PE20180358A1 - Derivados de etinilo - Google Patents
Derivados de etiniloInfo
- Publication number
- PE20180358A1 PE20180358A1 PE2017002460A PE2017002460A PE20180358A1 PE 20180358 A1 PE20180358 A1 PE 20180358A1 PE 2017002460 A PE2017002460 A PE 2017002460A PE 2017002460 A PE2017002460 A PE 2017002460A PE 20180358 A1 PE20180358 A1 PE 20180358A1
- Authority
- PE
- Peru
- Prior art keywords
- ethinyl
- compounds
- ona
- heptan
- pyridin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C11/00—Aliphatic unsaturated hydrocarbons
- C07C11/22—Aliphatic unsaturated hydrocarbons containing carbon-to-carbon triple bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ETINILO DE FORMULA (I) DONDE R1 ES H O FLUOR; n ES 1 O 2. SON COMPUESTOS PREFERIDOS: (1S,5R)-2-METIL-4-(5-(FENILETINIL)PIRIDIN-2-IL)-2,4-DIAZABICICLO[3.2.0]HEPTAN-3-ONA; (1R,5S)-2-(5-((4-FLUOROFENIL)ETINIL)PIRIDIN-2-IL)-4-METIL-2,4-DIAZABICICLO[3.2.0]HEPTAN-3-ONA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE GLUTAMATO METABOTROPICO 5 (mGluR5), ES DECIR ACTUAN COMO MODULADORES ALOSTERICOS NEGATIVOS, SIENDO UTILES EN EL TRATAMIENTO DE LA ANSIEDAD, DOLOR, DEPRESION, ENFERMEDAD DE PARKINSON
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15170401 | 2015-06-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20180358A1 true PE20180358A1 (es) | 2018-02-21 |
Family
ID=53276789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2017002460A PE20180358A1 (es) | 2015-06-03 | 2016-05-31 | Derivados de etinilo |
Country Status (31)
Country | Link |
---|---|
US (2) | US11059766B2 (es) |
EP (1) | EP3303316B1 (es) |
JP (1) | JP6603334B2 (es) |
KR (1) | KR102035048B1 (es) |
CN (1) | CN107849006B (es) |
AR (1) | AR104842A1 (es) |
AU (1) | AU2016273751B2 (es) |
BR (1) | BR112017023894A2 (es) |
CA (1) | CA2985301A1 (es) |
CL (1) | CL2017002969A1 (es) |
CO (1) | CO2017012260A2 (es) |
CR (1) | CR20170536A (es) |
DK (1) | DK3303316T3 (es) |
ES (1) | ES2786673T3 (es) |
HK (1) | HK1249096A1 (es) |
HR (1) | HRP20200638T1 (es) |
HU (1) | HUE048867T2 (es) |
IL (1) | IL255367B (es) |
LT (1) | LT3303316T (es) |
MA (1) | MA42508B1 (es) |
MX (1) | MX2017015043A (es) |
PE (1) | PE20180358A1 (es) |
PH (1) | PH12017502128A1 (es) |
PL (1) | PL3303316T3 (es) |
PT (1) | PT3303316T (es) |
RS (1) | RS60199B1 (es) |
RU (1) | RU2712633C1 (es) |
SI (1) | SI3303316T1 (es) |
TW (1) | TWI589571B (es) |
UA (1) | UA120309C2 (es) |
WO (1) | WO2016193234A1 (es) |
Family Cites Families (49)
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US3549655A (en) * | 1967-12-21 | 1970-12-22 | Dow Chemical Co | N-(substituted phenyl) cyclobutanedicarboximides |
FI90869C (fi) | 1986-11-14 | 1994-04-11 | Tanabe Seiyaku Co | Menetelmä lääkeaineena käyttökelpoisten imidatsolidinonijohdannaisten valmistamiseksi |
JP3213780B2 (ja) | 1993-12-21 | 2001-10-02 | キヤノン株式会社 | 光学活性化合物、これを含有する液晶組成物、該液晶組成物を用いた液晶素子並びにこれらを用いた表示方法、表示装置 |
GB9510744D0 (en) | 1995-05-26 | 1995-07-19 | Zeneca Ltd | Chemical process |
JPH09151179A (ja) | 1995-11-30 | 1997-06-10 | Canon Inc | 光学活性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた液晶装置及び表示方法 |
JP2002526408A (ja) | 1998-10-02 | 2002-08-20 | ノバルティス アクチエンゲゼルシャフト | 疼痛および不安の処置のためのmglur5アンタゴニスト |
EP1214303A1 (en) | 1999-08-31 | 2002-06-19 | Merck & Co., Inc. | Heterocyclic compounds and methods of use thereof |
CN100334085C (zh) | 1999-09-28 | 2007-08-29 | 卫材R&D管理有限公司 | 奎宁环化合物和包含该化合物作为活性成分的药物 |
WO2002014517A1 (en) | 2000-08-11 | 2002-02-21 | Monsanto Technology Llc | BROAD-SPECTRUM δ-ENDOTOXINS |
US6410728B1 (en) | 2000-08-31 | 2002-06-25 | Abbott Laboratories | Oxazolidinone chemotherapeutic agents |
GB0103045D0 (en) * | 2001-02-07 | 2001-03-21 | Novartis Ag | Organic Compounds |
EP1375496B1 (en) | 2001-03-27 | 2007-07-04 | Eisai R&D Management Co., Ltd. | N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient |
WO2002078745A2 (en) | 2001-04-02 | 2002-10-10 | Brown University Research Foundation | Use of mglur5 antagonists in the manufacture of a medicament in the treatment of autism, mental retardation, schizophrenia |
EP1556142A4 (en) | 2002-10-24 | 2006-11-08 | Merck & Co Inc | ALKYNE DERIVATIVES AS MARKERS FOR METABOTROPIC GLUTAMATE RECEPTOR BINDING |
DE10250708A1 (de) | 2002-10-31 | 2004-05-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
ATE445399T1 (de) | 2004-03-22 | 2009-10-15 | Lilly Co Eli | Pyridyl-derivate und ihre verwendung als mglu5- rezeptorantagonisten |
WO2005108370A1 (ja) | 2004-04-16 | 2005-11-17 | Ajinomoto Co., Inc. | ベンゼン化合物 |
AU2005336513B2 (en) | 2004-10-07 | 2012-08-09 | Merck Sharp & Dohme Llc | Thiazolyl mGluR5 antagonists and methods for their use |
WO2006048771A1 (en) | 2004-11-04 | 2006-05-11 | Addex Pharmaceuticals Sa | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
GB0514296D0 (en) | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
MX2008002063A (es) | 2005-08-19 | 2008-04-16 | Astrazeneca Ab | Derivados de pirazolona para el tratamiento de tuberculosis. |
WO2007035823A2 (en) * | 2005-09-20 | 2007-03-29 | Molecular Neuroimaging, Llc | Partial mglur5 antagonists and methods of use thereof |
EA200971143A1 (ru) | 2007-06-03 | 2010-06-30 | Вандербилт Юниверсити | Бензамидные mglur5 позитивные аллостерические модуляторы и способы их получения и применения |
US8853392B2 (en) | 2007-06-03 | 2014-10-07 | Vanderbilt University | Benzamide mGluR5 positive allosteric modulators and methods of making and using same |
US8034806B2 (en) | 2007-11-02 | 2011-10-11 | Vanderbilt University | Bicyclic mGluR5 positive allosteric modulators and methods of making and using same |
JP2011511030A (ja) | 2008-02-05 | 2011-04-07 | ノイロサーチ アクティーゼルスカブ | 8−アザ−ビシクロ[3.2.1]オクタンの新規なフェニルエチニル誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用 |
WO2010063487A1 (en) | 2008-12-05 | 2010-06-10 | Merz Pharma Gmbh & Co. Kgaa | Pyrazolopyrimidines, a process for their preparation and their use as medicine |
TW201116532A (en) | 2009-08-05 | 2011-05-16 | Merz Pharma Gmbh & Co Kgaa | Metabotropic glutamate receptor modulators |
US8389536B2 (en) | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
US8586581B2 (en) | 2009-12-17 | 2013-11-19 | Hoffmann-La Roche Inc | Ethynyl compounds useful for treatment of CNS disorders |
US8420661B2 (en) | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
EP2590985B1 (en) | 2010-07-09 | 2014-05-14 | Recordati Ireland Limited | Novel spiroheterocyclic compounds as mglu5 antagonists |
EP2599775A4 (en) | 2010-07-29 | 2014-04-30 | Taisho Pharmaceutical Co Ltd | ETHINYLPYRAZOLDERIVAT |
US8691821B2 (en) | 2010-11-11 | 2014-04-08 | Bristol-Myers Squibb Company | Oxazolidinones as modulators of mGluR5 |
US8772300B2 (en) | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
MY163164A (en) * | 2011-04-26 | 2017-08-15 | Hoffmann La Roche | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
ES2580333T3 (es) | 2011-04-26 | 2016-08-23 | F. Hoffmann-La Roche Ag | Derivados de pirazolidin-3-ona |
US20130123254A1 (en) | 2011-09-30 | 2013-05-16 | Barbara Biemans | Pharmaceutically acceptable mglur5 positive allosteric modulators and their methods of identification |
UA110862C2 (uk) | 2011-10-07 | 2016-02-25 | Ф. Хоффманн-Ля Рош Аг | Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5 |
UA110995C2 (uk) | 2011-10-07 | 2016-03-10 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як модулятори метаботропного глутаматного рецептора |
UA114911C2 (uk) | 2012-07-17 | 2017-08-28 | Ф. Хоффманн-Ля Рош Аг | Арилетинілові похідні |
UA113223C2 (xx) | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
MX366136B (es) * | 2012-09-27 | 2019-06-28 | Hoffmann La Roche | Derivados de ariletinilo. |
MY171517A (en) | 2012-10-18 | 2019-10-16 | Hoffmann La Roche | Ethynyl derivatives as modulators of mglur5 receptor activity |
AU2013333988B2 (en) * | 2012-10-18 | 2017-03-09 | F. Hoffmann-La Roche Ag | Ethynyl derivatives as modulators of mGluR5 receptor activity |
UA116023C2 (uk) | 2013-07-08 | 2018-01-25 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як антагоністи метаботропного глутаматного рецептора |
PL3110802T3 (pl) | 2014-02-25 | 2019-03-29 | F. Hoffmann-La Roche Ag | Pochodne etynylowe |
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2016
- 2016-05-31 BR BR112017023894-2A patent/BR112017023894A2/pt not_active Application Discontinuation
- 2016-05-31 PT PT167276617T patent/PT3303316T/pt unknown
- 2016-05-31 CN CN201680027269.6A patent/CN107849006B/zh active Active
- 2016-05-31 SI SI201630723T patent/SI3303316T1/sl unknown
- 2016-05-31 LT LTEP16727661.7T patent/LT3303316T/lt unknown
- 2016-05-31 KR KR1020177036318A patent/KR102035048B1/ko active IP Right Grant
- 2016-05-31 CR CR20170536A patent/CR20170536A/es unknown
- 2016-05-31 CA CA2985301A patent/CA2985301A1/en not_active Abandoned
- 2016-05-31 RS RS20200456A patent/RS60199B1/sr unknown
- 2016-05-31 DK DK16727661.7T patent/DK3303316T3/da active
- 2016-05-31 EP EP16727661.7A patent/EP3303316B1/en active Active
- 2016-05-31 JP JP2017561662A patent/JP6603334B2/ja active Active
- 2016-05-31 WO PCT/EP2016/062202 patent/WO2016193234A1/en active Application Filing
- 2016-05-31 AU AU2016273751A patent/AU2016273751B2/en not_active Ceased
- 2016-05-31 PE PE2017002460A patent/PE20180358A1/es unknown
- 2016-05-31 ES ES16727661T patent/ES2786673T3/es active Active
- 2016-05-31 RU RU2017144620A patent/RU2712633C1/ru active
- 2016-05-31 PL PL16727661T patent/PL3303316T3/pl unknown
- 2016-05-31 UA UAA201713000A patent/UA120309C2/uk unknown
- 2016-05-31 MX MX2017015043A patent/MX2017015043A/es unknown
- 2016-05-31 MA MA42508A patent/MA42508B1/fr unknown
- 2016-05-31 HU HUE16727661A patent/HUE048867T2/hu unknown
- 2016-06-01 AR ARP160101596A patent/AR104842A1/es unknown
- 2016-06-02 TW TW105117451A patent/TWI589571B/zh not_active IP Right Cessation
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2017
- 2017-11-01 IL IL255367A patent/IL255367B/en active IP Right Grant
- 2017-11-22 PH PH12017502128A patent/PH12017502128A1/en unknown
- 2017-11-22 CL CL2017002969A patent/CL2017002969A1/es unknown
- 2017-11-29 CO CONC2017/0012260A patent/CO2017012260A2/es unknown
- 2017-12-01 US US15/829,481 patent/US11059766B2/en active Active
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2018
- 2018-07-03 HK HK18108573.8A patent/HK1249096A1/zh unknown
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2020
- 2020-04-22 HR HRP20200638TT patent/HRP20200638T1/hr unknown
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2021
- 2021-06-03 US US17/338,643 patent/US20210300844A1/en active Pending
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