PE4698A1 - Agentes antifungicos derivados de triazol - Google Patents

Agentes antifungicos derivados de triazol

Info

Publication number
PE4698A1
PE4698A1 PE1996000475A PE00047596A PE4698A1 PE 4698 A1 PE4698 A1 PE 4698A1 PE 1996000475 A PE1996000475 A PE 1996000475A PE 00047596 A PE00047596 A PE 00047596A PE 4698 A1 PE4698 A1 PE 4698A1
Authority
PE
Peru
Prior art keywords
het
triazol
alkyl
formula
triazole
Prior art date
Application number
PE1996000475A
Other languages
English (en)
Inventor
Kenneth Richardson
Peter Thomas Stephenson
Michael Jonathan Fray
Peter John Whittle
Andrew Simon Bell
Alan Patrick Marchington
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of PE4698A1 publication Critical patent/PE4698A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) O (II), EN DONDE AR ES PREFERENTEMENTE 2,4 DIFLUOROFENIL; "X" ES PREFERENTEMENTE FENILO SUSTITUIDO CON "Z" Y "HET", EN DONDE "Z" ES H o F Y "HET" ES PREFERENTEMENTE IMIDAZOL-1-IL, 1,2,3 o 1,2,4 TRIAZOL -1, -3 o -4-IL; 1-METIL PIRAZOL-5-IL O -CO-CH2-R, EN DONDE R ES H o ALQUILO C1-C4. TAMBIEN SE REFIERE A LOS PROCEDIMIENTOS DE PREPARACION DE (I), QUE COMPRENDEN: 1) REDUCIR UN DERIVADO DE 3-BUTEN-2-OL DE FORMULA (II); O 2) HACER REACCIONAR (I) EN DONDE "HET" ES -CO-CH2-R Y R YA SE INDICO, CON UN COMPUESTO DE FORMULA [(Ra)2N]3PN3(+)X(-), EN DONDE Ra ES ALQUILO C1-C4, CICLOALQUILO C5-C7 O CADA Ra JUNTO CON EL NITROGENO AL QUE ESTAN ENLAZADOS SON PIRROLIDINO O PIPERIDINO Y "X" ES UN CONTRAION EN PRESENCIA DE UNA BASE FUERTE [ OBTENIENDOSE (I), EN EL QUE "HET" ES 1,2,3-TRIAZOL-4-IL O ES 5-ALQUIL C1-C4 1,2,3-TRIAZOL-4-IL ]; O 3) HACER REACCIONAR (I) EN DONDE "X" ES FENILO SUSTITUIDO CON -C�CH CON UN AZIDO-TRI(ALQUIL C1-C4)SILANO Y DESPUES CON AGUA. SIENDO USADOS TANTO EN MEDICINA COMO EN VETERINARIA PARA TRATAR INFECCIONES FUNGICAS SISTEMICAS, SUPERFICIALES O DE MUCOSA, CAUSADAS POR CANDIDA ALBICANS, ENTRE OTRAS
PE1996000475A 1995-06-26 1996-06-21 Agentes antifungicos derivados de triazol PE4698A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9512961.5A GB9512961D0 (en) 1995-06-26 1995-06-26 Antifungal agents

Publications (1)

Publication Number Publication Date
PE4698A1 true PE4698A1 (es) 1998-03-03

Family

ID=10776672

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000475A PE4698A1 (es) 1995-06-26 1996-06-21 Agentes antifungicos derivados de triazol

Country Status (25)

