PE20130808A1 - Derivados de cis-tetrahidro-espiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4-amina - Google Patents

Derivados de cis-tetrahidro-espiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4-amina

Info

Publication number
PE20130808A1
PE20130808A1 PE2013000150A PE2013000150A PE20130808A1 PE 20130808 A1 PE20130808 A1 PE 20130808A1 PE 2013000150 A PE2013000150 A PE 2013000150A PE 2013000150 A PE2013000150 A PE 2013000150A PE 20130808 A1 PE20130808 A1 PE 20130808A1
Authority
PE
Peru
Prior art keywords
cyclohexan
indol
tetrahidro
pirido
spiro
Prior art date
Application number
PE2013000150A
Other languages
English (en)
Inventor
Klaus Linz
Saskia Zemolka
Bert Nolte
Stefan Schunk
Hans Schick
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44315152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20130808(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20130808A1 publication Critical patent/PE20130808A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A DERIVADOS DE CIS-TETRAHIDRO-ESPIRO(CICLOHEXAN-1,1'-PIRIDO[3,4-B]INDOL)-4-AMINA, CARACTERIZADOS PORQUE COMPRENDEN COMPUESTOS DE FORMULA GENERAL (I), EN DONDE R1 ES HIDROGENO, CH3; R2 Y R3 SON H, HALOGENO; R4 Y R5 ES H, HALOGENO, ALQUILO C1-C3, ENTRE OTROS; Q1-Q2 FORMAN -CH2-, -CR6=CH-; R6 Y R7 SON H, JUNTOS FORMAN UN ANILLO DE CINCO ELEMENTOS SOBRE EL PUENTE -S-, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(4-CLOROFENIL)-1-((1s,4s)-4-(DIMETILAMINO)-4-(3-FLUOROFENIL)-3',4'-DIHIDRO-ESPIRO[CICLOHEXAN-1,1'-PIRIDO[3,4-b]INDOL]-2'(9'H)-IL)ETANONA; BENZO[b]TIOFEN-2IL((1s,4s)-4-(DIMETILAMINO)-4-(3-FLUOROFENIL)-3',4'-DIHIDRO-ESPIRO[CICLOHEXAN-1,1'-PIRIDO[3,4-b]INDOL]-2'(9'H)-IL)METANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA FORMULACION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DEL DOLOR NEUROPATICO Y CRONICO.
PE2013000150A 2010-07-28 2011-07-27 Derivados de cis-tetrahidro-espiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4-amina PE20130808A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10007822 2010-07-28

Publications (1)

Publication Number Publication Date
PE20130808A1 true PE20130808A1 (es) 2013-07-06

Family

ID=44315152

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013000150A PE20130808A1 (es) 2010-07-28 2011-07-27 Derivados de cis-tetrahidro-espiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4-amina

Country Status (32)

Country Link
US (3) US20120029006A1 (es)
EP (2) EP2598503B1 (es)
JP (1) JP5898193B2 (es)
KR (1) KR101927054B1 (es)
CN (1) CN103025732B (es)
AR (1) AR082393A1 (es)
AU (1) AU2011285217B8 (es)
BR (1) BR112013003642A2 (es)
CA (1) CA2806633C (es)
CL (1) CL2013000266A1 (es)
CO (1) CO6650378A2 (es)
CY (2) CY1115186T1 (es)
DK (2) DK2740476T3 (es)
EC (1) ECSP13012409A (es)
ES (2) ES2708930T3 (es)
HK (1) HK1183660A1 (es)
HR (2) HRP20140569T1 (es)
HU (1) HUE042732T2 (es)
IL (1) IL223756A (es)
LT (1) LT2740476T (es)
MX (1) MX2013000751A (es)
NZ (1) NZ607529A (es)
PE (1) PE20130808A1 (es)
PL (2) PL2598503T3 (es)
PT (2) PT2598503E (es)
RS (2) RS53341B (es)
RU (1) RU2592283C2 (es)
SI (2) SI2740476T1 (es)
TR (1) TR201821273T4 (es)
TW (1) TWI582092B (es)
WO (1) WO2012013343A1 (es)
ZA (1) ZA201301505B (es)

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ES2658193T3 (es) * 2013-03-15 2018-03-08 Grünenthal GmbH Cis-(E)-4-(3-fluorofenil)-2',3',4',9'-tetrahidro-N,N-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclohexano-1,1'[1H]-pirido[3,4-b]indol]-4-amina cristalina
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
TWI654181B (zh) 2016-01-13 2019-03-21 歌林達有限公司 ８－胺基－２－側氧基－１，３－二氮－螺－［４．５］－癸烷衍生物
TWI635082B (zh) 2016-01-13 2018-09-11 歌林達有限公司 ３－（（雜－）芳基）－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物
HUE049134T2 (hu) * 2016-01-13 2020-08-28 Gruenenthal Gmbh 3-(karboximetil)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-dekán származékok
AU2017206909B2 (en) 2016-01-13 2020-07-09 Grünenthal GmbH 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
AU2017207467B2 (en) 2016-01-13 2020-07-16 Grünenthal GmbH 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
RU2743513C2 (ru) 2016-01-26 2021-02-19 Интра-Селлулар Терапиз, Инк. Органические соединения
TW201832765A (zh) 2017-02-24 2018-09-16 德商歌林達有限公司 膀胱內投藥用於治療膀胱痛之組合物
TW201908295A (zh) 2017-07-12 2019-03-01 德商歌林達有限公司 １，３－二氮雜－螺－［３．４］－辛烷衍生物
JP2019073493A (ja) * 2017-10-17 2019-05-16 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヴルヴォディニアの治療
WO2020030777A1 (en) 2018-08-10 2020-02-13 Grünenthal GmbH Composition for treating urinary frequency and/or urinary urgency
KR20210148318A (ko) * 2019-04-04 2021-12-07 인트라-셀룰라 써래피스, 인코퍼레이티드. 신경병증성 통증 치료 방법
JP2023508469A (ja) 2019-12-26 2023-03-02 ギルガメッシュ・ファーマシューティカルズ・インコーポレイテッド アリールシクロヘキシルアミン誘導体及び精神障害の処置におけるそれらの使用
RU2725197C1 (ru) * 2020-02-12 2020-06-30 федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации Метод оценки висцеральной гиперчувствительности
CN115135320B (zh) 2020-02-18 2023-08-29 吉尔伽美什制药公司 用于治疗情绪障碍的特定色胺

Family Cites Families (17)

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DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10323172A1 (de) 2003-05-22 2004-12-09 Ina-Schaeffler Kg Treiberstufe für ein Solenoidventil
DE10360792A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360793A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102004019502A1 (de) 2004-04-22 2005-11-17 Rheinmetall Landsysteme Gmbh Munitionsmagazin
DE102004039382A1 (de) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US8425881B2 (en) 2005-03-18 2013-04-23 Colgate-Palmolive Company Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
EP1869344A2 (en) 2005-04-12 2007-12-26 The Ohio State University All wheel drive electrically-variable transmission
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DE102006019597A1 (de) * 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de) 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
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NZ587831A (en) * 2008-03-27 2012-03-30 Gruenenthal Chemie Substituted spirocyclic cyclohexane derivatives
ES2658193T3 (es) * 2013-03-15 2018-03-08 Grünenthal GmbH Cis-(E)-4-(3-fluorofenil)-2',3',4',9'-tetrahidro-N,N-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclohexano-1,1'[1H]-pirido[3,4-b]indol]-4-amina cristalina

Also Published As

Publication number Publication date
HRP20140569T1 (hr) 2014-08-15
HRP20182078T1 (hr) 2019-02-08
RS58036B1 (sr) 2019-02-28
AU2011285217A8 (en) 2014-04-24
MX2013000751A (es) 2013-01-29
CY1115186T1 (el) 2017-01-04
CA2806633C (en) 2019-08-20
PL2740476T3 (pl) 2019-06-28
RU2592283C2 (ru) 2016-07-20
ES2708930T3 (es) 2019-04-12
DK2740476T3 (en) 2019-01-14
CY1120993T1 (el) 2019-12-11
JP5898193B2 (ja) 2016-04-06
EP2740476B1 (de) 2018-12-05
AU2011285217B2 (en) 2014-04-10
KR101927054B1 (ko) 2018-12-10
EP2740476A1 (de) 2014-06-11
RU2013108696A (ru) 2014-09-10
EP2598503A1 (de) 2013-06-05
PT2598503E (pt) 2014-05-06
LT2740476T (lt) 2018-12-27
SI2598503T1 (sl) 2014-05-30
TWI582092B (zh) 2017-05-11
US20160159787A1 (en) 2016-06-09
NZ607529A (en) 2014-05-30
JP2013532669A (ja) 2013-08-19
PT2740476T (pt) 2019-03-18
DK2598503T3 (da) 2014-04-14
TW201204724A (en) 2012-02-01
PL2598503T3 (pl) 2014-08-29
ZA201301505B (en) 2014-08-27
US20120029006A1 (en) 2012-02-02
BR112013003642A2 (pt) 2016-09-06
CN103025732B (zh) 2016-06-01
SI2740476T1 (sl) 2019-02-28
HUE042732T2 (hu) 2019-07-29
EP2598503B1 (de) 2014-03-26
WO2012013343A1 (de) 2012-02-02
US20170313703A1 (en) 2017-11-02
KR20130098315A (ko) 2013-09-04
AU2011285217A1 (en) 2013-03-14
RS53341B (en) 2014-10-31
IL223756A (en) 2015-06-30
TR201821273T4 (tr) 2019-01-21
CA2806633A1 (en) 2012-02-02
AR082393A1 (es) 2012-12-05
CL2013000266A1 (es) 2013-05-24
CO6650378A2 (es) 2013-04-15
ES2474644T3 (es) 2014-07-09
ECSP13012409A (es) 2013-06-28
AU2011285217B8 (en) 2014-04-24
HK1183660A1 (en) 2014-01-03
CN103025732A (zh) 2013-04-03

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