PE20120544A1 - Derivados nuevos de tipo amida de compuestos de [3,2-c]pirazol esteroideos con actividad glucocorticoide - Google Patents
Derivados nuevos de tipo amida de compuestos de [3,2-c]pirazol esteroideos con actividad glucocorticoideInfo
- Publication number
- PE20120544A1 PE20120544A1 PE2011001757A PE2011001757A PE20120544A1 PE 20120544 A1 PE20120544 A1 PE 20120544A1 PE 2011001757 A PE2011001757 A PE 2011001757A PE 2011001757 A PE2011001757 A PE 2011001757A PE 20120544 A1 PE20120544 A1 PE 20120544A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- pirazole
- carbonyl
- halogen
- alkyl
- Prior art date
Links
- -1 STEROID COMPOUNDS Chemical class 0.000 title abstract 3
- 239000003862 glucocorticoid Substances 0.000 title abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 4
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 2
- 201000002661 Spondylitis Diseases 0.000 abstract 1
- 101000977048 Streptomyces cinnamonensis Uncharacterized protein in mutB 3'region Proteins 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical group F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16632409P | 2009-04-03 | 2009-04-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20120544A1 true PE20120544A1 (es) | 2012-06-03 |
Family
ID=42826696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011001757A PE20120544A1 (es) | 2009-04-03 | 2010-03-31 | Derivados nuevos de tipo amida de compuestos de [3,2-c]pirazol esteroideos con actividad glucocorticoide |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20100256104A1 (https=) |
| EP (1) | EP2414375A4 (https=) |
| JP (1) | JP2012522766A (https=) |
| KR (1) | KR20120034608A (https=) |
| CN (1) | CN102459306A (https=) |
| AR (1) | AR076176A1 (https=) |
| AU (1) | AU2010231954B2 (https=) |
| CA (1) | CA2757423A1 (https=) |
| CL (1) | CL2011002461A1 (https=) |
| CO (1) | CO6501167A2 (https=) |
| CR (1) | CR20110518A (https=) |
| CU (1) | CU20110186A7 (https=) |
| DO (1) | DOP2011000305A (https=) |
| EA (1) | EA201190234A1 (https=) |
| EC (1) | ECSP11011368A (https=) |
| IL (1) | IL215342A0 (https=) |
| MX (1) | MX2011010263A (https=) |
| NI (1) | NI201100177A (https=) |
| PE (1) | PE20120544A1 (https=) |
| SG (1) | SG174506A1 (https=) |
| TW (1) | TW201040196A (https=) |
| UY (1) | UY32525A (https=) |
| WO (1) | WO2010114471A1 (https=) |
| ZA (1) | ZA201108050B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201000436A1 (ru) * | 2007-10-04 | 2010-10-29 | Астразенека Аб | Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью |
| JP2011507836A (ja) * | 2007-12-20 | 2011-03-10 | アストラゼネカ・アクチエボラーグ | グルココルチコステロイド受容体アゴニストとして作用するステロイド誘導体 |
| UY32520A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
| UY32523A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| EP2723718A1 (en) | 2011-06-24 | 2014-04-30 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| JP2014527511A (ja) | 2011-06-24 | 2014-10-16 | アムジエン・インコーポレーテツド | Ｔｒｐｍ８拮抗剤及び治療におけるそれらの使用 |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| JP2016531852A (ja) * | 2013-09-25 | 2016-10-13 | ヴァン アンデル リサーチ インスティテュート | 非常に強力なグルココルチコイド |
| EP3525870B1 (en) * | 2016-10-14 | 2023-05-10 | Van Andel Research Institute | Highly potent glucocorticoids |
| WO2024159212A1 (en) * | 2023-01-27 | 2024-08-02 | University Of South Florida | Compositions and methods of treating respiratory syncytial virus |
| CN117024499A (zh) * | 2023-07-17 | 2023-11-10 | 陕西汉江药业集团股份有限公司 | 在2位引入亚甲基羟基的甾体化合物制备方法 |
| WO2025119398A1 (zh) * | 2023-12-08 | 2025-06-12 | 浙江柏拉阿图医药科技有限公司 | 高效力糖皮质激素多晶型及其制备方法和用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3129218A (en) * | 1961-11-01 | 1964-04-14 | Merck & Co Inc | 2-alkoxymethylene steroids of the androstane and pregnane series |
| US3072639A (en) * | 1962-03-05 | 1963-01-08 | Merck & Co Inc | 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them |
