IN2014CN02478A - - Google Patents
Download PDFInfo
- Publication number
- IN2014CN02478A IN2014CN02478A IN2478CHN2014A IN2014CN02478A IN 2014CN02478 A IN2014CN02478 A IN 2014CN02478A IN 2478CHN2014 A IN2478CHN2014 A IN 2478CHN2014A IN 2014CN02478 A IN2014CN02478 A IN 2014CN02478A
- Authority
- IN
- India
- Prior art keywords
- lower alkyl
- hydrogen
- cycloalkyl
- attached
- form together
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The present invention relates to ethynyl derivatives of formula (I) wherein U is N or CH R is hydrogen halogen lower alkyl or lower alkoxy;Y is N(R) O or C(RR ) ; wherein R4 is hydrogen or lower alkyl and R/R are independently hydrogen hydroxy lower alkyl or lower alkoxy; V is N(R) or C(RR) wherein R6 is hydrogen or lower alkyl and R/R are independently from each other hydrogen lower alkyl CH lower alkoxy or may form together with the carbon atom to which they are attached a C C cycloalkyl; R is phenyl or heteroaryl which are optionally substituted by halogen lower alkyl or lower alkoxy; m is 0 or 1; in case m is 1 R/R are independently from each other hydrogen lower alkyl CH lower alkoxy or may form together with the carbon atom to which they are attached a C C cycloalkyl; n is 0 or 1; in case n is 1 R/R are independently from each other hydrogen lower alkyl CH lower alkoxy or may form together with the carbon atom to which they are attached a C C cycloalkyl; or if m is 1 and n is 0 R and R may form together with the carbon atoms to which they are attached a C cycloalkyl; or if m is 1 and n is 1 R and R or R and R may form together with the carbon atoms to which they are attached a C cycloalkyl; or to a pharmaceutically acceptable acid addition salt to a racemic mixture or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has been found that the compounds of general formula (I) are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11184331 | 2011-10-07 | ||
| PCT/EP2012/069599 WO2013050454A1 (en) | 2011-10-07 | 2012-10-04 | Ethynyl derivatives as mglur5 allosteric modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2014CN02478A true IN2014CN02478A (en) | 2015-06-19 |
Family
ID=46968237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN2478CHN2014 IN2014CN02478A (en) | 2011-10-07 | 2012-10-04 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8969338B2 (en) |
| EP (1) | EP2763977B1 (en) |
| JP (1) | JP5840793B2 (en) |
| KR (1) | KR101637792B1 (en) |
| CN (1) | CN103857668B (en) |
| AR (1) | AR088246A1 (en) |
| AU (1) | AU2012320598B2 (en) |
| BR (1) | BR112014007898A2 (en) |
| CA (1) | CA2850082C (en) |
| CL (1) | CL2014000819A1 (en) |
| CO (1) | CO6900143A2 (en) |
| CR (1) | CR20140094A (en) |
| EA (1) | EA024973B1 (en) |
| EC (1) | ECSP14013296A (en) |
| ES (1) | ES2564884T3 (en) |
| HK (1) | HK1195298A1 (en) |
| IL (1) | IL231783A (en) |
| IN (1) | IN2014CN02478A (en) |
| MX (1) | MX360667B (en) |
| MY (1) | MY170822A (en) |
| PE (1) | PE20141556A1 (en) |
| SG (1) | SG11201401322UA (en) |
| TW (1) | TWI468401B (en) |
| UA (1) | UA110862C2 (en) |
| WO (1) | WO2013050454A1 (en) |
| ZA (1) | ZA201402069B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| UA113223C2 (en) * | 2012-08-13 | 2016-12-26 | ARYLETINYLPYRIMIDINE | |
| AU2013331782B2 (en) * | 2012-10-18 | 2017-03-09 | F. Hoffmann-La Roche Ag | Ethynyl derivatives as modulators of mGluR5 receptor activity |
| UA116023C2 (en) * | 2013-07-08 | 2018-01-25 | Ф. Хоффманн-Ля Рош Аг | Ethynyl derivatives as metabotropic glutamate receptor antagonists |
| AU2014327504B2 (en) * | 2013-09-25 | 2018-01-04 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| CR20170536A (en) | 2015-06-03 | 2018-02-01 | Hoffmann La Roche | ETHYLENE DERIVATIVES |
| MA42442B1 (en) | 2015-07-15 | 2019-07-31 | Hoffmann La Roche | Ethynyl derivatives as modulators of the metabotropic glutamate receptor |
| CN106632243B (en) * | 2015-10-28 | 2019-03-15 | 华领医药技术（上海）有限公司 | Pyrrolidin derivatives |
| RU2745068C2 (en) | 2016-07-18 | 2021-03-18 | Ф. Хоффманн-Ля Рош Аг | Ethinyl derivatives |
| WO2019034713A1 (en) | 2017-08-17 | 2019-02-21 | F. Hoffmann-La Roche Ag | Imidazo[1,2-a]imidazol-2-one derivatives for the treatment of diseases such as parkinson's disease |
