PE38497A1 - Agentes antifungicos de peptidos ciclicos - Google Patents

Agentes antifungicos de peptidos ciclicos

Info

Publication number
PE38497A1
PE38497A1 PE1996000374A PE00037496A PE38497A1 PE 38497 A1 PE38497 A1 PE 38497A1 PE 1996000374 A PE1996000374 A PE 1996000374A PE 00037496 A PE00037496 A PE 00037496A PE 38497 A1 PE38497 A1 PE 38497A1
Authority
PE
Peru
Prior art keywords
bnrz1rz2
bencilo
alcoxy
ch2c
antifungal agents
Prior art date
Application number
PE1996000374A
Other languages
English (en)
Inventor
Lisa Marie Hannond Lagrandeur
Mark James Zweifel
James Andrew Jamison
Jr William Wilson Turner
Michael John Rodriguez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE38497A1 publication Critical patent/PE38497A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A PEPTIDOS CICLICOS SEMISINTETICOS DE FORMULA (I), EN DONDE: R`, R" Y R"' SON -H O -CH3 u R' ES -CH2C(O)NH2; Ry1, Ry2, Ry3, Ry4 Y Rx2 SON H O PREFERENTEMENTE -OH; Rx1 ES PREFERENTEMENTE -CH3, BENCILO, -CH2CHOHCH2OH, -CH2COOH , -(CH2)bNRz1Rz2 O -(CH2)2PORz3Rz4, ENTRE OTROS, DONDE: Rz1 Y Rz2 SON H O ALQUILO (C1-C6), ENTRE OTROS; Rz3 Y Rz4 SON PREFERENTEMENTE H O -OCH3; Ro ES -OP(O)(OH)2, -OP(O)(OH)(R1), -OP(O)(OH)(OR1) O PREFERENTEMENTE ES -OH; R1 ES PREFERENTEMENTE -CH3; R2 ES PREFERENTEMENTE (a) -C(O)-C6H4-C6H4-C6H4-O-(CH2)4-CH3, O (b) -C(O)-C6H4-Z-C6H4-R4, ENTRE OTROS, EN DONDE: SI i) R' ES -CH2C(O)NH2 Y Rx1 ES -CH3 O BENCILO O SI ii) Rx1 ES -(CH2)bNRz1Rz2, ENTONCES R2 NO ES (b), EN DONDE: Z ES UN ENLACE; R4 ES ALCOXI(C1-C12) OPCIONALMENTE SUSTITUIDO CON ALQUILAMINO(C1-C4), FENILO SUSTITUIDO CON ALCOXI(C1-C12) O ES -O-(CH2)r-W-R5, ENTRE OTROS, DONDE W ES PIPERIDINO, PIPERAZINO O PIRROLIDINO Y r ES 2, 3 o 4. TAMBIEN SE REFIERE A LA PREPARACION DE LOS COMPUESTO DE FORMULA (I), QUE COMPRENDE LA ETERIFICACION DEL GRUPO OH, OBTENIENDOSE ORx1, DONDE LOS SUSTITUYENTES DE Rx1 FUERON YA SENALADOS. SIENDO USADOS EN EL TRATAMIENTO DE INFECCIONES FUNGICAS DEL GENERO CANDIDA O ASPERGILLUS, ENTRE OTROS, TANTO COMO DE INFECCIONES OPORTUNISTAS EN INDIVIDUOS INMUNOSUPRIMIDOS, CAUSADA POR PNEUMOCYSTIS CARINII, ENTRE OTROS
PE1996000374A 1995-05-26 1996-05-22 Agentes antifungicos de peptidos ciclicos PE38497A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45305295A 1995-05-26 1995-05-26

Publications (1)

Publication Number Publication Date
PE38497A1 true PE38497A1 (es) 1997-10-09

Family

ID=23799020

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000374A PE38497A1 (es) 1995-05-26 1996-05-22 Agentes antifungicos de peptidos ciclicos

Country Status (13)

Country Link
US (1) US5652213A (es)
EP (1) EP0744405B1 (es)
JP (1) JPH11505845A (es)
AR (1) AR002103A1 (es)
AT (1) ATE245162T1 (es)
AU (1) AU5799196A (es)
CA (1) CA2220728A1 (es)
DE (1) DE69629075T2 (es)
ES (1) ES2201154T3 (es)
IL (1) IL118334A0 (es)
PE (1) PE38497A1 (es)
WO (1) WO1996037510A1 (es)
ZA (1) ZA964014B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743777B1 (en) * 1992-03-19 2004-06-01 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
US5965525A (en) * 1992-03-19 1999-10-12 Eli Lilly And Company Cyclic peptide antifungal agents
US6384013B1 (en) 1992-03-19 2002-05-07 Eli Lilly And Company Cyclic peptide antifungal agents and process for preparation thereof
EP0881907A4 (en) * 1996-02-01 2000-05-10 Lilly Co Eli FUNGICIDES IN THE FORM OF CYCLIC PEPTIDES
US6323176B1 (en) * 1998-02-25 2001-11-27 Eli Lilly And Company Cyclic peptide antifungal agents
ATE287899T1 (de) 1998-08-20 2005-02-15 Lilly Co Eli Verfahren zur herstellung von ring-modifizierten zyklischen peptidanalogen
WO2000020441A2 (en) * 1998-10-05 2000-04-13 Abbott Laboratories Cyclic peptides as antifungal agents
EP1137663B1 (en) 1998-12-09 2006-08-30 Eli Lilly And Company Purification of echinocandin cyclopeptide compounds
EP1140991A1 (en) * 1998-12-16 2001-10-10 Eli Lilly And Company Cyclic peptide antifungal agents
CA2362826A1 (en) * 1999-03-03 2000-09-08 Michael Anthony Dotlich Formation and anion-exchange of crystalline echinocandin ammonium salts
PT1157030E (pt) * 1999-03-03 2004-01-30 Lilly Co Eli Complexos equinocandina/hidrato de carbono
DE60019902D1 (de) * 1999-03-03 2005-06-09 Lilly Co Eli Echinocandin pharmazeutische zusammensetzungen
JP2002538097A (ja) 1999-03-03 2002-11-12 イーライ リリー アンド カンパニー 薬学的経口ｅｃｂ処方物および組成物の作製方法
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
US6991800B2 (en) * 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
JP2013503179A (ja) * 2009-08-27 2013-01-31 シーチェイド ファーマシューティカルズ，インコーポレーテッド エキノキャンディン誘導体
LT2680873T (lt) 2011-03-03 2017-11-27 Cidara Therapeutics, Inc. Priešgrybeliniai agentai ir jų panaudojimas
PT2827710T (pt) 2012-03-19 2020-02-25 Cidara Therapeutics Inc Regimes de dosagem para compostos da classe equinocandina
EP2883915A1 (en) * 2013-12-13 2015-06-17 Ecole Polytechnique Federale de Lausanne (EPFL) Porphyrin based sensitizer for dye-sensitized solar cell
CN108883152A (zh) 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
MA43825A (fr) 2016-03-16 2021-04-07 Cidara Therapeutics Inc Schémas posologiques pour le traitement d'infections fongiques
CA3069423A1 (en) 2017-07-12 2019-01-17 Cidara Therapeutics, Inc. Formulations for the treatment of fungal infections
TW202134257A (zh) * 2019-12-06 2021-09-16 大陸商上海森輝醫藥有限公司 棘白菌素類似物及其製備方法
JP2024520500A (ja) * 2021-06-03 2024-05-24 上海森▲輝▼医▲葯▼有限公司 アニデュラファンギン誘導体の調製方法
CN116903706B (zh) * 2023-06-13 2024-05-17 深圳市祥根生物有限公司 一种棘白菌素类药物及其制备方法和用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320052A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293488A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912B nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
CA2037957A1 (en) * 1990-03-12 1991-09-13 Merck & Co., Inc. N-acylated cyclohexapeptide compounds
GB2241956A (en) * 1990-03-16 1991-09-18 Merck & Co Inc N-acylated cyclohexapeptide compounds
IL97347A0 (en) * 1990-03-19 1992-05-25 Merck & Co Inc Lipopeptide derivatives and antimicrobial compositions containing them
US5330973A (en) * 1990-03-19 1994-07-19 Merck & Co., Inc. Lipopeptide derivatives
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
IE990233A1 (en) * 1990-06-18 2000-11-15 Fujisawa Pharmaceutical Co New Polypeptide Compound and a Process for Preparation thereof
US5369093A (en) * 1991-03-15 1994-11-29 Merck & Co., Inc. Lipopeptide derivatives
US5233023A (en) * 1991-07-30 1993-08-03 Merck & Co., Inc. Process for phosphate ester compounds of certain cyclohexapeptides
US6030944A (en) * 1991-10-01 2000-02-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compounds
US5399552A (en) * 1991-10-17 1995-03-21 Merck & Co, Inc Antibiotic peptides bearing aminoalkylthioether moieties
NZ299314A (en) * 1992-03-19 2001-09-28 Lilly Co Eli Cyclic peptide for inhibiting parasitic and antifungal activity
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
WO1994025045A1 (en) * 1993-05-04 1994-11-10 Merck & Co., Inc. Cyclohexapeptidyl aminoalkyl ethers
WO1995008341A1 (en) * 1993-09-22 1995-03-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use

Also Published As

Publication number Publication date
EP0744405A3 (en) 1998-05-27
IL118334A0 (en) 1996-09-12
ES2201154T3 (es) 2004-03-16
JPH11505845A (ja) 1999-05-25
AR002103A1 (es) 1998-01-07
EP0744405B1 (en) 2003-07-16
EP0744405A2 (en) 1996-11-27
WO1996037510A1 (en) 1996-11-28
DE69629075T2 (de) 2004-04-15
AU5799196A (en) 1996-12-11
US5652213A (en) 1997-07-29
ZA964014B (en) 1997-11-20
CA2220728A1 (en) 1996-11-28
ATE245162T1 (de) 2003-08-15
DE69629075D1 (de) 2003-08-21

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