PE20191006A1 - Compuestos de aza-indazol para usar en lesiones de tendones y/o ligamentos - Google Patents
Compuestos de aza-indazol para usar en lesiones de tendones y/o ligamentosInfo
- Publication number
- PE20191006A1 PE20191006A1 PE2019000681A PE2019000681A PE20191006A1 PE 20191006 A1 PE20191006 A1 PE 20191006A1 PE 2019000681 A PE2019000681 A PE 2019000681A PE 2019000681 A PE2019000681 A PE 2019000681A PE 20191006 A1 PE20191006 A1 PE 20191006A1
- Authority
- PE
- Peru
- Prior art keywords
- aza
- compounds
- injury
- ligament injuries
- indazol
- Prior art date
Links
- 208000027418 Wounds and injury Diseases 0.000 title 2
- 230000006378 damage Effects 0.000 title 2
- 208000014674 injury Diseases 0.000 title 2
- 210000003041 ligament Anatomy 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- GNFFRCBFWWJGIK-UHFFFAOYSA-N 4-(3-amino-1H-pyrazolo[4,3-b]pyridin-5-yl)-3-chloro-N-[3-hydroxy-3-(trifluoromethyl)cyclobutyl]benzenesulfonamide Chemical compound NC1=NNC=2C1=NC(=CC=2)C1=C(C=C(C=C1)S(=O)(=O)NC1CC(C1)(C(F)(F)F)O)Cl GNFFRCBFWWJGIK-UHFFFAOYSA-N 0.000 abstract 1
- 206010061223 Ligament injury Diseases 0.000 abstract 1
- 208000021945 Tendon injury Diseases 0.000 abstract 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical class C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002435 tendon Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
Abstract
Referido a un compuestos de aza-indazol, de formula (I) en forma libre o en forma de sal farmaceuticamente aceptable, R1 es alquiloC1-C3 y halogeno; R2 es NHSO2(CH2)nR3 o SO2NR5R6. Un compuesto seleccionado es 4-(3-amino-1H-pirazolo[4,3-b]piridin-5-il)-3-cloro-N-(3-hidroxi-3-(trifluorometil)ciclobutil)bencenosulfonamida. Tambien se refiere a un metodo para la elaboracion de dichos compuestos y a una composicion farmaceutica para usar en lesiones de tendones y/o ligamentos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662398865P | 2016-09-23 | 2016-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20191006A1 true PE20191006A1 (es) | 2019-07-15 |
Family
ID=60164748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019000681A PE20191006A1 (es) | 2016-09-23 | 2017-09-21 | Compuestos de aza-indazol para usar en lesiones de tendones y/o ligamentos |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US10766894B2 (es) |
| EP (1) | EP3515913B1 (es) |
| JP (1) | JP7008065B2 (es) |
| KR (1) | KR102472017B1 (es) |
| CN (1) | CN109715629B (es) |
| AU (1) | AU2017332868B2 (es) |
| BR (1) | BR112019005318A2 (es) |
| CA (1) | CA3033253A1 (es) |
| CL (1) | CL2019000768A1 (es) |
| CO (1) | CO2019002618A2 (es) |
| CR (1) | CR20190144A (es) |
| CU (1) | CU24550B1 (es) |
| DO (1) | DOP2019000070A (es) |
| EA (1) | EA039908B1 (es) |
| EC (1) | ECSP19019613A (es) |
| ES (1) | ES2924104T3 (es) |
| IL (1) | IL264763B (es) |
| JO (1) | JOP20190053A1 (es) |
| MX (1) | MX2019003373A (es) |
| MY (1) | MY197464A (es) |
| PE (1) | PE20191006A1 (es) |
| PH (1) | PH12019500328A1 (es) |
| RU (1) | RU2758256C2 (es) |
| SG (1) | SG11201901249YA (es) |
| WO (1) | WO2018055551A1 (es) |
| ZA (1) | ZA201900861B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190053A1 (ar) * | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| GB201813312D0 (en) | 2018-08-15 | 2018-09-26 | Modern Biosciences Ltd | Compounds and their therapeutic use |
| EP4442315A2 (en) | 2019-01-11 | 2024-10-09 | Novartis AG | Lta4h inhibitor for the treatment or prevention of hidradenitis suppurativa |