| PE20232046A1 (en) | 2020-12-17 | 2023-12-27 | Astrazeneca Ab | N-(2-(4-CYANOTHIAZOLIDIN-3-IL)-2-OXOETIL)-QUINOLIN-4-CARBOXAMIDES |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3213780B2 (en) | 1993-12-21 | 2001-10-02 | キヤノン株式会社 | Optically active compound, liquid crystal composition containing the same, liquid crystal element using the liquid crystal composition, display method and display device using the same |
| JPH09151179A (en) | 1995-11-30 | 1997-06-10 | Canon Inc | Optically active compound, liquid crystal composition containing the same, liquid crystal element having the composition, liquid crystal apparatus and displaying method using them |
| US6410728B1 (en) | 2000-08-31 | 2002-06-25 | Abbott Laboratories | Oxazolidinone chemotherapeutic agents |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| EP1809620B1 (en) | 2004-11-04 | 2010-12-29 | Addex Pharma SA | Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors |
| GB0510139D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B1 |
| EA200971143A1 (en) * | 2007-06-03 | 2010-06-30 | Вандербилт Юниверсити | BENZAMIDE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS FOR THEIR RECEIVING AND APPLICATION |
| US8389536B2 (en) | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
| US8586581B2 (en) * | 2009-12-17 | 2013-11-19 | Hoffmann-La Roche Inc | Ethynyl compounds useful for treatment of CNS disorders |
| US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| US8772300B2 (en) * | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
| DK2702051T3 (en) * | 2011-04-26 | 2015-03-16 | Hoffmann La Roche | Ethynyl derivatives AS POSITIVE allosteric modulators mGluR5 |
| MY165141A (en) * | 2011-04-26 | 2018-02-28 | Hoffmann La Roche | Pyrazolidin-3-one derivatives |
-
2012
- 2012-04-10 UA UAA201404621A patent/UA110862C2/en unknown
- 2012-09-27 US US13/628,136 patent/US8969338B2/en active Active
- 2012-10-04 ES ES12767005.7T patent/ES2564884T3/en active Active
- 2012-10-04 AU AU2012320598A patent/AU2012320598B2/en not_active Ceased
- 2012-10-04 WO PCT/EP2012/069599 patent/WO2013050454A1/en active Application Filing
- 2012-10-04 EA EA201490722A patent/EA024973B1/en not_active IP Right Cessation
- 2012-10-04 JP JP2014533884A patent/JP5840793B2/en active Active
- 2012-10-04 IN IN2478CHN2014 patent/IN2014CN02478A/en unknown
- 2012-10-04 CN CN201280049430.1A patent/CN103857668B/en active Active
- 2012-10-04 KR KR1020147011355A patent/KR101637792B1/en active IP Right Grant
- 2012-10-04 CA CA2850082A patent/CA2850082C/en not_active Expired - Fee Related
- 2012-10-04 PE PE2014000496A patent/PE20141556A1/en active IP Right Grant
- 2012-10-04 SG SG11201401322UA patent/SG11201401322UA/en unknown
- 2012-10-04 EP EP12767005.7A patent/EP2763977B1/en active Active
- 2012-10-04 MY MYPI2014001004A patent/MY170822A/en unknown
- 2012-10-04 MX MX2014004144A patent/MX360667B/en active IP Right Grant
- 2012-10-04 TW TW101136749A patent/TWI468401B/en not_active IP Right Cessation
- 2012-10-04 BR BR112014007898A patent/BR112014007898A2/en not_active IP Right Cessation
- 2012-10-05 AR ARP120103716A patent/AR088246A1/en unknown
-
2014
- 2014-02-26 CR CR20140094A patent/CR20140094A/en unknown
- 2014-02-28 CO CO14043450A patent/CO6900143A2/en active IP Right Grant
- 2014-03-20 ZA ZA2014/02069A patent/ZA201402069B/en unknown
- 2014-03-27 IL IL231783A patent/IL231783A/en active IP Right Grant
- 2014-04-03 CL CL2014000819A patent/CL2014000819A1/en unknown
- 2014-04-07 EC ECSP14013296 patent/ECSP14013296A/en unknown
- 2014-07-08 HK HK14106907.3A patent/HK1195298A1/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2014CN02478A (en) | ||
| PH12018500106A1 (en) | Ethynyl derivatives as metabotropic glutamate receptor modulators | |
| AR080878A1 (en) | HETEROCICLIC DERIVATIVES OF ARYLETINYL, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, METHOD FOR PREPARING THEM AND USE OF THE SAME IN THE TREATMENT OF CHICHOPHRENIA AND COGNITIVE DISORDERS. | |
| EA201391537A1 (en) | ETHYNAL DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS mGluR5 | |
| MY162998A (en) | Ethynyl derivatives | |
| MX338631B (en) | 5-(phenyl/pyridinyl-ethinyl)-2-pyridine/ 2-pyrimidine-carborxamid es as mglur5 modulators. | |
| AR085088A1 (en) | INHIBITORS OF HISTONA DEACETILASE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| MY165141A (en) | Pyrazolidin-3-one derivatives | |
| PH12016500427A1 (en) | Ethynyl derivatives | |
| IN2014CN02477A (en) | ||
| PH12014502695A1 (en) | Arylethynyl derivatives | |
| PH12015500261A1 (en) | Arylethynyl pyrimidines | |
| PH12015500538B1 (en) | Arylethynyl derivatives |