PE20141556A1 - Derivados de etinilo como moduladores alostericos de mglur5 - Google Patents
Derivados de etinilo como moduladores alostericos de mglur5Info
- Publication number
- PE20141556A1 PE20141556A1 PE2014000496A PE2014000496A PE20141556A1 PE 20141556 A1 PE20141556 A1 PE 20141556A1 PE 2014000496 A PE2014000496 A PE 2014000496A PE 2014000496 A PE2014000496 A PE 2014000496A PE 20141556 A1 PE20141556 A1 PE 20141556A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxy
- independently
- mglur5
- compounds
- Prior art date
Links
- 101150087728 Grm5 gene Proteins 0.000 title 1
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 abstract 2
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 abstract 2
- 101000977048 Streptomyces cinnamonensis Uncharacterized protein in mutB 3'region Proteins 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 206010003805 Autism Diseases 0.000 abstract 1
- 208000020706 Autistic disease Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11184331 | 2011-10-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20141556A1 true PE20141556A1 (es) | 2014-10-30 |
Family
ID=46968237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2014000496A PE20141556A1 (es) | 2011-10-07 | 2012-10-04 | Derivados de etinilo como moduladores alostericos de mglur5 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8969338B2 (OSRAM) |
| EP (1) | EP2763977B1 (OSRAM) |
| JP (1) | JP5840793B2 (OSRAM) |
| KR (1) | KR101637792B1 (OSRAM) |
| CN (1) | CN103857668B (OSRAM) |
| AR (1) | AR088246A1 (OSRAM) |
| AU (1) | AU2012320598B2 (OSRAM) |
| BR (1) | BR112014007898A2 (OSRAM) |
| CA (1) | CA2850082C (OSRAM) |
| CL (1) | CL2014000819A1 (OSRAM) |
| CO (1) | CO6900143A2 (OSRAM) |
| CR (1) | CR20140094A (OSRAM) |
| EA (1) | EA024973B1 (OSRAM) |
| EC (1) | ECSP14013296A (OSRAM) |
| ES (1) | ES2564884T3 (OSRAM) |
| IL (1) | IL231783A (OSRAM) |
| IN (1) | IN2014CN02478A (OSRAM) |
| MX (1) | MX360667B (OSRAM) |
| MY (1) | MY170822A (OSRAM) |
| PE (1) | PE20141556A1 (OSRAM) |
| PH (1) | PH12014500775A1 (OSRAM) |
| SG (1) | SG11201401322UA (OSRAM) |
| TW (1) | TWI468401B (OSRAM) |
| UA (1) | UA110862C2 (OSRAM) |
| WO (1) | WO2013050454A1 (OSRAM) |
| ZA (1) | ZA201402069B (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| KR20150070102A (ko) * | 2012-10-18 | 2015-06-24 | 에프. 호프만-라 로슈 아게 | mGluR5 수용체 활성의 조절제로서 에틴일 유도체 |
| UA116023C2 (uk) * | 2013-07-08 | 2018-01-25 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як антагоністи метаботропного глутаматного рецептора |
| JP6134441B2 (ja) * | 2013-09-25 | 2017-05-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | エチニル誘導体 |
| PT3303316T (pt) | 2015-06-03 | 2020-04-27 | Hoffmann La Roche | Derivados de etinilo |
| RS58929B1 (sr) | 2015-07-15 | 2019-08-30 | Hoffmann La Roche | Derivati etinila kao modulatori metabotropnih glutamatnih receptora |
| CN106632243B (zh) * | 2015-10-28 | 2019-03-15 | 华领医药技术（上海）有限公司 | 吡咯烷衍生物 |
| SI3484889T1 (sl) | 2016-07-18 | 2020-11-30 | F. Hoffmann-La Roche Ag | Derivati etinila |
| JP7364553B2 (ja) * | 2017-08-17 | 2023-10-18 | エフ． ホフマン－ラ ロシュ アーゲー | パーキンソン病等の疾患を処置するためのイミダゾ［１，２－ａ］イミダゾール－２－オン誘導体 |
| EP4049661A4 (en) * | 2019-10-21 | 2023-11-08 | SK Biopharmaceuticals Co., Ltd. | USE OF AN IMIDAZOPYRIMIDINE OR IMIDAZOTRIAZINE COMPOUND TO PREVENT, RELIEF OR TREAT DEVELOPMENTAL DISABILITIES |
| KR20230122080A (ko) | 2020-12-17 | 2023-08-22 | 아스트라제네카 아베 | N-(2-(4-시아노티아졸리딘-3-일)-2-옥소에틸)-퀴놀린-4-카르복스아미드 |