| TW202342048A (zh) | 2022-02-28 | 2023-11-01 | 瑞士商諾華公司 | 使用ｌｏｕ０６４治療化膿性汗腺炎之方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002222293A1 (en) | 2000-12-19 | 2002-07-01 | Smithkline Beecham P.L.C. | Pyrazolo(3,4-c)pyridines as gsk-3 inhibitors |
| JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
| FR2871158A1 (fr) | 2004-06-04 | 2005-12-09 | Aventis Pharma Sa | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
| DE102004028862A1 (de) | 2004-06-15 | 2005-12-29 | Merck Patent Gmbh | 3-Aminoindazole |
| PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
| FR2889526B1 (fr) | 2005-08-04 | 2012-02-17 | Aventis Pharma Sa | 7-aza-indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
| US9554319B2 (en) * | 2005-09-27 | 2017-01-24 | Qualcomm Incorporated | Channel handoff methods in wireless broadcast systems |
| WO2008104473A2 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Pyrazolopyriidine derivatives and their use as kinase inhibitors |
| CN101790526A (zh) | 2007-06-08 | 2010-07-28 | 雅培制药有限公司 | 用作激酶抑制剂的5-杂芳基取代的吲唑化合物 |
| US20110237633A1 (en) | 2008-12-11 | 2011-09-29 | Bijoy Panicker | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| EP2464647B1 (en) | 2009-08-11 | 2016-09-21 | Bristol-Myers Squibb Company | Azaindazoles as btk kinase modulators and use thereof |
| IN2012DN03799A (es) * | 2009-10-29 | 2015-08-28 | Sirtris Pharmaceuticals Inc | |
| EP2637660A4 (en) | 2010-11-08 | 2014-04-09 | Glaxosmithkline Ip No 2 Ltd | GRAS SYNTHASE ACID INHIBITORS |
| WO2012158810A1 (en) | 2011-05-17 | 2012-11-22 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| UA112028C2 (uk) * | 2012-12-14 | 2016-07-11 | Пфайзер Лімітед | Похідні імідазопіридазину як модулятори гамка-рецептора |
| TWI629275B (zh) | 2013-03-13 | 2018-07-11 | 賽諾菲公司 | Ｎ－（４－（氮雜吲唑－６－基）－苯基）－磺醯胺及其作為醫藥之用途 |
| CN105991238A (zh) | 2015-03-06 | 2016-10-05 | 中兴通讯股份有限公司 | 信道状态信息的测量和反馈方法及发送端和接收端 |
| WO2016161571A1 (en) * | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | Indazole and azaindazole btk inhibitors |
| RU2749547C2 (ru) * | 2016-09-23 | 2021-06-15 | Новартис Аг | Индазольные соединения для применения при повреждениях сухожилий и/или связок |
| JOP20190053A1 (ar) | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
-
2017
- 2017-06-16 JO JOP/2019/0053A patent/JOP20190053A1/ar unknown
- 2017-09-21 RU RU2019111886A patent/RU2758256C2/ru active
- 2017-09-21 US US16/335,496 patent/US10766894B2/en active Active
- 2017-09-21 AU AU2017332868A patent/AU2017332868B2/en not_active Ceased
- 2017-09-21 CN CN201780057672.8A patent/CN109715629B/zh not_active Expired - Fee Related
- 2017-09-21 CA CA3033253A patent/CA3033253A1/en active Pending
- 2017-09-21 KR KR1020197010513A patent/KR102472017B1/ko active IP Right Grant
- 2017-09-21 PE PE2019000681A patent/PE20191006A1/es unknown
- 2017-09-21 EA EA201990765A patent/EA039908B1/ru unknown
- 2017-09-21 CR CR20190144A patent/CR20190144A/es unknown
- 2017-09-21 ES ES17788297T patent/ES2924104T3/es active Active
- 2017-09-21 SG SG11201901249YA patent/SG11201901249YA/en unknown
- 2017-09-21 CU CU2019000029A patent/CU24550B1/es unknown
- 2017-09-21 MX MX2019003373A patent/MX2019003373A/es unknown
- 2017-09-21 WO PCT/IB2017/055737 patent/WO2018055551A1/en unknown
- 2017-09-21 MY MYPI2019000712A patent/MY197464A/en unknown
- 2017-09-21 JP JP2019515597A patent/JP7008065B2/ja active Active
- 2017-09-21 EP EP17788297.4A patent/EP3515913B1/en active Active
- 2017-09-21 BR BR112019005318A patent/BR112019005318A2/pt active Search and Examination
-
2019
- 2019-02-10 IL IL264763A patent/IL264763B/en active IP Right Grant
- 2019-02-11 ZA ZA2019/00861A patent/ZA201900861B/en unknown
- 2019-02-15 PH PH12019500328A patent/PH12019500328A1/en unknown
- 2019-03-20 EC ECSENADI201919613A patent/ECSP19019613A/es unknown
- 2019-03-20 DO DO2019000070A patent/DOP2019000070A/es unknown
- 2019-03-21 CO CONC2019/0002618A patent/CO2019002618A2/es unknown
- 2019-03-22 CL CL2019000768A patent/CL2019000768A1/es unknown
-
2020
- 2020-07-28 US US16/941,395 patent/US11203595B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20191006A1 (es) | Compuestos de aza-indazol para usar en lesiones de tendones y/o ligamentos | |
| PE20170189A1 (es) | Nuevos derivados de pirazolo pirimidina y su uso como inhibidores de malt1 | |
| AR121016A2 (es) | Sales de fenotiazindiaminio y su uso | |
| PE20181298A1 (es) | Inhibidores de bromodominio bivalentes y usos de los mismos | |
| EA201791256A1 (ru) | Производные хиназолина, применяемые для лечения вич | |
| CY1123616T1 (el) | 7-βενζυλ-4-(4-(τριφθορομεθυλ)βενζυλ)-1,2,6,7,8,9-εξαϋδροϊμιδαζο[1,2-α]πυριδο[3,4-ε]πυριμιδιν-5(4η)-ονη, και αλατα αυτης και χρηση αυτων στη θεραπεια | |
| PE20170666A1 (es) | 2-(morfolin-4-il)-1,7-naftiridinas | |
| UY35998A (es) | 1-(3-(tert-BUTIL)1-(p-TOLIL)-1H-PIRAZOL-5-IL)-3-(4-((2-((6-ETILPIRAZIN-2-IL)AMINO)PIRIDIN-4-IL)METOXI)NAFTALEN-1-IL) UREA Y SUS SALES DERIVADAS FARMACÉUTICAMENTE ACEPTABLES, COMO INHIBIDORES DE P38 M AP QUINASA | |
| EA201791305A1 (ru) | Конденсированные пиримидины для лечения вич | |
| CL2015000578A1 (es) | Compuesto n-(2-(6-fluoro-1-h-indol-3-il)etil)-3-(2,2,3,3-tetrafluoropropoxi)bencilamina o su sal, antagonista del receptor 5-ht6; composicion farmaceutica; uso en el tratamiento de la enfermedad de alzheimer. | |
| PE20161369A1 (es) | Inhibidores de monoacilglicerol aciltransferasa 2 (mgat2) de dihidropiridinona sustituidos con tetrazolona | |
| DOP2012000053A (es) | Derivados de (tio) morfolina como moduladores de s1p | |
| CY1122290T1 (el) | Παραγωγο 2-ακυλαμινοθειαζολιου για χρηση στην προληψη ή αντιμετωπιση νοσων της ουροδοχου κυστης/του ουροποιητικου συστηματος | |
| PE20240930A1 (es) | Analogos de benzoazepina como agentes inhibidores de la tirosina cinasa de bruton | |
| RS54899B1 (sr) | Jedinjenja tetrahidropirolotiazina | |
| DOP2017000188A (es) | Compuestos de benzoxaborol 4-sustituidos y uso de los mismos | |
| EA201590823A1 (ru) | 6-((s)-1-{1-[5-(2-гидроксиэтокси)пиридин-2-ил]-1h-пиразол-3-ил}этил)-3h-1,3-бензотиазол-2-он в качестве антагониста tarp-гамма 8-зависимого ampa-рецептора | |
| AR049121A1 (es) | Compuestos quimicos que contienen anillos de oxazolidinona e isoxazolina sustituida | |
| CY1124301T1 (el) | Ενωσεις ινδαζολης για χρηση σε κακωσεις του τενοντα ή/και των συνδεσμων | |
| PE20141789A1 (es) | Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2 | |
| AR099766A1 (es) | Inhibidores de la quinasa asociada al adaptador 1, composiciones que los comprenden y métodos para utilizarlos | |
| PE20231097A1 (es) | Compuestos heterociclicos como inhibidores de delta-5 desaturasa y metodos de uso | |
| CL2009001146A1 (es) | Compuestos derivados de 5-(5-(2-(3,5-bis(trifluorometil)fenil)-n,2-dimetilpropanoamida)-4-(4-fluoro-2-metilfenil)piridin-2-il)pirrolidin-2-carboxamida, antagonistas de los receptores nk-1; composicion farmaceutica; y uso del compuesto para el tratamiento de la depresion; ansiedad, trastornos del sueño o emesis. | |
| PE20190109A1 (es) | Nuevos derivados de [1,2,3]triazolo[4,5-d]pirimidina | |
| PE20181895A1 (es) | Compuestos de cinnolin-4-amina y su uso en el tratamiento del cancer |