PH12590A - 4a-aryl octahydro-1h-2-pyrindines and pharmaceutical composition thereof - Google Patents

4a-aryl octahydro-1h-2-pyrindines and pharmaceutical composition thereof

Info

Publication number
PH12590A
PH12590A PH20380A PH20380A PH12590A PH 12590 A PH12590 A PH 12590A PH 20380 A PH20380 A PH 20380A PH 20380 A PH20380 A PH 20380A PH 12590 A PH12590 A PH 12590A
Authority
PH
Philippines
Prior art keywords
pyrindines
octahydro
aryl
pharmaceutical composition
pharmaceutical
Prior art date
Application number
PH20380A
Other languages
English (en)
Inventor
D Zimmerman
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PH12590A publication Critical patent/PH12590A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
PH20380A 1976-11-02 1977-10-28 4a-aryl octahydro-1h-2-pyrindines and pharmaceutical composition thereof PH12590A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73795876A 1976-11-02 1976-11-02

Publications (1)

Publication Number Publication Date
PH12590A true PH12590A (en) 1979-06-27

Family

ID=24965981

Family Applications (1)

Application Number Title Priority Date Filing Date
PH20380A PH12590A (en) 1976-11-02 1977-10-28 4a-aryl octahydro-1h-2-pyrindines and pharmaceutical composition thereof

Country Status (26)

Country Link
JP (1) JPS5356669A (sv)
AR (1) AR223454A1 (sv)
AT (1) ATA782177A (sv)
AU (1) AU513679B2 (sv)
BE (1) BE860314A (sv)
CA (1) CA1100136A (sv)
CS (1) CS211380B2 (sv)
DD (1) DD133795A5 (sv)
DE (1) DE2748466A1 (sv)
DK (1) DK485277A (sv)
ES (3) ES463784A1 (sv)
FR (1) FR2369267A1 (sv)
GB (1) GB1590155A (sv)
GR (1) GR70053B (sv)
HU (1) HU176231B (sv)
IE (1) IE45901B1 (sv)
IL (1) IL53236A0 (sv)
NL (1) NL7712053A (sv)
NZ (1) NZ185539A (sv)
PH (1) PH12590A (sv)
PL (3) PL108466B1 (sv)
PT (1) PT67194B (sv)
RO (3) RO77935A (sv)
SE (3) SE7712218L (sv)
SU (3) SU812174A3 (sv)
ZA (1) ZA776497B (sv)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ189230A (en) * 1977-12-27 1981-05-15 Lilly Co Eli Trans-4a-aryl-2-substituted-octahydro-1h-2-pyrindines
US4277608A (en) * 1979-06-21 1981-07-07 Eli Lilly And Company Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines
US4236009A (en) * 1979-06-21 1980-11-25 Eli Lilly And Company Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines
ZA9510829B (en) * 1994-12-23 1996-07-03 Smithkline Beecham Corp 3,3-(disubstituted)cyclohexan-1-one monomers and related compounds
HUE028983T2 (en) 2010-05-06 2017-01-30 Vertex Pharma Heterocyclic chromene-spirocyclic piperidine amides as ion channel modulators
EP3056495A1 (en) 2011-02-02 2016-08-17 Vertex Pharmaceuticals Inc. Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
US10385070B2 (en) 2011-02-18 2019-08-20 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
WO2012125613A1 (en) 2011-03-14 2012-09-20 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels

Also Published As

Publication number Publication date
PT67194B (en) 1979-03-23
SE8103107L (sv) 1981-05-18
FR2369267B1 (sv) 1980-05-16
BE860314A (fr) 1978-04-28
DK485277A (da) 1978-05-03
GB1590155A (en) 1981-05-28
ES463783A1 (es) 1979-07-16
NZ185539A (en) 1979-12-11
PL108610B1 (en) 1980-04-30
GR70053B (sv) 1982-07-26
PT67194A (en) 1977-11-01
IE45901B1 (en) 1982-12-29
PL201885A1 (pl) 1978-12-04
IE45901L (en) 1978-05-02
SU812174A3 (ru) 1981-03-07
HU176231B (en) 1981-01-28
CA1100136A (en) 1981-04-28
RO78300A (ro) 1982-04-12
AR223454A1 (es) 1981-08-31
NL7712053A (nl) 1978-05-05
SE8103106L (sv) 1981-05-18
ES463784A1 (es) 1978-06-16
ATA782177A (de) 1981-10-15
AU513679B2 (en) 1980-12-18
PL109690B1 (en) 1980-06-30
SU845777A3 (ru) 1981-07-07
RO77935A (ro) 1981-12-25
RO72900A (ro) 1981-11-04
ES472276A1 (es) 1979-10-01
DE2748466A1 (de) 1978-05-03
FR2369267A1 (fr) 1978-05-26
SE7712218L (sv) 1978-05-03
JPS5356669A (en) 1978-05-23
AU3023577A (en) 1979-05-10
SU913941A3 (en) 1982-03-15
DD133795A5 (de) 1979-01-24
CS211380B2 (en) 1982-02-26
ZA776497B (en) 1979-06-27
IL53236A0 (en) 1977-12-30
PL108466B1 (en) 1980-04-30

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