PE20181319A1 - Compuestos de isoindol - Google Patents

Compuestos de isoindol

Info

Publication number
PE20181319A1
PE20181319A1 PE2018001126A PE2018001126A PE20181319A1 PE 20181319 A1 PE20181319 A1 PE 20181319A1 PE 2018001126 A PE2018001126 A PE 2018001126A PE 2018001126 A PE2018001126 A PE 2018001126A PE 20181319 A1 PE20181319 A1 PE 20181319A1
Authority
PE
Peru
Prior art keywords
compounds
isoindole
alkyl
hydroxypropan
ethylsulfonyl
Prior art date
Application number
PE2018001126A
Other languages
English (en)
Inventor
Sarah LEVER
Frank Narjes
Roine Ingemar Olsson
Berg Stefan Von
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20181319A1 publication Critical patent/PE20181319A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se refiere a compuestos derivado de isoindol de formula (I), R1 es H o (CO)R4; R2 es alquilo C1-6, ciclopropilo, entre otros; R3 es H, alquilo C1-6, entre otros; R4 es H, alquilo C1-6, entre otros. Tambien se refiere a composiciones farmaceuticas que comprenden dichos compuestos, sus sales farmaceuticamente aceptables y procesos para prepararlos. Son compuestos preferidos: 5-(etilsulfonil)-N-[4-(1,1,1,3,3,3-hexafluoro-2-hidroxipropan-2-il)fenil]-2,3-dihidro-1H-isoindol-1-carboxamida, 5-(etilsulfonil)-2-formil-N-[4-(1,1,1,3,3,3-hexafluoro-2-hidroxipropan-2-il)fenil]-2,3-dihidro-1H-isoindol-1-carboxamida, entre otros. Dichos compuestos regulan la actividad del receptor de acido retinoico (ROR) y son utiles para el tratamiento o prevencion de enfermedades tales como psoriasis, espondilitis anquilosante, artritis psoriasica, entre otras
PE2018001126A 2015-12-15 2016-12-14 Compuestos de isoindol PE20181319A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562267391P 2015-12-15 2015-12-15

Publications (1)

Publication Number Publication Date
PE20181319A1 true PE20181319A1 (es) 2018-08-14

Family

ID=57708552

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018001126A PE20181319A1 (es) 2015-12-15 2016-12-14 Compuestos de isoindol

Country Status (27)

Country Link
US (4) US10011566B2 (es)
EP (1) EP3390396B1 (es)
JP (1) JP6448867B2 (es)
KR (1) KR101947976B1 (es)
CN (1) CN109071516B (es)
AR (1) AR107054A1 (es)
AU (1) AU2016374294B2 (es)
BR (1) BR112018011851A2 (es)
CA (1) CA3007893A1 (es)
CL (1) CL2018001573A1 (es)
CO (1) CO2018005983A2 (es)
CR (1) CR20180328A (es)
DO (1) DOP2018000148A (es)
EA (1) EA034514B1 (es)
ES (1) ES2927631T3 (es)
IL (1) IL259818B (es)
MX (1) MX2018007296A (es)
MY (1) MY196276A (es)
NI (1) NI201800071A (es)
PE (1) PE20181319A1 (es)
PH (1) PH12018501237A1 (es)
SG (1) SG11201804587QA (es)
SV (1) SV2018005713A (es)
TN (1) TN2018000188A1 (es)
TW (1) TWI728017B (es)
WO (1) WO2017102784A1 (es)
ZA (1) ZA201804618B (es)

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CN109071516B (zh) 2021-08-31
BR112018011851A2 (pt) 2018-12-04
SG11201804587QA (en) 2018-06-28
SV2018005713A (es) 2018-08-08
AU2016374294A1 (en) 2018-07-19
PH12018501237A1 (en) 2019-02-18
US20200181084A1 (en) 2020-06-11
US20190084934A1 (en) 2019-03-21
CA3007893A1 (en) 2017-06-22
US11453644B1 (en) 2022-09-27
ES2927631T3 (es) 2022-11-08
EA201891342A1 (ru) 2019-01-31
IL259818A (en) 2018-07-31
EP3390396B1 (en) 2022-07-06
AR107054A1 (es) 2018-03-14
TN2018000188A1 (en) 2019-10-04
ZA201804618B (en) 2020-09-30
JP2018537485A (ja) 2018-12-20
CN109071516A (zh) 2018-12-21
KR101947976B1 (ko) 2019-02-13
WO2017102784A1 (en) 2017-06-22
US10011566B2 (en) 2018-07-03
JP6448867B2 (ja) 2019-01-09
US10526286B2 (en) 2020-01-07
DOP2018000148A (es) 2018-07-15
US20170166527A1 (en) 2017-06-15
TWI728017B (zh) 2021-05-21
MX2018007296A (es) 2019-01-10
EA034514B1 (ru) 2020-02-14
NI201800071A (es) 2018-10-18
KR20180086269A (ko) 2018-07-30
CR20180328A (es) 2018-08-09
EP3390396A1 (en) 2018-10-24
CO2018005983A2 (es) 2018-06-20
WO2017102784A9 (en) 2018-04-05
CL2018001573A1 (es) 2018-07-27
US10988445B2 (en) 2021-04-27
IL259818B (en) 2021-05-31
TW201738210A (zh) 2017-11-01
MY196276A (en) 2023-03-24
AU2016374294B2 (en) 2019-06-27

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