PE37897A1 - Agentes antifungicos de peptidos ciclicos - Google Patents

Agentes antifungicos de peptidos ciclicos

Info

Publication number
PE37897A1
PE37897A1 PE1996000373A PE00037396A PE37897A1 PE 37897 A1 PE37897 A1 PE 37897A1 PE 1996000373 A PE1996000373 A PE 1996000373A PE 00037396 A PE00037396 A PE 00037396A PE 37897 A1 PE37897 A1 PE 37897A1
Authority
PE
Peru
Prior art keywords
antifungal agents
cyclic peptide
alkyl
refers
compound
Prior art date
Application number
PE1996000373A
Other languages
English (en)
Inventor
Peter Stanley Borromeo
William Wilson Turner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE37897A1 publication Critical patent/PE37897A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A PEPTIDOS CICLICOS SEMISINTETICOS DE FORMULA (I), DONDE R`, R" Y R"' SON CH3 O H O R' ES -CH2C(O)NH2; Rx1, Rx2, Ry1, Ry2, Ry3 Y Ry4 SON -OH O -H O Rx1 ES -OR DONDE R ES ALQUILO(C1-C6) O BENCILO, ENTRE OTROS; Ro ES -OH, -OP(O)(OH)2, -OP(O)(OH)(R1) O -OP(O)(OH)(OR1); R1 PREFERENTEMENTE ES -CH3; R2 ES UN COMPUESTO DE FORMULA (II), EN DONDE R2a PREFERENTEMENTE ES METILO, HALO O METOXI Y a ES 1, 2, 3 o 4, PREFERENTEMENTE 1; R3 PREFERENTEMENTE ES ALCOXI (C1-C12) O -O-(CH2)-[0]-ALQUILO(C1-C12). TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE (I), QUE COMPRENDE LA ACILACION DEL COMPUESTO (I) EN LA POSICION DEL SUSTITUYENTE R2, DONDE R2 ERA INICIALMENTE HIDROGENO. ESTOS COMPUESTOS TIENEN ESTABILIDAD Y SOLUBILIDAD MEJORADA EN EL AGUA, SIENDO USADOS EN EL TRATAMIENTO DE INFECCIONES FUNGICAS DEL GENERO CANDIDA O ASPERGILLUS, ADEMAS DE INFECCIONES OPORTUNISTAS EN INDIVIDUOS INMUNOSUPRIMIDOS, CAUSADA POR PNEUMOCYSTIS CARINII
PE1996000373A 1995-05-26 1996-05-22 Agentes antifungicos de peptidos ciclicos PE37897A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45133795A 1995-05-26 1995-05-26

Publications (1)

Publication Number Publication Date
PE37897A1 true PE37897A1 (es) 1997-10-09

Family

ID=23791818

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000373A PE37897A1 (es) 1995-05-26 1996-05-22 Agentes antifungicos de peptidos ciclicos

Country Status (11)

Country Link
US (1) US5786325A (es)
EP (1) EP0744407B1 (es)
AR (1) AR002104A1 (es)
AT (1) ATE225804T1 (es)
AU (1) AU5799096A (es)
DE (1) DE69624167T2 (es)
ES (1) ES2180699T3 (es)
IL (1) IL118331A0 (es)
PE (1) PE37897A1 (es)
WO (1) WO1996037509A1 (es)
ZA (1) ZA964011B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
WO1999006062A1 (en) * 1997-08-04 1999-02-11 Eli Lilly And Company Cyclic peptide antifungal agents
US6323176B1 (en) 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
JP2002528388A (ja) 1998-08-20 2002-09-03 イーライ リリー アンド カンパニー 環改変された環状ペプチドアナログ
PT1137663E (pt) 1998-12-09 2006-12-29 Lilly Co Eli Purificação de compostos ciclopéptidos equinocandina
EP1582204B1 (en) * 1999-03-03 2013-09-25 Eli Lilly & Company Echinocandin pharmaceutical formulations containing micelle-forming surfactants
DE60030415T2 (de) 1999-03-03 2007-08-30 Eli Lilly And Co., Indianapolis Bildung und anionenaustausch von inneren kristallinen ammoniumsalzen des echinocandins b
JP2002538097A (ja) 1999-03-03 2002-11-12 イーライ リリー アンド カンパニー 薬学的経口ｅｃｂ処方物および組成物の作製方法
ATE248187T1 (de) * 1999-03-03 2003-09-15 Lilly Co Eli Echinocandin-kohlenhydrate-komplexe
AU5871000A (en) * 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
JP2004536034A (ja) * 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
AU2002364552A1 (en) 2001-12-13 2003-06-30 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
EP1620422A2 (en) * 2003-04-30 2006-02-01 The Institutes for Pharmaceutical Discovery, LLC Phenyl substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
US10825328B2 (en) 2017-07-03 2020-11-03 Motorola Solutions, Inc. Apparatus for managing a plurality of devices in a portable communication system

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320052A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) * 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
FI912873A (fi) * 1990-06-18 1991-12-19 Fujisawa Pharmaceutical Co Ny polypeptidfoerening och foerfarande foer dess framstaellning.
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) * 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
IL122315A (en) * 1992-03-19 2002-03-10 Lilly Co Eli Cyclic peptides and antifungal pharmaceutical compositions containing them
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
AU674233B2 (en) * 1993-05-04 1996-12-12 Merck & Co., Inc. Cyclohexapeptidyl aminoalkyl ethers
US5541160A (en) * 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
EP0744407B1 (en) 2002-10-09
ATE225804T1 (de) 2002-10-15
DE69624167D1 (de) 2002-11-14
WO1996037509A1 (en) 1996-11-28
ES2180699T3 (es) 2003-02-16
AR002104A1 (es) 1998-01-07
US5786325A (en) 1998-07-28
EP0744407A3 (en) 1998-05-20
DE69624167T2 (de) 2003-02-13
IL118331A0 (en) 1996-09-12
EP0744407A2 (en) 1996-11-27
AU5799096A (en) 1996-12-11
ZA964011B (en) 1997-11-20

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FA Abandonment or withdrawal