PH25645A - New 1,4-dihydropyridine, pharmaceutical compostions containg them, method of usethereof - Google Patents

New 1,4-dihydropyridine, pharmaceutical compostions containg them, method of usethereof

Info

Publication number
PH25645A
PH25645A PH37337A PH37337A PH25645A PH 25645 A PH25645 A PH 25645A PH 37337 A PH37337 A PH 37337A PH 37337 A PH37337 A PH 37337A PH 25645 A PH25645 A PH 25645A
Authority
PH
Philippines
Prior art keywords
new
methyl
usethereof
containg
dihydropyridine
Prior art date
Application number
PH37337A
Other languages
English (en)
Inventor
Carlos Fernadez Torija
Joaquin Alvaro Galiano Ramos
Original Assignee
Inst Investigacion Desarrollo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Investigacion Desarrollo filed Critical Inst Investigacion Desarrollo
Publication of PH25645A publication Critical patent/PH25645A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PH37337A 1987-08-03 1988-08-03 New 1,4-dihydropyridine, pharmaceutical compostions containg them, method of usethereof PH25645A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87401799A EP0302980B1 (fr) 1987-08-03 1987-08-03 1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments

Publications (1)

Publication Number Publication Date
PH25645A true PH25645A (en) 1991-08-21

Family

ID=8198243

Family Applications (1)

Application Number Title Priority Date Filing Date
PH37337A PH25645A (en) 1987-08-03 1988-08-03 New 1,4-dihydropyridine, pharmaceutical compostions containg them, method of usethereof

Country Status (34)

Country Link
US (1) US4952592A (xx)
EP (1) EP0302980B1 (xx)
JP (1) JPH0733383B2 (xx)
KR (1) KR960001724B1 (xx)
CN (1) CN1038587C (xx)
AT (1) ATE61588T1 (xx)
BE (1) BE1001055A4 (xx)
CA (2) CA1306261C (xx)
CH (1) CH675999A5 (xx)
CZ (1) CZ282077B6 (xx)
DD (1) DD282008A5 (xx)
DE (2) DE3768658D1 (xx)
DK (1) DK430288A (xx)
ES (1) ES2007543A6 (xx)
FI (1) FI91406C (xx)
GB (1) GB2208861B (xx)
GR (2) GR880100507A (xx)
HU (1) HU204523B (xx)
IE (1) IE60358B1 (xx)
IL (1) IL87321A (xx)
IN (1) IN167550B (xx)
IS (1) IS1549B (xx)
IT (1) IT1235013B (xx)
LU (1) LU87297A1 (xx)
MA (1) MA21344A1 (xx)
NO (1) NO170934C (xx)
NZ (1) NZ225661A (xx)
PH (1) PH25645A (xx)
PT (1) PT88173B (xx)
RU (1) RU2036922C1 (xx)
SK (1) SK278775B6 (xx)
TN (1) TNSN88081A1 (xx)
YU (1) YU46547B (xx)
ZA (1) ZA885684B (xx)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242933A (en) * 1990-07-10 1993-09-07 Adir Et Compagnie Piperidine, tetrahydropyridine and pyrrolidine compounds
JP2002515854A (ja) * 1995-08-02 2002-05-28 スミスクライン・ビーチャム・コーポレイション エンドセリン受容体拮抗薬
AU2001246883B2 (en) * 2000-04-11 2004-08-12 Sankyo Company, Limited Stabilized pharmaceutical compositions containing calcium channel blockers
AU2003250483A1 (en) 2002-08-19 2004-03-11 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
EP1796653A2 (en) * 2004-07-26 2007-06-20 Actelion Pharmaceuticals Ltd. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
ATE551059T1 (de) * 2005-10-26 2012-04-15 Asahi Kasei Pharma Corp Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのcetp阻害剤としてのn−((3−ベンジル)−2,2−(ビス−フェニル)−プロパン−1−アミン誘導体
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのn−ピペリジン−3−イルベンズアミド誘導体
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
JOP20210193A1 (ar) 2019-01-18 2023-01-30 Astrazeneca Ab مثبطات pcsk9 وطرق استخدامها

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
JPS5978186A (ja) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd 1,4−ジヒドロピリジン−3,5−ジカルボン酸エステル誘導体
ES531033A0 (es) * 1984-03-27 1985-09-01 Inst Investigacion Desarrollo Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
JPH068294B2 (ja) * 1985-02-26 1994-02-02 富山化学工業株式会社 新規な1,4−ジヒドロピリジン誘導体およびその塩
EP0174131A3 (en) * 1984-09-01 1989-06-07 FISONS plc Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
JPH01207267A (ja) * 1987-03-05 1989-08-21 Yamanouchi Pharmaceut Co Ltd ピリジン誘導体及び該化合物を含有する肝疾患治療剤

Also Published As

Publication number Publication date
IE882364L (en) 1989-02-03
NO170934B (no) 1992-09-21
IT8848259A0 (it) 1988-08-02
CZ282077B6 (cs) 1997-05-14
AU2033088A (en) 1989-02-09
GB2208861A (en) 1989-04-19
JPH01294675A (ja) 1989-11-28
CA1306261C (fr) 1992-08-11
DE3768658D1 (de) 1991-04-18
TNSN88081A1 (fr) 1990-07-10
KR960001724B1 (ko) 1996-02-03
CN1031531A (zh) 1989-03-08
NZ225661A (en) 1990-08-28
ZA885684B (en) 1989-04-26
DE3825962A1 (de) 1989-02-16
IL87321A (en) 1993-04-04
PT88173A (pt) 1989-06-30
SK541388A3 (en) 1998-02-04
NO883406L (no) 1989-02-06
CA1306262C (fr) 1992-08-11
MA21344A1 (fr) 1989-04-01
FI883603A (fi) 1989-02-04
GR880100507A (el) 1989-05-25
JPH0733383B2 (ja) 1995-04-12
CN1038587C (zh) 1998-06-03
ES2007543A6 (es) 1989-06-16
FI883603A0 (fi) 1988-08-01
DD282008A5 (de) 1990-08-29
GR3001984T3 (en) 1992-11-23
GB2208861B (en) 1991-07-17
IN167550B (xx) 1990-11-10
GB8818356D0 (en) 1988-09-07
IL87321A0 (en) 1989-01-31
IT1235013B (it) 1992-06-16
FI91406C (fi) 1994-06-27
NO883406D0 (no) 1988-08-01
HUT54142A (en) 1991-01-28
SK278775B6 (sk) 1998-02-04
AU606441B2 (en) 1991-02-07
EP0302980B1 (fr) 1991-03-13
IS3378A7 (is) 1989-02-04
IS1549B (is) 1994-06-08
LU87297A1 (fr) 1989-02-02
FI91406B (fi) 1994-03-15
IE60358B1 (en) 1994-06-29
ATE61588T1 (de) 1991-03-15
CH675999A5 (en) 1990-11-30
KR890003743A (ko) 1989-04-17
YU46547B (sh) 1993-11-16
DK430288D0 (da) 1988-08-02
US4952592A (en) 1990-08-28
HU204523B (en) 1992-01-28
NO170934C (no) 1992-12-30
DK430288A (da) 1989-02-03
PT88173B (pt) 1995-03-01
CZ541388A3 (en) 1997-01-15
YU147088A (en) 1990-04-30
BE1001055A4 (fr) 1989-06-20
EP0302980A1 (fr) 1989-02-15
RU2036922C1 (ru) 1995-06-09

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