| US3364203A (en) * | 1965-09-09 | 1968-01-16 | Syntex Corp | 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation |
| US3471477A (en) * | 1967-10-18 | 1969-10-07 | Syntex Corp | 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids |
| DE2727367A1 (de) * | 1977-06-14 | 1979-01-04 | Schering Ag | Neue kortikoide |
| DE2735110A1 (de) * | 1977-08-04 | 1979-02-15 | Hoechst Ag | Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung |
| DE2817988A1 (de) * | 1978-04-25 | 1979-11-08 | Hoechst Ag | Corticoid 17-alkylcarbonate und verfahren zu deren herstellung |
| SE8306370D0 (sv) * | 1983-11-18 | 1983-11-18 | Draco Ab | Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions |
| KR100831534B1 (ko) * | 2001-04-30 | 2008-05-22 | 글락소 그룹 리미티드 | 17.알파 위치에 시클릭 에스테르기를 지닌 항염증성의안드로스탄의 17.베타.-카르보티오에이트 에스테르 유도체 |
| GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
| EA201000436A1 (ru) * | 2007-10-04 | 2010-10-29 | Астразенека Аб | Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью |
| UY32520A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
| UY32521A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Combinación para emplear en el tratamiento de enfermedades respiratorias |
-
2010
- 2010-03-26 UY UY0001032525A patent/UY32525A/es not_active Application Discontinuation
- 2010-03-30 US US12/749,903 patent/US20100256104A1/en not_active Abandoned
- 2010-03-31 AR ARP100101088A patent/AR076176A1/es unknown
- 2010-03-31 AU AU2010231954A patent/AU2010231954B2/en not_active Ceased
- 2010-03-31 EA EA201190234A patent/EA201190234A1/ru unknown
- 2010-03-31 MX MX2011010263A patent/MX2011010263A/es not_active Application Discontinuation
- 2010-03-31 JP JP2012503371A patent/JP2012522766A/ja active Pending
- 2010-03-31 KR KR1020117026112A patent/KR20120034608A/ko not_active Withdrawn
- 2010-03-31 CA CA2757423A patent/CA2757423A1/en not_active Abandoned
- 2010-03-31 CN CN2010800248242A patent/CN102459306A/zh active Pending
- 2010-03-31 SG SG2011068327A patent/SG174506A1/en unknown
- 2010-03-31 WO PCT/SE2010/050354 patent/WO2010114471A1/en not_active Ceased
- 2010-03-31 PE PE2011001757A patent/PE20120544A1/es not_active Application Discontinuation
- 2010-03-31 EP EP10759125A patent/EP2414375A4/en not_active Withdrawn
- 2010-04-02 TW TW099110330A patent/TW201040196A/zh unknown
-
2011
- 2011-09-22 IL IL215342A patent/IL215342A0/en unknown
- 2011-09-30 CO CO11129266A patent/CO6501167A2/es not_active Application Discontinuation
- 2011-10-03 CL CL2011002461A patent/CL2011002461A1/es unknown
- 2011-10-03 EC EC2011011368A patent/ECSP11011368A/es unknown
- 2011-10-03 DO DO2011000305A patent/DOP2011000305A/es unknown
- 2011-10-03 NI NI201100177A patent/NI201100177A/es unknown
- 2011-10-03 CU CU20110186A patent/CU20110186A7/es unknown
- 2011-10-03 CR CR20110518A patent/CR20110518A/es unknown
- 2011-11-02 ZA ZA2011/08050A patent/ZA201108050B/en unknown
-
2013
- 2013-04-17 US US13/864,644 patent/US20130237507A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2757423A1 (en) | 2010-10-07 |
| AU2010231954A1 (en) | 2011-10-27 |
| EA201190234A1 (ru) | 2012-04-30 |
| CN102459306A (zh) | 2012-05-16 |
| US20100256104A1 (en) | 2010-10-07 |
| SG174506A1 (en) | 2011-10-28 |
| KR20120034608A (ko) | 2012-04-12 |
| EP2414375A1 (en) | 2012-02-08 |
| IL215342A0 (en) | 2011-12-29 |
| CU20110186A7 (es) | 2012-02-15 |
| AR076176A1 (es) | 2011-05-26 |
| ZA201108050B (en) | 2014-04-30 |
| WO2010114471A1 (en) | 2010-10-07 |
| JP2012522766A (ja) | 2012-09-27 |
| CR20110518A (es) | 2011-11-07 |
| CO6501167A2 (es) | 2012-08-15 |
| ECSP11011368A (es) | 2011-11-30 |
| AU2010231954B2 (en) | 2012-11-15 |
| MX2011010263A (es) | 2011-10-11 |
| CL2011002461A1 (es) | 2012-04-09 |
| DOP2011000305A (es) | 2012-05-31 |
| EP2414375A4 (en) | 2012-09-19 |
| UY32525A (es) | 2010-10-29 |
| TW201040196A (en) | 2010-11-16 |
| NI201100177A (es) | 2012-06-14 |
| US20130237507A1 (en) | 2013-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |