PH12016500930B1 - Exfoliative hair retention-promoting formulation - Google Patents
Exfoliative hair retention-promoting formulation Download PDFInfo
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- PH12016500930B1 PH12016500930B1 PH12016500930A PH12016500930A PH12016500930B1 PH 12016500930 B1 PH12016500930 B1 PH 12016500930B1 PH 12016500930 A PH12016500930 A PH 12016500930A PH 12016500930 A PH12016500930 A PH 12016500930A PH 12016500930 B1 PH12016500930 B1 PH 12016500930B1
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- composition
- scalp
- subject
- hair retention
- hair
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- 235000019148 tocotrienols Nutrition 0.000 description 1
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- 229910001428 transition metal ion Inorganic materials 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
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- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
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- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24066—Choriolysin L (3.4.24.66)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Birds (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361915988P | 2013-12-13 | 2013-12-13 | |
| PCT/US2014/070126 WO2015089461A1 (en) | 2013-12-13 | 2014-12-12 | Exfoliative hair retention-promoting formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12016500930A1 PH12016500930A1 (en) | 2016-06-27 |
| PH12016500930B1 true PH12016500930B1 (en) | 2017-10-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12016500930A PH12016500930B1 (en) | 2013-12-13 | 2016-05-19 | Exfoliative hair retention-promoting formulation |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9248167B2 (https=) |
| EP (1) | EP3091961A4 (https=) |
| JP (1) | JP6089152B2 (https=) |
| KR (1) | KR20160098294A (https=) |
| CN (1) | CN105813627A (https=) |
| AU (1) | AU2014361780B2 (https=) |
| CA (1) | CA2933367A1 (https=) |
| IL (1) | IL246041A (https=) |
| MX (1) | MX2016007617A (https=) |
| PH (1) | PH12016500930B1 (https=) |
| WO (1) | WO2015089461A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2016148865A (ru) | 2014-05-16 | 2018-06-19 | РИСТОРСИ, ЭлЭлСи | Двухфазное косметическое средство |
| US20160256370A1 (en) * | 2015-03-06 | 2016-09-08 | Restorsea, Llc | Hair retentive formulation and method of use |
| JP6890479B2 (ja) * | 2017-06-19 | 2021-06-18 | 株式会社ミルボン | 毛髪用組成物、及び毛髪処理方法 |
| KR102112736B1 (ko) * | 2017-08-01 | 2020-05-20 | 주식회사 씨케이바이오텍 | 탈모 방지 또는 발모 촉진용 조성물 |
| WO2019027239A2 (ko) * | 2017-08-01 | 2019-02-07 | 주식회사 씨케이바이오텍 | 탈모 방지 또는 발모 촉진용 조성물 |
| TWI808353B (zh) * | 2020-11-06 | 2023-07-11 | 德河海洋生技股份有限公司 | 魚類受精卵萃取物用於製備促毛髮生長組合物之用途 |
| PL246635B1 (pl) * | 2021-11-12 | 2025-02-17 | Aflofarm Farm Polska Spolka Z Ograniczona Odpowiedzialnoscia | Kompozycja kosmetyczna trychologicznego peelingu enzymatycznego do skóry głowy oraz sposób jej otrzymywania |
| CN114831212A (zh) * | 2022-04-18 | 2022-08-02 | 武汉新华扬生物股份有限公司 | 一种用于酶解蹄角的复合酶制剂及其应用 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6067409A (ja) | 1983-09-22 | 1985-04-17 | Suntory Ltd | 頭髪用化粧料 |
| GB9208339D0 (en) | 1992-04-15 | 1992-06-03 | Unilever Plc | Treatment composition |
| US5587168A (en) | 1994-05-16 | 1996-12-24 | Vanonou; Ilana | Cosmetic preparations |
| US6372234B1 (en) | 1997-05-27 | 2002-04-16 | Sembiosys Genetics Inc. | Products for topical applications comprising oil bodies |
| US6599513B2 (en) | 1997-05-27 | 2003-07-29 | Sembiosys Genetics Inc. | Products for topical applications comprising oil bodies |
| US6592866B2 (en) | 1997-12-11 | 2003-07-15 | Aqua Bio Technology As | Non-selfdegrading endoprotease |
| NO314594B1 (no) | 1997-12-11 | 2003-04-14 | Aqua Bio Technology As | Ikke-selvdegraderende endoprotease, fremgangsmåte for fremstilling samt anvendelser av denne |
| US6019991A (en) | 1998-01-23 | 2000-02-01 | Chesebrough-Pond's Usa Co., | Two-phase cosmetic composition |
| CH689821A5 (it) | 1998-06-22 | 1999-12-15 | Gecomwert Anstalt | Lozione tricologica ad uso topico. |