| US20240343707A1 (en) * | 2023-04-11 | 2024-10-17 | Southern Research Institute | Substituted phenyl ethynyl pyrimidines as potent inhibitors of alphaviruses |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3213780B2 (ja) | 1993-12-21 | 2001-10-02 | キヤノン株式会社 | 光学活性化合物、これを含有する液晶組成物、該液晶組成物を用いた液晶素子並びにこれらを用いた表示方法、表示装置 |
| JPH09151179A (ja) | 1995-11-30 | 1997-06-10 | Canon Inc | 光学活性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた液晶装置及び表示方法 |
| US6410728B1 (en) | 2000-08-31 | 2002-06-25 | Abbott Laboratories | Oxazolidinone chemotherapeutic agents |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| WO2006048771A1 (en) | 2004-11-04 | 2006-05-11 | Addex Pharmaceuticals Sa | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| NZ581817A (en) | 2007-06-03 | 2012-05-25 | Univ Vanderbilt | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
| US8389536B2 (en) | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| US8586581B2 (en) * | 2009-12-17 | 2013-11-19 | Hoffmann-La Roche Inc | Ethynyl compounds useful for treatment of CNS disorders |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| US8772300B2 (en) * | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
| EA023146B1 (ru) * | 2011-04-26 | 2016-04-29 | Ф.Хоффманн-Ля Рош Аг | Производные пиразолидин-3-она |
| SI2702051T1 (sl) * | 2011-04-26 | 2015-06-30 | F. Hoffmann-La Roche Ag | Etinilni derivati kot pozitivni alosteriäśni modulatorji mglur5 |
-
2012
- 2012-04-10 UA UAA201404621A patent/UA110862C2/uk unknown
- 2012-09-27 US US13/628,136 patent/US8969338B2/en active Active
- 2012-10-04 MY MYPI2014001004A patent/MY170822A/en unknown
- 2012-10-04 PH PH1/2014/500775A patent/PH12014500775A1/en unknown
- 2012-10-04 PE PE2014000496A patent/PE20141556A1/es active IP Right Grant
- 2012-10-04 SG SG11201401322UA patent/SG11201401322UA/en unknown
- 2012-10-04 CA CA2850082A patent/CA2850082C/en not_active Expired - Fee Related
- 2012-10-04 ES ES12767005.7T patent/ES2564884T3/es active Active
- 2012-10-04 TW TW101136749A patent/TWI468401B/zh not_active IP Right Cessation
- 2012-10-04 AU AU2012320598A patent/AU2012320598B2/en not_active Ceased
- 2012-10-04 WO PCT/EP2012/069599 patent/WO2013050454A1/en not_active Ceased
- 2012-10-04 KR KR1020147011355A patent/KR101637792B1/ko not_active Expired - Fee Related
- 2012-10-04 EA EA201490722A patent/EA024973B1/ru not_active IP Right Cessation
- 2012-10-04 JP JP2014533884A patent/JP5840793B2/ja not_active Expired - Fee Related
- 2012-10-04 EP EP12767005.7A patent/EP2763977B1/en active Active
- 2012-10-04 IN IN2478CHN2014 patent/IN2014CN02478A/en unknown
- 2012-10-04 CN CN201280049430.1A patent/CN103857668B/zh not_active Expired - Fee Related
- 2012-10-04 MX MX2014004144A patent/MX360667B/es active IP Right Grant
- 2012-10-04 BR BR112014007898A patent/BR112014007898A2/pt not_active IP Right Cessation
- 2012-10-05 AR ARP120103716A patent/AR088246A1/es unknown
-
2014
- 2014-02-26 CR CR20140094A patent/CR20140094A/es unknown
- 2014-02-28 CO CO14043450A patent/CO6900143A2/es active IP Right Grant
- 2014-03-20 ZA ZA2014/02069A patent/ZA201402069B/en unknown
- 2014-03-27 IL IL231783A patent/IL231783A/en active IP Right Grant
- 2014-04-03 CL CL2014000819A patent/CL2014000819A1/es unknown
- 2014-04-07 EC ECSP14013296 patent/ECSP14013296A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |