099A true PH26099A (en) | 1992-02-06 |
Family
ID=23137420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH39525A PH26099A (en) | 1989-01-11 | 1989-11-13 | Method for preparing 3-(N-phenylacetyl-aminopiperidine) 2,6-dion |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4918193A (pl) |
| KR (1) | KR0139204B1 (pl) |
| FI (1) | FI92391C (pl) |
| LT (1) | LT3518B (pl) |
| PH (1) | PH26099A (pl) |
| PL (1) | PL163552B1 (pl) |
| RU (1) | RU1809830C (pl) |
| UA (1) | UA15756A (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5463063A (en) * | 1993-07-02 | 1995-10-31 | Celgene Corporation | Ring closure of N-phthaloylglutamines |
| US7087219B2 (en) * | 2003-05-28 | 2006-08-08 | Stanislaw R. Burzynski | Toothpaste containing anticancer agents |
| US20060246016A1 (en) * | 2003-05-28 | 2006-11-02 | Burzynski Stanislaw R | Toothpaste containing anticancer agents |
| CN103232361A (zh) * | 2013-04-19 | 2013-08-07 | 苏州园方化工有限公司 | 一种n-苯乙酰基-l-谷氨酰胺 |
| CN104693108B (zh) * | 2013-12-06 | 2017-05-31 | 重庆博腾制药科技股份有限公司 | 一种布鲁顿酪氨酸激酶(Btk)中间体的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4558057A (en) * | 1981-12-15 | 1985-12-10 | Burzynski Stanislaw R | Purified antineoplaston fractions and methods of treating neoplastic disease |
-
1989
- 1989-01-11 US US07/295,372 patent/US4918193A/en not_active Expired - Lifetime
- 1989-11-13 PH PH39525A patent/PH26099A/en unknown
-
1990
- 1990-01-10 FI FI900129A patent/FI92391C/fi active IP Right Grant
- 1990-01-10 UA UA4742866A patent/UA15756A/uk unknown
- 1990-01-10 KR KR1019900000205A patent/KR0139204B1/ko not_active IP Right Cessation
- 1990-01-10 PL PL90283254A patent/PL163552B1/pl not_active IP Right Cessation
- 1990-01-10 RU SU904742866A patent/RU1809830C/ru active
-
1993
- 1993-06-23 LT LTIP681A patent/LT3518B/lt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FI900129A0 (fi) | 1990-01-10 |
| FI92391C (fi) | 1994-11-10 |
| PL163552B1 (pl) | 1994-04-29 |
| FI92391B (fi) | 1994-07-29 |
| KR900011748A (ko) | 1990-08-02 |
| FI900129A (fi) | 1990-07-12 |
| LT3518B (en) | 1995-11-27 |
| US4918193A (en) | 1990-04-17 |
| KR0139204B1 (ko) | 1998-05-15 |
| LTIP681A (en) | 1995-01-31 |
| UA15756A (uk) | 1997-06-30 |
| RU1809830C (ru) | 1993-04-15 |
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