Country Link
US (1) US6015825A (es)
EP (1) EP0835252B1 (es)
JP (1) JP3105926B2 (es)
KR (1) KR19990028390A (es)
AR (1) AR002761A1 (es)
AT (1) ATE246186T1 (es)
AU (1) AU697405B2 (es)
BR (1) BR9609298A (es)
CA (1) CA2224983C (es)
CO (1) CO4480719A1 (es)
CZ (1) CZ415597A3 (es)
DE (1) DE69629300T2 (es)
DK (1) DK0835252T3 (es)
ES (1) ES2202453T3 (es)
GB (1) GB9512961D0 (es)
HU (1) HUP9803022A2 (es)
IL (1) IL118698A0 (es)
NO (1) NO976047L (es)
NZ (1) NZ311651A (es)
PE (1) PE4698A1 (es)
PL (1) PL324336A1 (es)
PT (1) PT835252E (es)
TR (1) TR199701699T1 (es)
WO (1) WO1997001552A1 (es)
ZA (1) ZA965365B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
GB9713149D0 (en) * 1997-06-21 1997-08-27 Pfizer Ltd Pharmaceutical formulations
US6645990B2 (en) 2000-08-15 2003-11-11 Amgen Inc. Thiazolyl urea compounds and methods of uses
KR100572996B1 (ko) * 2003-08-12 2006-04-25 한국화학연구원 불소화 비닐 에테르 측쇄기를 갖는 아졸계 살균제 화합물및 그의 제조방법
AU2004303602C1 (en) 2003-12-23 2009-05-28 Astex Therapeutics Limited Pyrazole derivatives as protein kinase modulators
WO2006136821A1 (en) 2005-06-22 2006-12-28 Astex Therapeutics Limited Pharmaceutical compounds
JP5345842B2 (ja) 2005-06-23 2013-11-20 アステックス・セラピューティクス・リミテッド プロテインキナーゼモジュレーターとしてのピラゾール誘導体を含む医薬組み合わせ
KR100738228B1 (ko) * 2006-02-22 2007-07-12 한국화학연구원 아졸계 항균제 화합물 및 그의 제조방법
GB0704932D0 (en) 2007-03-14 2007-04-25 Astex Therapeutics Ltd Pharmaceutical compounds
PL2563771T3 (pl) * 2010-04-24 2016-06-30 Viamet Pharmaceuticals Nc Inc Związki inhibitora metaloenzymu
EP2630133A1 (de) 2010-10-22 2013-08-28 Bayer Intellectual Property GmbH Neue heterocylische verbindungen als schädlingsbekämpfungsmittel
CA2829785C (en) * 2011-03-15 2019-02-26 Fdc Limited Enantiomers of fluconazole analogues containing thieno-[2,3-d]pyrimidin-4(3h)-one moiety as antifungal agents
CA2838909A1 (en) * 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
EA201490052A1 (ru) * 2011-06-23 2014-04-30 Вайамет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
ES2774267T3 (es) 2012-01-20 2020-07-20 Mycovia Pharmaceuticals Inc Compuestos inhibidores de metaloenzimas
TWI646088B (zh) * 2012-03-16 2019-01-01 維愛美製藥公司 金屬酶抑制劑化合物
WO2013144224A1 (en) * 2012-03-27 2013-10-03 Syngenta Participations Ag Acetylenic microbiocides
EP3044212B1 (en) * 2013-09-13 2017-11-29 Suven Life Sciences Limited Process for the large scale production of 1h- [1,2,3]triazole and its intermediate 1-benzyl-1h-[1,2,3]triazole

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729523A (en) * 1984-06-11 1988-03-08 Kabushiki Kaisha Tokai-Rika-Denki-Seisakusho Locking mechanism for webbing retractor
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
GB9107055D0 (en) * 1991-04-04 1991-05-22 Pfizer Ltd Triazole antifungal agents
GB9121456D0 (en) * 1991-10-10 1991-11-27 Pfizer Ltd Triazole antifungal agents
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
CA2145458A1 (en) * 1994-03-28 1995-09-29 Hiroki Kodama Triazole compound and production process and use thereof

Also Published As

Publication number Publication date
ZA965365B (en) 1997-12-29
ES2202453T3 (es) 2004-04-01
EP0835252B1 (en) 2003-07-30
NO976047L (no) 1998-02-25
DE69629300D1 (de) 2003-09-04
JP3105926B2 (ja) 2000-11-06
WO1997001552A1 (en) 1997-01-16
JPH10506652A (ja) 1998-06-30
NZ311651A (en) 1999-09-29
EP0835252A1 (en) 1998-04-15
TR199701699T1 (xx) 1998-06-22
NO976047D0 (no) 1997-12-22
US6015825A (en) 2000-01-18
PL324336A1 (en) 1998-05-25
AU6301096A (en) 1997-01-30
ATE246186T1 (de) 2003-08-15
AR002761A1 (es) 1998-04-29
BR9609298A (pt) 1999-05-18
GB9512961D0 (en) 1995-08-30
DE69629300T2 (de) 2004-03-04
CA2224983C (en) 2003-04-08
HUP9803022A2 (hu) 1999-10-28
DK0835252T3 (da) 2003-10-27
IL118698A0 (en) 1996-10-16
CZ415597A3 (cs) 1998-11-11
MX9800046A (es) 1998-08-30
KR19990028390A (ko) 1999-04-15
CA2224983A1 (en) 1997-01-16
CO4480719A1 (es) 1997-07-09
AU697405B2 (en) 1998-10-08
PT835252E (pt) 2003-11-28

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed