TR201821273T4 - Cis-tetrahidro-spiro(sikloheksan-1,1'-pirido [3,4-b] indol)-4-amin türevleri. - Google Patents

Cis-tetrahidro-spiro(sikloheksan-1,1'-pirido [3,4-b] indol)-4-amin türevleri. Download PDF

Info

Publication number
TR201821273T4
TR201821273T4 TR2018/21273T TR201821273T TR201821273T4 TR 201821273 T4 TR201821273 T4 TR 201821273T4 TR 2018/21273 T TR2018/21273 T TR 2018/21273T TR 201821273 T TR201821273 T TR 201821273T TR 201821273 T4 TR201821273 T4 TR 201821273T4
Authority
TR
Turkey
Prior art keywords
pyrido
indole
cyclohexane
gen
cis
Prior art date
Application number
TR2018/21273T
Other languages
English (en)
Inventor
Linz Klaus
Zemolka Saskia
Nolte Bert
Schunk Stefan
Schick Hans
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44315152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201821273(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of TR201821273T4 publication Critical patent/TR201821273T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Cis-tetrahidrospiro(sikloheksan-1,1'-pirido[3,4-b]indol)-4-amin türevleri (I) ve bunların tuzları ve serbest bazları yenidir. Formülün (I) cis-tetrahidrospiro(sikloheksan-1,1'-pirido[3,4-b]indol)-4-amin türevleri ve bunların tuzları ve serbest bazları yenidir. R 1> : H ya da CH 3; R 2>, R 3> : H ya da halo; R 4>, R 5> : H, halo ya da O-1-3C-alkil; Q 1>-Q 2>- : -CH 2- ya da -CR 6>=CH-; veya R 6>, R 7> : H; ya da R 6>R 7> : beş üyeli bir halka. Bir bağımsız istem (I)'i kapsayan bir bileşim için dahil edilmiştir. [Image] ETKİNLİK : Analjezik; Sakinleştirici; Antidepresan; Antikonvülzan; Sinir koruyucu; Nootropik; Antialkolik; Anti bağımlılık yapıcı; Endokrin-Gen.; Kalp ve damar-Gen.; Hipertansif; Hipotansif; İşitme; Antipruritik; Gastrointestinal-Gen.; Beslenme-Bozuklukları-Gen.; Anabolik; Anorektik; Antidiyareik; Uropatik. ETKİ MEKANİZMASI: Nosiseptin reseptör bağlayıcı; mu -Opioid reseptör bağlayıcı. Nosiseptin reseptörü bağlamaya yönelik yetenek (I) radyo-bağlama tahlili kullanılarak test edildi. Sonuçlar 2',3',4',9'-tetrahidro-N,N-dimetil-4-(3-florofenil)-2'-(benzotiyofen-2 il)karbonilspiro[sikloheksan-1,1'(1'H)-pirido[3,4-b]indol]-4-aminin 16 nM'lik bir önleme sabit değerini sergilediğini gösterdi.
TR2018/21273T 2010-07-28 2011-07-27 Cis-tetrahidro-spiro(sikloheksan-1,1'-pirido [3,4-b] indol)-4-amin türevleri. TR201821273T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10007822 2010-07-28

Publications (1)

Publication Number Publication Date
TR201821273T4 true TR201821273T4 (tr) 2019-01-21

Family

ID=44315152

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/21273T TR201821273T4 (tr) 2010-07-28 2011-07-27 Cis-tetrahidro-spiro(sikloheksan-1,1'-pirido [3,4-b] indol)-4-amin türevleri.

Country Status (32)

Country Link
US (3) US20120029006A1 (tr)
EP (2) EP2598503B1 (tr)
JP (1) JP5898193B2 (tr)
KR (1) KR101927054B1 (tr)
CN (1) CN103025732B (tr)
AR (1) AR082393A1 (tr)
AU (1) AU2011285217B8 (tr)
BR (1) BR112013003642A2 (tr)
CA (1) CA2806633C (tr)
CL (1) CL2013000266A1 (tr)
CO (1) CO6650378A2 (tr)
CY (2) CY1115186T1 (tr)
DK (2) DK2740476T3 (tr)
EC (1) ECSP13012409A (tr)
ES (2) ES2474644T3 (tr)
HK (1) HK1183660A1 (tr)
HR (2) HRP20140569T1 (tr)
HU (1) HUE042732T2 (tr)
IL (1) IL223756A (tr)
LT (1) LT2740476T (tr)
MX (1) MX2013000751A (tr)
NZ (1) NZ607529A (tr)
PE (1) PE20130808A1 (tr)
PL (2) PL2740476T3 (tr)
PT (2) PT2740476T (tr)
RS (2) RS53341B (tr)
RU (1) RU2592283C2 (tr)
SI (2) SI2740476T1 (tr)
TR (1) TR201821273T4 (tr)
TW (1) TWI582092B (tr)
WO (1) WO2012013343A1 (tr)
ZA (1) ZA201301505B (tr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2970284T (pt) 2013-03-15 2018-02-08 Gruenenthal Gmbh Cis-(e)-4-(3-fluorofenil)-2',3',4',9'-tetra-hidro-n,n-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclo-hexano-1,1'[1h]-pirido[3,4-b]indol]-4-amina cristalina
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
EA034898B1 (ru) 2016-01-13 2020-04-03 Грюненталь Гмбх Производные 8-амино-2-оксо-1,3-диазаспиро[4,5]декана
TWI640514B (zh) 2016-01-13 2018-11-11 歌林達有限公司 ３－（羧甲基）－８－胺基－２－側氧基－１，３－二氮－螺－［４．５］－癸烷衍生物
AU2017206908B2 (en) 2016-01-13 2020-07-09 Grünenthal GmbH 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
MX2018008644A (es) 2016-01-13 2018-11-19 Gruenenthal Gmbh Derivados de 3-((hetero)aril)-alquil-8-amino-2-oxo-1,3-diaza-espir o-[4.5]-decano.
BR112018014302B1 (pt) 2016-01-13 2023-10-17 Grünenthal GmbH Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
PL3407888T3 (pl) 2016-01-26 2021-08-30 Intra-Cellular Therapies, Inc. Związki pirydopirolochinoksaliny, ich kompozycje i zastosowania
TW201832765A (zh) * 2017-02-24 2018-09-16 德商歌林達有限公司 膀胱內投藥用於治療膀胱痛之組合物
TW201908295A (zh) 2017-07-12 2019-03-01 德商歌林達有限公司 １，３－二氮雜－螺－［３．４］－辛烷衍生物
JP2019073493A (ja) * 2017-10-17 2019-05-16 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヴルヴォディニアの治療
WO2020030777A1 (en) 2018-08-10 2020-02-13 Grünenthal GmbH Composition for treating urinary frequency and/or urinary urgency
MX2021011986A (es) * 2019-04-04 2021-11-03 Intra Cellular Therapies Inc Metodos de tratamiento de dolor neuropatico.
MX2022007994A (es) 2019-12-26 2022-09-23 Gilgamesh Pharmaceuticals Inc Derivados de arilciclohexilamina y su uso en el tratamiento de trastornos psiquiátricos.
RU2725197C1 (ru) * 2020-02-12 2020-06-30 федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации Метод оценки висцеральной гиперчувствительности
CA3172046A1 (en) 2020-02-18 2021-08-26 Gilgamesh Pharmaceuticals, Inc. Specific tryptamines for use in the treatment of mood disorders

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10323172A1 (de) 2003-05-22 2004-12-09 Ina-Schaeffler Kg Treiberstufe für ein Solenoidventil
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360793A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102004019502A1 (de) 2004-04-22 2005-11-17 Rheinmetall Landsysteme Gmbh Munitionsmagazin
DE102004039382A1 (de) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US8425881B2 (en) 2005-03-18 2013-04-23 Colgate-Palmolive Company Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
EP1869344A2 (en) 2005-04-12 2007-12-26 The Ohio State University All wheel drive electrically-variable transmission
WO2007112490A1 (en) 2006-03-30 2007-10-11 Innovative Dairy Products Pty Ltd As Trustee For The Participants Of The Cooperative Research Centre For Innovative Dairy Products Chromosomal blocks as markers for traits
WO2007117173A1 (en) 2006-04-07 2007-10-18 Closed Joint Stock Company 'biocad' Fluid dispensing system, methods and products
DE102006019597A1 (de) * 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de) 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
WO2008100941A2 (en) 2007-02-12 2008-08-21 Correlogic Systems Inc. A method for calibrating an analytical instrument
CL2009000731A1 (es) * 2008-03-27 2009-05-15 Gruenenthal Gmbh Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea.
PT2970284T (pt) * 2013-03-15 2018-02-08 Gruenenthal Gmbh Cis-(e)-4-(3-fluorofenil)-2',3',4',9'-tetra-hidro-n,n-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclo-hexano-1,1'[1h]-pirido[3,4-b]indol]-4-amina cristalina

Also Published As

Publication number Publication date
CY1115186T1 (el) 2017-01-04
CN103025732B (zh) 2016-06-01
LT2740476T (lt) 2018-12-27
CY1120993T1 (el) 2019-12-11
CO6650378A2 (es) 2013-04-15
CN103025732A (zh) 2013-04-03
RU2592283C2 (ru) 2016-07-20
PL2598503T3 (pl) 2014-08-29
AU2011285217B8 (en) 2014-04-24
US20120029006A1 (en) 2012-02-02
HK1183660A1 (en) 2014-01-03
BR112013003642A2 (pt) 2016-09-06
DK2598503T3 (da) 2014-04-14
PT2598503E (pt) 2014-05-06
HUE042732T2 (hu) 2019-07-29
KR101927054B1 (ko) 2018-12-10
EP2740476A1 (de) 2014-06-11
JP5898193B2 (ja) 2016-04-06
RS58036B1 (sr) 2019-02-28
HRP20182078T1 (hr) 2019-02-08
US20160159787A1 (en) 2016-06-09
AU2011285217A8 (en) 2014-04-24
EP2598503B1 (de) 2014-03-26
RS53341B (en) 2014-10-31
WO2012013343A1 (de) 2012-02-02
US20170313703A1 (en) 2017-11-02
CA2806633A1 (en) 2012-02-02
ZA201301505B (en) 2014-08-27
JP2013532669A (ja) 2013-08-19
CA2806633C (en) 2019-08-20
CL2013000266A1 (es) 2013-05-24
AR082393A1 (es) 2012-12-05
MX2013000751A (es) 2013-01-29
PE20130808A1 (es) 2013-07-06
PT2740476T (pt) 2019-03-18
TW201204724A (en) 2012-02-01
ECSP13012409A (es) 2013-06-28
DK2740476T3 (en) 2019-01-14
EP2598503A1 (de) 2013-06-05
ES2708930T3 (es) 2019-04-12
ES2474644T3 (es) 2014-07-09
AU2011285217B2 (en) 2014-04-10
EP2740476B1 (de) 2018-12-05
PL2740476T3 (pl) 2019-06-28
SI2598503T1 (sl) 2014-05-30
HRP20140569T1 (hr) 2014-08-15
AU2011285217A1 (en) 2013-03-14
RU2013108696A (ru) 2014-09-10
SI2740476T1 (sl) 2019-02-28
IL223756A (en) 2015-06-30
KR20130098315A (ko) 2013-09-04
NZ607529A (en) 2014-05-30
TWI582092B (zh) 2017-05-11

Similar Documents

Publication Publication Date Title
TR201821273T4 (tr) Cis-tetrahidro-spiro(sikloheksan-1,1'-pirido [3,4-b] indol)-4-amin türevleri.
SI1910381T1 (sl) Substituirane spojine 1-oksa-3,8-diazaspiro(4,5)-dekan-2-on in njihova uporaba za pripravo zdravil
MY160665A (en) Spiropiperidine compounds as orl-1 receptor antagonists
UA100400C2 (uk) Похідні спіроциклічних амідів
EA201290355A1 (ru) Спиропиперидиновые соединения в качестве антагонистов рецептора orl-1
UY31727A (es) Derivados polisustituidos de 2-aril-6-fenil-imidazo[1,2-a]piridinas, su preparación y su aplicación en terapéutica
EA200901253A1 (ru) ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
AU2011234398A8 (en) Novel NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
EA201390766A1 (ru) БЕНЗОКСАЗЕПИНЫ КАК ИНГИБИТОРЫ PI3K/mTOR И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ И ПОЛУЧЕНИЯ
NO20081250L (no) Kombinasjon av hypnotisk middel med langtidsvirkning og hypnotisk middel med korttidsvirkning, samt terapeutisk anvendelse av samme
EA200970207A1 (ru) Соединения пиридо[2,3-d]пиримидинона и их применение в качестве pi3 ингибиторов
BR112013014854A2 (pt) compostos de n-(1h-indazol-4-il)midazo [1,2-a] piridina-3-carboxamida substituídos como inibidores de tirosina quinase de receptor tipo iii
CL2009000161A1 (es) Compuestos derivados de 2,3,4,5-tetrahidro-1h-pirido[4,3-b]indol; composicion farmaceutica que los comprende; uso en el tratamiento de trastornos neurodegenerativos, cognitivos o psicoticos, enfermedad de alzheimer, entre otros; y un kit que contiene a los compuestos.
ECSP066856A (es) Compuestos novedosos como moduladores del receptor opioide
GEP20146124B (en) Novel ccr2 receptor antagonists and usage thereof
UA94600C2 (en) Indole sulfonamide modulators of progesterone receptors
MY156552A (en) Isoxazole derivatives and their use as metabotropic glutamate receptor potentiators
MX2010009955A (es) Derivados de ciclohexano espirociclicos sustituidos.
UA107334C2 (ru) Производные аминоэфиров алкалоидов и их лекарственные композиции
UY31604A1 (es) Compuestos tricíclicos y uso de los mismos
UY29798A1 (es) Derivados de carboxamida como antagonistas del receptor muscarínico
PE20110207A1 (es) Tetrahidrocinolinas como inhibidores de la 11-beta-hsd1 para la diabetes
WO2007143468A3 (en) Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
MX2010010337A (es) Derivados de espiro(5.5)undecano.
TNSN07015A1 (en) Kynurenic acid amide derivatives as nr2b receptor antagonists