| AU5027299A (en) * | 1998-07-31 | 2000-02-28 | Novo Nordisk A/S | Use of glp-1 and analogues for preventing type ii diabetes |
| US6284234B1 (en) * | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
| US7163679B1 (en) | 1999-05-06 | 2007-01-16 | The General Hospital Corporation | Versican and epithelial-mesenchymal interaction |
| DE19927229B4 (de) | 1999-06-10 | 2004-09-09 | Coty B.V. | Enzymhaltiges Kosmetikum und dessen Verwendung |
| RU2264824C2 (ru) | 1999-06-18 | 2005-11-27 | Йон Браги БЬЯРНАСОН | Сериновые протеиназы рыб и их фармацевтическое и косметическое применение |
| US6416769B1 (en) * | 2000-03-03 | 2002-07-09 | Australian Importers, Ltd. | Cosmetic compositions comprising exfoliating enzymes and uses thereof |
| US6376557B1 (en) | 2000-03-16 | 2002-04-23 | Chanda Bhuwalka Zaveri | Methods for treating alopecia |
| US6716450B1 (en) | 2000-05-18 | 2004-04-06 | The United States Of America As Represented By The Secretary Of The Army | Enhancing protein activity through nanoencapsulation |
| JP2002326924A (ja) | 2001-05-07 | 2002-11-15 | Hayashibara Biochem Lab Inc | 洗顔料 |
| EP1392623A4 (en) | 2001-05-14 | 2005-05-04 | Martek Biosciences Corp | PREPARATION AND USE OF A POLAR LIPID RICH FRACTION CONTAINING HIGHLY UNSATURATED OMEGA-3 AND / OR OMEGA-6 FATTY ACIDS FROM MICROBES, SEEDS OF GENETICALLY MODIFIED PLANTS AND MARINE ORGANISMS |
| DE10127526A1 (de) | 2001-05-31 | 2002-12-12 | Novosom Ag | Verfahren zur Herstellung und Auflösung von Nano- und Mikrokapseln |
| US20030003117A1 (en) | 2001-06-18 | 2003-01-02 | Michael Marenick | Hydrolyzed whole egg products & related methods |
| US20060105005A1 (en) | 2002-01-08 | 2006-05-18 | Michael Marenick | Skin care formulation containing whole egg powder |
| US20060073211A1 (en) | 2001-06-18 | 2006-04-06 | Michael Marenick | Cellulite formulation containing whole egg |
| US20030115686A1 (en) | 2001-12-22 | 2003-06-26 | Gary Grey | Hair relaxer or straightener without lye or drying effect |
| AU2003284633B2 (en) | 2002-11-22 | 2008-07-10 | Nippon Suisan Kaisha, Ltd. | External composition containing polyunsaturated fatty acid or its salt or ester |
| US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
| US20050075265A1 (en) | 2003-09-12 | 2005-04-07 | L'oreal | Two-phase compositions and uses thereof |
| WO2005034891A2 (en) * | 2003-10-10 | 2005-04-21 | Access Business Group International Llc. | Composition comprising a rosmarinus officinalis plant extract, a centella, echinacea or alpinia plant extract and a dna repair enzyme |
| US20050163872A1 (en) | 2004-01-23 | 2005-07-28 | Cargill, Incorporated | Compositions and methods for reducing cholesterol |
| EP1604647B1 (en) * | 2004-05-12 | 2008-05-07 | Chisso Corporation | Cosmetic composition containing polyorganosiloxane-containing epsilon-polylysine polymer, and polyhydric alcohol, and production thereof |
| US20090036385A1 (en) * | 2005-06-13 | 2009-02-05 | Nissei Bio Co., Ltd. | Hair care preparation |
| AU2006326870A1 (en) | 2005-12-22 | 2007-06-28 | Apollo Life Sciences | Transdermal delivery of pharmaceutical agents |
| AU2007200216A1 (en) | 2006-01-19 | 2007-08-02 | Belinda Riley | Skin formulation usable as a therapeutic application for the treatment of general skin disorders and a method of preparation thereof |
| AU2007285483B2 (en) | 2006-05-11 | 2011-12-22 | Regenics As | Administration of cells and cellular extracts for rejuvenation |
| JP5210513B2 (ja) * | 2006-11-21 | 2013-06-12 | 株式会社アテナ | 化粧料及びそれに含有される抽出物 |
| US20080161229A1 (en) | 2006-12-21 | 2008-07-03 | Nissei Bio Co., Ltd. | Compounding ingredients for basic cosmetics and basic cosmetics |
| KR101450681B1 (ko) | 2006-12-22 | 2014-10-14 | 가부시키가이샤 니폰 배리어 프리 | 화장료 |
| US20090035240A1 (en) | 2007-07-31 | 2009-02-05 | Maes Daniel H | Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent |
| MX2010003536A (es) | 2007-10-02 | 2010-04-27 | Kuhs Gmbh | Composicion cosmetica o farmaceutica para aplicacion topica. |
| JP5086154B2 (ja) | 2008-03-04 | 2012-11-28 | 眞 八藤 | 魚卵外皮エキスの製造方法 |
| CA2723848C (en) | 2008-05-09 | 2013-01-08 | Regenics As | Method of making salmon egg cytoplasmic extracts and use for increasing collagen production in skin |
