CL2013000266A1 - Compuestos derivados de cis-tetrahidroespiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4-amina; combinacion y formulacion farmaceutica; y uso en el tratamiento del dolor neuropatico y/o cronico. - Google Patents

Compuestos derivados de cis-tetrahidroespiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4-amina; combinacion y formulacion farmaceutica; y uso en el tratamiento del dolor neuropatico y/o cronico.

Info

Publication number
CL2013000266A1
CL2013000266A1 CL2013000266A CL2013000266A CL2013000266A1 CL 2013000266 A1 CL2013000266 A1 CL 2013000266A1 CL 2013000266 A CL2013000266 A CL 2013000266A CL 2013000266 A CL2013000266 A CL 2013000266A CL 2013000266 A1 CL2013000266 A1 CL 2013000266A1
Authority
CL
Chile
Prior art keywords
tetrahydrospiro
cyclohexan
pyrido
neuropathic
indole
Prior art date
Application number
CL2013000266A
Other languages
English (en)
Inventor
Klaus Linz
Saskia Zemolka
Nolte Bert
Stefan Schunk
Hans Schick
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44315152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2013000266(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of CL2013000266A1 publication Critical patent/CL2013000266A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos derivados de cis-tetrahidroespiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4-amina; combinación y formulación farmacéutica; y uso en el tratamiento del dolor neuropático y/o crónico.
CL2013000266A 2010-07-28 2013-01-28 Compuestos derivados de cis-tetrahidroespiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4-amina; combinacion y formulacion farmaceutica; y uso en el tratamiento del dolor neuropatico y/o cronico. CL2013000266A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10007822 2010-07-28

Publications (1)

Publication Number Publication Date
CL2013000266A1 true CL2013000266A1 (es) 2013-05-24

Family

ID=44315152

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013000266A CL2013000266A1 (es) 2010-07-28 2013-01-28 Compuestos derivados de cis-tetrahidroespiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4-amina; combinacion y formulacion farmaceutica; y uso en el tratamiento del dolor neuropatico y/o cronico.

Country Status (32)

Country Link
US (3) US20120029006A1 (es)
EP (2) EP2598503B1 (es)
JP (1) JP5898193B2 (es)
KR (1) KR101927054B1 (es)
CN (1) CN103025732B (es)
AR (1) AR082393A1 (es)
AU (1) AU2011285217B8 (es)
BR (1) BR112013003642A2 (es)
CA (1) CA2806633C (es)
CL (1) CL2013000266A1 (es)
CO (1) CO6650378A2 (es)
CY (2) CY1115186T1 (es)
DK (2) DK2598503T3 (es)
EC (1) ECSP13012409A (es)
ES (2) ES2474644T3 (es)
HK (1) HK1183660A1 (es)
HR (2) HRP20140569T1 (es)
HU (1) HUE042732T2 (es)
IL (1) IL223756A (es)
LT (1) LT2740476T (es)
MX (1) MX2013000751A (es)
NZ (1) NZ607529A (es)
PE (1) PE20130808A1 (es)
PL (2) PL2598503T3 (es)
PT (2) PT2598503E (es)
RS (2) RS53341B (es)
RU (1) RU2592283C2 (es)
SI (2) SI2740476T1 (es)
TR (1) TR201821273T4 (es)
TW (1) TWI582092B (es)
WO (1) WO2012013343A1 (es)
ZA (1) ZA201301505B (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10793556B2 (en) 2016-01-13 2020-10-06 Gruenenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10807989B2 (en) 2016-01-13 2020-10-20 Grünenthal GmbH 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10807988B2 (en) 2016-01-13 2020-10-20 Grünenthal GmbH 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10829480B2 (en) 2016-01-13 2020-11-10 Gruenenthal Gmbh 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2970284T3 (pl) 2013-03-15 2018-03-30 Grünenthal GmbH Krystaliczna cis-(E)-4-(3-fluorofenylo)-2',3',4',9'-tetrahydro-N,N-dimetylo-2'-(1-okso-3-fenylo-2-propenylo)-spiro[cykloheksano-1,1'[1H]-pirydo[3,4-b]indolo]-4-amina
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
WO2017121646A1 (en) 2016-01-13 2017-07-20 Grünenthal GmbH 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
BR112018015283B1 (pt) 2016-01-26 2023-09-26 Intra-Cellular Therapies, Inc Compostos orgânicos, composição farmacêutica compreendendo os ditos compostos e uso dos mesmos para o tratamento ou profilaxia de um distúrbio do sistema nervoso central
TW201832765A (zh) 2017-02-24 2018-09-16 德商歌林達有限公司 膀胱內投藥用於治療膀胱痛之組合物
TW201908295A (zh) 2017-07-12 2019-03-01 德商歌林達有限公司 １，３－二氮雜－螺－［３．４］－辛烷衍生物
JP2019073493A (ja) * 2017-10-17 2019-05-16 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヴルヴォディニアの治療
WO2020030777A1 (en) 2018-08-10 2020-02-13 Grünenthal GmbH Composition for treating urinary frequency and/or urinary urgency
JP2022526596A (ja) * 2019-04-04 2022-05-25 イントラ－セルラー・セラピーズ・インコーポレイテッド 神経障害性疼痛の治療方法
KR20220131520A (ko) 2019-12-26 2022-09-28 길가메쉬 파마슈티컬스, 인코포레이티드 아릴시클로헥실아민 유도체 및 정신장애 치료에서의 이의 용도
RU2725197C1 (ru) * 2020-02-12 2020-06-30 федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации Метод оценки висцеральной гиперчувствительности
MX2022010082A (es) 2020-02-18 2022-11-14 Gilgamesh Pharmaceuticals Inc Triptaminas especificas para usarse en el tratamiento de trastornos de estado de animo.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10323172A1 (de) 2003-05-22 2004-12-09 Ina-Schaeffler Kg Treiberstufe für ein Solenoidventil
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360793A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102004019502A1 (de) 2004-04-22 2005-11-17 Rheinmetall Landsysteme Gmbh Munitionsmagazin
DE102004039382A1 (de) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US8425881B2 (en) 2005-03-18 2013-04-23 Colgate-Palmolive Company Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods
DE102005016460A1 (de) 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
JP4819878B2 (ja) 2005-04-12 2011-11-24 ジ・オハイオ・ステート・ユニバーシティ 全輪駆動用の電気的に可変なトランスミッション
WO2007112490A1 (en) 2006-03-30 2007-10-11 Innovative Dairy Products Pty Ltd As Trustee For The Participants Of The Cooperative Research Centre For Innovative Dairy Products Chromosomal blocks as markers for traits
WO2007117173A1 (en) 2006-04-07 2007-10-18 Closed Joint Stock Company 'biocad' Fluid dispensing system, methods and products
DE102006019597A1 (de) * 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de) 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
US20080201095A1 (en) 2007-02-12 2008-08-21 Yip Ping F Method for Calibrating an Analytical Instrument
DK2260042T3 (da) * 2008-03-27 2011-10-31 Gruenenthal Gmbh Substituerede spirocykliske cyklohexan-derivater
PL2970284T3 (pl) * 2013-03-15 2018-03-30 Grünenthal GmbH Krystaliczna cis-(E)-4-(3-fluorofenylo)-2',3',4',9'-tetrahydro-N,N-dimetylo-2'-(1-okso-3-fenylo-2-propenylo)-spiro[cykloheksano-1,1'[1H]-pirydo[3,4-b]indolo]-4-amina

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10793556B2 (en) 2016-01-13 2020-10-06 Gruenenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10807989B2 (en) 2016-01-13 2020-10-20 Grünenthal GmbH 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10807988B2 (en) 2016-01-13 2020-10-20 Grünenthal GmbH 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10829480B2 (en) 2016-01-13 2020-11-10 Gruenenthal Gmbh 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives

Also Published As

Publication number Publication date
CN103025732B (zh) 2016-06-01
ES2474644T3 (es) 2014-07-09
HRP20140569T1 (hr) 2014-08-15
TW201204724A (en) 2012-02-01
PL2740476T3 (pl) 2019-06-28
RU2013108696A (ru) 2014-09-10
TR201821273T4 (tr) 2019-01-21
EP2740476A1 (de) 2014-06-11
BR112013003642A2 (pt) 2016-09-06
SI2598503T1 (sl) 2014-05-30
CN103025732A (zh) 2013-04-03
RU2592283C2 (ru) 2016-07-20
AR082393A1 (es) 2012-12-05
HRP20182078T1 (hr) 2019-02-08
AU2011285217B8 (en) 2014-04-24
NZ607529A (en) 2014-05-30
AU2011285217A8 (en) 2014-04-24
ES2708930T3 (es) 2019-04-12
DK2598503T3 (da) 2014-04-14
HK1183660A1 (en) 2014-01-03
ZA201301505B (en) 2014-08-27
WO2012013343A1 (de) 2012-02-02
JP2013532669A (ja) 2013-08-19
AU2011285217B2 (en) 2014-04-10
KR20130098315A (ko) 2013-09-04
EP2740476B1 (de) 2018-12-05
PT2598503E (pt) 2014-05-06
CA2806633A1 (en) 2012-02-02
SI2740476T1 (sl) 2019-02-28
LT2740476T (lt) 2018-12-27
IL223756A (en) 2015-06-30
ECSP13012409A (es) 2013-06-28
US20160159787A1 (en) 2016-06-09
JP5898193B2 (ja) 2016-04-06
EP2598503A1 (de) 2013-06-05
US20170313703A1 (en) 2017-11-02
HUE042732T2 (hu) 2019-07-29
RS53341B (en) 2014-10-31
CO6650378A2 (es) 2013-04-15
TWI582092B (zh) 2017-05-11
KR101927054B1 (ko) 2018-12-10
DK2740476T3 (en) 2019-01-14
AU2011285217A1 (en) 2013-03-14
CY1120993T1 (el) 2019-12-11
US20120029006A1 (en) 2012-02-02
MX2013000751A (es) 2013-01-29
EP2598503B1 (de) 2014-03-26
PL2598503T3 (pl) 2014-08-29
PE20130808A1 (es) 2013-07-06
RS58036B1 (sr) 2019-02-28
PT2740476T (pt) 2019-03-18
CY1115186T1 (el) 2017-01-04
CA2806633C (en) 2019-08-20

Similar Documents

Publication Publication Date Title
CL2013000266A1 (es) Compuestos derivados de cis-tetrahidroespiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4-amina; combinacion y formulacion farmaceutica; y uso en el tratamiento del dolor neuropatico y/o cronico.
CL2013000016A1 (es) Compuestos derivados de imidazopiridina; procedimiento de preparacion; composicion farmaceutica y su uso en el tratamiento del cancer.
CL2008001540A1 (es) Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer.
CL2013000018A1 (es) Compuestos derivados de indolizina , su procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento del cancer, entre otros.
CL2016001629A1 (es) Compuestos tricíclicos como agentes anticancerígenos
UA122868C2 (uk) Тетрагідропіридо[3,4-в]індолові модулятори естрогенових рецепторів та їх застосування
CL2009000447A1 (es) Compuestos derivados de (1h-pirrolo{2,3-b}piridin-5-il)-sulfonamido-benzamida sustituida; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento del cancer, a travez de la inhibicion de raf.
CL2009000448A1 (es) Compuestos derivados de 3-sulfonilamino-n-(1h-pirazolo-[3,4-b]piridin-5il)benzamida; procesos de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento del cancer, tal como sarcoma, carcinoma, adenoma, entre otros.
CL2008001373A1 (es) Compuestos derivados de fenilamino-benceno sustituidos; metodo de preparacion; composicion farmaceutica; kit farmceuticos; y uso de dichos compuestos en el tratamiento del cancer.
CR20110596A (es) Composiciones sublinguales de dexmedetomidina y métodos de uso de ellas
CL2012003026A1 (es) Composicion farmaceutica que comprende pioglitazona y linagliptina; procedimiento de preparacion; uso en el tratamiento de la diabetes tipo 2 o la obesidad.
CL2008001114A1 (es) Compuestos derivados de bencimidazol; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como vejiga sobreactiva, dolor, obesidad, convulsiones, entre otras.
CL2008001745A1 (es) Compuestos derivados de imidazo[1,2-a]pirazina; composición farmacéutica; y uso de los compuestos como inhibidores de la proteína quinasa en el tratamiento del cáncer.
CL2012000248A1 (es) Compuesto conjugado de insulina; procedimiento de preparacion; composicion farmaceutica que lo comprende; combinacion farmaceutica; kit farmaceutico; uso en el tratamiento de trastornos mediados por insulina.
PH12015501955B1 (en) Heterocyclic compounds and use thereof as modulators of type iii receptor tyrosine kinases
CL2011000116A1 (es) Compuestos derivados de imidazo[1,2-a]piridina; procedimiento de preparacion; composicion farmaceutica; compuestos intermediarios; y uso en el tratamiento del cancer.
CL2012000772A1 (es) Compuestos derivados de hetorociclos carboxamidicos sustituidos, antagonista ar; composición farmacéutica que los comprende; y uso en el tratamiento del cáncer de próstata.
CL2012003048A1 (es) Compuestos derivados de n-fenil-3-(1h-pirazol-4-il)quinoxalin-6-amina, inhibidores de tirosino quinasa fgfr; proceso de preparación; composición farmacéutica; y su uso en la prevención o tratamiento de cáncer.
CL2012000163A1 (es) Compuestos derivados de quinazolina o pirido[2,3-d]pirimidina, inhibidores de la autofagia; composicion farmaceutica; y su uso para el tratamiento del cancer, pancreatitis, neurodegeneracion, entre otras.
CL2014002557A1 (es) Compuestos bicíclicos de pirazinona; procedimiento de preparacion; composicion farmaceutica; kit; y uso en el tratamiento y/o prevencion de enfermedades cardiovasculares, cancer, entre otras.
CL2009000119A1 (es) Compuestos derivados de amino-bencimidazoles sustituidos; composicion farmaceutica; y su uso en el tratamiento del alzheimer.
CL2015002897A1 (es) Inhibidores de bace1
CL2011000119A1 (es) Compuestos derivados de triazolo[4,3-a]piridina; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer.
CL2014001959A1 (es) Compuestos derivados de fenil-1h-imidazo[1,2-b]pirazol sustituidos; procedimiento de preparacion; composicion farmaceutica; y el uso en el tratamiento del cancer.
CL2011000168A1 (es) Compuestos derivados de narciclasina y pancratistatina; procedimiento de preparación; composición farmacéutica; combinación farmacéutica; y su uso para el tratamiento del cáncer.