PH12014502369A1 - 1h-pyrazolo [3,4-b] pyridines and therapeutic uses thereof - Google Patents

1h-pyrazolo [3,4-b] pyridines and therapeutic uses thereof

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Publication number
PH12014502369A1
PH12014502369A1 PH12014502369A PH12014502369A PH12014502369A1 PH 12014502369 A1 PH12014502369 A1 PH 12014502369A1 PH 12014502369 A PH12014502369 A PH 12014502369A PH 12014502369 A PH12014502369 A PH 12014502369A PH 12014502369 A1 PH12014502369 A1 PH 12014502369A1
Authority
PH
Philippines
Prior art keywords
pyrazolo
pyridines
therapeutic uses
disease
osteoarthritis
Prior art date
Application number
PH12014502369A
Other languages
English (en)
Other versions
PH12014502369B1 (en
Inventor
Hood John
Kc Sunil Kumar
Wallace David Mark
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of PH12014502369A1 publication Critical patent/PH12014502369A1/en
Publication of PH12014502369B1 publication Critical patent/PH12014502369B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Diabetes (AREA)
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  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
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  • Obesity (AREA)
  • Dermatology (AREA)
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  • Oncology (AREA)
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  • Cardiology (AREA)
  • Dispersion Chemistry (AREA)
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  • Child & Adolescent Psychology (AREA)
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  • Ophthalmology & Optometry (AREA)
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PH12014502369A 2012-05-04 2014-10-22 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof PH12014502369B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261642915P 2012-05-04 2012-05-04
PCT/US2013/039484 WO2013166396A2 (en) 2012-05-04 2013-05-03 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
PH12014502369A1 true PH12014502369A1 (en) 2015-01-12
PH12014502369B1 PH12014502369B1 (en) 2015-01-12

Family

ID=49513001

Family Applications (3)

Application Number Title Priority Date Filing Date
PH12014502369A PH12014502369B1 (en) 2012-05-04 2014-10-22 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
PH12017501661A PH12017501661A1 (en) 2012-05-04 2017-09-11 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
PH12018501552A PH12018501552A1 (en) 2012-05-04 2018-07-19 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
PH12017501661A PH12017501661A1 (en) 2012-05-04 2017-09-11 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
PH12018501552A PH12018501552A1 (en) 2012-05-04 2018-07-19 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof

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US (8) US8883822B2 (enExample)
EP (2) EP3593800A1 (enExample)
JP (3) JP6209593B2 (enExample)
KR (1) KR102223301B1 (enExample)
CN (2) CN104271133B (enExample)
AU (2) AU2013256141B2 (enExample)
BR (1) BR112014024284B1 (enExample)
CA (1) CA2854229C (enExample)
CL (1) CL2014002983A1 (enExample)
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DK (1) DK2770994T3 (enExample)
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HR (1) HRP20191799T1 (enExample)
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MA (1) MA37577B1 (enExample)
ME (1) ME03573B (enExample)
MX (1) MX362466B (enExample)
MY (1) MY173049A (enExample)
NZ (3) NZ629282A (enExample)
PE (1) PE20142365A1 (enExample)
PH (3) PH12014502369B1 (enExample)
PL (1) PL2770994T3 (enExample)
PT (1) PT2770994T (enExample)
RS (1) RS59668B1 (enExample)
RU (1) RU2689141C2 (enExample)
SG (2) SG11201407148XA (enExample)
SI (1) SI2770994T1 (enExample)
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BR112012002854B1 (pt) 2009-08-10 2020-02-18 Samumed, Llc Composto ou sal farmaceuticamente aceitável, composição farmacêutica e uso dos mesmos
WO2011084486A1 (en) 2009-12-21 2011-07-14 Epitherix, Llc 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
WO2012177647A2 (en) 2011-06-20 2012-12-27 Kerry Lane Mycotoxin diagnostics and methods thereof
AU2012308570B2 (en) 2011-09-14 2016-11-10 Samumed, Llc Indazole-3-carboxamides and their use as Wnt/b-catenin signaling pathway inhibitors
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
RU2689141C2 (ru) * 2012-05-04 2019-05-24 СЭМЬЮМЕД, ЭлЭлСи 1н-пиразоло[3,4-b]пиридины и их терапевтические применения
CN105120862A (zh) 2013-01-08 2015-12-02 萨穆梅德有限公司 Wnt信号途径的3-(苯并咪唑-2-基)-吲唑抑制剂及其治疗应用
JP6430512B2 (ja) * 2013-12-11 2018-11-28 セルジーン クオンティセル リサーチ，インク． リジン特異的デメチラーゼ−１の阻害剤
ES2720324T3 (es) * 2014-03-27 2019-07-19 Merck Patent Gmbh Piridil piperidinas
WO2016040181A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
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