| JPWO2009142200A1 (ja) | 2008-05-19 | 2011-09-29 | 東和酵素株式会社 | 頭髪の育毛または養毛方法 |
| EP2752116A1 (en) | 2008-10-06 | 2014-07-09 | Woodcliff Skincare Solutions, Inc. | Natural preservative alternatives comprising lonicera extract and compositions containing same |
| GB0819883D0 (en) | 2008-10-29 | 2008-12-03 | Azyme Res As | Product and uses |
| US20100260695A1 (en) | 2009-04-09 | 2010-10-14 | Mary Kay Inc. | Combination of plant extracts to improve skin tone |
| US8849216B2 (en) | 2009-07-16 | 2014-09-30 | Futurewei Technologies, Inc. | System and method for adjusting downlink channel quality index in a wireless communications system |
| WO2011006508A2 (en) | 2009-07-17 | 2011-01-20 | Coloplast A/S | Adhesive patch with zonase |
| US20110020302A1 (en) | 2009-07-23 | 2011-01-27 | Professional Compounding Centers Of America, Ltd. | Natural preservative blend |
| US20110097293A1 (en) | 2009-10-27 | 2011-04-28 | Gary Grey | Multiple component systems and methods for hair relaxation of variable strength |
| DE102009055970B4 (de) | 2009-11-27 | 2014-04-17 | Marcus Asam | Kosmetische Wirkstoffzubereitung |
| GB0921001D0 (en) | 2009-11-30 | 2010-01-13 | Aqua Bio Technology Asa | Products and uses |
| GB201007202D0 (en) | 2010-04-29 | 2010-06-16 | Walther Bernt T | Product and uses |
| AU2011249478B2 (en) | 2010-05-06 | 2014-12-04 | Regenics As | Use of cellular extracts for skin rejuvenation |
| JP4643754B1 (ja) * | 2010-07-02 | 2011-03-02 | 株式会社日本バリアフリー | 育毛剤 |
| MX356540B (es) | 2011-05-10 | 2018-06-01 | Mary Kay Inc | Composiciones cosmeticas. |
| GB201110777D0 (en) | 2011-06-24 | 2011-08-10 | Aqua Bio Technology Asa | Methods and uses |
| GB201110783D0 (en) | 2011-06-24 | 2011-08-10 | Aqua Bio Technology Asa | Methods and uses |
| CA2856847A1 (en) | 2011-11-25 | 2013-05-30 | Adrianna Janell JACKSON | Oil compositions and methods for increasing hair growth and/or preventing hair loss |
| PH12013502372A1 (en) | 2012-01-23 | 2019-07-03 | Restorsea Llc | Cosmetic |
| CA2862363C (en) | 2012-02-02 | 2021-06-08 | Joan M. Fallon | Enzyme compositions and use thereof for wound healing |
| EP3459522B1 (en) | 2012-12-10 | 2021-02-17 | Regenics AS | Use of egg cellular extracts for wound treatment |
| CN105025906B (zh) | 2012-12-21 | 2020-08-25 | 阿克生物科技公司 | 来自鱼孵化液的化妆品组合物 |
| GB201223330D0 (en) | 2012-12-21 | 2013-02-06 | Aqua Bio Technology Asa | Products, methods and uses |
| US20140275289A1 (en) | 2013-03-15 | 2014-09-18 | Concept Laboratories, Inc. | Concentrate for forming water-gel emulsion matrix and kit including same |
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2014
- 2014-12-12 CA CA2933367A patent/CA2933367A1/en not_active Abandoned
- 2014-12-12 KR KR1020167017607A patent/KR20160098294A/ko not_active Ceased
- 2014-12-12 CN CN201480067589.5A patent/CN105813627A/zh active Pending
- 2014-12-12 WO PCT/US2014/070126 patent/WO2015089461A1/en not_active Ceased
- 2014-12-12 AU AU2014361780A patent/AU2014361780B2/en not_active Ceased
- 2014-12-12 EP EP14869587.7A patent/EP3091961A4/en not_active Withdrawn
- 2014-12-12 JP JP2016538005A patent/JP6089152B2/ja active Active
- 2014-12-12 MX MX2016007617A patent/MX2016007617A/es unknown
- 2014-12-15 US US14/571,087 patent/US9248167B2/en active Active
-
2016
- 2016-05-19 PH PH12016500930A patent/PH12016500930B1/en unknown
- 2016-06-05 IL IL246041A patent/IL246041A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JP6089152B2 (ja) | 2017-03-01 |
| EP3091961A1 (en) | 2016-11-16 |
| AU2014361780A1 (en) | 2016-06-02 |
| US20150165002A1 (en) | 2015-06-18 |
| AU2014361780A2 (en) | 2016-06-23 |
| US9248167B2 (en) | 2016-02-02 |
| KR20160098294A (ko) | 2016-08-18 |
| EP3091961A4 (en) | 2017-11-15 |
| CA2933367A1 (en) | 2015-06-18 |
| CN105813627A (zh) | 2016-07-27 |
| IL246041A (en) | 2017-04-30 |
| PH12016500930A1 (en) | 2016-06-27 |
| AU2014361780B2 (en) | 2016-11-24 |
| MX2016007617A (es) | 2016-10-04 |
| WO2015089461A1 (en) | 2015-06-18 |
| JP2016539987A (ja) | 2016-12-22 |
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